Rudhira/BCAS3 is essential for mouse development and cardiovascular patterning View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-04-04

AUTHORS

Ronak Shetty, Divyesh Joshi, Mamta Jain, Madavan Vasudevan, Jasper Chrysolite Paul, Ganesh Bhat, Poulomi Banerjee, Takaya Abe, Hiroshi Kiyonari, K. VijayRaghavan, Maneesha S. Inamdar

ABSTRACT

Rudhira/Breast Carcinoma Amplified Sequence 3 (BCAS3) is a cytoskeletal protein that promotes directional cell migration and angiogenesis in vitro and is implicated in human carcinomas and coronary artery disease. To study the role of Rudhira during development in vivo, we generated the first knockout mouse for rudhira and show that Rudhira is essential for mouse development. Rudhira null embryos die at embryonic day (E) 9.5 accompanied by severe vascular patterning defects in embryonic and extra-embryonic tissues. To identify the molecular processes downstream of rudhira, we analyzed the transcriptome of intact knockout yolk sacs. Genome-wide transcriptome analysis showed that Rudhira functions in angiogenesis and its related processes such as cell adhesion, extracellular matrix organization, peptidase activity and TGFβ signaling. Since Rudhira is also expressed in endothelial cells (ECs), we further generated Tie2Cre-mediated endothelial knockout (CKO) of rudhira. CKO embryos survive to E11.5 and similar to the global knockout, display gross vascular patterning defects, showing that endothelial Rudhira is vital for development. Further, Rudhira knockdown ECs in culture fail to sprout in a spheroid-sprouting assay, strongly supporting its role in vascular patterning. Our study identifies an essential role for Rudhira in blood vessel remodeling and provides a mouse model for cardiovascular development. More... »

PAGES

5632

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41598-018-24014-w

DOI

http://dx.doi.org/10.1038/s41598-018-24014-w

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1101862188

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29618843


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