Activation of Eosinophils and Mast Cells in Functional Dyspepsia: an Ultrastructural Evaluation View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-12

AUTHORS

Hanne Vanheel, Maria Vicario, Werend Boesmans, Tim Vanuytsel, Eloisa Salvo-Romero, Jan Tack, Ricard Farré

ABSTRACT

We recently identified mucosal mast cell and eosinophil hyperplasia in association with a duodenal impaired barrier function in functional dyspepsia (FD). We aimed to further describe the implication of these immune cells by assessing their activation state at the ultrastructural level and by evaluating the association between impaired epithelial integrity and immune activation. Duodenal biopsies were obtained from 24 FD patients and 37 healthy controls. The ultrastructure of mast cells and eosinophils was analyzed by transmission electron microscopy. Transepithelial electrical resistance and paracellular permeability were measured to evaluate epithelial barrier function. The type of degranulation in eosinophils and mast cells was piecemeal. Eosinophils displayed higher degree of degranulation in FD patients than in controls (p < 0.0001). Quantification revealed a decreased granular density in eosinophils of FD patients (p < 0.0001). The degree of degranulation in mast cells was similar in both groups. However, a more heterogeneous profile was found in the FD group (p < 0.0001). No association between epithelial integrity and the number and activation state of mucosal eosinophils and mast cells was found. We demonstrated ultrastructural changes in degranulation state of eosinophils and mast cells, suggesting that eosinophil and mast cell activation play a role in the pathophysiology of FD. More... »

PAGES

5383

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41598-018-23620-y

DOI

http://dx.doi.org/10.1038/s41598-018-23620-y

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1101832511

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29599471


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Immunology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "KU Leuven", 
          "id": "https://www.grid.ac/institutes/grid.5596.f", 
          "name": [
            "Translational Research Center for Gastrointestinal Disorders (TARGID), KU Leuven, Leuven, Belgium"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Vanheel", 
        "givenName": "Hanne", 
        "id": "sg:person.0650071724.42", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0650071724.42"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas", 
          "id": "https://www.grid.ac/institutes/grid.452371.6", 
          "name": [
            "Digestive Diseases Research Unit, Institut de Recerca Vall d\u2019Hebron, Department of Gastroenterology, Hospital Universitari Vall d\u2019Hebron, Universitat Aut\u00f2noma de Barcelona, Barcelona, Spain", 
            "Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd), Barcelona, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Vicario", 
        "givenName": "Maria", 
        "id": "sg:person.01167664073.52", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01167664073.52"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Maastricht University Medical Centre", 
          "id": "https://www.grid.ac/institutes/grid.412966.e", 
          "name": [
            "Translational Research Center for Gastrointestinal Disorders (TARGID), KU Leuven, Leuven, Belgium", 
            "Department of Pathology, GROW-School for Oncology and Developmental Biology, Maastricht University Medical Center, Maastricht, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Boesmans", 
        "givenName": "Werend", 
        "id": "sg:person.01237411655.42", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01237411655.42"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "KU Leuven", 
          "id": "https://www.grid.ac/institutes/grid.5596.f", 
          "name": [
            "Translational Research Center for Gastrointestinal Disorders (TARGID), KU Leuven, Leuven, Belgium"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Vanuytsel", 
        "givenName": "Tim", 
        "id": "sg:person.01167103032.18", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01167103032.18"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Digestive Diseases Research Unit, Institut de Recerca Vall d\u2019Hebron, Department of Gastroenterology, Hospital Universitari Vall d\u2019Hebron, Universitat Aut\u00f2noma de Barcelona, Barcelona, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Salvo-Romero", 
        "givenName": "Eloisa", 
        "id": "sg:person.0740076567.79", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0740076567.79"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "KU Leuven", 
          "id": "https://www.grid.ac/institutes/grid.5596.f", 
          "name": [
            "Translational Research Center for Gastrointestinal Disorders (TARGID), KU Leuven, Leuven, Belgium"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tack", 
        "givenName": "Jan", 
        "id": "sg:person.01211761755.17", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01211761755.17"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas", 
          "id": "https://www.grid.ac/institutes/grid.452371.6", 
          "name": [
            "Translational Research Center for Gastrointestinal Disorders (TARGID), KU Leuven, Leuven, Belgium", 
            "Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd), Barcelona, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Farr\u00e9", 
        "givenName": "Ricard", 
        "id": "sg:person.01052654432.29", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01052654432.29"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1136/gut.2008.150888", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002375762"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ajg.2010.151", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005787538", 
          "https://doi.org/10.1038/ajg.2010.151"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ajg.2010.151", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005787538", 
          "https://doi.org/10.1038/ajg.2010.151"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/gutjnl-2012-303857", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010931038"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2982.2009.01299.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011087463"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2982.2009.01299.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011087463"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/j.gastro.2005.11.059", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013146576"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cgh.2007.05.015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017283197"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/srep34305", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017970123", 
          "https://doi.org/10.1038/srep34305"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2982.2007.00988.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021401886"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000058790", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021865037"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2982.2008.01097.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023670911"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2036.2009.03937.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027506491"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00005176-200209000-00017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029969831"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00005176-200209000-00017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029969831"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/j.gastro.2011.01.042", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031716693"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpgi.00015.2005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032223343"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpgi.00015.2005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032223343"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1189/jlb.0707503", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033983966"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/j.gastro.2016.02.011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036055701"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/gutjnl-2015-309151", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042163818"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/gut.2009.181701", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042368733"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/j.gastro.2005.04.012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046050787"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1078/0065-1281-00610", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046903922"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1078/0065-1281-00610", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046903922"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/thorax.56.5.341", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047237405"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/thorax.56.5.341", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047237405"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0123498", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048417951"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1369/jhc.5r6647.2005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049744787"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1369/jhc.5r6647.2005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049744787"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1369/jhc.5r6647.2005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049744787"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0016-5085(15)30133-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051848352"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrgastro.2012.255", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053132619", 
          "https://doi.org/10.1038/nrgastro.2012.255"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jlb.67.4.585", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074625224"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078517081", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajplung.1997.273.5.l1096", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083174288"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/jgh.13787", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084214860"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2018-12", 
    "datePublishedReg": "2018-12-01", 
    "description": "We recently identified mucosal mast cell and eosinophil hyperplasia in association with a duodenal impaired barrier function in functional dyspepsia (FD). We aimed to further describe the implication of these immune cells by assessing their activation state at the ultrastructural level and by evaluating the association between impaired epithelial integrity and immune activation. Duodenal biopsies were obtained from 24 FD patients and 37 healthy controls. The ultrastructure of mast cells and eosinophils was analyzed by transmission electron microscopy. Transepithelial electrical resistance and paracellular permeability were measured to evaluate epithelial barrier function. The type of degranulation in eosinophils and mast cells was piecemeal. Eosinophils displayed higher degree of degranulation in FD patients than in controls (p\u2009<\u20090.0001). Quantification revealed a decreased granular density in eosinophils of FD patients (p\u2009<\u20090.0001). The degree of degranulation in mast cells was similar in both groups. However, a more heterogeneous profile was found in the FD group (p\u2009<\u20090.0001). No association between epithelial integrity and the number and activation state of mucosal eosinophils and mast cells was found. We demonstrated ultrastructural changes in degranulation state of eosinophils and mast cells, suggesting that eosinophil and mast cell activation play a role in the pathophysiology of FD.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/s41598-018-23620-y", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.3723841", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1045337", 
        "issn": [
          "2045-2322"
        ], 
        "name": "Scientific Reports", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "8"
      }
    ], 
    "name": "Activation of Eosinophils and Mast Cells in Functional Dyspepsia: an Ultrastructural Evaluation", 
    "pagination": "5383", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "3b1037814638d15cfafd7dd45ea9f90a9c279fcc1459ab7666c83e2861e6d883"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "29599471"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101563288"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/s41598-018-23620-y"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1101832511"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/s41598-018-23620-y", 
      "https://app.dimensions.ai/details/publication/pub.1101832511"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T13:19", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000368_0000000368/records_78953_00000000.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/s41598-018-23620-y"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-23620-y'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-23620-y'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-23620-y'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-23620-y'


 

This table displays all metadata directly associated to this object as RDF triples.

212 TRIPLES      21 PREDICATES      58 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/s41598-018-23620-y schema:about anzsrc-for:11
2 anzsrc-for:1107
3 schema:author Nf29256e3576242459c75d8a3ec95db50
4 schema:citation sg:pub.10.1038/ajg.2010.151
5 sg:pub.10.1038/nrgastro.2012.255
6 sg:pub.10.1038/srep34305
7 https://app.dimensions.ai/details/publication/pub.1078517081
8 https://doi.org/10.1002/jlb.67.4.585
9 https://doi.org/10.1016/j.cgh.2007.05.015
10 https://doi.org/10.1016/s0016-5085(15)30133-5
11 https://doi.org/10.1053/j.gastro.2005.04.012
12 https://doi.org/10.1053/j.gastro.2005.11.059
13 https://doi.org/10.1053/j.gastro.2011.01.042
14 https://doi.org/10.1053/j.gastro.2016.02.011
15 https://doi.org/10.1078/0065-1281-00610
16 https://doi.org/10.1097/00005176-200209000-00017
17 https://doi.org/10.1111/j.1365-2036.2009.03937.x
18 https://doi.org/10.1111/j.1365-2982.2007.00988.x
19 https://doi.org/10.1111/j.1365-2982.2008.01097.x
20 https://doi.org/10.1111/j.1365-2982.2009.01299.x
21 https://doi.org/10.1111/jgh.13787
22 https://doi.org/10.1136/gut.2008.150888
23 https://doi.org/10.1136/gut.2009.181701
24 https://doi.org/10.1136/gutjnl-2012-303857
25 https://doi.org/10.1136/gutjnl-2015-309151
26 https://doi.org/10.1136/thorax.56.5.341
27 https://doi.org/10.1152/ajpgi.00015.2005
28 https://doi.org/10.1152/ajplung.1997.273.5.l1096
29 https://doi.org/10.1159/000058790
30 https://doi.org/10.1189/jlb.0707503
31 https://doi.org/10.1369/jhc.5r6647.2005
32 https://doi.org/10.1371/journal.pone.0123498
33 schema:datePublished 2018-12
34 schema:datePublishedReg 2018-12-01
35 schema:description We recently identified mucosal mast cell and eosinophil hyperplasia in association with a duodenal impaired barrier function in functional dyspepsia (FD). We aimed to further describe the implication of these immune cells by assessing their activation state at the ultrastructural level and by evaluating the association between impaired epithelial integrity and immune activation. Duodenal biopsies were obtained from 24 FD patients and 37 healthy controls. The ultrastructure of mast cells and eosinophils was analyzed by transmission electron microscopy. Transepithelial electrical resistance and paracellular permeability were measured to evaluate epithelial barrier function. The type of degranulation in eosinophils and mast cells was piecemeal. Eosinophils displayed higher degree of degranulation in FD patients than in controls (p < 0.0001). Quantification revealed a decreased granular density in eosinophils of FD patients (p < 0.0001). The degree of degranulation in mast cells was similar in both groups. However, a more heterogeneous profile was found in the FD group (p < 0.0001). No association between epithelial integrity and the number and activation state of mucosal eosinophils and mast cells was found. We demonstrated ultrastructural changes in degranulation state of eosinophils and mast cells, suggesting that eosinophil and mast cell activation play a role in the pathophysiology of FD.
36 schema:genre research_article
37 schema:inLanguage en
38 schema:isAccessibleForFree true
39 schema:isPartOf N29093b5bb4c941c98a8cb69bee2e0af8
40 Ne8ee3a4e4c444ff89fe77c4760b1525c
41 sg:journal.1045337
42 schema:name Activation of Eosinophils and Mast Cells in Functional Dyspepsia: an Ultrastructural Evaluation
43 schema:pagination 5383
44 schema:productId N2c974e0b91874850a5861cdbe7f2358b
45 N370e6a044c764c50b8f0755a00254883
46 N3970951c7e4a4e17a58727f9b8052243
47 Nd92d11f7b1c54167ae2e975e463a4f4f
48 Ndb3e521d0ff84ae594d4d25856aa779a
49 schema:sameAs https://app.dimensions.ai/details/publication/pub.1101832511
50 https://doi.org/10.1038/s41598-018-23620-y
51 schema:sdDatePublished 2019-04-11T13:19
52 schema:sdLicense https://scigraph.springernature.com/explorer/license/
53 schema:sdPublisher Nd4d1216c4a2e40189fcc6984a0eebb2d
54 schema:url https://www.nature.com/articles/s41598-018-23620-y
55 sgo:license sg:explorer/license/
56 sgo:sdDataset articles
57 rdf:type schema:ScholarlyArticle
58 N12ad28afac9b487bbe0a6202a97f9b51 rdf:first sg:person.01237411655.42
59 rdf:rest N1e5a08f16d3d4073ad1d079e7f3c26e6
60 N187a6cb5e5784df7b9fd59820bcaf120 schema:name Digestive Diseases Research Unit, Institut de Recerca Vall d’Hebron, Department of Gastroenterology, Hospital Universitari Vall d’Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain
61 rdf:type schema:Organization
62 N1e5a08f16d3d4073ad1d079e7f3c26e6 rdf:first sg:person.01167103032.18
63 rdf:rest Nec47d4a1b9464e2097df053f77fa91b9
64 N29093b5bb4c941c98a8cb69bee2e0af8 schema:issueNumber 1
65 rdf:type schema:PublicationIssue
66 N2c3c550f46e14b50a79960088f47f118 rdf:first sg:person.01211761755.17
67 rdf:rest Ne3c703bd0ddd47568d44d0cb9835bf5d
68 N2c974e0b91874850a5861cdbe7f2358b schema:name doi
69 schema:value 10.1038/s41598-018-23620-y
70 rdf:type schema:PropertyValue
71 N370e6a044c764c50b8f0755a00254883 schema:name dimensions_id
72 schema:value pub.1101832511
73 rdf:type schema:PropertyValue
74 N3970951c7e4a4e17a58727f9b8052243 schema:name pubmed_id
75 schema:value 29599471
76 rdf:type schema:PropertyValue
77 Nd4d1216c4a2e40189fcc6984a0eebb2d schema:name Springer Nature - SN SciGraph project
78 rdf:type schema:Organization
79 Nd92d11f7b1c54167ae2e975e463a4f4f schema:name nlm_unique_id
80 schema:value 101563288
81 rdf:type schema:PropertyValue
82 Ndb3e521d0ff84ae594d4d25856aa779a schema:name readcube_id
83 schema:value 3b1037814638d15cfafd7dd45ea9f90a9c279fcc1459ab7666c83e2861e6d883
84 rdf:type schema:PropertyValue
85 Ne3c703bd0ddd47568d44d0cb9835bf5d rdf:first sg:person.01052654432.29
86 rdf:rest rdf:nil
87 Ne5482610b0014ac3adf0a164a8ef29ac rdf:first sg:person.01167664073.52
88 rdf:rest N12ad28afac9b487bbe0a6202a97f9b51
89 Ne8ee3a4e4c444ff89fe77c4760b1525c schema:volumeNumber 8
90 rdf:type schema:PublicationVolume
91 Nec47d4a1b9464e2097df053f77fa91b9 rdf:first sg:person.0740076567.79
92 rdf:rest N2c3c550f46e14b50a79960088f47f118
93 Nf29256e3576242459c75d8a3ec95db50 rdf:first sg:person.0650071724.42
94 rdf:rest Ne5482610b0014ac3adf0a164a8ef29ac
95 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
96 schema:name Medical and Health Sciences
97 rdf:type schema:DefinedTerm
98 anzsrc-for:1107 schema:inDefinedTermSet anzsrc-for:
99 schema:name Immunology
100 rdf:type schema:DefinedTerm
101 sg:grant.3723841 http://pending.schema.org/fundedItem sg:pub.10.1038/s41598-018-23620-y
102 rdf:type schema:MonetaryGrant
103 sg:journal.1045337 schema:issn 2045-2322
104 schema:name Scientific Reports
105 rdf:type schema:Periodical
106 sg:person.01052654432.29 schema:affiliation https://www.grid.ac/institutes/grid.452371.6
107 schema:familyName Farré
108 schema:givenName Ricard
109 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01052654432.29
110 rdf:type schema:Person
111 sg:person.01167103032.18 schema:affiliation https://www.grid.ac/institutes/grid.5596.f
112 schema:familyName Vanuytsel
113 schema:givenName Tim
114 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01167103032.18
115 rdf:type schema:Person
116 sg:person.01167664073.52 schema:affiliation https://www.grid.ac/institutes/grid.452371.6
117 schema:familyName Vicario
118 schema:givenName Maria
119 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01167664073.52
120 rdf:type schema:Person
121 sg:person.01211761755.17 schema:affiliation https://www.grid.ac/institutes/grid.5596.f
122 schema:familyName Tack
123 schema:givenName Jan
124 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01211761755.17
125 rdf:type schema:Person
126 sg:person.01237411655.42 schema:affiliation https://www.grid.ac/institutes/grid.412966.e
127 schema:familyName Boesmans
128 schema:givenName Werend
129 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01237411655.42
130 rdf:type schema:Person
131 sg:person.0650071724.42 schema:affiliation https://www.grid.ac/institutes/grid.5596.f
132 schema:familyName Vanheel
133 schema:givenName Hanne
134 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0650071724.42
135 rdf:type schema:Person
136 sg:person.0740076567.79 schema:affiliation N187a6cb5e5784df7b9fd59820bcaf120
137 schema:familyName Salvo-Romero
138 schema:givenName Eloisa
139 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0740076567.79
140 rdf:type schema:Person
141 sg:pub.10.1038/ajg.2010.151 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005787538
142 https://doi.org/10.1038/ajg.2010.151
143 rdf:type schema:CreativeWork
144 sg:pub.10.1038/nrgastro.2012.255 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053132619
145 https://doi.org/10.1038/nrgastro.2012.255
146 rdf:type schema:CreativeWork
147 sg:pub.10.1038/srep34305 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017970123
148 https://doi.org/10.1038/srep34305
149 rdf:type schema:CreativeWork
150 https://app.dimensions.ai/details/publication/pub.1078517081 schema:CreativeWork
151 https://doi.org/10.1002/jlb.67.4.585 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074625224
152 rdf:type schema:CreativeWork
153 https://doi.org/10.1016/j.cgh.2007.05.015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017283197
154 rdf:type schema:CreativeWork
155 https://doi.org/10.1016/s0016-5085(15)30133-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051848352
156 rdf:type schema:CreativeWork
157 https://doi.org/10.1053/j.gastro.2005.04.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046050787
158 rdf:type schema:CreativeWork
159 https://doi.org/10.1053/j.gastro.2005.11.059 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013146576
160 rdf:type schema:CreativeWork
161 https://doi.org/10.1053/j.gastro.2011.01.042 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031716693
162 rdf:type schema:CreativeWork
163 https://doi.org/10.1053/j.gastro.2016.02.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036055701
164 rdf:type schema:CreativeWork
165 https://doi.org/10.1078/0065-1281-00610 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046903922
166 rdf:type schema:CreativeWork
167 https://doi.org/10.1097/00005176-200209000-00017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029969831
168 rdf:type schema:CreativeWork
169 https://doi.org/10.1111/j.1365-2036.2009.03937.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1027506491
170 rdf:type schema:CreativeWork
171 https://doi.org/10.1111/j.1365-2982.2007.00988.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1021401886
172 rdf:type schema:CreativeWork
173 https://doi.org/10.1111/j.1365-2982.2008.01097.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1023670911
174 rdf:type schema:CreativeWork
175 https://doi.org/10.1111/j.1365-2982.2009.01299.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1011087463
176 rdf:type schema:CreativeWork
177 https://doi.org/10.1111/jgh.13787 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084214860
178 rdf:type schema:CreativeWork
179 https://doi.org/10.1136/gut.2008.150888 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002375762
180 rdf:type schema:CreativeWork
181 https://doi.org/10.1136/gut.2009.181701 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042368733
182 rdf:type schema:CreativeWork
183 https://doi.org/10.1136/gutjnl-2012-303857 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010931038
184 rdf:type schema:CreativeWork
185 https://doi.org/10.1136/gutjnl-2015-309151 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042163818
186 rdf:type schema:CreativeWork
187 https://doi.org/10.1136/thorax.56.5.341 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047237405
188 rdf:type schema:CreativeWork
189 https://doi.org/10.1152/ajpgi.00015.2005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032223343
190 rdf:type schema:CreativeWork
191 https://doi.org/10.1152/ajplung.1997.273.5.l1096 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083174288
192 rdf:type schema:CreativeWork
193 https://doi.org/10.1159/000058790 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021865037
194 rdf:type schema:CreativeWork
195 https://doi.org/10.1189/jlb.0707503 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033983966
196 rdf:type schema:CreativeWork
197 https://doi.org/10.1369/jhc.5r6647.2005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049744787
198 rdf:type schema:CreativeWork
199 https://doi.org/10.1371/journal.pone.0123498 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048417951
200 rdf:type schema:CreativeWork
201 https://www.grid.ac/institutes/grid.412966.e schema:alternateName Maastricht University Medical Centre
202 schema:name Department of Pathology, GROW-School for Oncology and Developmental Biology, Maastricht University Medical Center, Maastricht, The Netherlands
203 Translational Research Center for Gastrointestinal Disorders (TARGID), KU Leuven, Leuven, Belgium
204 rdf:type schema:Organization
205 https://www.grid.ac/institutes/grid.452371.6 schema:alternateName Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas
206 schema:name Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Barcelona, Spain
207 Digestive Diseases Research Unit, Institut de Recerca Vall d’Hebron, Department of Gastroenterology, Hospital Universitari Vall d’Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain
208 Translational Research Center for Gastrointestinal Disorders (TARGID), KU Leuven, Leuven, Belgium
209 rdf:type schema:Organization
210 https://www.grid.ac/institutes/grid.5596.f schema:alternateName KU Leuven
211 schema:name Translational Research Center for Gastrointestinal Disorders (TARGID), KU Leuven, Leuven, Belgium
212 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...