A prominent air pollutant, Indeno[1,2,3-cd]pyrene, enhances allergic lung inflammation via aryl hydrocarbon receptor View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-03-26

AUTHORS

Tzu-Hsuan Wong, Chon-Lin Lee, Hsiang-Han Su, Chin-Lai Lee, Chao-Chien Wu, Chin-Chou Wang, Chau-Chyun Sheu, Ruay-Sheng Lai, Sum-Yee Leung, Chi-Cheng Lin, Yu-Feng Wei, Chien-Jen Wang, Yu-Chun Lin, Hua-Ling Chen, Ming-Shyan Huang, Jeng-Hsien Yen, Shau-Ku Huang, Jau-Ling Suen

ABSTRACT

Chronic exposure to ambient polycyclic aromatic hydrocarbons (PAHs) is associated with asthma, but its regulatory mechanisms remain incompletely defined. We report herein that elevated levels of urinary 1-hydroxypyrene, a biomarker of PAH exposure, were found in asthmatic subjects (n = 39) as compared to those in healthy subjects (n = 43) living in an industrial city of Taiwan, where indeno[1,2,3-cd]pyrene (IP) was found to be a prominent PAH associated with ambient PM2.5. In a mouse model, intranasal exposure of mice with varying doses of IP significantly enhanced antigen-induced allergic inflammation, including increased airway eosinophilia, Th2 cytokines, including IL-4 and IL-5, as well as antigen-specific IgE level, which was absent in dendritic cell (DC)-specific aryl hydrocarbon receptor (AhR)-null mice. Mechanistically, IP treatment significantly altered DC’s function, including increased level of pro-inflammatory IL-6 and decreased generation of anti-inflammatory IL-10. The IP’s effect was lost in DCs from mice carrying an AhR-mutant allele. Taken together, these results suggest that chronic exposure to environmental PAHs may pose a significant risk for asthma, in which IP, a prominent ambient PAH in Taiwan, was shown to enhance the severity of allergic lung inflammation in mice through, at least in part, its ability in modulating DC’s function in an AhR-dependent manner. More... »

PAGES

5198

References to SciGraph publications

  • 2007-11-01. Monitoring of environmental exposure to polycyclic aromatic hydrocarbons: a review in ENVIRONMENTAL CHEMISTRY LETTERS
  • 2018-05-16. Correction to: Aryl hydrocarbon receptor signaling promotes ORMDL3-dependent generation of sphingosine-1-phosphate by inhibiting sphingosine-1-phosphate lyase in CELLULAR & MOLECULAR IMMUNOLOGY
  • 2016-10-05. SHP-2 phosphatase controls aryl hydrocarbon receptor-mediated ER stress response in mast cells in ARCHIVES OF TOXICOLOGY
  • 2016-04-12. Ablating the aryl hydrocarbon receptor (AhR) in CD11c+ cells perturbs intestinal epithelium development and intestinal immunity in SCIENTIFIC REPORTS
  • 2017-05-12. Establishment of a Strong Link Between Smoking and Cancer Pathogenesis through DNA Methylation Analysis in SCIENTIFIC REPORTS
  • 2017-03-20. Burden of disease attributed to ambient PM2.5 and PM10 exposure in 190 cities in China in ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
  • 2008-03-23. Control of Treg and TH17 cell differentiation by the aryl hydrocarbon receptor in NATURE
  • 2012-09-12. Pulmonary dendritic cell development and antigen acquisition in IMMUNOLOGIC RESEARCH
  • 2008-03-23. The aryl hydrocarbon receptor links TH17-cell-mediated autoimmunity to environmental toxins in NATURE
  • 2016-11-25. Epigenetic synergism between interleukin-4 and aryl-hydrocarbon receptor in human macrophages in JOURNAL OF MOLECULAR MEDICINE
  • 2018-03-23. Aryl hydrocarbon receptor signaling promotes ORMDL3-dependent generation of sphingosine-1-phosphate by inhibiting sphingosine-1-phosphate lyase in CELLULAR & MOLECULAR IMMUNOLOGY
  • Journal

    TITLE

    Scientific Reports

    ISSUE

    1

    VOLUME

    8

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41598-018-23542-9

    DOI

    http://dx.doi.org/10.1038/s41598-018-23542-9

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1101760427

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/29581487


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1102", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Cardiorespiratory Medicine and Haematology", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Immunology", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Adolescent", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Adult", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Air Pollutants", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Animals", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Asthma", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Dendritic Cells", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Female", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Hypersensitivity", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Lung", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Male", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mice", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Middle Aged", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Particulate Matter", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Pneumonia", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Pyrenes", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Receptors, Aryl Hydrocarbon", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Taiwan", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Young Adult", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan", 
              "id": "http://www.grid.ac/institutes/grid.412019.f", 
              "name": [
                "Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Wong", 
            "givenName": "Tzu-Hsuan", 
            "id": "sg:person.014225133165.59", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014225133165.59"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Research Center of Environmental Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan", 
              "id": "http://www.grid.ac/institutes/grid.412019.f", 
              "name": [
                "Department of Marine Environment and Engineering, National Sun Yat-sen University, Kaohsiung, Taiwan", 
                "Research Center of Environmental Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lee", 
            "givenName": "Chon-Lin", 
            "id": "sg:person.01115062177.38", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01115062177.38"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan", 
              "id": "http://www.grid.ac/institutes/grid.412019.f", 
              "name": [
                "Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Su", 
            "givenName": "Hsiang-Han", 
            "id": "sg:person.010327275334.08", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010327275334.08"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan", 
              "id": "http://www.grid.ac/institutes/grid.412019.f", 
              "name": [
                "Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lee", 
            "givenName": "Chin-Lai", 
            "id": "sg:person.0666742306.85", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0666742306.85"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and College of Medicine, Chang Gung University, Kaohsiung, Taiwan", 
              "id": "http://www.grid.ac/institutes/grid.145695.a", 
              "name": [
                "Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and College of Medicine, Chang Gung University, Kaohsiung, Taiwan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Wu", 
            "givenName": "Chao-Chien", 
            "id": "sg:person.01216452407.34", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01216452407.34"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Public Health, Kaohsiung Medical University, Kaohsiung, Taiwan", 
              "id": "http://www.grid.ac/institutes/grid.412019.f", 
              "name": [
                "Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and College of Medicine, Chang Gung University, Kaohsiung, Taiwan", 
                "Department of Public Health, Kaohsiung Medical University, Kaohsiung, Taiwan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Wang", 
            "givenName": "Chin-Chou", 
            "id": "sg:person.01172461141.07", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01172461141.07"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan", 
              "id": "http://www.grid.ac/institutes/grid.412019.f", 
              "name": [
                "Research Center of Environmental Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan", 
                "Divison of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan", 
                "College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Sheu", 
            "givenName": "Chau-Chyun", 
            "id": "sg:person.01146531727.16", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01146531727.16"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Division of Chest Medicine, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan", 
              "id": "http://www.grid.ac/institutes/grid.415011.0", 
              "name": [
                "Division of Chest Medicine, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lai", 
            "givenName": "Ruay-Sheng", 
            "id": "sg:person.01261173563.13", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01261173563.13"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and College of Medicine, Chang Gung University, Kaohsiung, Taiwan", 
              "id": "http://www.grid.ac/institutes/grid.145695.a", 
              "name": [
                "Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and College of Medicine, Chang Gung University, Kaohsiung, Taiwan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Leung", 
            "givenName": "Sum-Yee", 
            "id": "sg:person.010063113400.78", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010063113400.78"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Chest Division, Department of Internal Medicine, Antai Medical Care Cooperation Antai Tian-Sheng Memorial Hospital, Ping-Tung, Taiwan", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Chest Division, Department of Internal Medicine, Antai Medical Care Cooperation Antai Tian-Sheng Memorial Hospital, Ping-Tung, Taiwan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lin", 
            "givenName": "Chi-Cheng", 
            "id": "sg:person.01326315670.42", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01326315670.42"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Division of Chest Medicine, Department of Internal Medicine, E-Da Hospital, I-Shou University, Kaohsiung, Taiwan", 
              "id": "http://www.grid.ac/institutes/grid.411447.3", 
              "name": [
                "Division of Chest Medicine, Department of Internal Medicine, E-Da Hospital, I-Shou University, Kaohsiung, Taiwan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Wei", 
            "givenName": "Yu-Feng", 
            "id": "sg:person.01313204465.67", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01313204465.67"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "National Institute of Environmental Health Sciences, National Health Research Institutes, Miaoli, Taiwan", 
              "id": "http://www.grid.ac/institutes/grid.59784.37", 
              "name": [
                "National Institute of Environmental Health Sciences, National Health Research Institutes, Miaoli, Taiwan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Wang", 
            "givenName": "Chien-Jen", 
            "id": "sg:person.01125150622.11", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01125150622.11"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "National Institute of Environmental Health Sciences, National Health Research Institutes, Miaoli, Taiwan", 
              "id": "http://www.grid.ac/institutes/grid.59784.37", 
              "name": [
                "National Institute of Environmental Health Sciences, National Health Research Institutes, Miaoli, Taiwan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lin", 
            "givenName": "Yu-Chun", 
            "id": "sg:person.011770351534.42", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011770351534.42"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "National Institute of Environmental Health Sciences, National Health Research Institutes, Miaoli, Taiwan", 
              "id": "http://www.grid.ac/institutes/grid.59784.37", 
              "name": [
                "National Institute of Environmental Health Sciences, National Health Research Institutes, Miaoli, Taiwan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Chen", 
            "givenName": "Hua-Ling", 
            "id": "sg:person.01012730433.40", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01012730433.40"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan", 
              "id": "http://www.grid.ac/institutes/grid.412019.f", 
              "name": [
                "Divison of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan", 
                "College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Huang", 
            "givenName": "Ming-Shyan", 
            "id": "sg:person.011441631207.11", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011441631207.11"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Division of Rheumatology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan", 
              "id": "http://www.grid.ac/institutes/grid.412027.2", 
              "name": [
                "Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan", 
                "Division of Rheumatology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Yen", 
            "givenName": "Jeng-Hsien", 
            "id": "sg:person.012107731622.75", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012107731622.75"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA", 
              "id": "http://www.grid.ac/institutes/grid.21107.35", 
              "name": [
                "Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan", 
                "Research Center of Environmental Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan", 
                "National Institute of Environmental Health Sciences, National Health Research Institutes, Miaoli, Taiwan", 
                "Lou-Hu Hospital, Shen-Zhen University, Shen-Zhen, China", 
                "Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Huang", 
            "givenName": "Shau-Ku", 
            "id": "sg:person.01125345404.32", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01125345404.32"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Medical Research, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan", 
              "id": "http://www.grid.ac/institutes/grid.412027.2", 
              "name": [
                "Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan", 
                "Research Center of Environmental Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan", 
                "Department of Medical Research, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Suen", 
            "givenName": "Jau-Ling", 
            "id": "sg:person.01242377424.30", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01242377424.30"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1038/s41423-018-0022-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1101695269", 
              "https://doi.org/10.1038/s41423-018-0022-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10311-007-0095-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023945460", 
              "https://doi.org/10.1007/s10311-007-0095-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41423-018-0040-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1104011209", 
              "https://doi.org/10.1038/s41423-018-0040-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature06881", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024002249", 
              "https://doi.org/10.1038/nature06881"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41598-017-01856-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1085347044", 
              "https://doi.org/10.1038/s41598-017-01856-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s12026-012-8359-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022906122", 
              "https://doi.org/10.1007/s12026-012-8359-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00109-016-1493-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042004017", 
              "https://doi.org/10.1007/s00109-016-1493-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00204-016-1861-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041774004", 
              "https://doi.org/10.1007/s00204-016-1861-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/srep23820", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008420812", 
              "https://doi.org/10.1038/srep23820"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11356-017-8575-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1084504716", 
              "https://doi.org/10.1007/s11356-017-8575-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature06880", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025127308", 
              "https://doi.org/10.1038/nature06880"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2018-03-26", 
        "datePublishedReg": "2018-03-26", 
        "description": "Chronic exposure to ambient polycyclic aromatic hydrocarbons (PAHs) is associated with asthma, but its regulatory mechanisms remain incompletely defined. We report herein that elevated levels of urinary 1-hydroxypyrene, a biomarker of PAH exposure, were found in asthmatic subjects (n\u2009=\u200939) as compared to those in healthy subjects (n\u2009=\u200943) living in an industrial city of Taiwan, where indeno[1,2,3-cd]pyrene (IP) was found to be a prominent PAH associated with ambient PM2.5. In a mouse model, intranasal exposure of mice with varying doses of IP significantly enhanced antigen-induced allergic inflammation, including increased airway eosinophilia, Th2 cytokines, including IL-4 and IL-5, as well as antigen-specific IgE level, which was absent in dendritic cell (DC)-specific aryl hydrocarbon receptor (AhR)-null mice. Mechanistically, IP treatment significantly altered DC\u2019s function, including increased level of pro-inflammatory IL-6 and decreased generation of anti-inflammatory IL-10. The IP\u2019s effect was lost in DCs from mice carrying an AhR-mutant allele. Taken together, these results suggest that chronic exposure to environmental PAHs may pose a significant risk for asthma, in which IP, a prominent ambient PAH in Taiwan, was shown to enhance the severity of allergic lung inflammation in mice through, at least in part, its ability in modulating DC\u2019s function in an AhR-dependent manner.", 
        "genre": "article", 
        "id": "sg:pub.10.1038/s41598-018-23542-9", 
        "isAccessibleForFree": true, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.9710450", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1045337", 
            "issn": [
              "2045-2322"
            ], 
            "name": "Scientific Reports", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "1", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "8"
          }
        ], 
        "keywords": [
          "allergic lung inflammation", 
          "aryl hydrocarbon receptor", 
          "lung inflammation", 
          "DC function", 
          "chronic exposure", 
          "anti-inflammatory IL-10", 
          "antigen-specific IgE levels", 
          "pro-inflammatory IL-6", 
          "hydrocarbon receptor", 
          "AhR-dependent manner", 
          "airway eosinophilia", 
          "asthmatic subjects", 
          "intranasal exposure", 
          "IgE levels", 
          "allergic inflammation", 
          "dendritic cells", 
          "IL-10", 
          "Th2 cytokines", 
          "IL-6", 
          "IL-4", 
          "IL-5", 
          "healthy subjects", 
          "mouse model", 
          "IP treatment", 
          "null mice", 
          "inflammation", 
          "mice", 
          "significant risk", 
          "PAH exposure", 
          "environmental polycyclic aromatic hydrocarbons", 
          "asthma", 
          "exposure", 
          "receptors", 
          "ambient polycyclic aromatic hydrocarbons", 
          "prominent polycyclic aromatic hydrocarbons", 
          "ambient PM2.5", 
          "subjects", 
          "eosinophilia", 
          "regulatory mechanisms", 
          "cytokines", 
          "levels", 
          "doses", 
          "biomarkers", 
          "severity", 
          "Mechanistically", 
          "treatment", 
          "risk", 
          "air pollutants", 
          "function", 
          "effect", 
          "cells", 
          "Taiwan", 
          "alleles", 
          "polycyclic aromatic hydrocarbons", 
          "manner", 
          "mechanism", 
          "IP", 
          "ability", 
          "PM2.5", 
          "results", 
          "part", 
          "IP effects", 
          "prominent air pollutant", 
          "aromatic hydrocarbons", 
          "DC", 
          "model", 
          "city", 
          "generation", 
          "industrial city", 
          "pollutants", 
          "hydrocarbons"
        ], 
        "name": "A prominent air pollutant, Indeno[1,2,3-cd]pyrene, enhances allergic lung inflammation via aryl hydrocarbon receptor", 
        "pagination": "5198", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1101760427"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/s41598-018-23542-9"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "29581487"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/s41598-018-23542-9", 
          "https://app.dimensions.ai/details/publication/pub.1101760427"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2022-09-02T16:03", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20220902/entities/gbq_results/article/article_793.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1038/s41598-018-23542-9"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-23542-9'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-23542-9'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-23542-9'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-23542-9'


     

    This table displays all metadata directly associated to this object as RDF triples.

    414 TRIPLES      21 PREDICATES      127 URIs      107 LITERALS      26 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/s41598-018-23542-9 schema:about N19c697b86c304d719f20beeb11c82ffd
    2 N238e3f29b7674c66b246c6a2f5fe71a9
    3 N2827c3b3853e4a8bbe4d3189c1143ce6
    4 N302c5885ec1743488e79dab568b7492e
    5 N3577b51550424c31a6efe2fd98bc0947
    6 N4fc5158a44c648cd820afe47548cf7c3
    7 N5519dff5da4a4806b2cde2ef653b9726
    8 N85a988d3bb3a4f4197a95b7e4d19a27e
    9 N92a5834cc0164733b9fef4160de431e4
    10 N941352637307468c9efc3b867049dc30
    11 Na4a7c619274e4fad9d9f561a5ea57b5a
    12 Naff22e7b3af94e15ac84b068265233db
    13 Nb92b73aa55684bbb9ed3481153f345cd
    14 Nc1a599ee723d440a995c5610d2a35ac9
    15 Nc426bf48d4ad44fbb796c45f04badf14
    16 Nd183738ec49d4f598214a56a16dbb475
    17 Nd8f151b2cfb14172aee25ea0e42162c1
    18 Nf54bd71abd634d609f4c7d6d9eb77aed
    19 Nfebd4d8c09d34273a91beaea1000461c
    20 anzsrc-for:11
    21 anzsrc-for:1102
    22 anzsrc-for:1107
    23 schema:author Nf880bdb747b64a1ba3c9dd16930ae184
    24 schema:citation sg:pub.10.1007/s00109-016-1493-1
    25 sg:pub.10.1007/s00204-016-1861-1
    26 sg:pub.10.1007/s10311-007-0095-0
    27 sg:pub.10.1007/s11356-017-8575-7
    28 sg:pub.10.1007/s12026-012-8359-6
    29 sg:pub.10.1038/nature06880
    30 sg:pub.10.1038/nature06881
    31 sg:pub.10.1038/s41423-018-0022-2
    32 sg:pub.10.1038/s41423-018-0040-0
    33 sg:pub.10.1038/s41598-017-01856-4
    34 sg:pub.10.1038/srep23820
    35 schema:datePublished 2018-03-26
    36 schema:datePublishedReg 2018-03-26
    37 schema:description Chronic exposure to ambient polycyclic aromatic hydrocarbons (PAHs) is associated with asthma, but its regulatory mechanisms remain incompletely defined. We report herein that elevated levels of urinary 1-hydroxypyrene, a biomarker of PAH exposure, were found in asthmatic subjects (n = 39) as compared to those in healthy subjects (n = 43) living in an industrial city of Taiwan, where indeno[1,2,3-cd]pyrene (IP) was found to be a prominent PAH associated with ambient PM2.5. In a mouse model, intranasal exposure of mice with varying doses of IP significantly enhanced antigen-induced allergic inflammation, including increased airway eosinophilia, Th2 cytokines, including IL-4 and IL-5, as well as antigen-specific IgE level, which was absent in dendritic cell (DC)-specific aryl hydrocarbon receptor (AhR)-null mice. Mechanistically, IP treatment significantly altered DC’s function, including increased level of pro-inflammatory IL-6 and decreased generation of anti-inflammatory IL-10. The IP’s effect was lost in DCs from mice carrying an AhR-mutant allele. Taken together, these results suggest that chronic exposure to environmental PAHs may pose a significant risk for asthma, in which IP, a prominent ambient PAH in Taiwan, was shown to enhance the severity of allergic lung inflammation in mice through, at least in part, its ability in modulating DC’s function in an AhR-dependent manner.
    38 schema:genre article
    39 schema:isAccessibleForFree true
    40 schema:isPartOf N48fbad61731e466cb63b9209772a59c1
    41 Ne006bef830794ed28e465e5f914898b4
    42 sg:journal.1045337
    43 schema:keywords AhR-dependent manner
    44 DC
    45 DC function
    46 IL-10
    47 IL-4
    48 IL-5
    49 IL-6
    50 IP
    51 IP effects
    52 IP treatment
    53 IgE levels
    54 Mechanistically
    55 PAH exposure
    56 PM2.5
    57 Taiwan
    58 Th2 cytokines
    59 ability
    60 air pollutants
    61 airway eosinophilia
    62 alleles
    63 allergic inflammation
    64 allergic lung inflammation
    65 ambient PM2.5
    66 ambient polycyclic aromatic hydrocarbons
    67 anti-inflammatory IL-10
    68 antigen-specific IgE levels
    69 aromatic hydrocarbons
    70 aryl hydrocarbon receptor
    71 asthma
    72 asthmatic subjects
    73 biomarkers
    74 cells
    75 chronic exposure
    76 city
    77 cytokines
    78 dendritic cells
    79 doses
    80 effect
    81 environmental polycyclic aromatic hydrocarbons
    82 eosinophilia
    83 exposure
    84 function
    85 generation
    86 healthy subjects
    87 hydrocarbon receptor
    88 hydrocarbons
    89 industrial city
    90 inflammation
    91 intranasal exposure
    92 levels
    93 lung inflammation
    94 manner
    95 mechanism
    96 mice
    97 model
    98 mouse model
    99 null mice
    100 part
    101 pollutants
    102 polycyclic aromatic hydrocarbons
    103 pro-inflammatory IL-6
    104 prominent air pollutant
    105 prominent polycyclic aromatic hydrocarbons
    106 receptors
    107 regulatory mechanisms
    108 results
    109 risk
    110 severity
    111 significant risk
    112 subjects
    113 treatment
    114 schema:name A prominent air pollutant, Indeno[1,2,3-cd]pyrene, enhances allergic lung inflammation via aryl hydrocarbon receptor
    115 schema:pagination 5198
    116 schema:productId N28be1b097fc64165b060e3067f79b463
    117 N4c740bde5c2c43cfbba3bf6abce80599
    118 Nb42c3719ee0e417b8b7b693f25c72763
    119 schema:sameAs https://app.dimensions.ai/details/publication/pub.1101760427
    120 https://doi.org/10.1038/s41598-018-23542-9
    121 schema:sdDatePublished 2022-09-02T16:03
    122 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    123 schema:sdPublisher Nb18ec6d9dbeb440b92b10237d3039246
    124 schema:url https://doi.org/10.1038/s41598-018-23542-9
    125 sgo:license sg:explorer/license/
    126 sgo:sdDataset articles
    127 rdf:type schema:ScholarlyArticle
    128 N0afd792a3f7a4f3d96f8f68c71d45953 rdf:first sg:person.0666742306.85
    129 rdf:rest N0f9b6a9caaa44b3186668ced643f97b6
    130 N0f9b6a9caaa44b3186668ced643f97b6 rdf:first sg:person.01216452407.34
    131 rdf:rest N5e1f638bb82b413cb84a0f0e33034b3f
    132 N19c697b86c304d719f20beeb11c82ffd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    133 schema:name Humans
    134 rdf:type schema:DefinedTerm
    135 N238e3f29b7674c66b246c6a2f5fe71a9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    136 schema:name Male
    137 rdf:type schema:DefinedTerm
    138 N2827c3b3853e4a8bbe4d3189c1143ce6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    139 schema:name Pneumonia
    140 rdf:type schema:DefinedTerm
    141 N28be1b097fc64165b060e3067f79b463 schema:name pubmed_id
    142 schema:value 29581487
    143 rdf:type schema:PropertyValue
    144 N29fbcb71cd4547d3b561909a73167916 rdf:first sg:person.011441631207.11
    145 rdf:rest Nfb079ab6dae64c7d80512700dfe48e0c
    146 N302c5885ec1743488e79dab568b7492e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    147 schema:name Pyrenes
    148 rdf:type schema:DefinedTerm
    149 N32b119caf8bd4ebbbb45cf413872cd4e rdf:first sg:person.01125150622.11
    150 rdf:rest Nb0e31ee4ac7047a9b7e6c1561d75b6e9
    151 N3577b51550424c31a6efe2fd98bc0947 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    152 schema:name Air Pollutants
    153 rdf:type schema:DefinedTerm
    154 N3ded1acd98d343738e3a5cca112adb1d rdf:first sg:person.010327275334.08
    155 rdf:rest N0afd792a3f7a4f3d96f8f68c71d45953
    156 N48fbad61731e466cb63b9209772a59c1 schema:issueNumber 1
    157 rdf:type schema:PublicationIssue
    158 N4c740bde5c2c43cfbba3bf6abce80599 schema:name doi
    159 schema:value 10.1038/s41598-018-23542-9
    160 rdf:type schema:PropertyValue
    161 N4fc5158a44c648cd820afe47548cf7c3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    162 schema:name Taiwan
    163 rdf:type schema:DefinedTerm
    164 N5519dff5da4a4806b2cde2ef653b9726 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    165 schema:name Mice
    166 rdf:type schema:DefinedTerm
    167 N5e1f638bb82b413cb84a0f0e33034b3f rdf:first sg:person.01172461141.07
    168 rdf:rest Na1e2f8ef27894de785cef8abe3a4aff9
    169 N7ced3958f22a4cebaf9073611c522fa3 rdf:first sg:person.010063113400.78
    170 rdf:rest Nf09460d9fb9a44e2818e2009a795800c
    171 N84e546eb0ea44595ac6701e4aacf8e9d rdf:first sg:person.01012730433.40
    172 rdf:rest N29fbcb71cd4547d3b561909a73167916
    173 N85a988d3bb3a4f4197a95b7e4d19a27e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    174 schema:name Hypersensitivity
    175 rdf:type schema:DefinedTerm
    176 N92a5834cc0164733b9fef4160de431e4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    177 schema:name Young Adult
    178 rdf:type schema:DefinedTerm
    179 N941352637307468c9efc3b867049dc30 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    180 schema:name Receptors, Aryl Hydrocarbon
    181 rdf:type schema:DefinedTerm
    182 N97bc342199db4a3b9c6aff4ee5699642 rdf:first sg:person.01261173563.13
    183 rdf:rest N7ced3958f22a4cebaf9073611c522fa3
    184 Na1e2f8ef27894de785cef8abe3a4aff9 rdf:first sg:person.01146531727.16
    185 rdf:rest N97bc342199db4a3b9c6aff4ee5699642
    186 Na4a7c619274e4fad9d9f561a5ea57b5a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    187 schema:name Dendritic Cells
    188 rdf:type schema:DefinedTerm
    189 Nab99c131bfd34869b8dc65d106d9e247 rdf:first sg:person.01242377424.30
    190 rdf:rest rdf:nil
    191 Naff22e7b3af94e15ac84b068265233db schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    192 schema:name Adolescent
    193 rdf:type schema:DefinedTerm
    194 Nb0e31ee4ac7047a9b7e6c1561d75b6e9 rdf:first sg:person.011770351534.42
    195 rdf:rest N84e546eb0ea44595ac6701e4aacf8e9d
    196 Nb18ec6d9dbeb440b92b10237d3039246 schema:name Springer Nature - SN SciGraph project
    197 rdf:type schema:Organization
    198 Nb42c3719ee0e417b8b7b693f25c72763 schema:name dimensions_id
    199 schema:value pub.1101760427
    200 rdf:type schema:PropertyValue
    201 Nb92b73aa55684bbb9ed3481153f345cd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    202 schema:name Particulate Matter
    203 rdf:type schema:DefinedTerm
    204 Nbb21f40536f944b4a1f29bca28c1c3bb rdf:first sg:person.01115062177.38
    205 rdf:rest N3ded1acd98d343738e3a5cca112adb1d
    206 Nbfab4e458b564549bca3ea7e6e56434e rdf:first sg:person.01125345404.32
    207 rdf:rest Nab99c131bfd34869b8dc65d106d9e247
    208 Nc1a599ee723d440a995c5610d2a35ac9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    209 schema:name Lung
    210 rdf:type schema:DefinedTerm
    211 Nc426bf48d4ad44fbb796c45f04badf14 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    212 schema:name Adult
    213 rdf:type schema:DefinedTerm
    214 Nd183738ec49d4f598214a56a16dbb475 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    215 schema:name Middle Aged
    216 rdf:type schema:DefinedTerm
    217 Nd8f151b2cfb14172aee25ea0e42162c1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    218 schema:name Animals
    219 rdf:type schema:DefinedTerm
    220 Ne006bef830794ed28e465e5f914898b4 schema:volumeNumber 8
    221 rdf:type schema:PublicationVolume
    222 Nf09460d9fb9a44e2818e2009a795800c rdf:first sg:person.01326315670.42
    223 rdf:rest Nfe8a64b90944486e91995f9371cadfc6
    224 Nf54bd71abd634d609f4c7d6d9eb77aed schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    225 schema:name Female
    226 rdf:type schema:DefinedTerm
    227 Nf880bdb747b64a1ba3c9dd16930ae184 rdf:first sg:person.014225133165.59
    228 rdf:rest Nbb21f40536f944b4a1f29bca28c1c3bb
    229 Nfb079ab6dae64c7d80512700dfe48e0c rdf:first sg:person.012107731622.75
    230 rdf:rest Nbfab4e458b564549bca3ea7e6e56434e
    231 Nfe8a64b90944486e91995f9371cadfc6 rdf:first sg:person.01313204465.67
    232 rdf:rest N32b119caf8bd4ebbbb45cf413872cd4e
    233 Nfebd4d8c09d34273a91beaea1000461c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    234 schema:name Asthma
    235 rdf:type schema:DefinedTerm
    236 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    237 schema:name Medical and Health Sciences
    238 rdf:type schema:DefinedTerm
    239 anzsrc-for:1102 schema:inDefinedTermSet anzsrc-for:
    240 schema:name Cardiorespiratory Medicine and Haematology
    241 rdf:type schema:DefinedTerm
    242 anzsrc-for:1107 schema:inDefinedTermSet anzsrc-for:
    243 schema:name Immunology
    244 rdf:type schema:DefinedTerm
    245 sg:grant.9710450 http://pending.schema.org/fundedItem sg:pub.10.1038/s41598-018-23542-9
    246 rdf:type schema:MonetaryGrant
    247 sg:journal.1045337 schema:issn 2045-2322
    248 schema:name Scientific Reports
    249 schema:publisher Springer Nature
    250 rdf:type schema:Periodical
    251 sg:person.010063113400.78 schema:affiliation grid-institutes:grid.145695.a
    252 schema:familyName Leung
    253 schema:givenName Sum-Yee
    254 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010063113400.78
    255 rdf:type schema:Person
    256 sg:person.01012730433.40 schema:affiliation grid-institutes:grid.59784.37
    257 schema:familyName Chen
    258 schema:givenName Hua-Ling
    259 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01012730433.40
    260 rdf:type schema:Person
    261 sg:person.010327275334.08 schema:affiliation grid-institutes:grid.412019.f
    262 schema:familyName Su
    263 schema:givenName Hsiang-Han
    264 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010327275334.08
    265 rdf:type schema:Person
    266 sg:person.01115062177.38 schema:affiliation grid-institutes:grid.412019.f
    267 schema:familyName Lee
    268 schema:givenName Chon-Lin
    269 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01115062177.38
    270 rdf:type schema:Person
    271 sg:person.01125150622.11 schema:affiliation grid-institutes:grid.59784.37
    272 schema:familyName Wang
    273 schema:givenName Chien-Jen
    274 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01125150622.11
    275 rdf:type schema:Person
    276 sg:person.01125345404.32 schema:affiliation grid-institutes:grid.21107.35
    277 schema:familyName Huang
    278 schema:givenName Shau-Ku
    279 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01125345404.32
    280 rdf:type schema:Person
    281 sg:person.011441631207.11 schema:affiliation grid-institutes:grid.412019.f
    282 schema:familyName Huang
    283 schema:givenName Ming-Shyan
    284 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011441631207.11
    285 rdf:type schema:Person
    286 sg:person.01146531727.16 schema:affiliation grid-institutes:grid.412019.f
    287 schema:familyName Sheu
    288 schema:givenName Chau-Chyun
    289 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01146531727.16
    290 rdf:type schema:Person
    291 sg:person.01172461141.07 schema:affiliation grid-institutes:grid.412019.f
    292 schema:familyName Wang
    293 schema:givenName Chin-Chou
    294 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01172461141.07
    295 rdf:type schema:Person
    296 sg:person.011770351534.42 schema:affiliation grid-institutes:grid.59784.37
    297 schema:familyName Lin
    298 schema:givenName Yu-Chun
    299 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011770351534.42
    300 rdf:type schema:Person
    301 sg:person.012107731622.75 schema:affiliation grid-institutes:grid.412027.2
    302 schema:familyName Yen
    303 schema:givenName Jeng-Hsien
    304 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012107731622.75
    305 rdf:type schema:Person
    306 sg:person.01216452407.34 schema:affiliation grid-institutes:grid.145695.a
    307 schema:familyName Wu
    308 schema:givenName Chao-Chien
    309 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01216452407.34
    310 rdf:type schema:Person
    311 sg:person.01242377424.30 schema:affiliation grid-institutes:grid.412027.2
    312 schema:familyName Suen
    313 schema:givenName Jau-Ling
    314 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01242377424.30
    315 rdf:type schema:Person
    316 sg:person.01261173563.13 schema:affiliation grid-institutes:grid.415011.0
    317 schema:familyName Lai
    318 schema:givenName Ruay-Sheng
    319 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01261173563.13
    320 rdf:type schema:Person
    321 sg:person.01313204465.67 schema:affiliation grid-institutes:grid.411447.3
    322 schema:familyName Wei
    323 schema:givenName Yu-Feng
    324 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01313204465.67
    325 rdf:type schema:Person
    326 sg:person.01326315670.42 schema:affiliation grid-institutes:None
    327 schema:familyName Lin
    328 schema:givenName Chi-Cheng
    329 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01326315670.42
    330 rdf:type schema:Person
    331 sg:person.014225133165.59 schema:affiliation grid-institutes:grid.412019.f
    332 schema:familyName Wong
    333 schema:givenName Tzu-Hsuan
    334 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014225133165.59
    335 rdf:type schema:Person
    336 sg:person.0666742306.85 schema:affiliation grid-institutes:grid.412019.f
    337 schema:familyName Lee
    338 schema:givenName Chin-Lai
    339 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0666742306.85
    340 rdf:type schema:Person
    341 sg:pub.10.1007/s00109-016-1493-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042004017
    342 https://doi.org/10.1007/s00109-016-1493-1
    343 rdf:type schema:CreativeWork
    344 sg:pub.10.1007/s00204-016-1861-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041774004
    345 https://doi.org/10.1007/s00204-016-1861-1
    346 rdf:type schema:CreativeWork
    347 sg:pub.10.1007/s10311-007-0095-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023945460
    348 https://doi.org/10.1007/s10311-007-0095-0
    349 rdf:type schema:CreativeWork
    350 sg:pub.10.1007/s11356-017-8575-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084504716
    351 https://doi.org/10.1007/s11356-017-8575-7
    352 rdf:type schema:CreativeWork
    353 sg:pub.10.1007/s12026-012-8359-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022906122
    354 https://doi.org/10.1007/s12026-012-8359-6
    355 rdf:type schema:CreativeWork
    356 sg:pub.10.1038/nature06880 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025127308
    357 https://doi.org/10.1038/nature06880
    358 rdf:type schema:CreativeWork
    359 sg:pub.10.1038/nature06881 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024002249
    360 https://doi.org/10.1038/nature06881
    361 rdf:type schema:CreativeWork
    362 sg:pub.10.1038/s41423-018-0022-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1101695269
    363 https://doi.org/10.1038/s41423-018-0022-2
    364 rdf:type schema:CreativeWork
    365 sg:pub.10.1038/s41423-018-0040-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1104011209
    366 https://doi.org/10.1038/s41423-018-0040-0
    367 rdf:type schema:CreativeWork
    368 sg:pub.10.1038/s41598-017-01856-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085347044
    369 https://doi.org/10.1038/s41598-017-01856-4
    370 rdf:type schema:CreativeWork
    371 sg:pub.10.1038/srep23820 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008420812
    372 https://doi.org/10.1038/srep23820
    373 rdf:type schema:CreativeWork
    374 grid-institutes:None schema:alternateName Chest Division, Department of Internal Medicine, Antai Medical Care Cooperation Antai Tian-Sheng Memorial Hospital, Ping-Tung, Taiwan
    375 schema:name Chest Division, Department of Internal Medicine, Antai Medical Care Cooperation Antai Tian-Sheng Memorial Hospital, Ping-Tung, Taiwan
    376 rdf:type schema:Organization
    377 grid-institutes:grid.145695.a schema:alternateName Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and College of Medicine, Chang Gung University, Kaohsiung, Taiwan
    378 schema:name Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and College of Medicine, Chang Gung University, Kaohsiung, Taiwan
    379 rdf:type schema:Organization
    380 grid-institutes:grid.21107.35 schema:alternateName Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    381 schema:name Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    382 Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
    383 Lou-Hu Hospital, Shen-Zhen University, Shen-Zhen, China
    384 National Institute of Environmental Health Sciences, National Health Research Institutes, Miaoli, Taiwan
    385 Research Center of Environmental Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
    386 rdf:type schema:Organization
    387 grid-institutes:grid.411447.3 schema:alternateName Division of Chest Medicine, Department of Internal Medicine, E-Da Hospital, I-Shou University, Kaohsiung, Taiwan
    388 schema:name Division of Chest Medicine, Department of Internal Medicine, E-Da Hospital, I-Shou University, Kaohsiung, Taiwan
    389 rdf:type schema:Organization
    390 grid-institutes:grid.412019.f schema:alternateName College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
    391 Department of Public Health, Kaohsiung Medical University, Kaohsiung, Taiwan
    392 Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
    393 Research Center of Environmental Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
    394 schema:name College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
    395 Department of Marine Environment and Engineering, National Sun Yat-sen University, Kaohsiung, Taiwan
    396 Department of Public Health, Kaohsiung Medical University, Kaohsiung, Taiwan
    397 Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and College of Medicine, Chang Gung University, Kaohsiung, Taiwan
    398 Divison of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan
    399 Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
    400 Research Center of Environmental Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
    401 rdf:type schema:Organization
    402 grid-institutes:grid.412027.2 schema:alternateName Department of Medical Research, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan
    403 Division of Rheumatology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan
    404 schema:name Department of Medical Research, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan
    405 Division of Rheumatology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan
    406 Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
    407 Research Center of Environmental Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
    408 rdf:type schema:Organization
    409 grid-institutes:grid.415011.0 schema:alternateName Division of Chest Medicine, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan
    410 schema:name Division of Chest Medicine, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan
    411 rdf:type schema:Organization
    412 grid-institutes:grid.59784.37 schema:alternateName National Institute of Environmental Health Sciences, National Health Research Institutes, Miaoli, Taiwan
    413 schema:name National Institute of Environmental Health Sciences, National Health Research Institutes, Miaoli, Taiwan
    414 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...