Proteomic analysis of plasma extracellular vesicles reveals mitochondrial stress upon HTLV-1 infection View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-03-26

AUTHORS

Patricia Jeannin, Thibault Chaze, Quentin Giai Gianetto, Mariette Matondo, Olivier Gout, Antoine Gessain, Philippe V. Afonso

ABSTRACT

Extracellular vesicles (EVs) can participate in intercellular communication and pathogenesis. EVs contain many cargos, including proteins, and the composition of EVs differs between cell-types and activation levels. Thus, plasma EVs can be used as a biomarker of systemic response to infection and/or disease progression. In this study, we aimed at describing alterations in the protein content of plasma EVs upon infection with the human T-lymphotropic retrovirus type 1 (HTLV-1). HTLV-1 is the etiological agent of a lymphoproliferative disease (ATL) and a series of inflammatory diseases, including a neurodegenerative inflammatory disease (HAM/TSP). We found that plasma EVs are more abundant and smaller in HTLV-1 asymptomatic carriers or HAM/TSP patients when compared to uninfected healthy donors. Moreover, EVs from HTLV-1 infected donors contain markers of metabolic and mitochondrial stress. More... »

PAGES

5170

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41598-018-23505-0

DOI

http://dx.doi.org/10.1038/s41598-018-23505-0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1101763982

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29581472


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