Efficacy and safety of boosted darunavir-based antiretroviral therapy in HIV-1-positive patients: results from a meta-analysis of clinical trials View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-12

AUTHORS

A. Antinori, A. Lazzarin, A. Uglietti, M. Palma, D. Mancusi, R. Termini

ABSTRACT

Darunavir/ritonavir (DRV/r) is a second-generation protease inhibitor used in treatment-naïve and -experienced HIV-positive adult patients. To evaluate efficacy and safety in these patient settings, we performed a meta-analysis of randomized controlled trials. We considered eight studies involving 4240 antiretroviral treatment (ART)-naïve patients and 14 studies involving 2684 ART-experienced patients. Regarding efficacy in the ART-naive patients, the virological response rate was not significantly different between DRV/r and the comparator. For the ART-experienced failing patients, the virological response rate was significantly higher with DRV/r than with the comparator (RR 1.45, 95% CI: 1.01-2.08); conversely, no significant differences were found between the treatment-experienced and virologically controlled DRV/r and comparator groups. Regarding safety, the discontinuation rates due to adverse events (AEs) and DRV/r-related serious adverse events (SAEs) did not significantly differ from the rates in the comparator group (RR 0.84, 95% CI: 0.59-1.19 and RR 0.78, 95% CI: 0.57-1.05, respectively). Our meta-analysis indicated that DRV/r-based regimens were effective and tolerable for both types of patients, which was consistent with published data. More... »

PAGES

5288

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41598-018-23375-6

DOI

http://dx.doi.org/10.1038/s41598-018-23375-6

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1101770983

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29588457


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Istituto Nazionale per le Malattie Infettive Lazzaro Spallanzani", 
          "id": "https://www.grid.ac/institutes/grid.419423.9", 
          "name": [
            "HIV/AIDS Department, National Institute for Infectious Diseases \u201cLazzaro Spallanzani\u201d IRCCS, Roma, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Antinori", 
        "givenName": "A.", 
        "id": "sg:person.0675523721.85", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0675523721.85"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "San Raffaele Hospital", 
          "id": "https://www.grid.ac/institutes/grid.18887.3e", 
          "name": [
            "Department of Infectious Diseases, San Raffaele Scientific Institute, Milan, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lazzarin", 
        "givenName": "A.", 
        "id": "sg:person.01254422361.62", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01254422361.62"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Janssen (Italy)", 
          "id": "https://www.grid.ac/institutes/grid.497527.a", 
          "name": [
            "Janssen-Cilag SpA, Medical Affairs Department, Infectious Diseases, Cologno Monzese, (MI), Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Uglietti", 
        "givenName": "A.", 
        "id": "sg:person.014743135317.15", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014743135317.15"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Janssen (Italy)", 
          "id": "https://www.grid.ac/institutes/grid.497527.a", 
          "name": [
            "Janssen-Cilag SpA, Medical Affairs Department, Infectious Diseases, Cologno Monzese, (MI), Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Palma", 
        "givenName": "M.", 
        "id": "sg:person.011144106333.17", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011144106333.17"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Janssen (Italy)", 
          "id": "https://www.grid.ac/institutes/grid.497527.a", 
          "name": [
            "Janssen-Cilag SpA, Medical Affairs Department, Infectious Diseases, Cologno Monzese, (MI), Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mancusi", 
        "givenName": "D.", 
        "id": "sg:person.01106600242.71", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01106600242.71"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Janssen (Italy)", 
          "id": "https://www.grid.ac/institutes/grid.497527.a", 
          "name": [
            "Janssen-Cilag SpA, Medical Affairs Department, Infectious Diseases, Cologno Monzese, (MI), Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Termini", 
        "givenName": "R.", 
        "id": "sg:person.01154713442.75", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01154713442.75"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/s0140-6736(07)61049-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001156956"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1468-1293.2012.01004.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002810008"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.meegid.2016.08.031", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002919216"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1473-3099(15)70021-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003521277"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/bmj.327.7414.557", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005003882"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1318249111", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005652483"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(14)60084-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006262181"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s2352-3018(15)00027-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011596125"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/qad.0b013e32833dec20", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016139282"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/qad.0b013e32833dec20", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016139282"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/qai.0000000000000966", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016608078"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/qai.0000000000000966", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016608078"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2147/dddt.s104875", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021597433"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/qad.0b013e32832d7350", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029890881"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/qad.0b013e32832d7350", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029890881"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/qad.0b013e32832d7350", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029890881"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(14)61170-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033681539"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s40265-013-0159-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033873781", 
          "https://doi.org/10.1007/s40265-013-0159-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/qad.0b013e3283348944", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034237969"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/qad.0b013e3283348944", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034237969"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/qad.0b013e3283348944", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034237969"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0073639", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034291509"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0197-2456(86)90046-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034546744"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0197-2456(86)90046-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034546744"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/hiv.12121", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036527294"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jac/dkr199", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038120606"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/qad.0b013e328345ee95", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039219066"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/qad.0b013e328345ee95", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039219066"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1517/14656566.2015.1109632", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040178726"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/cid/civ193", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042054638"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jac/dku516", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042571260"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1468-1293.2012.01060.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044568143"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/hiv.12118", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045855583"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/hiv.12386", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048210167"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/aid.2011.0327", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049300855"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/qad.0000000000000778", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052121840"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/qad.0000000000000778", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052121840"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(07)60497-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052178656"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/cid/ciu773", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053073486"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/qad.0b013e32830285fb", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053740277"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/qad.0b013e32830285fb", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053740277"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/qad.0b013e32830285fb", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053740277"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/aid.2015.0248", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059216280"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/aid.2015.0248", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059216280"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/aid.2007.0275", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059225589"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jac/dkw103", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059736233"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/bmj.315.7109.629", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062780726"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/bmj.315.7109.629", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062780726"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1310/hct1404-140", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064986528"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2174/157016212799937218", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1069197907"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2307/2533446", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1069978841"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3851/imp1301", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071479035"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3851/imp1719", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071479275"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3851/imp2962", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071480012"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3851/imp3000", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071480050"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.7326/m14-1084", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1073742390"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079318519", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/oxfordjournals.epirev.a036298", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1079892369"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0171611", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083813689"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00705-017-3346-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084023148", 
          "https://doi.org/10.1007/s00705-017-3346-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00705-017-3346-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084023148", 
          "https://doi.org/10.1007/s00705-017-3346-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s2352-3018(17)30179-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1092127863"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2018-12", 
    "datePublishedReg": "2018-12-01", 
    "description": "Darunavir/ritonavir (DRV/r) is a second-generation protease inhibitor used in treatment-na\u00efve and -experienced HIV-positive adult patients. To evaluate efficacy and safety in these patient settings, we performed a meta-analysis of randomized controlled trials. We considered eight studies involving 4240 antiretroviral treatment (ART)-na\u00efve patients and 14 studies involving 2684 ART-experienced patients. Regarding efficacy in the ART-naive patients, the virological response rate was not significantly different between DRV/r and the comparator. For the ART-experienced failing patients, the virological response rate was significantly higher with DRV/r than with the comparator (RR 1.45, 95% CI: 1.01-2.08); conversely, no significant differences were found between the treatment-experienced and virologically controlled DRV/r and comparator groups. Regarding safety, the discontinuation rates due to adverse events (AEs) and DRV/r-related serious adverse events (SAEs) did not significantly differ from the rates in the comparator group (RR 0.84, 95% CI: 0.59-1.19 and RR 0.78, 95% CI: 0.57-1.05, respectively). Our meta-analysis indicated that DRV/r-based regimens were effective and tolerable for both types of patients, which was consistent with published data.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/s41598-018-23375-6", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1045337", 
        "issn": [
          "2045-2322"
        ], 
        "name": "Scientific Reports", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "8"
      }
    ], 
    "name": "Efficacy and safety of boosted darunavir-based antiretroviral therapy in HIV-1-positive patients: results from a meta-analysis of clinical trials", 
    "pagination": "5288", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "5086a6d44b492b887f0524ef9d7d7bcfcb13aa9cc14fb6f32600ee819f4e8204"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "29588457"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101563288"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/s41598-018-23375-6"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1101770983"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/s41598-018-23375-6", 
      "https://app.dimensions.ai/details/publication/pub.1101770983"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T13:07", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000367_0000000367/records_88218_00000001.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/s41598-018-23375-6"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-23375-6'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-23375-6'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-23375-6'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-23375-6'


 

This table displays all metadata directly associated to this object as RDF triples.

254 TRIPLES      21 PREDICATES      77 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/s41598-018-23375-6 schema:about anzsrc-for:11
2 anzsrc-for:1103
3 schema:author N521f0b4d3a0f40388ca16689b2e007ef
4 schema:citation sg:pub.10.1007/s00705-017-3346-9
5 sg:pub.10.1007/s40265-013-0159-3
6 https://app.dimensions.ai/details/publication/pub.1079318519
7 https://doi.org/10.1016/0197-2456(86)90046-2
8 https://doi.org/10.1016/j.meegid.2016.08.031
9 https://doi.org/10.1016/s0140-6736(07)60497-8
10 https://doi.org/10.1016/s0140-6736(07)61049-6
11 https://doi.org/10.1016/s0140-6736(14)60084-2
12 https://doi.org/10.1016/s0140-6736(14)61170-3
13 https://doi.org/10.1016/s1473-3099(15)70021-6
14 https://doi.org/10.1016/s2352-3018(15)00027-2
15 https://doi.org/10.1016/s2352-3018(17)30179-0
16 https://doi.org/10.1073/pnas.1318249111
17 https://doi.org/10.1089/aid.2007.0275
18 https://doi.org/10.1089/aid.2011.0327
19 https://doi.org/10.1089/aid.2015.0248
20 https://doi.org/10.1093/cid/ciu773
21 https://doi.org/10.1093/cid/civ193
22 https://doi.org/10.1093/jac/dkr199
23 https://doi.org/10.1093/jac/dku516
24 https://doi.org/10.1093/jac/dkw103
25 https://doi.org/10.1093/oxfordjournals.epirev.a036298
26 https://doi.org/10.1097/qad.0000000000000778
27 https://doi.org/10.1097/qad.0b013e32830285fb
28 https://doi.org/10.1097/qad.0b013e32832d7350
29 https://doi.org/10.1097/qad.0b013e3283348944
30 https://doi.org/10.1097/qad.0b013e32833dec20
31 https://doi.org/10.1097/qad.0b013e328345ee95
32 https://doi.org/10.1097/qai.0000000000000966
33 https://doi.org/10.1111/hiv.12118
34 https://doi.org/10.1111/hiv.12121
35 https://doi.org/10.1111/hiv.12386
36 https://doi.org/10.1111/j.1468-1293.2012.01004.x
37 https://doi.org/10.1111/j.1468-1293.2012.01060.x
38 https://doi.org/10.1136/bmj.315.7109.629
39 https://doi.org/10.1136/bmj.327.7414.557
40 https://doi.org/10.1310/hct1404-140
41 https://doi.org/10.1371/journal.pone.0073639
42 https://doi.org/10.1371/journal.pone.0171611
43 https://doi.org/10.1517/14656566.2015.1109632
44 https://doi.org/10.2147/dddt.s104875
45 https://doi.org/10.2174/157016212799937218
46 https://doi.org/10.2307/2533446
47 https://doi.org/10.3851/imp1301
48 https://doi.org/10.3851/imp1719
49 https://doi.org/10.3851/imp2962
50 https://doi.org/10.3851/imp3000
51 https://doi.org/10.7326/m14-1084
52 schema:datePublished 2018-12
53 schema:datePublishedReg 2018-12-01
54 schema:description Darunavir/ritonavir (DRV/r) is a second-generation protease inhibitor used in treatment-naïve and -experienced HIV-positive adult patients. To evaluate efficacy and safety in these patient settings, we performed a meta-analysis of randomized controlled trials. We considered eight studies involving 4240 antiretroviral treatment (ART)-naïve patients and 14 studies involving 2684 ART-experienced patients. Regarding efficacy in the ART-naive patients, the virological response rate was not significantly different between DRV/r and the comparator. For the ART-experienced failing patients, the virological response rate was significantly higher with DRV/r than with the comparator (RR 1.45, 95% CI: 1.01-2.08); conversely, no significant differences were found between the treatment-experienced and virologically controlled DRV/r and comparator groups. Regarding safety, the discontinuation rates due to adverse events (AEs) and DRV/r-related serious adverse events (SAEs) did not significantly differ from the rates in the comparator group (RR 0.84, 95% CI: 0.59-1.19 and RR 0.78, 95% CI: 0.57-1.05, respectively). Our meta-analysis indicated that DRV/r-based regimens were effective and tolerable for both types of patients, which was consistent with published data.
55 schema:genre research_article
56 schema:inLanguage en
57 schema:isAccessibleForFree true
58 schema:isPartOf N27790a4e663d47a985c7af029c489327
59 Na39ebc05c4d14312a6a42c1fd53eb926
60 sg:journal.1045337
61 schema:name Efficacy and safety of boosted darunavir-based antiretroviral therapy in HIV-1-positive patients: results from a meta-analysis of clinical trials
62 schema:pagination 5288
63 schema:productId N11cb69eac5f2401c8259c680120d6b1d
64 N7d198324adc54d0d9fe708a4dfd6c12e
65 N9eba8354d4dd45e9b6383ebad9109ae6
66 Nbdbc955f45094a3a8914431a64e608ec
67 Nef101fd0e3f8460c8661a9d87622b090
68 schema:sameAs https://app.dimensions.ai/details/publication/pub.1101770983
69 https://doi.org/10.1038/s41598-018-23375-6
70 schema:sdDatePublished 2019-04-11T13:07
71 schema:sdLicense https://scigraph.springernature.com/explorer/license/
72 schema:sdPublisher N7ac700241ac94ae0850dd7a7fd0909b3
73 schema:url https://www.nature.com/articles/s41598-018-23375-6
74 sgo:license sg:explorer/license/
75 sgo:sdDataset articles
76 rdf:type schema:ScholarlyArticle
77 N11cb69eac5f2401c8259c680120d6b1d schema:name doi
78 schema:value 10.1038/s41598-018-23375-6
79 rdf:type schema:PropertyValue
80 N27790a4e663d47a985c7af029c489327 schema:issueNumber 1
81 rdf:type schema:PublicationIssue
82 N2caac28ed6164ae79a3fc829fcf661c5 rdf:first sg:person.01154713442.75
83 rdf:rest rdf:nil
84 N30eebdc81256401ab83c89bb9625321b rdf:first sg:person.01106600242.71
85 rdf:rest N2caac28ed6164ae79a3fc829fcf661c5
86 N48a2fb108a9143d8b72350d9cf5def9f rdf:first sg:person.014743135317.15
87 rdf:rest N50236583b9444f7cb47948b5dc5c4c8d
88 N50236583b9444f7cb47948b5dc5c4c8d rdf:first sg:person.011144106333.17
89 rdf:rest N30eebdc81256401ab83c89bb9625321b
90 N521f0b4d3a0f40388ca16689b2e007ef rdf:first sg:person.0675523721.85
91 rdf:rest N5409fe104fb3467aa0f8c5b2239724fb
92 N5409fe104fb3467aa0f8c5b2239724fb rdf:first sg:person.01254422361.62
93 rdf:rest N48a2fb108a9143d8b72350d9cf5def9f
94 N7ac700241ac94ae0850dd7a7fd0909b3 schema:name Springer Nature - SN SciGraph project
95 rdf:type schema:Organization
96 N7d198324adc54d0d9fe708a4dfd6c12e schema:name dimensions_id
97 schema:value pub.1101770983
98 rdf:type schema:PropertyValue
99 N9eba8354d4dd45e9b6383ebad9109ae6 schema:name pubmed_id
100 schema:value 29588457
101 rdf:type schema:PropertyValue
102 Na39ebc05c4d14312a6a42c1fd53eb926 schema:volumeNumber 8
103 rdf:type schema:PublicationVolume
104 Nbdbc955f45094a3a8914431a64e608ec schema:name readcube_id
105 schema:value 5086a6d44b492b887f0524ef9d7d7bcfcb13aa9cc14fb6f32600ee819f4e8204
106 rdf:type schema:PropertyValue
107 Nef101fd0e3f8460c8661a9d87622b090 schema:name nlm_unique_id
108 schema:value 101563288
109 rdf:type schema:PropertyValue
110 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
111 schema:name Medical and Health Sciences
112 rdf:type schema:DefinedTerm
113 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
114 schema:name Clinical Sciences
115 rdf:type schema:DefinedTerm
116 sg:journal.1045337 schema:issn 2045-2322
117 schema:name Scientific Reports
118 rdf:type schema:Periodical
119 sg:person.01106600242.71 schema:affiliation https://www.grid.ac/institutes/grid.497527.a
120 schema:familyName Mancusi
121 schema:givenName D.
122 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01106600242.71
123 rdf:type schema:Person
124 sg:person.011144106333.17 schema:affiliation https://www.grid.ac/institutes/grid.497527.a
125 schema:familyName Palma
126 schema:givenName M.
127 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011144106333.17
128 rdf:type schema:Person
129 sg:person.01154713442.75 schema:affiliation https://www.grid.ac/institutes/grid.497527.a
130 schema:familyName Termini
131 schema:givenName R.
132 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01154713442.75
133 rdf:type schema:Person
134 sg:person.01254422361.62 schema:affiliation https://www.grid.ac/institutes/grid.18887.3e
135 schema:familyName Lazzarin
136 schema:givenName A.
137 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01254422361.62
138 rdf:type schema:Person
139 sg:person.014743135317.15 schema:affiliation https://www.grid.ac/institutes/grid.497527.a
140 schema:familyName Uglietti
141 schema:givenName A.
142 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014743135317.15
143 rdf:type schema:Person
144 sg:person.0675523721.85 schema:affiliation https://www.grid.ac/institutes/grid.419423.9
145 schema:familyName Antinori
146 schema:givenName A.
147 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0675523721.85
148 rdf:type schema:Person
149 sg:pub.10.1007/s00705-017-3346-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084023148
150 https://doi.org/10.1007/s00705-017-3346-9
151 rdf:type schema:CreativeWork
152 sg:pub.10.1007/s40265-013-0159-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033873781
153 https://doi.org/10.1007/s40265-013-0159-3
154 rdf:type schema:CreativeWork
155 https://app.dimensions.ai/details/publication/pub.1079318519 schema:CreativeWork
156 https://doi.org/10.1016/0197-2456(86)90046-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034546744
157 rdf:type schema:CreativeWork
158 https://doi.org/10.1016/j.meegid.2016.08.031 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002919216
159 rdf:type schema:CreativeWork
160 https://doi.org/10.1016/s0140-6736(07)60497-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052178656
161 rdf:type schema:CreativeWork
162 https://doi.org/10.1016/s0140-6736(07)61049-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001156956
163 rdf:type schema:CreativeWork
164 https://doi.org/10.1016/s0140-6736(14)60084-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006262181
165 rdf:type schema:CreativeWork
166 https://doi.org/10.1016/s0140-6736(14)61170-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033681539
167 rdf:type schema:CreativeWork
168 https://doi.org/10.1016/s1473-3099(15)70021-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003521277
169 rdf:type schema:CreativeWork
170 https://doi.org/10.1016/s2352-3018(15)00027-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011596125
171 rdf:type schema:CreativeWork
172 https://doi.org/10.1016/s2352-3018(17)30179-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092127863
173 rdf:type schema:CreativeWork
174 https://doi.org/10.1073/pnas.1318249111 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005652483
175 rdf:type schema:CreativeWork
176 https://doi.org/10.1089/aid.2007.0275 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059225589
177 rdf:type schema:CreativeWork
178 https://doi.org/10.1089/aid.2011.0327 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049300855
179 rdf:type schema:CreativeWork
180 https://doi.org/10.1089/aid.2015.0248 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059216280
181 rdf:type schema:CreativeWork
182 https://doi.org/10.1093/cid/ciu773 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053073486
183 rdf:type schema:CreativeWork
184 https://doi.org/10.1093/cid/civ193 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042054638
185 rdf:type schema:CreativeWork
186 https://doi.org/10.1093/jac/dkr199 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038120606
187 rdf:type schema:CreativeWork
188 https://doi.org/10.1093/jac/dku516 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042571260
189 rdf:type schema:CreativeWork
190 https://doi.org/10.1093/jac/dkw103 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059736233
191 rdf:type schema:CreativeWork
192 https://doi.org/10.1093/oxfordjournals.epirev.a036298 schema:sameAs https://app.dimensions.ai/details/publication/pub.1079892369
193 rdf:type schema:CreativeWork
194 https://doi.org/10.1097/qad.0000000000000778 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052121840
195 rdf:type schema:CreativeWork
196 https://doi.org/10.1097/qad.0b013e32830285fb schema:sameAs https://app.dimensions.ai/details/publication/pub.1053740277
197 rdf:type schema:CreativeWork
198 https://doi.org/10.1097/qad.0b013e32832d7350 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029890881
199 rdf:type schema:CreativeWork
200 https://doi.org/10.1097/qad.0b013e3283348944 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034237969
201 rdf:type schema:CreativeWork
202 https://doi.org/10.1097/qad.0b013e32833dec20 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016139282
203 rdf:type schema:CreativeWork
204 https://doi.org/10.1097/qad.0b013e328345ee95 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039219066
205 rdf:type schema:CreativeWork
206 https://doi.org/10.1097/qai.0000000000000966 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016608078
207 rdf:type schema:CreativeWork
208 https://doi.org/10.1111/hiv.12118 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045855583
209 rdf:type schema:CreativeWork
210 https://doi.org/10.1111/hiv.12121 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036527294
211 rdf:type schema:CreativeWork
212 https://doi.org/10.1111/hiv.12386 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048210167
213 rdf:type schema:CreativeWork
214 https://doi.org/10.1111/j.1468-1293.2012.01004.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1002810008
215 rdf:type schema:CreativeWork
216 https://doi.org/10.1111/j.1468-1293.2012.01060.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1044568143
217 rdf:type schema:CreativeWork
218 https://doi.org/10.1136/bmj.315.7109.629 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062780726
219 rdf:type schema:CreativeWork
220 https://doi.org/10.1136/bmj.327.7414.557 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005003882
221 rdf:type schema:CreativeWork
222 https://doi.org/10.1310/hct1404-140 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064986528
223 rdf:type schema:CreativeWork
224 https://doi.org/10.1371/journal.pone.0073639 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034291509
225 rdf:type schema:CreativeWork
226 https://doi.org/10.1371/journal.pone.0171611 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083813689
227 rdf:type schema:CreativeWork
228 https://doi.org/10.1517/14656566.2015.1109632 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040178726
229 rdf:type schema:CreativeWork
230 https://doi.org/10.2147/dddt.s104875 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021597433
231 rdf:type schema:CreativeWork
232 https://doi.org/10.2174/157016212799937218 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069197907
233 rdf:type schema:CreativeWork
234 https://doi.org/10.2307/2533446 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069978841
235 rdf:type schema:CreativeWork
236 https://doi.org/10.3851/imp1301 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071479035
237 rdf:type schema:CreativeWork
238 https://doi.org/10.3851/imp1719 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071479275
239 rdf:type schema:CreativeWork
240 https://doi.org/10.3851/imp2962 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071480012
241 rdf:type schema:CreativeWork
242 https://doi.org/10.3851/imp3000 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071480050
243 rdf:type schema:CreativeWork
244 https://doi.org/10.7326/m14-1084 schema:sameAs https://app.dimensions.ai/details/publication/pub.1073742390
245 rdf:type schema:CreativeWork
246 https://www.grid.ac/institutes/grid.18887.3e schema:alternateName San Raffaele Hospital
247 schema:name Department of Infectious Diseases, San Raffaele Scientific Institute, Milan, Italy
248 rdf:type schema:Organization
249 https://www.grid.ac/institutes/grid.419423.9 schema:alternateName Istituto Nazionale per le Malattie Infettive Lazzaro Spallanzani
250 schema:name HIV/AIDS Department, National Institute for Infectious Diseases “Lazzaro Spallanzani” IRCCS, Roma, Italy
251 rdf:type schema:Organization
252 https://www.grid.ac/institutes/grid.497527.a schema:alternateName Janssen (Italy)
253 schema:name Janssen-Cilag SpA, Medical Affairs Department, Infectious Diseases, Cologno Monzese, (MI), Italy
254 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...