Bone-related Circulating MicroRNAs miR-29b-3p, miR-550a-3p, and miR-324-3p and their Association to Bone Microstructure and Histomorphometry View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-12

AUTHORS

Xaver Feichtinger, Christian Muschitz, Patrick Heimel, Andreas Baierl, Astrid Fahrleitner-Pammer, Heinz Redl, Heinrich Resch, Elisabeth Geiger, Susanna Skalicky, Rainer Dormann, Fabian Plachel, Peter Pietschmann, Johannes Grillari, Matthias Hackl, Roland Kocijan

ABSTRACT

The assessment of bone quality and the prediction of fracture risk in idiopathic osteoporosis (IOP) are complex prospects as bone mineral density (BMD) and bone turnover markers (BTM) do not indicate fracture-risk. MicroRNAs (miRNAs) are promising new biomarkers for bone diseases, but the current understanding of the biological information contained in the variability of miRNAs is limited. Here, we investigated the association between serum-levels of 19 miRNA biomarkers of idiopathic osteoporosis to bone microstructure and bone histomorphometry based upon bone biopsies and µCT (9.3 μm) scans from 36 patients. Four miRNAs were found to be correlated to bone microarchitecture and seven miRNAs to dynamic histomorphometry (p < 0.05). Three miRNAs, namely, miR-29b-3p, miR-324-3p, and miR-550a-3p showed significant correlations to histomorphometric parameters of bone formation as well as microstructure parameters. miR-29b-3p and miR-324-p were found to be reduced in patients undergoing anti-resorptive therapy. This is the first study to report that serum levels of bone-related miRNAs might be surrogates of dynamic histomorphometry and potentially reveal changes in bone microstructure. Although these findings enhance the potential value of circulating miRNAs as bone biomarkers, further experimental studies are required to qualify the clinical utility of miRNAs to reflect dynamic changes in bone formation and microstructure. More... »

PAGES

4867

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41598-018-22844-2

DOI

http://dx.doi.org/10.1038/s41598-018-22844-2

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1101582167

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29559644


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Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-22844-2'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-22844-2'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-22844-2'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-22844-2'


 

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298 https://www.grid.ac/institutes/grid.454388.6 schema:alternateName Ludwig Boltzmann Institute for Experimental and Clinical Traumatology
299 schema:name Austrian Cluster for Tissue Regeneration, Vienna, Austria Department of Traumatology, Medical University of Vienna, Vienna, Austria
300 Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, Vienna, Austria
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302 https://www.grid.ac/institutes/grid.461839.1 schema:alternateName Lehrkrankenhäuser
303 schema:name Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, Vienna, Austria
304 St. Vincent Hospital – Medical Department II, The VINFORCE Study Group, Academic Teaching Hospital of the Medical University of Vienna, Vienna, Austria
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306 https://www.grid.ac/institutes/grid.5173.0 schema:alternateName University of Natural Resources and Life Sciences
307 schema:name Christian Doppler Laboratory on Biotechnology of Skin Aging, Department of Biotechnology, BOKU - University of Natural Resources and Life Sciences Vienna, Vienna, Austria
308 TAmiRNA GmbH, Vienna, Austria
309 rdf:type schema:Organization
 




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