Porous 3D Prussian blue/cellulose aerogel as a decorporation agent for removal of ingested cesium from the gastrointestinal tract View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-12

AUTHORS

Ilsong Lee, Sung-Hyun Kim, Muruganantham Rethinasabapathy, Yuvaraj Haldorai, Go-Woon Lee, Sang Rak Choe, Sung-Chan Jang, Sung-Min Kang, Young-Kyu Han, Changhyun Roh, Wan-Seob Cho, Yun Suk Huh

ABSTRACT

In the present study, we successfully synthesized a porous three-dimensional Prussian blue-cellulose aerogel (PB-CA) composite and used it as a decorporation agent for the selective removal of ingested cesium ions (Cs+) from the gastrointestinal (GI) tract. The safety of the PB-CA composite was evaluated through an in vitro cytotoxicity study using macrophage-like THP-1 cells and Caco-2 intestinal epithelial cells. The results revealed that the PB-CA composite was not cytotoxic. An adsorption study to examine the efficiency of the decorporation agent was conducted using a simulated intestinal fluid (SIF). The adsorption isotherm was fitted to the Langmuir model with a maximum Cs+ adsorption capacity of 13.70 mg/g in SIF that followed pseudo-second-order kinetics. The PB-CA composite showed excellent stability in SIF with a maximum Cs+ removal efficiency of 99.43%. The promising safety toxicology profile, remarkable Cs+ adsorption efficacy, and excellent stability of the composite demonstrated its great potential for use as an orally administered drug for the decorporation of Cs+ from the GI tract. More... »

PAGES

4540

References to SciGraph publications

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41598-018-22715-w

    DOI

    http://dx.doi.org/10.1038/s41598-018-22715-w

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1101481641

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/29540724


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