Rearrangement of Actin Microfilaments in the Development of Olfactory Receptor Cells in Fish View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-12

AUTHORS

Igor V. Klimenkov, Nikolay P. Sudakov, Mikhail V. Pastukhov, Mikhail M. Svinov, Nikolay S. Kositsyn

ABSTRACT

At present, it remains poorly understood how the olfactory neuron migrates through the thick neuroepithelium during its maturation from a stem cell and how it develops a specific sensitivity to environmental odorants after maturation. We investigated the cytochemical features associated with the development of olfactory cells before and after the incorporation of dendrites into the surface of the olfactory epithelium. Using cytochemical staining for the actin cytoskeleton and other cell components, we found that immature neurons acquire a streamlined shape that resembles a «hot-dog» during their migration: a dense layer of actin microfilaments forms beneath the surface membrane of the growing dendrite, and the bulk of the nuclear material moves inside this layer. We have found that when the cell makes contact with its environment, the dendritic terminal develops a wide actin layer, inside which a pore is formed. It is assumed that the functional receptors of odorants generate across this pore the first intracellular signal from environmental water-soluble odorants. These data illustrate the important role of the cytoskeleton in the differentiation of olfactory cells. More... »

PAGES

3692

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41598-018-22049-7

DOI

http://dx.doi.org/10.1038/s41598-018-22049-7

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1101148933

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29487380


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Download the RDF metadata as:  json-ld nt turtle xml License info

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RDF/XML is a standard XML format for linked data.

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283 schema:name Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, 5a Butlerova St., 117485, Moscow, Russia
284 rdf:type schema:Organization
 




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