Nanodelivery of a functional membrane receptor to manipulate cellular phenotype View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-12

AUTHORS

Tommaso Patriarchi, Ao Shen, Wei He, Mo Baikoghli, R. Holland Cheng, Yang K. Xiang, Matthew A. Coleman, Lin Tian

ABSTRACT

Modification of membrane receptor makeup is one of the most efficient ways to control input-output signals but is usually achieved by expressing DNA or RNA-encoded proteins or by using other genome-editing methods, which can be technically challenging and produce unwanted side effects. Here we develop and validate a nanodelivery approach to transfer in vitro synthesized, functional membrane receptors into the plasma membrane of living cells. Using β2-adrenergic receptor (β2AR), a prototypical G-protein coupled receptor, as an example, we demonstrated efficient incorporation of a full-length β2AR into a variety of mammalian cells, which imparts pharmacologic control over cellular signaling and affects cellular phenotype in an ex-vivo wound-healing model. Our approach for nanodelivery of functional membrane receptors expands the current toolkit for DNA and RNA-free manipulation of cellular function. We expect this approach to be readily applicable to the synthesis and nanodelivery of other types of GPCRs and membrane receptors, opening new doors for therapeutic development at the intersection between synthetic biology and nanomedicine. More... »

PAGES

3556

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41598-018-21863-3

DOI

http://dx.doi.org/10.1038/s41598-018-21863-3

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1101113744

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29476125


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of California, Davis", 
          "id": "https://www.grid.ac/institutes/grid.27860.3b", 
          "name": [
            "University of California Davis, School of Medicine, Department of Biochemistry and Molecular Medicine, Davis, California, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Patriarchi", 
        "givenName": "Tommaso", 
        "id": "sg:person.01255203347.42", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01255203347.42"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of California, Davis", 
          "id": "https://www.grid.ac/institutes/grid.27860.3b", 
          "name": [
            "University of California Davis, School of Medicine, Department of Pharmacology, Davis, California, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shen", 
        "givenName": "Ao", 
        "id": "sg:person.0652230777.78", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0652230777.78"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Lawrence Livermore National Laboratory", 
          "id": "https://www.grid.ac/institutes/grid.250008.f", 
          "name": [
            "Lawrence Livermore National Laboratory, Livermore, California, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "He", 
        "givenName": "Wei", 
        "id": "sg:person.01227173045.60", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01227173045.60"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "University of California Davis, Department of Molecular and Cellular Biology, California, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Baikoghli", 
        "givenName": "Mo", 
        "id": "sg:person.012320733275.15", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012320733275.15"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "University of California Davis, Department of Molecular and Cellular Biology, California, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cheng", 
        "givenName": "R. Holland", 
        "id": "sg:person.0606151267.52", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0606151267.52"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "VA Northern California Health Care System", 
          "id": "https://www.grid.ac/institutes/grid.413933.f", 
          "name": [
            "University of California Davis, School of Medicine, Department of Pharmacology, Davis, California, USA", 
            "VA Northern California Health care system, Mather, California, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Xiang", 
        "givenName": "Yang K.", 
        "id": "sg:person.0735330577.69", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0735330577.69"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of California, Davis", 
          "id": "https://www.grid.ac/institutes/grid.27860.3b", 
          "name": [
            "Lawrence Livermore National Laboratory, Livermore, California, USA", 
            "University of California Davis School of Medicine, Radiation Oncology, Sacramento, California, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Coleman", 
        "givenName": "Matthew A.", 
        "id": "sg:person.016522417722.99", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016522417722.99"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of California, Davis", 
          "id": "https://www.grid.ac/institutes/grid.27860.3b", 
          "name": [
            "University of California Davis, School of Medicine, Department of Biochemistry and Molecular Medicine, Davis, California, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tian", 
        "givenName": "Lin", 
        "id": "sg:person.0644233705.25", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0644233705.25"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/srep21508", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004651654", 
          "https://doi.org/10.1038/srep21508"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature12000", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006179705", 
          "https://doi.org/10.1038/nature12000"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1039/b823243a", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007576600"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1039/b823243a", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007576600"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nmeth1024", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008053204", 
          "https://doi.org/10.1038/nmeth1024"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/mt.2015.121", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008663602"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature10361", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008768060", 
          "https://doi.org/10.1038/nature10361"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/srep30399", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008833930", 
          "https://doi.org/10.1038/srep30399"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2217/nnm.13.35", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009787647"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0044911", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010742192"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2147/ijn.s39888", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011540088"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/bs.mie.2014.12.033", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011567108"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2015.03.028", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012478310"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2015.03.028", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012478310"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1242/jcs.02772", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016852071"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.febslet.2015.05.045", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018390915"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jmb.2007.05.087", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019669472"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1472-6750-11-57", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019823397", 
          "https://doi.org/10.1186/1472-6750-11-57"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1476-5381.2010.00754.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021256002"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.febslet.2009.10.024", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023924777"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/srep30442", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029400865", 
          "https://doi.org/10.1038/srep30442"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nmat4822", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030847378", 
          "https://doi.org/10.1038/nmat4822"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0093342", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031262425"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbamem.2011.10.020", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032713599"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature10016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033855926", 
          "https://doi.org/10.1038/nature10016"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1414162111", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037774255"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/srep12896", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037786795", 
          "https://doi.org/10.1038/srep12896"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/jid.2014.312", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038538957", 
          "https://doi.org/10.1038/jid.2014.312"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0023036", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038780894"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrm3933", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039394630", 
          "https://doi.org/10.1038/nrm3933"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nprot.2011.452", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043250794", 
          "https://doi.org/10.1038/nprot.2011.452"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nsmb.3195", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050220121", 
          "https://doi.org/10.1038/nsmb.3195"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-1-4939-2230-7_10", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053458102", 
          "https://doi.org/10.1007/978-1-4939-2230-7_10"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2144/000112169", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1069095301"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/s41598-017-01227-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084946873", 
          "https://doi.org/10.1038/s41598-017-01227-z"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2018-12", 
    "datePublishedReg": "2018-12-01", 
    "description": "Modification of membrane receptor makeup is one of the most efficient ways to control input-output signals but is usually achieved by expressing DNA or RNA-encoded proteins or by using other genome-editing methods, which can be technically challenging and produce unwanted side effects. Here we develop and validate a nanodelivery approach to transfer in vitro synthesized, functional membrane receptors into the plasma membrane of living cells. Using \u03b22-adrenergic receptor (\u03b22AR), a prototypical G-protein coupled receptor, as an example, we demonstrated efficient incorporation of a full-length \u03b22AR into a variety of mammalian cells, which imparts pharmacologic control over cellular signaling and affects cellular phenotype in an ex-vivo wound-healing model. Our approach for nanodelivery of functional membrane receptors expands the current toolkit for DNA and RNA-free manipulation of cellular function. We expect this approach to be readily applicable to the synthesis and nanodelivery of other types of GPCRs and membrane receptors, opening new doors for therapeutic development at the intersection between synthetic biology and nanomedicine.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/s41598-018-21863-3", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.5054633", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2666653", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.3806144", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.4455269", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.4103115", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2481263", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2425017", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.3803510", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.3932319", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.4454752", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1045337", 
        "issn": [
          "2045-2322"
        ], 
        "name": "Scientific Reports", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "8"
      }
    ], 
    "name": "Nanodelivery of a functional membrane receptor to manipulate cellular phenotype", 
    "pagination": "3556", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "9457fea1cd6a2c8da0b79aba219ccd6ae52c3740b6cb87e6a4d04fea9c9fb400"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "29476125"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101563288"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/s41598-018-21863-3"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1101113744"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/s41598-018-21863-3", 
      "https://app.dimensions.ai/details/publication/pub.1101113744"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T09:30", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000346_0000000346/records_99802_00000004.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/s41598-018-21863-3"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-21863-3'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-21863-3'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-21863-3'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-21863-3'


 

This table displays all metadata directly associated to this object as RDF triples.

266 TRIPLES      21 PREDICATES      62 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/s41598-018-21863-3 schema:about anzsrc-for:06
2 anzsrc-for:0601
3 schema:author N77491db8f7ec4b348d1793af1d0d4893
4 schema:citation sg:pub.10.1007/978-1-4939-2230-7_10
5 sg:pub.10.1038/jid.2014.312
6 sg:pub.10.1038/nature10016
7 sg:pub.10.1038/nature10361
8 sg:pub.10.1038/nature12000
9 sg:pub.10.1038/nmat4822
10 sg:pub.10.1038/nmeth1024
11 sg:pub.10.1038/nprot.2011.452
12 sg:pub.10.1038/nrm3933
13 sg:pub.10.1038/nsmb.3195
14 sg:pub.10.1038/s41598-017-01227-z
15 sg:pub.10.1038/srep12896
16 sg:pub.10.1038/srep21508
17 sg:pub.10.1038/srep30399
18 sg:pub.10.1038/srep30442
19 sg:pub.10.1186/1472-6750-11-57
20 https://doi.org/10.1016/bs.mie.2014.12.033
21 https://doi.org/10.1016/j.bbamem.2011.10.020
22 https://doi.org/10.1016/j.cell.2015.03.028
23 https://doi.org/10.1016/j.febslet.2009.10.024
24 https://doi.org/10.1016/j.febslet.2015.05.045
25 https://doi.org/10.1016/j.jmb.2007.05.087
26 https://doi.org/10.1038/mt.2015.121
27 https://doi.org/10.1039/b823243a
28 https://doi.org/10.1073/pnas.1414162111
29 https://doi.org/10.1111/j.1476-5381.2010.00754.x
30 https://doi.org/10.1242/jcs.02772
31 https://doi.org/10.1371/journal.pone.0023036
32 https://doi.org/10.1371/journal.pone.0044911
33 https://doi.org/10.1371/journal.pone.0093342
34 https://doi.org/10.2144/000112169
35 https://doi.org/10.2147/ijn.s39888
36 https://doi.org/10.2217/nnm.13.35
37 schema:datePublished 2018-12
38 schema:datePublishedReg 2018-12-01
39 schema:description Modification of membrane receptor makeup is one of the most efficient ways to control input-output signals but is usually achieved by expressing DNA or RNA-encoded proteins or by using other genome-editing methods, which can be technically challenging and produce unwanted side effects. Here we develop and validate a nanodelivery approach to transfer in vitro synthesized, functional membrane receptors into the plasma membrane of living cells. Using β<sub>2</sub>-adrenergic receptor (β<sub>2</sub>AR), a prototypical G-protein coupled receptor, as an example, we demonstrated efficient incorporation of a full-length β<sub>2</sub>AR into a variety of mammalian cells, which imparts pharmacologic control over cellular signaling and affects cellular phenotype in an ex-vivo wound-healing model. Our approach for nanodelivery of functional membrane receptors expands the current toolkit for DNA and RNA-free manipulation of cellular function. We expect this approach to be readily applicable to the synthesis and nanodelivery of other types of GPCRs and membrane receptors, opening new doors for therapeutic development at the intersection between synthetic biology and nanomedicine.
40 schema:genre research_article
41 schema:inLanguage en
42 schema:isAccessibleForFree true
43 schema:isPartOf N1f4f0b7be05c47c293fd802cd65cb54f
44 N6e6763c9508a4a52bd5817aacdddefd6
45 sg:journal.1045337
46 schema:name Nanodelivery of a functional membrane receptor to manipulate cellular phenotype
47 schema:pagination 3556
48 schema:productId N642060c305514e728a874dbe3a6af9e0
49 N7c0d2fd638734fe591caa397960a4ecd
50 N88a44f7b5b80422cac03755675a1c708
51 N993720bc2bf64468891eef865bebd8fc
52 Ne5068de390c64177a6f9e1776add2358
53 schema:sameAs https://app.dimensions.ai/details/publication/pub.1101113744
54 https://doi.org/10.1038/s41598-018-21863-3
55 schema:sdDatePublished 2019-04-11T09:30
56 schema:sdLicense https://scigraph.springernature.com/explorer/license/
57 schema:sdPublisher N56f9a4e326694ae59ebec0a47d1602d4
58 schema:url https://www.nature.com/articles/s41598-018-21863-3
59 sgo:license sg:explorer/license/
60 sgo:sdDataset articles
61 rdf:type schema:ScholarlyArticle
62 N11aa48bcbd9647088648bd4d9243a2be rdf:first sg:person.0652230777.78
63 rdf:rest N7915e37d8429415dafc12a56cb883253
64 N1f4f0b7be05c47c293fd802cd65cb54f schema:issueNumber 1
65 rdf:type schema:PublicationIssue
66 N4b73206c35d24882b81607e9b163a9cd rdf:first sg:person.016522417722.99
67 rdf:rest Ne7ce120e8df147f3b735e0e7d2e982e1
68 N561b2cf3c1194e2f956f991cebe452c9 rdf:first sg:person.0735330577.69
69 rdf:rest N4b73206c35d24882b81607e9b163a9cd
70 N56f9a4e326694ae59ebec0a47d1602d4 schema:name Springer Nature - SN SciGraph project
71 rdf:type schema:Organization
72 N642060c305514e728a874dbe3a6af9e0 schema:name readcube_id
73 schema:value 9457fea1cd6a2c8da0b79aba219ccd6ae52c3740b6cb87e6a4d04fea9c9fb400
74 rdf:type schema:PropertyValue
75 N6e6763c9508a4a52bd5817aacdddefd6 schema:volumeNumber 8
76 rdf:type schema:PublicationVolume
77 N77491db8f7ec4b348d1793af1d0d4893 rdf:first sg:person.01255203347.42
78 rdf:rest N11aa48bcbd9647088648bd4d9243a2be
79 N7915e37d8429415dafc12a56cb883253 rdf:first sg:person.01227173045.60
80 rdf:rest Naf7737baa3c3469c8785f2e50daf2d21
81 N7c0d2fd638734fe591caa397960a4ecd schema:name nlm_unique_id
82 schema:value 101563288
83 rdf:type schema:PropertyValue
84 N88a44f7b5b80422cac03755675a1c708 schema:name pubmed_id
85 schema:value 29476125
86 rdf:type schema:PropertyValue
87 N993720bc2bf64468891eef865bebd8fc schema:name doi
88 schema:value 10.1038/s41598-018-21863-3
89 rdf:type schema:PropertyValue
90 Naf7737baa3c3469c8785f2e50daf2d21 rdf:first sg:person.012320733275.15
91 rdf:rest Nb3c6fbf757cf4466b20beea8390e27ed
92 Nb0d85df3063f4a4497df24410a22483f schema:name University of California Davis, Department of Molecular and Cellular Biology, California, USA
93 rdf:type schema:Organization
94 Nb3c6fbf757cf4466b20beea8390e27ed rdf:first sg:person.0606151267.52
95 rdf:rest N561b2cf3c1194e2f956f991cebe452c9
96 Nce90c3a54f8749d1a70522589c74648b schema:name University of California Davis, Department of Molecular and Cellular Biology, California, USA
97 rdf:type schema:Organization
98 Ne5068de390c64177a6f9e1776add2358 schema:name dimensions_id
99 schema:value pub.1101113744
100 rdf:type schema:PropertyValue
101 Ne7ce120e8df147f3b735e0e7d2e982e1 rdf:first sg:person.0644233705.25
102 rdf:rest rdf:nil
103 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
104 schema:name Biological Sciences
105 rdf:type schema:DefinedTerm
106 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
107 schema:name Biochemistry and Cell Biology
108 rdf:type schema:DefinedTerm
109 sg:grant.2425017 http://pending.schema.org/fundedItem sg:pub.10.1038/s41598-018-21863-3
110 rdf:type schema:MonetaryGrant
111 sg:grant.2481263 http://pending.schema.org/fundedItem sg:pub.10.1038/s41598-018-21863-3
112 rdf:type schema:MonetaryGrant
113 sg:grant.2666653 http://pending.schema.org/fundedItem sg:pub.10.1038/s41598-018-21863-3
114 rdf:type schema:MonetaryGrant
115 sg:grant.3803510 http://pending.schema.org/fundedItem sg:pub.10.1038/s41598-018-21863-3
116 rdf:type schema:MonetaryGrant
117 sg:grant.3806144 http://pending.schema.org/fundedItem sg:pub.10.1038/s41598-018-21863-3
118 rdf:type schema:MonetaryGrant
119 sg:grant.3932319 http://pending.schema.org/fundedItem sg:pub.10.1038/s41598-018-21863-3
120 rdf:type schema:MonetaryGrant
121 sg:grant.4103115 http://pending.schema.org/fundedItem sg:pub.10.1038/s41598-018-21863-3
122 rdf:type schema:MonetaryGrant
123 sg:grant.4454752 http://pending.schema.org/fundedItem sg:pub.10.1038/s41598-018-21863-3
124 rdf:type schema:MonetaryGrant
125 sg:grant.4455269 http://pending.schema.org/fundedItem sg:pub.10.1038/s41598-018-21863-3
126 rdf:type schema:MonetaryGrant
127 sg:grant.5054633 http://pending.schema.org/fundedItem sg:pub.10.1038/s41598-018-21863-3
128 rdf:type schema:MonetaryGrant
129 sg:journal.1045337 schema:issn 2045-2322
130 schema:name Scientific Reports
131 rdf:type schema:Periodical
132 sg:person.01227173045.60 schema:affiliation https://www.grid.ac/institutes/grid.250008.f
133 schema:familyName He
134 schema:givenName Wei
135 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01227173045.60
136 rdf:type schema:Person
137 sg:person.012320733275.15 schema:affiliation Nce90c3a54f8749d1a70522589c74648b
138 schema:familyName Baikoghli
139 schema:givenName Mo
140 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012320733275.15
141 rdf:type schema:Person
142 sg:person.01255203347.42 schema:affiliation https://www.grid.ac/institutes/grid.27860.3b
143 schema:familyName Patriarchi
144 schema:givenName Tommaso
145 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01255203347.42
146 rdf:type schema:Person
147 sg:person.016522417722.99 schema:affiliation https://www.grid.ac/institutes/grid.27860.3b
148 schema:familyName Coleman
149 schema:givenName Matthew A.
150 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016522417722.99
151 rdf:type schema:Person
152 sg:person.0606151267.52 schema:affiliation Nb0d85df3063f4a4497df24410a22483f
153 schema:familyName Cheng
154 schema:givenName R. Holland
155 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0606151267.52
156 rdf:type schema:Person
157 sg:person.0644233705.25 schema:affiliation https://www.grid.ac/institutes/grid.27860.3b
158 schema:familyName Tian
159 schema:givenName Lin
160 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0644233705.25
161 rdf:type schema:Person
162 sg:person.0652230777.78 schema:affiliation https://www.grid.ac/institutes/grid.27860.3b
163 schema:familyName Shen
164 schema:givenName Ao
165 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0652230777.78
166 rdf:type schema:Person
167 sg:person.0735330577.69 schema:affiliation https://www.grid.ac/institutes/grid.413933.f
168 schema:familyName Xiang
169 schema:givenName Yang K.
170 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0735330577.69
171 rdf:type schema:Person
172 sg:pub.10.1007/978-1-4939-2230-7_10 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053458102
173 https://doi.org/10.1007/978-1-4939-2230-7_10
174 rdf:type schema:CreativeWork
175 sg:pub.10.1038/jid.2014.312 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038538957
176 https://doi.org/10.1038/jid.2014.312
177 rdf:type schema:CreativeWork
178 sg:pub.10.1038/nature10016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033855926
179 https://doi.org/10.1038/nature10016
180 rdf:type schema:CreativeWork
181 sg:pub.10.1038/nature10361 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008768060
182 https://doi.org/10.1038/nature10361
183 rdf:type schema:CreativeWork
184 sg:pub.10.1038/nature12000 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006179705
185 https://doi.org/10.1038/nature12000
186 rdf:type schema:CreativeWork
187 sg:pub.10.1038/nmat4822 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030847378
188 https://doi.org/10.1038/nmat4822
189 rdf:type schema:CreativeWork
190 sg:pub.10.1038/nmeth1024 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008053204
191 https://doi.org/10.1038/nmeth1024
192 rdf:type schema:CreativeWork
193 sg:pub.10.1038/nprot.2011.452 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043250794
194 https://doi.org/10.1038/nprot.2011.452
195 rdf:type schema:CreativeWork
196 sg:pub.10.1038/nrm3933 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039394630
197 https://doi.org/10.1038/nrm3933
198 rdf:type schema:CreativeWork
199 sg:pub.10.1038/nsmb.3195 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050220121
200 https://doi.org/10.1038/nsmb.3195
201 rdf:type schema:CreativeWork
202 sg:pub.10.1038/s41598-017-01227-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1084946873
203 https://doi.org/10.1038/s41598-017-01227-z
204 rdf:type schema:CreativeWork
205 sg:pub.10.1038/srep12896 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037786795
206 https://doi.org/10.1038/srep12896
207 rdf:type schema:CreativeWork
208 sg:pub.10.1038/srep21508 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004651654
209 https://doi.org/10.1038/srep21508
210 rdf:type schema:CreativeWork
211 sg:pub.10.1038/srep30399 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008833930
212 https://doi.org/10.1038/srep30399
213 rdf:type schema:CreativeWork
214 sg:pub.10.1038/srep30442 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029400865
215 https://doi.org/10.1038/srep30442
216 rdf:type schema:CreativeWork
217 sg:pub.10.1186/1472-6750-11-57 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019823397
218 https://doi.org/10.1186/1472-6750-11-57
219 rdf:type schema:CreativeWork
220 https://doi.org/10.1016/bs.mie.2014.12.033 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011567108
221 rdf:type schema:CreativeWork
222 https://doi.org/10.1016/j.bbamem.2011.10.020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032713599
223 rdf:type schema:CreativeWork
224 https://doi.org/10.1016/j.cell.2015.03.028 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012478310
225 rdf:type schema:CreativeWork
226 https://doi.org/10.1016/j.febslet.2009.10.024 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023924777
227 rdf:type schema:CreativeWork
228 https://doi.org/10.1016/j.febslet.2015.05.045 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018390915
229 rdf:type schema:CreativeWork
230 https://doi.org/10.1016/j.jmb.2007.05.087 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019669472
231 rdf:type schema:CreativeWork
232 https://doi.org/10.1038/mt.2015.121 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008663602
233 rdf:type schema:CreativeWork
234 https://doi.org/10.1039/b823243a schema:sameAs https://app.dimensions.ai/details/publication/pub.1007576600
235 rdf:type schema:CreativeWork
236 https://doi.org/10.1073/pnas.1414162111 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037774255
237 rdf:type schema:CreativeWork
238 https://doi.org/10.1111/j.1476-5381.2010.00754.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1021256002
239 rdf:type schema:CreativeWork
240 https://doi.org/10.1242/jcs.02772 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016852071
241 rdf:type schema:CreativeWork
242 https://doi.org/10.1371/journal.pone.0023036 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038780894
243 rdf:type schema:CreativeWork
244 https://doi.org/10.1371/journal.pone.0044911 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010742192
245 rdf:type schema:CreativeWork
246 https://doi.org/10.1371/journal.pone.0093342 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031262425
247 rdf:type schema:CreativeWork
248 https://doi.org/10.2144/000112169 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069095301
249 rdf:type schema:CreativeWork
250 https://doi.org/10.2147/ijn.s39888 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011540088
251 rdf:type schema:CreativeWork
252 https://doi.org/10.2217/nnm.13.35 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009787647
253 rdf:type schema:CreativeWork
254 https://www.grid.ac/institutes/grid.250008.f schema:alternateName Lawrence Livermore National Laboratory
255 schema:name Lawrence Livermore National Laboratory, Livermore, California, USA
256 rdf:type schema:Organization
257 https://www.grid.ac/institutes/grid.27860.3b schema:alternateName University of California, Davis
258 schema:name Lawrence Livermore National Laboratory, Livermore, California, USA
259 University of California Davis School of Medicine, Radiation Oncology, Sacramento, California, USA
260 University of California Davis, School of Medicine, Department of Biochemistry and Molecular Medicine, Davis, California, USA
261 University of California Davis, School of Medicine, Department of Pharmacology, Davis, California, USA
262 rdf:type schema:Organization
263 https://www.grid.ac/institutes/grid.413933.f schema:alternateName VA Northern California Health Care System
264 schema:name University of California Davis, School of Medicine, Department of Pharmacology, Davis, California, USA
265 VA Northern California Health care system, Mather, California, USA
266 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...