Exogenous hydrogen sulfide gas does not induce hypothermia in normoxic mice View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-12

AUTHORS

Sebastiaan D. Hemelrijk, Marcel C. Dirkes, Marit H. N. van Velzen, Rick Bezemer, Thomas M. van Gulik, Michal Heger

ABSTRACT

Hydrogen sulfide (H2S, 80 ppm) gas in an atmosphere of 17.5% oxygen reportedly induces suspended animation in mice; a state analogous to hibernation that entails hypothermia and hypometabolism. However, exogenous H2S in combination with 17.5% oxygen is able to induce hypoxia, which in itself is a trigger of hypometabolism/hypothermia. Using non-invasive thermographic imaging, we demonstrated that mice exposed to hypoxia (5% oxygen) reduce their body temperature to ambient temperature. In contrast, animals exposed to 80 ppm H2S under normoxic conditions did not exhibit a reduction in body temperature compared to normoxic controls. In conclusion, mice induce hypothermia in response to hypoxia but not H2S gas, which contradicts the reported findings and putative contentions. More... »

PAGES

3855

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41598-018-21729-8

DOI

http://dx.doi.org/10.1038/s41598-018-21729-8

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1101201711

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29497053


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