Evaluation of Macaca radiata as a non-human primate model of Dengue virus infection View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-12

AUTHORS

Fumihiro Kato, Yuki Ishida, Akihiko Kawakami, Tomohiko Takasaki, Masayuki Saijo, Tomoyuki Miura, Takayuki Hishiki

ABSTRACT

Dengue virus (DENV) causes a wide range of illnesses in humans, including dengue fever and dengue haemorrhagic fever. Current animal models of DENV infection are limited for understanding infectious diseases in humans. Bonnet monkeys (Macaca radiata), a type of Old World monkey, have been used to study experimental and natural infections by flaviviruses, but Old World monkeys have not yet been used as DENV infection models. In this study, the replication levels of several DENV strains were evaluated using peripheral blood mononuclear cells. Our findings indicated that DENV-4 09-48 strain, isolated from a traveller returning from India in 2009, was a highly replicative virus. Three bonnet monkeys were infected with 09-48 strain and antibody responses were assessed. DENV nonstructural protein 1 antigen was detected and high viraemia was observed. These results indicated that bonnet monkeys and 09-48 strain could be used as a reliable primate model for the study of DENV. More... »

PAGES

3421

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41598-018-21582-9

DOI

http://dx.doi.org/10.1038/s41598-018-21582-9

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1101059607

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29467430


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1108", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical Microbiology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "National Institute of Infectious Diseases", 
          "id": "https://www.grid.ac/institutes/grid.410795.e", 
          "name": [
            "Laboratory of Primate Model, Institute for Frontier Life and Medical Sciences, Kyoto University, Kyoto, Japan", 
            "Department of Virology 1, National Institute of Infectious Diseases, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kato", 
        "givenName": "Fumihiro", 
        "id": "sg:person.01262677252.85", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01262677252.85"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Kyoto University", 
          "id": "https://www.grid.ac/institutes/grid.258799.8", 
          "name": [
            "Laboratory of Primate Model, Institute for Frontier Life and Medical Sciences, Kyoto University, Kyoto, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ishida", 
        "givenName": "Yuki", 
        "id": "sg:person.01331012452.05", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01331012452.05"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Kyoto University", 
          "id": "https://www.grid.ac/institutes/grid.258799.8", 
          "name": [
            "Laboratory of Primate Model, Institute for Frontier Life and Medical Sciences, Kyoto University, Kyoto, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kawakami", 
        "givenName": "Akihiko", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Kanagawa Prefectural Institute of Public Health", 
          "id": "https://www.grid.ac/institutes/grid.414984.4", 
          "name": [
            "Department of Virology 1, National Institute of Infectious Diseases, Tokyo, Japan", 
            "Kanagawa Prefectural Institute of Public Health, Kanagawa, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Takasaki", 
        "givenName": "Tomohiko", 
        "id": "sg:person.01027475323.33", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01027475323.33"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Institute of Infectious Diseases", 
          "id": "https://www.grid.ac/institutes/grid.410795.e", 
          "name": [
            "Department of Virology 1, National Institute of Infectious Diseases, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Saijo", 
        "givenName": "Masayuki", 
        "id": "sg:person.01344605367.30", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01344605367.30"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Kyoto University", 
          "id": "https://www.grid.ac/institutes/grid.258799.8", 
          "name": [
            "Laboratory of Primate Model, Institute for Frontier Life and Medical Sciences, Kyoto University, Kyoto, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Miura", 
        "givenName": "Tomoyuki", 
        "id": "sg:person.011623020462.72", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011623020462.72"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Tokyo Metropolitan Institute of Medical Science", 
          "id": "https://www.grid.ac/institutes/grid.272456.0", 
          "name": [
            "Laboratory of Primate Model, Institute for Frontier Life and Medical Sciences, Kyoto University, Kyoto, Japan", 
            "Department of Microbiology and Cell Biology, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hishiki", 
        "givenName": "Takayuki", 
        "id": "sg:person.01116061263.59", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01116061263.59"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1182/blood-2009-09-242990", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000194546"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.ppat.1000409", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000994269"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmra1110265", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005131799"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.virol.2013.01.018", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005243617"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3201/eid1611.100721", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006986569"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3389/fmicb.2013.00305", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007989402"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3390/v4010062", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008160019"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1348-0421.1998.tb02279.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008365846"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1749-6632.2009.05057.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012845186"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1749-6632.2009.05057.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012845186"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jvi.01848-10", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018797789"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jvi.01083-09", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019860307"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1266/ggs.90.133", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020836897"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1600-0684.2012.00552.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025734023"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.12688/f1000research.1-61.v1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029656987"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0165-0378(99)00026-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030443138"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.virol.2011.11.018", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031950666"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1708-8305.2007.00130.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033781535"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pntd.0000423", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034633513"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1742-4690-10-118", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035007895", 
          "https://doi.org/10.1186/1742-4690-10-118"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.tvjl.2012.08.019", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035127367"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf02629608", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036915541", 
          "https://doi.org/10.1007/bf02629608"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf02629608", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036915541", 
          "https://doi.org/10.1007/bf02629608"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.vaccine.2007.04.079", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038556152"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-3-642-02215-9_11", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039800077", 
          "https://doi.org/10.1007/978-3-642-02215-9_11"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrmicro2595", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039932505", 
          "https://doi.org/10.1038/nrmicro2595"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.virol.2011.11.024", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043668786"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01734359", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044065382", 
          "https://doi.org/10.1007/bf01734359"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01734359", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044065382", 
          "https://doi.org/10.1007/bf01734359"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0065-3527(03)61001-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045645426"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.humimm.2009.07.017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046690760"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.virol.2008.08.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047731955"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.antiviral.2016.04.014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049619121"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0882-4010(92)90083-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052340463"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1099/jgv.0.000421", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060390014"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1099/vir.0.031229-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060398778"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1099/vir.0.055343-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060399363"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1099/vir.0.060384-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060399450"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075872640", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4269/ajtmh.1990.43.212", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1077956426"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079067029", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4269/ajtmh.1974.23.118", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1080188812"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1081564460", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/cmr.11.3.480", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083291657"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2018-12", 
    "datePublishedReg": "2018-12-01", 
    "description": "Dengue virus (DENV) causes a wide range of illnesses in humans, including dengue fever and dengue haemorrhagic fever. Current animal models of DENV infection are limited for understanding infectious diseases in humans. Bonnet monkeys (Macaca radiata), a type of Old World monkey, have been used to study experimental and natural infections by flaviviruses, but Old World monkeys have not yet been used as DENV infection models. In this study, the replication levels of several DENV strains were evaluated using peripheral blood mononuclear cells. Our findings indicated that DENV-4 09-48 strain, isolated from a traveller returning from India in 2009, was a highly replicative virus. Three bonnet monkeys were infected with 09-48 strain and antibody responses were assessed. DENV nonstructural protein 1 antigen was detected and high viraemia was observed. These results indicated that bonnet monkeys and 09-48 strain could be used as a reliable primate model for the study of DENV.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/s41598-018-21582-9", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.6834404", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.5882343", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1045337", 
        "issn": [
          "2045-2322"
        ], 
        "name": "Scientific Reports", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "8"
      }
    ], 
    "name": "Evaluation of Macaca radiata as a non-human primate model of Dengue virus infection", 
    "pagination": "3421", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "6290e0a00697c48da34054174f4cad39417562293381bfffcf342f358a912306"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "29467430"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101563288"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/s41598-018-21582-9"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1101059607"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/s41598-018-21582-9", 
      "https://app.dimensions.ai/details/publication/pub.1101059607"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T09:36", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000346_0000000346/records_99824_00000004.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/s41598-018-21582-9"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-21582-9'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-21582-9'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-21582-9'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-21582-9'


 

This table displays all metadata directly associated to this object as RDF triples.

250 TRIPLES      21 PREDICATES      70 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/s41598-018-21582-9 schema:about anzsrc-for:11
2 anzsrc-for:1108
3 schema:author N86de34eca6084d5bab7da6535e5f5038
4 schema:citation sg:pub.10.1007/978-3-642-02215-9_11
5 sg:pub.10.1007/bf01734359
6 sg:pub.10.1007/bf02629608
7 sg:pub.10.1038/nrmicro2595
8 sg:pub.10.1186/1742-4690-10-118
9 https://app.dimensions.ai/details/publication/pub.1075872640
10 https://app.dimensions.ai/details/publication/pub.1079067029
11 https://app.dimensions.ai/details/publication/pub.1081564460
12 https://doi.org/10.1016/0882-4010(92)90083-z
13 https://doi.org/10.1016/j.antiviral.2016.04.014
14 https://doi.org/10.1016/j.humimm.2009.07.017
15 https://doi.org/10.1016/j.tvjl.2012.08.019
16 https://doi.org/10.1016/j.vaccine.2007.04.079
17 https://doi.org/10.1016/j.virol.2008.08.008
18 https://doi.org/10.1016/j.virol.2011.11.018
19 https://doi.org/10.1016/j.virol.2011.11.024
20 https://doi.org/10.1016/j.virol.2013.01.018
21 https://doi.org/10.1016/s0065-3527(03)61001-8
22 https://doi.org/10.1016/s0165-0378(99)00026-1
23 https://doi.org/10.1056/nejmra1110265
24 https://doi.org/10.1099/jgv.0.000421
25 https://doi.org/10.1099/vir.0.031229-0
26 https://doi.org/10.1099/vir.0.055343-0
27 https://doi.org/10.1099/vir.0.060384-0
28 https://doi.org/10.1111/j.1348-0421.1998.tb02279.x
29 https://doi.org/10.1111/j.1600-0684.2012.00552.x
30 https://doi.org/10.1111/j.1708-8305.2007.00130.x
31 https://doi.org/10.1111/j.1749-6632.2009.05057.x
32 https://doi.org/10.1128/cmr.11.3.480
33 https://doi.org/10.1128/jvi.01083-09
34 https://doi.org/10.1128/jvi.01848-10
35 https://doi.org/10.1182/blood-2009-09-242990
36 https://doi.org/10.1266/ggs.90.133
37 https://doi.org/10.12688/f1000research.1-61.v1
38 https://doi.org/10.1371/journal.pntd.0000423
39 https://doi.org/10.1371/journal.ppat.1000409
40 https://doi.org/10.3201/eid1611.100721
41 https://doi.org/10.3389/fmicb.2013.00305
42 https://doi.org/10.3390/v4010062
43 https://doi.org/10.4269/ajtmh.1974.23.118
44 https://doi.org/10.4269/ajtmh.1990.43.212
45 schema:datePublished 2018-12
46 schema:datePublishedReg 2018-12-01
47 schema:description Dengue virus (DENV) causes a wide range of illnesses in humans, including dengue fever and dengue haemorrhagic fever. Current animal models of DENV infection are limited for understanding infectious diseases in humans. Bonnet monkeys (Macaca radiata), a type of Old World monkey, have been used to study experimental and natural infections by flaviviruses, but Old World monkeys have not yet been used as DENV infection models. In this study, the replication levels of several DENV strains were evaluated using peripheral blood mononuclear cells. Our findings indicated that DENV-4 09-48 strain, isolated from a traveller returning from India in 2009, was a highly replicative virus. Three bonnet monkeys were infected with 09-48 strain and antibody responses were assessed. DENV nonstructural protein 1 antigen was detected and high viraemia was observed. These results indicated that bonnet monkeys and 09-48 strain could be used as a reliable primate model for the study of DENV.
48 schema:genre research_article
49 schema:inLanguage en
50 schema:isAccessibleForFree true
51 schema:isPartOf N12cb3e011bc64a13afa770439a63e90a
52 N20f1dd98771d40e78e9a3cca1395c0d9
53 sg:journal.1045337
54 schema:name Evaluation of Macaca radiata as a non-human primate model of Dengue virus infection
55 schema:pagination 3421
56 schema:productId N34a891549a5d40bfa26dcde64761e112
57 Na70b437ad16c4817a9907a7014541059
58 Nabab1d34b1cc494faf798efe7b0d0515
59 Nb82ea65f72ed4cae9100904ba24ee484
60 Nc2c7833b919a424ea40d2b052b4fc662
61 schema:sameAs https://app.dimensions.ai/details/publication/pub.1101059607
62 https://doi.org/10.1038/s41598-018-21582-9
63 schema:sdDatePublished 2019-04-11T09:36
64 schema:sdLicense https://scigraph.springernature.com/explorer/license/
65 schema:sdPublisher N7d0df27092264ac0925c638a15590512
66 schema:url https://www.nature.com/articles/s41598-018-21582-9
67 sgo:license sg:explorer/license/
68 sgo:sdDataset articles
69 rdf:type schema:ScholarlyArticle
70 N1027824c4f7d4fac9d994d33ba317b70 schema:affiliation https://www.grid.ac/institutes/grid.258799.8
71 schema:familyName Kawakami
72 schema:givenName Akihiko
73 rdf:type schema:Person
74 N12cb3e011bc64a13afa770439a63e90a schema:volumeNumber 8
75 rdf:type schema:PublicationVolume
76 N20d92a75548b4d63ba4a3fd479e48969 rdf:first sg:person.01331012452.05
77 rdf:rest N3a09e2d59ca341baa62ee8c07b8178aa
78 N20f1dd98771d40e78e9a3cca1395c0d9 schema:issueNumber 1
79 rdf:type schema:PublicationIssue
80 N2bdec87fec0c4c628482e0ae3141b797 rdf:first sg:person.01344605367.30
81 rdf:rest N46395896305b4d99afa587a88ec51af1
82 N34a891549a5d40bfa26dcde64761e112 schema:name nlm_unique_id
83 schema:value 101563288
84 rdf:type schema:PropertyValue
85 N3a09e2d59ca341baa62ee8c07b8178aa rdf:first N1027824c4f7d4fac9d994d33ba317b70
86 rdf:rest N85825f0afeef4583ba4cba45272af69a
87 N46395896305b4d99afa587a88ec51af1 rdf:first sg:person.011623020462.72
88 rdf:rest Nda0839b2ce354b90ad5013a22986fe6d
89 N7d0df27092264ac0925c638a15590512 schema:name Springer Nature - SN SciGraph project
90 rdf:type schema:Organization
91 N85825f0afeef4583ba4cba45272af69a rdf:first sg:person.01027475323.33
92 rdf:rest N2bdec87fec0c4c628482e0ae3141b797
93 N86de34eca6084d5bab7da6535e5f5038 rdf:first sg:person.01262677252.85
94 rdf:rest N20d92a75548b4d63ba4a3fd479e48969
95 Na70b437ad16c4817a9907a7014541059 schema:name doi
96 schema:value 10.1038/s41598-018-21582-9
97 rdf:type schema:PropertyValue
98 Nabab1d34b1cc494faf798efe7b0d0515 schema:name pubmed_id
99 schema:value 29467430
100 rdf:type schema:PropertyValue
101 Nb82ea65f72ed4cae9100904ba24ee484 schema:name readcube_id
102 schema:value 6290e0a00697c48da34054174f4cad39417562293381bfffcf342f358a912306
103 rdf:type schema:PropertyValue
104 Nc2c7833b919a424ea40d2b052b4fc662 schema:name dimensions_id
105 schema:value pub.1101059607
106 rdf:type schema:PropertyValue
107 Nda0839b2ce354b90ad5013a22986fe6d rdf:first sg:person.01116061263.59
108 rdf:rest rdf:nil
109 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
110 schema:name Medical and Health Sciences
111 rdf:type schema:DefinedTerm
112 anzsrc-for:1108 schema:inDefinedTermSet anzsrc-for:
113 schema:name Medical Microbiology
114 rdf:type schema:DefinedTerm
115 sg:grant.5882343 http://pending.schema.org/fundedItem sg:pub.10.1038/s41598-018-21582-9
116 rdf:type schema:MonetaryGrant
117 sg:grant.6834404 http://pending.schema.org/fundedItem sg:pub.10.1038/s41598-018-21582-9
118 rdf:type schema:MonetaryGrant
119 sg:journal.1045337 schema:issn 2045-2322
120 schema:name Scientific Reports
121 rdf:type schema:Periodical
122 sg:person.01027475323.33 schema:affiliation https://www.grid.ac/institutes/grid.414984.4
123 schema:familyName Takasaki
124 schema:givenName Tomohiko
125 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01027475323.33
126 rdf:type schema:Person
127 sg:person.01116061263.59 schema:affiliation https://www.grid.ac/institutes/grid.272456.0
128 schema:familyName Hishiki
129 schema:givenName Takayuki
130 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01116061263.59
131 rdf:type schema:Person
132 sg:person.011623020462.72 schema:affiliation https://www.grid.ac/institutes/grid.258799.8
133 schema:familyName Miura
134 schema:givenName Tomoyuki
135 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011623020462.72
136 rdf:type schema:Person
137 sg:person.01262677252.85 schema:affiliation https://www.grid.ac/institutes/grid.410795.e
138 schema:familyName Kato
139 schema:givenName Fumihiro
140 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01262677252.85
141 rdf:type schema:Person
142 sg:person.01331012452.05 schema:affiliation https://www.grid.ac/institutes/grid.258799.8
143 schema:familyName Ishida
144 schema:givenName Yuki
145 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01331012452.05
146 rdf:type schema:Person
147 sg:person.01344605367.30 schema:affiliation https://www.grid.ac/institutes/grid.410795.e
148 schema:familyName Saijo
149 schema:givenName Masayuki
150 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01344605367.30
151 rdf:type schema:Person
152 sg:pub.10.1007/978-3-642-02215-9_11 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039800077
153 https://doi.org/10.1007/978-3-642-02215-9_11
154 rdf:type schema:CreativeWork
155 sg:pub.10.1007/bf01734359 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044065382
156 https://doi.org/10.1007/bf01734359
157 rdf:type schema:CreativeWork
158 sg:pub.10.1007/bf02629608 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036915541
159 https://doi.org/10.1007/bf02629608
160 rdf:type schema:CreativeWork
161 sg:pub.10.1038/nrmicro2595 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039932505
162 https://doi.org/10.1038/nrmicro2595
163 rdf:type schema:CreativeWork
164 sg:pub.10.1186/1742-4690-10-118 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035007895
165 https://doi.org/10.1186/1742-4690-10-118
166 rdf:type schema:CreativeWork
167 https://app.dimensions.ai/details/publication/pub.1075872640 schema:CreativeWork
168 https://app.dimensions.ai/details/publication/pub.1079067029 schema:CreativeWork
169 https://app.dimensions.ai/details/publication/pub.1081564460 schema:CreativeWork
170 https://doi.org/10.1016/0882-4010(92)90083-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1052340463
171 rdf:type schema:CreativeWork
172 https://doi.org/10.1016/j.antiviral.2016.04.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049619121
173 rdf:type schema:CreativeWork
174 https://doi.org/10.1016/j.humimm.2009.07.017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046690760
175 rdf:type schema:CreativeWork
176 https://doi.org/10.1016/j.tvjl.2012.08.019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035127367
177 rdf:type schema:CreativeWork
178 https://doi.org/10.1016/j.vaccine.2007.04.079 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038556152
179 rdf:type schema:CreativeWork
180 https://doi.org/10.1016/j.virol.2008.08.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047731955
181 rdf:type schema:CreativeWork
182 https://doi.org/10.1016/j.virol.2011.11.018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031950666
183 rdf:type schema:CreativeWork
184 https://doi.org/10.1016/j.virol.2011.11.024 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043668786
185 rdf:type schema:CreativeWork
186 https://doi.org/10.1016/j.virol.2013.01.018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005243617
187 rdf:type schema:CreativeWork
188 https://doi.org/10.1016/s0065-3527(03)61001-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045645426
189 rdf:type schema:CreativeWork
190 https://doi.org/10.1016/s0165-0378(99)00026-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030443138
191 rdf:type schema:CreativeWork
192 https://doi.org/10.1056/nejmra1110265 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005131799
193 rdf:type schema:CreativeWork
194 https://doi.org/10.1099/jgv.0.000421 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060390014
195 rdf:type schema:CreativeWork
196 https://doi.org/10.1099/vir.0.031229-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060398778
197 rdf:type schema:CreativeWork
198 https://doi.org/10.1099/vir.0.055343-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060399363
199 rdf:type schema:CreativeWork
200 https://doi.org/10.1099/vir.0.060384-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060399450
201 rdf:type schema:CreativeWork
202 https://doi.org/10.1111/j.1348-0421.1998.tb02279.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1008365846
203 rdf:type schema:CreativeWork
204 https://doi.org/10.1111/j.1600-0684.2012.00552.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1025734023
205 rdf:type schema:CreativeWork
206 https://doi.org/10.1111/j.1708-8305.2007.00130.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1033781535
207 rdf:type schema:CreativeWork
208 https://doi.org/10.1111/j.1749-6632.2009.05057.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1012845186
209 rdf:type schema:CreativeWork
210 https://doi.org/10.1128/cmr.11.3.480 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083291657
211 rdf:type schema:CreativeWork
212 https://doi.org/10.1128/jvi.01083-09 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019860307
213 rdf:type schema:CreativeWork
214 https://doi.org/10.1128/jvi.01848-10 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018797789
215 rdf:type schema:CreativeWork
216 https://doi.org/10.1182/blood-2009-09-242990 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000194546
217 rdf:type schema:CreativeWork
218 https://doi.org/10.1266/ggs.90.133 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020836897
219 rdf:type schema:CreativeWork
220 https://doi.org/10.12688/f1000research.1-61.v1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029656987
221 rdf:type schema:CreativeWork
222 https://doi.org/10.1371/journal.pntd.0000423 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034633513
223 rdf:type schema:CreativeWork
224 https://doi.org/10.1371/journal.ppat.1000409 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000994269
225 rdf:type schema:CreativeWork
226 https://doi.org/10.3201/eid1611.100721 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006986569
227 rdf:type schema:CreativeWork
228 https://doi.org/10.3389/fmicb.2013.00305 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007989402
229 rdf:type schema:CreativeWork
230 https://doi.org/10.3390/v4010062 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008160019
231 rdf:type schema:CreativeWork
232 https://doi.org/10.4269/ajtmh.1974.23.118 schema:sameAs https://app.dimensions.ai/details/publication/pub.1080188812
233 rdf:type schema:CreativeWork
234 https://doi.org/10.4269/ajtmh.1990.43.212 schema:sameAs https://app.dimensions.ai/details/publication/pub.1077956426
235 rdf:type schema:CreativeWork
236 https://www.grid.ac/institutes/grid.258799.8 schema:alternateName Kyoto University
237 schema:name Laboratory of Primate Model, Institute for Frontier Life and Medical Sciences, Kyoto University, Kyoto, Japan
238 rdf:type schema:Organization
239 https://www.grid.ac/institutes/grid.272456.0 schema:alternateName Tokyo Metropolitan Institute of Medical Science
240 schema:name Department of Microbiology and Cell Biology, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan
241 Laboratory of Primate Model, Institute for Frontier Life and Medical Sciences, Kyoto University, Kyoto, Japan
242 rdf:type schema:Organization
243 https://www.grid.ac/institutes/grid.410795.e schema:alternateName National Institute of Infectious Diseases
244 schema:name Department of Virology 1, National Institute of Infectious Diseases, Tokyo, Japan
245 Laboratory of Primate Model, Institute for Frontier Life and Medical Sciences, Kyoto University, Kyoto, Japan
246 rdf:type schema:Organization
247 https://www.grid.ac/institutes/grid.414984.4 schema:alternateName Kanagawa Prefectural Institute of Public Health
248 schema:name Department of Virology 1, National Institute of Infectious Diseases, Tokyo, Japan
249 Kanagawa Prefectural Institute of Public Health, Kanagawa, Japan
250 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...