Ontology type: schema:ScholarlyArticle Open Access: True
2018-02-16
AUTHORSChung-Jen Chen, Chia-Chun Tseng, Jeng-Hsien Yen, Jan-Gowth Chang, Wen-Cheng Chou, Hou-Wei Chu, Shun-Jen Chang, Wei-Ting Liao
ABSTRACTAlthough many genome-wide association studies (GWASs) of hyperuricemia or gout have been reported, the related genetic factors and the mechanisms from hyperuricemia to gouty attack remain unclear. This study aimed to identify genetic factors and pathogenesis of gout from hyperuricemia by genome-wide association study (GWAS). 747 gout patients, 747 hyperuricemia and 2071 age-matched controls were recruited and analyzed with Affymetrix 650 K chip to find the related genetic variants. The functions of the related genes were investigated in an endothelial cell (EC) with urate crystal stimulation. The GWAS results showed 36 SNPs to be strongly associated with gout compared to controls (all p-values < 10−7). Whereas the rs2231142 in ABCG2 gene had significant associations between gout and controls, between gout and hyperuricemia, and between hyperuricemia and controls (all p-values < 10−7), and the ORs were 4.34, 3.37 and 2.15 (all p-values < 0.001) after adjustment of potential confounders, respectively. The cell model showed significantly higher IL-8 release from EC combined with ABCG2 knockdown. We concluded that ABCG2 gene contributed to hyperuricemia but also gout, and that it was involved in the inflammation dysregulation via augmented IL-8 release in EC. More... »
PAGES3137
http://scigraph.springernature.com/pub.10.1038/s41598-018-21425-7
DOIhttp://dx.doi.org/10.1038/s41598-018-21425-7
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1101008516
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/29453348
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Biological Sciences",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Genetics",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "ATP Binding Cassette Transporter, Subfamily G, Member 2",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Female",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Genome-Wide Association Study",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Gout",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Humans",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Hyperuricemia",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Male",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Middle Aged",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Polymorphism, Single Nucleotide",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "Department of Internal Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan",
"id": "http://www.grid.ac/institutes/grid.412019.f",
"name": [
"Division of General Internal Medicine, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan",
"Department of Internal Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan"
],
"type": "Organization"
},
"familyName": "Chen",
"givenName": "Chung-Jen",
"id": "sg:person.01042542222.54",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01042542222.54"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Internal Medicine, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung, Kaohsiung Medical University, Kaohsiung, Taiwan",
"id": "http://www.grid.ac/institutes/grid.415007.7",
"name": [
"Department of Internal Medicine, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung, Kaohsiung Medical University, Kaohsiung, Taiwan"
],
"type": "Organization"
},
"familyName": "Tseng",
"givenName": "Chia-Chun",
"id": "sg:person.0660345743.43",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0660345743.43"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan",
"id": "http://www.grid.ac/institutes/grid.412019.f",
"name": [
"Division of Rheumatology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan",
"Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan"
],
"type": "Organization"
},
"familyName": "Yen",
"givenName": "Jeng-Hsien",
"id": "sg:person.012107731622.75",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012107731622.75"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Laboratory Medicine and Epigenome Research Center, China Medical University Hospital, China Medical University, Kaohsiung, Taichung, Taiwan",
"id": "http://www.grid.ac/institutes/None",
"name": [
"Department of Laboratory Medicine and Epigenome Research Center, China Medical University Hospital, China Medical University, Kaohsiung, Taichung, Taiwan"
],
"type": "Organization"
},
"familyName": "Chang",
"givenName": "Jan-Gowth",
"id": "sg:person.013621667704.15",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013621667704.15"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan",
"id": "http://www.grid.ac/institutes/grid.482251.8",
"name": [
"Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan"
],
"type": "Organization"
},
"familyName": "Chou",
"givenName": "Wen-Cheng",
"id": "sg:person.01242102035.28",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01242102035.28"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan",
"id": "http://www.grid.ac/institutes/grid.482251.8",
"name": [
"Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan"
],
"type": "Organization"
},
"familyName": "Chu",
"givenName": "Hou-Wei",
"id": "sg:person.01224552441.76",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01224552441.76"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Kinesiology, Health and Leisure Studies, National University of Kaohsiung, Kaohsiung, Taiwan",
"id": "http://www.grid.ac/institutes/grid.412111.6",
"name": [
"Department of Kinesiology, Health and Leisure Studies, National University of Kaohsiung, Kaohsiung, Taiwan"
],
"type": "Organization"
},
"familyName": "Chang",
"givenName": "Shun-Jen",
"id": "sg:person.01113076753.08",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01113076753.08"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Biotechnology, College of Life Science, Kaohsiung Medical University, Kaohsiung, Taiwan",
"id": "http://www.grid.ac/institutes/grid.412019.f",
"name": [
"Department of Medical Research, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan",
"Department of Biotechnology, College of Life Science, Kaohsiung Medical University, Kaohsiung, Taiwan"
],
"type": "Organization"
},
"familyName": "Liao",
"givenName": "Wei-Ting",
"id": "sg:person.0716366123.80",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0716366123.80"
],
"type": "Person"
}
],
"citation": [
{
"id": "sg:pub.10.1007/s10067-015-2933-y",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1048556452",
"https://doi.org/10.1007/s10067-015-2933-y"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/ng.106",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1012332421",
"https://doi.org/10.1038/ng.106"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/ng.531",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1004197131",
"https://doi.org/10.1038/ng.531"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/ng.2500",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1021326074",
"https://doi.org/10.1038/ng.2500"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/srep31003",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1004871792",
"https://doi.org/10.1038/srep31003"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/ng.972",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1020612247",
"https://doi.org/10.1038/ng.972"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/ncb754",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1042398135",
"https://doi.org/10.1038/ncb754"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1186/ar4316",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1009664742",
"https://doi.org/10.1186/ar4316"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/ncomms1033",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1038660365",
"https://doi.org/10.1038/ncomms1033"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s10753-015-0271-5",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1007128242",
"https://doi.org/10.1007/s10753-015-0271-5"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature742",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1009325209",
"https://doi.org/10.1038/nature742"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/srep43614",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1084131531",
"https://doi.org/10.1038/srep43614"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/srep02014",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1006103959",
"https://doi.org/10.1038/srep02014"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1186/ar4250",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1046635930",
"https://doi.org/10.1186/ar4250"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nrrheum.2012.144",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1009228324",
"https://doi.org/10.1038/nrrheum.2012.144"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00109-014-1236-0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1015679846",
"https://doi.org/10.1007/s00109-014-1236-0"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/ncomms8041",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1031524864",
"https://doi.org/10.1038/ncomms8041"
],
"type": "CreativeWork"
}
],
"datePublished": "2018-02-16",
"datePublishedReg": "2018-02-16",
"description": "Although many genome-wide association studies (GWASs) of hyperuricemia or gout have been reported, the related genetic factors and the mechanisms from hyperuricemia to gouty attack remain unclear. This study aimed to identify genetic factors and pathogenesis of gout from hyperuricemia by genome-wide association study (GWAS). 747 gout patients, 747 hyperuricemia and 2071 age-matched controls were recruited and analyzed with Affymetrix 650\u2009K chip to find the related genetic variants. The functions of the related genes were investigated in an endothelial cell (EC) with urate crystal stimulation. The GWAS results showed 36 SNPs to be strongly associated with gout compared to controls (all p-values\u2009<\u200910\u22127). Whereas the rs2231142 in ABCG2 gene had significant associations between gout and controls, between gout and hyperuricemia, and between hyperuricemia and controls (all p-values\u2009<\u200910\u22127), and the ORs were 4.34, 3.37 and 2.15 (all p-values\u2009<\u20090.001) after adjustment of potential confounders, respectively. The cell model showed significantly higher IL-8 release from EC combined with ABCG2 knockdown. We concluded that ABCG2 gene contributed to hyperuricemia but also gout, and that it was involved in the inflammation dysregulation via augmented IL-8 release in EC.",
"genre": "article",
"id": "sg:pub.10.1038/s41598-018-21425-7",
"inLanguage": "en",
"isAccessibleForFree": true,
"isPartOf": [
{
"id": "sg:journal.1045337",
"issn": [
"2045-2322"
],
"name": "Scientific Reports",
"publisher": "Springer Nature",
"type": "Periodical"
},
{
"issueNumber": "1",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "8"
}
],
"keywords": [
"genome-wide association studies",
"association studies",
"ABCG2 gene",
"wide association study",
"endothelial cells",
"GWAS results",
"genetic factors",
"K chip",
"genetic variants",
"genes",
"related genetic variants",
"higher IL-8 release",
"cell model",
"IL-8 release",
"related genetic factors",
"knockdown",
"SNPs",
"pathogenesis of gout",
"ABCG2",
"dysregulation",
"cells",
"variants",
"release",
"mechanism",
"factors",
"pathogenesis",
"control",
"function",
"stimulation",
"study",
"rs2231142",
"development",
"significant association",
"association",
"development of gout",
"inflammation dysregulation",
"results",
"gout",
"age-matched controls",
"attacks",
"gout patients",
"model",
"chip",
"hyperuricemia",
"ORs",
"adjustment",
"patients",
"gouty attacks",
"confounders",
"potential confounders"
],
"name": "ABCG2 contributes to the development of gout and hyperuricemia in a genome-wide association study",
"pagination": "3137",
"productId": [
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1101008516"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1038/s41598-018-21425-7"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"29453348"
]
}
],
"sameAs": [
"https://doi.org/10.1038/s41598-018-21425-7",
"https://app.dimensions.ai/details/publication/pub.1101008516"
],
"sdDataset": "articles",
"sdDatePublished": "2022-06-01T22:20",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-springernature-scigraph/baseset/20220601/entities/gbq_results/article/article_794.jsonl",
"type": "ScholarlyArticle",
"url": "https://doi.org/10.1038/s41598-018-21425-7"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-21425-7'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-21425-7'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-21425-7'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-21425-7'
This table displays all metadata directly associated to this object as RDF triples.
283 TRIPLES
22 PREDICATES
102 URIs
77 LITERALS
16 BLANK NODES