Neuroprotection of the hypoxic-ischemic mouse brain by human CD117+CD90+CD105+ amniotic fluid stem cells View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-12

AUTHORS

Michelangelo Corcelli, Kate Hawkins, Filipa Vlahova, Avina Hunjan, Kate Dowding, Paolo De Coppi, Anna L. David, Donald Peebles, Pierre Gressens, Henrik Hagberg, Mariya Hristova, Pascale V. Guillot

ABSTRACT

Human amniotic fluid contains two morphologically-distinct sub-populations of stem cells with regenerative potential, spindle-shaped (SS-hAFSCs) and round-shaped human amniotic fluid stem cells (RS-hAFSCs). However, it is unclear whether morphological differences correlate with functionality, and this lack of knowledge limits their translational applications. Here, we show that SS-hAFSCs and RS-hAFSCs differ in their neuro-protective ability, demonstrating that a single contralateral injection of SS-hAFSCs into hypoxic-ischemic P7 mice conferred a 47% reduction in hippocampal tissue loss and 43-45% reduction in TUNEL-positive cells in the hippocampus and striatum 48 hours after the insult, decreased microglial activation and TGFβ1 levels, and prevented demyelination. On the other hand, RS-hAFSCs failed to show such neuro-protective effects. It is possible that SS-hAFSCs exert their neuroprotection via endoglin-dependent inhibition of TGFβ1 signaling in target cells. These findings identify a sub-population of CD117+CD90+CD105+ stem cells as a promising source for the neuro-protection of the developing brain. More... »

PAGES

2425

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41598-018-20710-9

DOI

http://dx.doi.org/10.1038/s41598-018-20710-9

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1100726950

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29402914


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