Endoscopic non-ablative fractional laser therapy in an orthotopic colon tumour model View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-12

AUTHORS

Su Woong Yoo, Gyungseok Oh, Abdul Mohaimen Safi, Soonjoo Hwang, Young-Seok Seo, Kyung-Hwa Lee, Young L. Kim, Euiheon Chung

ABSTRACT

Colorectal cancer is one of the leading causes of cancer-related deaths. Although several therapeutic management strategies are available at the early colon cancer stages, such as endoscopic mucosal or submucosal dissection, associated complications often include bleeding or bowel perforations. As an alternative approach, we investigated endoscopic non-ablative fractional laser (eNAFL) irradiation as a minimally invasive therapeutic modality for the treatment of early-stage colorectal cancer. By implanting SL4-DsRed colon cancer cells into the colons of the C57BL/6 mice, we developed an orthotopic colon tumour mouse model and demonstrated the early-stage tumour growth delay following the eNAFL irradiation. Additionally, we evaluated the temperature changes in the eNAFL-irradiated area using numerical simulations, and induced inflammation using histological analysis. Our results indicate a minimal thermal damage confined to the irradiated spot, sparing the adjacent tissue and alteration in the tumour microenvironment. eNAFL irradiation may be clinically useful as a minimally invasive therapeutic intervention at the early stage of tumourigenesis. In future, an optimal eNAFL therapeutic dose should be determined, in order to increase the efficacy of this approach. More... »

PAGES

1673

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41598-018-19792-2

DOI

http://dx.doi.org/10.1038/s41598-018-19792-2

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1100570950

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29374265


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