A new dry eye mouse model produced by exorbital and intraorbital lacrimal gland excision View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-01-24

AUTHORS

Katsuhiko Shinomiya, Mayumi Ueta, Shigeru Kinoshita

ABSTRACT

Chronic dry eye is an increasingly prevalent condition worldwide, with resulting loss of visual function and quality of life. Relevant, repeatable, and stable animal models of dry eye are still needed. We have developed an improved surgical mouse model for dry eye based on severe aqueous fluid deficiency, by excising both the exorbital and intraorbital lacrimal glands (ELG and ILG, respectively) of mice. After ELG plus ILG excision, dry eye symptoms were evaluated using fluorescein infiltration observation, tear production measurement, and histological evaluation of ocular surface. Tear production in the model mice was significantly decreased compared with the controls. The corneal fluorescein infiltration score of the model mice was also significantly increased compared with the controls. Histological examination revealed significant severe inflammatory changes in the cornea, conjunctiva or meibomian glands of the model mice after surgery. In the observation of LysM-eGFP(+/−) mice tissues, postsurgical infiltration of green fluorescent neutrophils was observed in the ocular surface tissues. We theorize that the inflammatory changes on the ocular surface of this model were induced secondarily by persistent severe tear reduction. The mouse model will be useful for investigations of both pathophysiology as well as new therapies for tear-volume-reduction type dry eye. More... »

PAGES

1483

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41598-018-19578-6

DOI

http://dx.doi.org/10.1038/s41598-018-19578-6

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1100512238

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29367638


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1113", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Ophthalmology and Optometry", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cornea", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Disease Models, Animal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Dry Eye Syndromes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lacrimal Apparatus", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lysine", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Inbred C57BL", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tears", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Pharmacology Group, Non-Clinical Research, Global R&D Division, Santen Pharmaceutical Co., Ltd., Ikoma, Japan", 
          "id": "http://www.grid.ac/institutes/grid.419503.a", 
          "name": [
            "Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan", 
            "Pharmacology Group, Non-Clinical Research, Global R&D Division, Santen Pharmaceutical Co., Ltd., Ikoma, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shinomiya", 
        "givenName": "Katsuhiko", 
        "id": "sg:person.01371244324.56", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01371244324.56"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Frontier Medical Science and Technology for Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan", 
          "id": "http://www.grid.ac/institutes/grid.272458.e", 
          "name": [
            "Department of Frontier Medical Science and Technology for Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ueta", 
        "givenName": "Mayumi", 
        "id": "sg:person.0741226323.70", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0741226323.70"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Frontier Medical Science and Technology for Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan", 
          "id": "http://www.grid.ac/institutes/grid.272458.e", 
          "name": [
            "Department of Frontier Medical Science and Technology for Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kinoshita", 
        "givenName": "Shigeru", 
        "id": "sg:person.01016754101.20", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01016754101.20"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/srep05981", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003061255", 
          "https://doi.org/10.1038/srep05981"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/srep04862", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032179384", 
          "https://doi.org/10.1038/srep04862"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/eye.2014.263", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041408682", 
          "https://doi.org/10.1038/eye.2014.263"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1471-2415-13-50", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019716475", 
          "https://doi.org/10.1186/1471-2415-13-50"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2018-01-24", 
    "datePublishedReg": "2018-01-24", 
    "description": "Chronic dry eye is an increasingly prevalent condition worldwide, with resulting loss of visual function and quality of life. Relevant, repeatable, and stable animal models of dry eye are still needed. We have developed an improved surgical mouse model for dry eye based on severe aqueous fluid deficiency, by excising both the exorbital and intraorbital lacrimal glands (ELG and ILG, respectively) of mice. After ELG plus ILG excision, dry eye symptoms were evaluated using fluorescein infiltration observation, tear production measurement, and histological evaluation of ocular surface. Tear production in the model mice was significantly decreased compared with the controls. The corneal fluorescein infiltration score of the model mice was also significantly increased compared with the controls. Histological examination revealed significant severe inflammatory changes in the cornea, conjunctiva or meibomian glands of the model mice after surgery. In the observation of LysM-eGFP(+/\u2212) mice tissues, postsurgical infiltration of green fluorescent neutrophils was observed in the ocular surface tissues. We theorize that the inflammatory changes on the ocular surface of this model were induced secondarily by persistent severe tear reduction. The mouse model will be useful for investigations of both pathophysiology as well as new therapies for tear-volume-reduction type dry eye.", 
    "genre": "article", 
    "id": "sg:pub.10.1038/s41598-018-19578-6", 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1045337", 
        "issn": [
          "2045-2322"
        ], 
        "name": "Scientific Reports", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "8"
      }
    ], 
    "keywords": [
      "dry eye", 
      "model mice", 
      "mouse model", 
      "inflammatory changes", 
      "ocular surface", 
      "dry eye mouse model", 
      "type dry eye", 
      "lacrimal gland excision", 
      "chronic dry eye", 
      "dry eye symptoms", 
      "severe inflammatory changes", 
      "intraorbital lacrimal gland", 
      "stable animal model", 
      "surgical mouse model", 
      "ocular surface tissues", 
      "quality of life", 
      "tear production measurement", 
      "eye symptoms", 
      "visual function", 
      "tear production", 
      "gland excision", 
      "infiltration score", 
      "prevalent condition", 
      "histological examination", 
      "histological evaluation", 
      "new therapies", 
      "animal models", 
      "lacrimal gland", 
      "meibomian glands", 
      "fluid deficiency", 
      "mice", 
      "tear reduction", 
      "fluorescent neutrophils", 
      "eyes", 
      "excision", 
      "gland", 
      "mouse tissues", 
      "surface tissues", 
      "tissue", 
      "surgery", 
      "pathophysiology", 
      "conjunctiva", 
      "neutrophils", 
      "therapy", 
      "symptoms", 
      "cornea", 
      "infiltration", 
      "scores", 
      "control", 
      "examination", 
      "deficiency", 
      "LysM", 
      "changes", 
      "evaluation", 
      "life", 
      "loss", 
      "reduction", 
      "function", 
      "quality", 
      "observations", 
      "model", 
      "investigation", 
      "ELG", 
      "production", 
      "conditions", 
      "measurements", 
      "production measurements", 
      "surface"
    ], 
    "name": "A new dry eye mouse model produced by exorbital and intraorbital lacrimal gland excision", 
    "pagination": "1483", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1100512238"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/s41598-018-19578-6"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "29367638"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/s41598-018-19578-6", 
      "https://app.dimensions.ai/details/publication/pub.1100512238"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-08-04T17:06", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220804/entities/gbq_results/article/article_782.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1038/s41598-018-19578-6"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-19578-6'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-19578-6'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-19578-6'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-19578-6'


 

This table displays all metadata directly associated to this object as RDF triples.

206 TRIPLES      21 PREDICATES      108 URIs      96 LITERALS      18 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/s41598-018-19578-6 schema:about N1d58505142b44562b60087d492b2dbd4
2 N216d6bb0b1474015b5b7394a8f91f5e9
3 N251cd99a330f4b8dbd2fd98e943ea096
4 N36ba8f2fa643459d992ba1f0d0b7f9ca
5 N486911e1b671443ca1f953c8b2b5ad7c
6 N6e4f44f3f9044a909ea08f655fd0bfc4
7 N7475f2edfbf74cada160c68e669f6021
8 N91ebf08ed582436a96dd8ddab747c394
9 Nb0af15ded7894b1ea72ff231e41922cf
10 Nbfb4772beb9d426ab500ec49ddc049cd
11 Nc60ff528e61844508c7d4c951b1041cc
12 anzsrc-for:11
13 anzsrc-for:1113
14 schema:author Ne7c652b646e84f7abb91366540b3b963
15 schema:citation sg:pub.10.1038/eye.2014.263
16 sg:pub.10.1038/srep04862
17 sg:pub.10.1038/srep05981
18 sg:pub.10.1186/1471-2415-13-50
19 schema:datePublished 2018-01-24
20 schema:datePublishedReg 2018-01-24
21 schema:description Chronic dry eye is an increasingly prevalent condition worldwide, with resulting loss of visual function and quality of life. Relevant, repeatable, and stable animal models of dry eye are still needed. We have developed an improved surgical mouse model for dry eye based on severe aqueous fluid deficiency, by excising both the exorbital and intraorbital lacrimal glands (ELG and ILG, respectively) of mice. After ELG plus ILG excision, dry eye symptoms were evaluated using fluorescein infiltration observation, tear production measurement, and histological evaluation of ocular surface. Tear production in the model mice was significantly decreased compared with the controls. The corneal fluorescein infiltration score of the model mice was also significantly increased compared with the controls. Histological examination revealed significant severe inflammatory changes in the cornea, conjunctiva or meibomian glands of the model mice after surgery. In the observation of LysM-eGFP(+/−) mice tissues, postsurgical infiltration of green fluorescent neutrophils was observed in the ocular surface tissues. We theorize that the inflammatory changes on the ocular surface of this model were induced secondarily by persistent severe tear reduction. The mouse model will be useful for investigations of both pathophysiology as well as new therapies for tear-volume-reduction type dry eye.
22 schema:genre article
23 schema:isAccessibleForFree true
24 schema:isPartOf N00ac5a926b6b4f4b8550e51e16009ff5
25 N3f50e51107a94362bda5b05e69a268e0
26 sg:journal.1045337
27 schema:keywords ELG
28 LysM
29 animal models
30 changes
31 chronic dry eye
32 conditions
33 conjunctiva
34 control
35 cornea
36 deficiency
37 dry eye
38 dry eye mouse model
39 dry eye symptoms
40 evaluation
41 examination
42 excision
43 eye symptoms
44 eyes
45 fluid deficiency
46 fluorescent neutrophils
47 function
48 gland
49 gland excision
50 histological evaluation
51 histological examination
52 infiltration
53 infiltration score
54 inflammatory changes
55 intraorbital lacrimal gland
56 investigation
57 lacrimal gland
58 lacrimal gland excision
59 life
60 loss
61 measurements
62 meibomian glands
63 mice
64 model
65 model mice
66 mouse model
67 mouse tissues
68 neutrophils
69 new therapies
70 observations
71 ocular surface
72 ocular surface tissues
73 pathophysiology
74 prevalent condition
75 production
76 production measurements
77 quality
78 quality of life
79 reduction
80 scores
81 severe inflammatory changes
82 stable animal model
83 surface
84 surface tissues
85 surgery
86 surgical mouse model
87 symptoms
88 tear production
89 tear production measurement
90 tear reduction
91 therapy
92 tissue
93 type dry eye
94 visual function
95 schema:name A new dry eye mouse model produced by exorbital and intraorbital lacrimal gland excision
96 schema:pagination 1483
97 schema:productId N24bf500db27c4aa8baf5cd08068d9290
98 N6810b3d20da042e39e21771bc228870f
99 N813e129a62364e519fd4db6523beb9c6
100 schema:sameAs https://app.dimensions.ai/details/publication/pub.1100512238
101 https://doi.org/10.1038/s41598-018-19578-6
102 schema:sdDatePublished 2022-08-04T17:06
103 schema:sdLicense https://scigraph.springernature.com/explorer/license/
104 schema:sdPublisher N63f5eb4ec6e14f79b31b43ccc83aea7f
105 schema:url https://doi.org/10.1038/s41598-018-19578-6
106 sgo:license sg:explorer/license/
107 sgo:sdDataset articles
108 rdf:type schema:ScholarlyArticle
109 N00ac5a926b6b4f4b8550e51e16009ff5 schema:issueNumber 1
110 rdf:type schema:PublicationIssue
111 N1d58505142b44562b60087d492b2dbd4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
112 schema:name Lysine
113 rdf:type schema:DefinedTerm
114 N216d6bb0b1474015b5b7394a8f91f5e9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
115 schema:name Mice
116 rdf:type schema:DefinedTerm
117 N24bf500db27c4aa8baf5cd08068d9290 schema:name doi
118 schema:value 10.1038/s41598-018-19578-6
119 rdf:type schema:PropertyValue
120 N251cd99a330f4b8dbd2fd98e943ea096 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name Mice, Inbred C57BL
122 rdf:type schema:DefinedTerm
123 N36ba8f2fa643459d992ba1f0d0b7f9ca schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Disease Models, Animal
125 rdf:type schema:DefinedTerm
126 N3f50e51107a94362bda5b05e69a268e0 schema:volumeNumber 8
127 rdf:type schema:PublicationVolume
128 N486911e1b671443ca1f953c8b2b5ad7c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name Cornea
130 rdf:type schema:DefinedTerm
131 N63f5eb4ec6e14f79b31b43ccc83aea7f schema:name Springer Nature - SN SciGraph project
132 rdf:type schema:Organization
133 N6810b3d20da042e39e21771bc228870f schema:name dimensions_id
134 schema:value pub.1100512238
135 rdf:type schema:PropertyValue
136 N6e4f44f3f9044a909ea08f655fd0bfc4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name Male
138 rdf:type schema:DefinedTerm
139 N7475f2edfbf74cada160c68e669f6021 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name Female
141 rdf:type schema:DefinedTerm
142 N813e129a62364e519fd4db6523beb9c6 schema:name pubmed_id
143 schema:value 29367638
144 rdf:type schema:PropertyValue
145 N91ebf08ed582436a96dd8ddab747c394 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
146 schema:name Lacrimal Apparatus
147 rdf:type schema:DefinedTerm
148 Na5af3dd52f8945708a05790cbb8c187b rdf:first sg:person.0741226323.70
149 rdf:rest Naed3ceb5a4194246aafaa70fdcd4af54
150 Naed3ceb5a4194246aafaa70fdcd4af54 rdf:first sg:person.01016754101.20
151 rdf:rest rdf:nil
152 Nb0af15ded7894b1ea72ff231e41922cf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
153 schema:name Animals
154 rdf:type schema:DefinedTerm
155 Nbfb4772beb9d426ab500ec49ddc049cd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
156 schema:name Dry Eye Syndromes
157 rdf:type schema:DefinedTerm
158 Nc60ff528e61844508c7d4c951b1041cc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
159 schema:name Tears
160 rdf:type schema:DefinedTerm
161 Ne7c652b646e84f7abb91366540b3b963 rdf:first sg:person.01371244324.56
162 rdf:rest Na5af3dd52f8945708a05790cbb8c187b
163 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
164 schema:name Medical and Health Sciences
165 rdf:type schema:DefinedTerm
166 anzsrc-for:1113 schema:inDefinedTermSet anzsrc-for:
167 schema:name Ophthalmology and Optometry
168 rdf:type schema:DefinedTerm
169 sg:journal.1045337 schema:issn 2045-2322
170 schema:name Scientific Reports
171 schema:publisher Springer Nature
172 rdf:type schema:Periodical
173 sg:person.01016754101.20 schema:affiliation grid-institutes:grid.272458.e
174 schema:familyName Kinoshita
175 schema:givenName Shigeru
176 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01016754101.20
177 rdf:type schema:Person
178 sg:person.01371244324.56 schema:affiliation grid-institutes:grid.419503.a
179 schema:familyName Shinomiya
180 schema:givenName Katsuhiko
181 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01371244324.56
182 rdf:type schema:Person
183 sg:person.0741226323.70 schema:affiliation grid-institutes:grid.272458.e
184 schema:familyName Ueta
185 schema:givenName Mayumi
186 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0741226323.70
187 rdf:type schema:Person
188 sg:pub.10.1038/eye.2014.263 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041408682
189 https://doi.org/10.1038/eye.2014.263
190 rdf:type schema:CreativeWork
191 sg:pub.10.1038/srep04862 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032179384
192 https://doi.org/10.1038/srep04862
193 rdf:type schema:CreativeWork
194 sg:pub.10.1038/srep05981 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003061255
195 https://doi.org/10.1038/srep05981
196 rdf:type schema:CreativeWork
197 sg:pub.10.1186/1471-2415-13-50 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019716475
198 https://doi.org/10.1186/1471-2415-13-50
199 rdf:type schema:CreativeWork
200 grid-institutes:grid.272458.e schema:alternateName Department of Frontier Medical Science and Technology for Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan
201 schema:name Department of Frontier Medical Science and Technology for Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan
202 rdf:type schema:Organization
203 grid-institutes:grid.419503.a schema:alternateName Pharmacology Group, Non-Clinical Research, Global R&D Division, Santen Pharmaceutical Co., Ltd., Ikoma, Japan
204 schema:name Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan
205 Pharmacology Group, Non-Clinical Research, Global R&D Division, Santen Pharmaceutical Co., Ltd., Ikoma, Japan
206 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...