Angiogenesis and evading immune destruction are the main related transcriptomic characteristics to the invasive process of oral tongue cancer View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-12

AUTHORS

Juan Alberto Pérez-Valencia, Francisco Prosdocimi, Italo M. Cesari, Igor Rodrigues da Costa, Carolina Furtado, Michelle Agostini, Franklin David Rumjanek

ABSTRACT

Metastasis of head and neck tumors is responsible for a high mortality rate. Understanding its biochemistry may allow insights into tumorigenesis. To that end we carried out RNA-Seq analyses of 5 SCC9 derived oral cancer cell lines displaying increased invasive potential. Differentially expressed genes (DEGs) were annotated based on p-values and false discovery rate (q-values). All 292 KEGG pathways related to the human genome were compared in order to pinpoint the absolute and relative contributions to the invasive process considering the 8 hallmarks of cancer plus 2 new defined categories, as well as we made with our transcriptomic data. In terms of absolute contribution, the highest correlations were associated to the categories of evading immune destruction and energy metabolism and for relative contributions, angiogenesis and evading immune destruction. DEGs were distributed into each one of all possible modes of regulation, regarding up, down and continuum expression, along the 3 stages of metastatic progression. For p-values twenty-six genes were consistently present along the tumoral progression and 4 for q-values. Among the DEGs, we found 2 novel potentially informative metastatic markers: PIGG and SLC8B1. Furthermore, interactome analysis showed that MYH14, ANGPTL4, PPARD and ENPP1 are amenable to pharmacological interventions. More... »

PAGES

2007

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    URI

    http://scigraph.springernature.com/pub.10.1038/s41598-017-19010-5

    DOI

    http://dx.doi.org/10.1038/s41598-017-19010-5

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1100657987

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/29386520


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