Specific Phospholipids Regulate the Acquisition of Neuronal and Astroglial Identities in Post-Mitotic Cells View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-12

AUTHORS

Aneley Montaner, Themis Taynah da Silva Santana, Timm Schroeder, Marcelo Einiker-Lamas, Javier Girardini, Marcos Romualdo Costa, Claudia Banchio

ABSTRACT

Hitherto, the known mechanisms underpinning cell-fate specification act on neural progenitors, affecting their commitment to generate neuron or glial cells. Here, we show that particular phospholipids supplemented in the culture media modify the commitment of post-mitotic neural cells in vitro. Phosphatidylcholine (PtdCho)-enriched media enhances neuronal differentiation at the expense of astroglial and unspecified cells. Conversely, phosphatidylethanolamine (PtdEtn) enhances astroglial differentiation and accelerates astrocyte maturation. The ability of phospholipids to modify the fate of post-mitotic cells depends on its presence during a narrow time-window during cell differentiation and it is mediated by the selective activation of particular signaling pathways. While PtdCho-mediated effect on neuronal differentiation depends on cAMP-dependent kinase (PKA)/calcium responsive element binding protein (CREB), PtdEtn stimulates astrogliogenesis through the activation of the MEK/ERK signaling pathway. Collectively, our results provide an additional degree of plasticity in neural cell specification and further support the notion that cell differentiation is a reversible phenomenon. They also contribute to our understanding of neuronal and glial lineage specification in the central nervous system, opening up new avenues to retrieve neurogenic capacity in the brain. More... »

PAGES

460

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41598-017-18700-4

DOI

http://dx.doi.org/10.1038/s41598-017-18700-4

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1100212445

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29323239


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1109", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Neurosciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "National University of Rosario", 
          "id": "https://www.grid.ac/institutes/grid.10814.3c", 
          "name": [
            "Instituto de Biolog\u00eda Molecular y Celular de Rosario (IBR, CONICET) Ocampo y Esmeralda, Predio CONICET and Departamento de Ciencias Biol\u00f3gicas, Facultad de Ciencias Bioqu\u00edmicas y Farmac\u00e9uticas, Universidad Nacional de Rosario, 2000, Rosario, Argentina"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Montaner", 
        "givenName": "Aneley", 
        "id": "sg:person.014042700755.74", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014042700755.74"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Federal University of Rio Grande do Norte", 
          "id": "https://www.grid.ac/institutes/grid.411233.6", 
          "name": [
            "Brain Institute, Federal University of Rio Grande do Norte, Av. Nascimento de Castro 2155, 59056-450, Natal, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "da Silva Santana", 
        "givenName": "Themis Taynah", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Swiss Federal Institute of Technology in Zurich", 
          "id": "https://www.grid.ac/institutes/grid.5801.c", 
          "name": [
            "Department of Biosystems Science and Engineering, Cell Systems Dynamics, ETH Zurich, Basel, Switzerland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Schroeder", 
        "givenName": "Timm", 
        "id": "sg:person.0743514320.12", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0743514320.12"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Federal University of Rio de Janeiro", 
          "id": "https://www.grid.ac/institutes/grid.8536.8", 
          "name": [
            "Instituto de Biof\u00edsica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, 21949\u2013902, Ilha do Fund\u00e3o, Rio de Janeiro, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Einiker-Lamas", 
        "givenName": "Marcelo", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National University of Rosario", 
          "id": "https://www.grid.ac/institutes/grid.10814.3c", 
          "name": [
            "Instituto de Biolog\u00eda Molecular y Celular de Rosario (IBR, CONICET) Ocampo y Esmeralda, Predio CONICET and Departamento de Ciencias Biol\u00f3gicas, Facultad de Ciencias Bioqu\u00edmicas y Farmac\u00e9uticas, Universidad Nacional de Rosario, 2000, Rosario, Argentina"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Girardini", 
        "givenName": "Javier", 
        "id": "sg:person.0640044740.63", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0640044740.63"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Federal University of Rio Grande do Norte", 
          "id": "https://www.grid.ac/institutes/grid.411233.6", 
          "name": [
            "Brain Institute, Federal University of Rio Grande do Norte, Av. Nascimento de Castro 2155, 59056-450, Natal, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Costa", 
        "givenName": "Marcos Romualdo", 
        "id": "sg:person.01007157475.35", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01007157475.35"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National University of Rosario", 
          "id": "https://www.grid.ac/institutes/grid.10814.3c", 
          "name": [
            "Instituto de Biolog\u00eda Molecular y Celular de Rosario (IBR, CONICET) Ocampo y Esmeralda, Predio CONICET and Departamento de Ciencias Biol\u00f3gicas, Facultad de Ciencias Bioqu\u00edmicas y Farmac\u00e9uticas, Universidad Nacional de Rosario, 2000, Rosario, Argentina"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Banchio", 
        "givenName": "Claudia", 
        "id": "sg:person.01100517200.92", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01100517200.92"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/s12031-015-0612-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000448938", 
          "https://doi.org/10.1007/s12031-015-0612-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/sj.emboj.7601923", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000745508"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrm1739", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001699881", 
          "https://doi.org/10.1038/nrm1739"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrm1739", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001699881", 
          "https://doi.org/10.1038/nrm1739"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0896-6273(00)00086-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003357988"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3727/096368911x627543", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003560992"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3727/096368911x627543", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003560992"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s12035-015-9528-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004656858", 
          "https://doi.org/10.1007/s12035-015-9528-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s12035-015-9528-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004656858", 
          "https://doi.org/10.1007/s12035-015-9528-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0306-4522(03)00198-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004688331"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0306-4522(03)00198-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004688331"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/cercor/bhp046", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005096620"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3389/fncel.2015.00501", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005128833"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1242/dev.009951", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005725296"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.taap.2015.06.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008079920"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature04598", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008587713", 
          "https://doi.org/10.1038/nature04598"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature04598", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008587713", 
          "https://doi.org/10.1038/nature04598"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature04598", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008587713", 
          "https://doi.org/10.1038/nature04598"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0076-6879(06)19001-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009381012"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/jn.00509.2016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010224903"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4103/1673-5374.137570", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010510356"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrn3618", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010950426", 
          "https://doi.org/10.1038/nrn3618"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.brainres.2010.02.071", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013311450"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/dbio.1996.0090", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014800916"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/cr.2011.177", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016074710", 
          "https://doi.org/10.1038/cr.2011.177"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nbt.3626", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017412223", 
          "https://doi.org/10.1038/nbt.3626"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neuron.2009.07.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022217052"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.yexcr.2009.08.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022803363"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1242/dev.061663", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022908330"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0003-2697(77)90428-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023913912"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3389/fphys.2012.00119", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024564770"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1242/dev.093096", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025473463"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.aaf4802", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026029724"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1517/14728222.12.10.1275", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026449443"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.4374-07.2008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027391093"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3109/10409238.2012.735643", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028212866"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jnutbio.2005.09.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029360162"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jnutbio.2005.09.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029360162"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/srep21096", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031029868", 
          "https://doi.org/10.1038/srep21096"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.aab3516", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031707054"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/embor.2010.66", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034240972"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.79.6.1698", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035207218"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.1054-09.2009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039946059"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.foodchem.2016.10.043", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039962317"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.4568-12.2013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040342581"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/43686", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040879470", 
          "https://doi.org/10.1038/43686"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/43686", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040879470", 
          "https://doi.org/10.1038/43686"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neuron.2012.08.031", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043735031"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0169-328x(02)00550-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046032993"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0169-328x(02)00550-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046032993"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cellsig.2015.11.016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047039363"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neuron.2007.04.019", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047827185"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m110.139477", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048299002"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2362.2008.01990.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050855503"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neuron.2015.01.009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051333134"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0022-1759(83)90303-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053705634"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0022-1759(83)90303-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053705634"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/cercor/bhw387", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059459000"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4238/gmr.15038376", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1072396020"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074652899", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.12-11-04565.1992", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1076424739"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2967/jnumed.117.193581", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085471943"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/iju.13386", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085615080"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.stemcr.2017.05.009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085938651"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.stem.2017.06.011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1090367385"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3390/molecules22101771", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1092275503"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3390/molecules22101771", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1092275503"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2018-12", 
    "datePublishedReg": "2018-12-01", 
    "description": "Hitherto, the known mechanisms underpinning cell-fate specification act on neural progenitors, affecting their commitment to generate neuron or glial cells. Here, we show that particular phospholipids supplemented in the culture media modify the commitment of post-mitotic neural cells in vitro. Phosphatidylcholine (PtdCho)-enriched media enhances neuronal differentiation at the expense of astroglial and unspecified cells. Conversely, phosphatidylethanolamine (PtdEtn) enhances astroglial differentiation and accelerates astrocyte maturation. The ability of phospholipids to modify the fate of post-mitotic cells depends on its presence during a narrow time-window during cell differentiation and it is mediated by the selective activation of particular signaling pathways. While PtdCho-mediated effect on neuronal differentiation depends on cAMP-dependent kinase (PKA)/calcium responsive element binding protein (CREB), PtdEtn stimulates astrogliogenesis through the activation of the MEK/ERK signaling pathway. Collectively, our results provide an additional degree of plasticity in neural cell specification and further support the notion that cell differentiation is a reversible phenomenon. They also contribute to our understanding of neuronal and glial lineage specification in the central nervous system, opening up new avenues to retrieve neurogenic capacity in the brain.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/s41598-017-18700-4", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1045337", 
        "issn": [
          "2045-2322"
        ], 
        "name": "Scientific Reports", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "8"
      }
    ], 
    "name": "Specific Phospholipids Regulate the Acquisition of Neuronal and Astroglial Identities in Post-Mitotic Cells", 
    "pagination": "460", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "b0e9be6d8a2153dede3b83eb02465aee27b3129c497d9717219e2cd7550f3355"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "29323239"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101563288"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/s41598-017-18700-4"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1100212445"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/s41598-017-18700-4", 
      "https://app.dimensions.ai/details/publication/pub.1100212445"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T00:24", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8695_00000555.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/s41598-017-18700-4"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41598-017-18700-4'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41598-017-18700-4'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41598-017-18700-4'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41598-017-18700-4'


 

This table displays all metadata directly associated to this object as RDF triples.

293 TRIPLES      21 PREDICATES      85 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/s41598-017-18700-4 schema:about anzsrc-for:11
2 anzsrc-for:1109
3 schema:author Nc19ef2b41a934e4b919cf9c3942f477f
4 schema:citation sg:pub.10.1007/s12031-015-0612-8
5 sg:pub.10.1007/s12035-015-9528-0
6 sg:pub.10.1038/43686
7 sg:pub.10.1038/cr.2011.177
8 sg:pub.10.1038/nature04598
9 sg:pub.10.1038/nbt.3626
10 sg:pub.10.1038/nrm1739
11 sg:pub.10.1038/nrn3618
12 sg:pub.10.1038/srep21096
13 https://app.dimensions.ai/details/publication/pub.1074652899
14 https://doi.org/10.1006/dbio.1996.0090
15 https://doi.org/10.1016/0003-2697(77)90428-6
16 https://doi.org/10.1016/0022-1759(83)90303-4
17 https://doi.org/10.1016/j.brainres.2010.02.071
18 https://doi.org/10.1016/j.cellsig.2015.11.016
19 https://doi.org/10.1016/j.foodchem.2016.10.043
20 https://doi.org/10.1016/j.jnutbio.2005.09.007
21 https://doi.org/10.1016/j.neuron.2007.04.019
22 https://doi.org/10.1016/j.neuron.2009.07.004
23 https://doi.org/10.1016/j.neuron.2012.08.031
24 https://doi.org/10.1016/j.neuron.2015.01.009
25 https://doi.org/10.1016/j.stem.2017.06.011
26 https://doi.org/10.1016/j.stemcr.2017.05.009
27 https://doi.org/10.1016/j.taap.2015.06.003
28 https://doi.org/10.1016/j.yexcr.2009.08.006
29 https://doi.org/10.1016/s0076-6879(06)19001-1
30 https://doi.org/10.1016/s0169-328x(02)00550-8
31 https://doi.org/10.1016/s0306-4522(03)00198-2
32 https://doi.org/10.1016/s0896-6273(00)00086-6
33 https://doi.org/10.1038/embor.2010.66
34 https://doi.org/10.1038/sj.emboj.7601923
35 https://doi.org/10.1073/pnas.79.6.1698
36 https://doi.org/10.1074/jbc.m110.139477
37 https://doi.org/10.1093/cercor/bhp046
38 https://doi.org/10.1093/cercor/bhw387
39 https://doi.org/10.1111/iju.13386
40 https://doi.org/10.1111/j.1365-2362.2008.01990.x
41 https://doi.org/10.1126/science.aab3516
42 https://doi.org/10.1126/science.aaf4802
43 https://doi.org/10.1152/jn.00509.2016
44 https://doi.org/10.1242/dev.009951
45 https://doi.org/10.1242/dev.061663
46 https://doi.org/10.1242/dev.093096
47 https://doi.org/10.1517/14728222.12.10.1275
48 https://doi.org/10.1523/jneurosci.1054-09.2009
49 https://doi.org/10.1523/jneurosci.12-11-04565.1992
50 https://doi.org/10.1523/jneurosci.4374-07.2008
51 https://doi.org/10.1523/jneurosci.4568-12.2013
52 https://doi.org/10.2967/jnumed.117.193581
53 https://doi.org/10.3109/10409238.2012.735643
54 https://doi.org/10.3389/fncel.2015.00501
55 https://doi.org/10.3389/fphys.2012.00119
56 https://doi.org/10.3390/molecules22101771
57 https://doi.org/10.3727/096368911x627543
58 https://doi.org/10.4103/1673-5374.137570
59 https://doi.org/10.4238/gmr.15038376
60 schema:datePublished 2018-12
61 schema:datePublishedReg 2018-12-01
62 schema:description Hitherto, the known mechanisms underpinning cell-fate specification act on neural progenitors, affecting their commitment to generate neuron or glial cells. Here, we show that particular phospholipids supplemented in the culture media modify the commitment of post-mitotic neural cells in vitro. Phosphatidylcholine (PtdCho)-enriched media enhances neuronal differentiation at the expense of astroglial and unspecified cells. Conversely, phosphatidylethanolamine (PtdEtn) enhances astroglial differentiation and accelerates astrocyte maturation. The ability of phospholipids to modify the fate of post-mitotic cells depends on its presence during a narrow time-window during cell differentiation and it is mediated by the selective activation of particular signaling pathways. While PtdCho-mediated effect on neuronal differentiation depends on cAMP-dependent kinase (PKA)/calcium responsive element binding protein (CREB), PtdEtn stimulates astrogliogenesis through the activation of the MEK/ERK signaling pathway. Collectively, our results provide an additional degree of plasticity in neural cell specification and further support the notion that cell differentiation is a reversible phenomenon. They also contribute to our understanding of neuronal and glial lineage specification in the central nervous system, opening up new avenues to retrieve neurogenic capacity in the brain.
63 schema:genre research_article
64 schema:inLanguage en
65 schema:isAccessibleForFree true
66 schema:isPartOf N5bd78ca0f0384d29b605bd47535c247c
67 Na2bea44ff0114fb299959c392021063a
68 sg:journal.1045337
69 schema:name Specific Phospholipids Regulate the Acquisition of Neuronal and Astroglial Identities in Post-Mitotic Cells
70 schema:pagination 460
71 schema:productId N297188518ea0466ca69b59ab522f41e6
72 N7680e3fefc464c1c9da4816151602365
73 Nb7115cc3cf2940f7a9412b265d947e08
74 Nbaeccfa256bb437f8b936cc9bc5aad8e
75 Nd3c9cba3df774911b13bba988c030908
76 schema:sameAs https://app.dimensions.ai/details/publication/pub.1100212445
77 https://doi.org/10.1038/s41598-017-18700-4
78 schema:sdDatePublished 2019-04-11T00:24
79 schema:sdLicense https://scigraph.springernature.com/explorer/license/
80 schema:sdPublisher N1894593ae28c423599be7186ab6654b1
81 schema:url https://www.nature.com/articles/s41598-017-18700-4
82 sgo:license sg:explorer/license/
83 sgo:sdDataset articles
84 rdf:type schema:ScholarlyArticle
85 N0cef59ea0b9b47969a3a372fe0894d17 schema:affiliation https://www.grid.ac/institutes/grid.411233.6
86 schema:familyName da Silva Santana
87 schema:givenName Themis Taynah
88 rdf:type schema:Person
89 N1894593ae28c423599be7186ab6654b1 schema:name Springer Nature - SN SciGraph project
90 rdf:type schema:Organization
91 N2284c62b3024491c8e00df02ac1c4edb rdf:first N4a11dbd3c01d4b32a4e67d3c4189b30c
92 rdf:rest N62ea4fdd8b1a4a5ebdc819e8aa2d0643
93 N297188518ea0466ca69b59ab522f41e6 schema:name readcube_id
94 schema:value b0e9be6d8a2153dede3b83eb02465aee27b3129c497d9717219e2cd7550f3355
95 rdf:type schema:PropertyValue
96 N4a11dbd3c01d4b32a4e67d3c4189b30c schema:affiliation https://www.grid.ac/institutes/grid.8536.8
97 schema:familyName Einiker-Lamas
98 schema:givenName Marcelo
99 rdf:type schema:Person
100 N5bd78ca0f0384d29b605bd47535c247c schema:issueNumber 1
101 rdf:type schema:PublicationIssue
102 N62ea4fdd8b1a4a5ebdc819e8aa2d0643 rdf:first sg:person.0640044740.63
103 rdf:rest N77b22200b0c248b7a8c85606dfd457e8
104 N7680e3fefc464c1c9da4816151602365 schema:name doi
105 schema:value 10.1038/s41598-017-18700-4
106 rdf:type schema:PropertyValue
107 N77b22200b0c248b7a8c85606dfd457e8 rdf:first sg:person.01007157475.35
108 rdf:rest Nc5416b56c562457baeed528912a89387
109 Na2bea44ff0114fb299959c392021063a schema:volumeNumber 8
110 rdf:type schema:PublicationVolume
111 Nb7115cc3cf2940f7a9412b265d947e08 schema:name pubmed_id
112 schema:value 29323239
113 rdf:type schema:PropertyValue
114 Nbaeccfa256bb437f8b936cc9bc5aad8e schema:name nlm_unique_id
115 schema:value 101563288
116 rdf:type schema:PropertyValue
117 Nc19ef2b41a934e4b919cf9c3942f477f rdf:first sg:person.014042700755.74
118 rdf:rest Nc426664c90964f798a96d8bfee279207
119 Nc2d2eeb2ded04637bbdb0ff7fd6faac7 rdf:first sg:person.0743514320.12
120 rdf:rest N2284c62b3024491c8e00df02ac1c4edb
121 Nc426664c90964f798a96d8bfee279207 rdf:first N0cef59ea0b9b47969a3a372fe0894d17
122 rdf:rest Nc2d2eeb2ded04637bbdb0ff7fd6faac7
123 Nc5416b56c562457baeed528912a89387 rdf:first sg:person.01100517200.92
124 rdf:rest rdf:nil
125 Nd3c9cba3df774911b13bba988c030908 schema:name dimensions_id
126 schema:value pub.1100212445
127 rdf:type schema:PropertyValue
128 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
129 schema:name Medical and Health Sciences
130 rdf:type schema:DefinedTerm
131 anzsrc-for:1109 schema:inDefinedTermSet anzsrc-for:
132 schema:name Neurosciences
133 rdf:type schema:DefinedTerm
134 sg:journal.1045337 schema:issn 2045-2322
135 schema:name Scientific Reports
136 rdf:type schema:Periodical
137 sg:person.01007157475.35 schema:affiliation https://www.grid.ac/institutes/grid.411233.6
138 schema:familyName Costa
139 schema:givenName Marcos Romualdo
140 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01007157475.35
141 rdf:type schema:Person
142 sg:person.01100517200.92 schema:affiliation https://www.grid.ac/institutes/grid.10814.3c
143 schema:familyName Banchio
144 schema:givenName Claudia
145 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01100517200.92
146 rdf:type schema:Person
147 sg:person.014042700755.74 schema:affiliation https://www.grid.ac/institutes/grid.10814.3c
148 schema:familyName Montaner
149 schema:givenName Aneley
150 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014042700755.74
151 rdf:type schema:Person
152 sg:person.0640044740.63 schema:affiliation https://www.grid.ac/institutes/grid.10814.3c
153 schema:familyName Girardini
154 schema:givenName Javier
155 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0640044740.63
156 rdf:type schema:Person
157 sg:person.0743514320.12 schema:affiliation https://www.grid.ac/institutes/grid.5801.c
158 schema:familyName Schroeder
159 schema:givenName Timm
160 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0743514320.12
161 rdf:type schema:Person
162 sg:pub.10.1007/s12031-015-0612-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000448938
163 https://doi.org/10.1007/s12031-015-0612-8
164 rdf:type schema:CreativeWork
165 sg:pub.10.1007/s12035-015-9528-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004656858
166 https://doi.org/10.1007/s12035-015-9528-0
167 rdf:type schema:CreativeWork
168 sg:pub.10.1038/43686 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040879470
169 https://doi.org/10.1038/43686
170 rdf:type schema:CreativeWork
171 sg:pub.10.1038/cr.2011.177 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016074710
172 https://doi.org/10.1038/cr.2011.177
173 rdf:type schema:CreativeWork
174 sg:pub.10.1038/nature04598 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008587713
175 https://doi.org/10.1038/nature04598
176 rdf:type schema:CreativeWork
177 sg:pub.10.1038/nbt.3626 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017412223
178 https://doi.org/10.1038/nbt.3626
179 rdf:type schema:CreativeWork
180 sg:pub.10.1038/nrm1739 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001699881
181 https://doi.org/10.1038/nrm1739
182 rdf:type schema:CreativeWork
183 sg:pub.10.1038/nrn3618 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010950426
184 https://doi.org/10.1038/nrn3618
185 rdf:type schema:CreativeWork
186 sg:pub.10.1038/srep21096 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031029868
187 https://doi.org/10.1038/srep21096
188 rdf:type schema:CreativeWork
189 https://app.dimensions.ai/details/publication/pub.1074652899 schema:CreativeWork
190 https://doi.org/10.1006/dbio.1996.0090 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014800916
191 rdf:type schema:CreativeWork
192 https://doi.org/10.1016/0003-2697(77)90428-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023913912
193 rdf:type schema:CreativeWork
194 https://doi.org/10.1016/0022-1759(83)90303-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053705634
195 rdf:type schema:CreativeWork
196 https://doi.org/10.1016/j.brainres.2010.02.071 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013311450
197 rdf:type schema:CreativeWork
198 https://doi.org/10.1016/j.cellsig.2015.11.016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047039363
199 rdf:type schema:CreativeWork
200 https://doi.org/10.1016/j.foodchem.2016.10.043 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039962317
201 rdf:type schema:CreativeWork
202 https://doi.org/10.1016/j.jnutbio.2005.09.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029360162
203 rdf:type schema:CreativeWork
204 https://doi.org/10.1016/j.neuron.2007.04.019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047827185
205 rdf:type schema:CreativeWork
206 https://doi.org/10.1016/j.neuron.2009.07.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022217052
207 rdf:type schema:CreativeWork
208 https://doi.org/10.1016/j.neuron.2012.08.031 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043735031
209 rdf:type schema:CreativeWork
210 https://doi.org/10.1016/j.neuron.2015.01.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051333134
211 rdf:type schema:CreativeWork
212 https://doi.org/10.1016/j.stem.2017.06.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1090367385
213 rdf:type schema:CreativeWork
214 https://doi.org/10.1016/j.stemcr.2017.05.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085938651
215 rdf:type schema:CreativeWork
216 https://doi.org/10.1016/j.taap.2015.06.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008079920
217 rdf:type schema:CreativeWork
218 https://doi.org/10.1016/j.yexcr.2009.08.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022803363
219 rdf:type schema:CreativeWork
220 https://doi.org/10.1016/s0076-6879(06)19001-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009381012
221 rdf:type schema:CreativeWork
222 https://doi.org/10.1016/s0169-328x(02)00550-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046032993
223 rdf:type schema:CreativeWork
224 https://doi.org/10.1016/s0306-4522(03)00198-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004688331
225 rdf:type schema:CreativeWork
226 https://doi.org/10.1016/s0896-6273(00)00086-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003357988
227 rdf:type schema:CreativeWork
228 https://doi.org/10.1038/embor.2010.66 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034240972
229 rdf:type schema:CreativeWork
230 https://doi.org/10.1038/sj.emboj.7601923 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000745508
231 rdf:type schema:CreativeWork
232 https://doi.org/10.1073/pnas.79.6.1698 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035207218
233 rdf:type schema:CreativeWork
234 https://doi.org/10.1074/jbc.m110.139477 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048299002
235 rdf:type schema:CreativeWork
236 https://doi.org/10.1093/cercor/bhp046 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005096620
237 rdf:type schema:CreativeWork
238 https://doi.org/10.1093/cercor/bhw387 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059459000
239 rdf:type schema:CreativeWork
240 https://doi.org/10.1111/iju.13386 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085615080
241 rdf:type schema:CreativeWork
242 https://doi.org/10.1111/j.1365-2362.2008.01990.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1050855503
243 rdf:type schema:CreativeWork
244 https://doi.org/10.1126/science.aab3516 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031707054
245 rdf:type schema:CreativeWork
246 https://doi.org/10.1126/science.aaf4802 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026029724
247 rdf:type schema:CreativeWork
248 https://doi.org/10.1152/jn.00509.2016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010224903
249 rdf:type schema:CreativeWork
250 https://doi.org/10.1242/dev.009951 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005725296
251 rdf:type schema:CreativeWork
252 https://doi.org/10.1242/dev.061663 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022908330
253 rdf:type schema:CreativeWork
254 https://doi.org/10.1242/dev.093096 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025473463
255 rdf:type schema:CreativeWork
256 https://doi.org/10.1517/14728222.12.10.1275 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026449443
257 rdf:type schema:CreativeWork
258 https://doi.org/10.1523/jneurosci.1054-09.2009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039946059
259 rdf:type schema:CreativeWork
260 https://doi.org/10.1523/jneurosci.12-11-04565.1992 schema:sameAs https://app.dimensions.ai/details/publication/pub.1076424739
261 rdf:type schema:CreativeWork
262 https://doi.org/10.1523/jneurosci.4374-07.2008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027391093
263 rdf:type schema:CreativeWork
264 https://doi.org/10.1523/jneurosci.4568-12.2013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040342581
265 rdf:type schema:CreativeWork
266 https://doi.org/10.2967/jnumed.117.193581 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085471943
267 rdf:type schema:CreativeWork
268 https://doi.org/10.3109/10409238.2012.735643 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028212866
269 rdf:type schema:CreativeWork
270 https://doi.org/10.3389/fncel.2015.00501 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005128833
271 rdf:type schema:CreativeWork
272 https://doi.org/10.3389/fphys.2012.00119 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024564770
273 rdf:type schema:CreativeWork
274 https://doi.org/10.3390/molecules22101771 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092275503
275 rdf:type schema:CreativeWork
276 https://doi.org/10.3727/096368911x627543 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003560992
277 rdf:type schema:CreativeWork
278 https://doi.org/10.4103/1673-5374.137570 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010510356
279 rdf:type schema:CreativeWork
280 https://doi.org/10.4238/gmr.15038376 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072396020
281 rdf:type schema:CreativeWork
282 https://www.grid.ac/institutes/grid.10814.3c schema:alternateName National University of Rosario
283 schema:name Instituto de Biología Molecular y Celular de Rosario (IBR, CONICET) Ocampo y Esmeralda, Predio CONICET and Departamento de Ciencias Biológicas, Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, 2000, Rosario, Argentina
284 rdf:type schema:Organization
285 https://www.grid.ac/institutes/grid.411233.6 schema:alternateName Federal University of Rio Grande do Norte
286 schema:name Brain Institute, Federal University of Rio Grande do Norte, Av. Nascimento de Castro 2155, 59056-450, Natal, Brazil
287 rdf:type schema:Organization
288 https://www.grid.ac/institutes/grid.5801.c schema:alternateName Swiss Federal Institute of Technology in Zurich
289 schema:name Department of Biosystems Science and Engineering, Cell Systems Dynamics, ETH Zurich, Basel, Switzerland
290 rdf:type schema:Organization
291 https://www.grid.ac/institutes/grid.8536.8 schema:alternateName Federal University of Rio de Janeiro
292 schema:name Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, 21949–902, Ilha do Fundão, Rio de Janeiro, Brazil
293 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...