COX-2 induces oncogenic micro RNA miR655 in human breast cancer View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-12

AUTHORS

Mousumi Majumder, Leanna Dunn, Ling Liu, Asma Hasan, Krista Vincent, Muriel Brackstone, David Hess, Peeyush K. Lala

ABSTRACT

We show that Cyclooxygenase-2 over-expression induces an oncogenic microRNA miR655 in human breast cancer cells by activation of EP4. MiR655 expression positively correlated with COX-2 in genetically disparate breast cancer cell lines and increased in all cell lines when grown as spheroids, implicating its link with stem-like cells (SLCs). Ectopic miR655 over-expression in MCF7 and SKBR3 cells resulted in increased proliferation, migration, invasion, spheroid formation and Epithelial to Masenchymal transition (EMT). Conversely, knocking down miR655 in aggressive MCF7-COX2 and SKBR3-COX2 cells reverted these phenotypes. MCF7-miR655 cells displayed upregulated NOTCH/WNT genes; both pathway inhibitors abrogated miR655-induced spheroid formation, linking miR655 with SLC-related pathways. MiR655 expression was dependent on EP4 activity and EP4 downstream signaling pathways PI3K/AKT, ERK and NF-kB and led to TGFβ resistance for Smad3 phosphorylation. Tail vein injection of MCF7-miR655 and SKBR3-miR655 cells in NOD/SCID/GUSB-null mice revealed increased lung colony growth and micrometastases to liver and spleen. MiR655 expression was significantly high in human breast tumors (n = 105) compared to non-tumor tissues (n = 20) and associated with reduced patient survival. Thus miR655 could serve as a prognostic breast cancer biomarker. More... »

PAGES

327

References to SciGraph publications

  • 2012-12. The miR-106b-25 cluster targets Smad7, activates TGF-β signaling, and induces EMT and tumor initiating cell characteristics downstream of Six1 in human breast cancer in ONCOGENE
  • 2010-12. Metastasis-related miRNAs, active players in breast cancer invasion, and metastasis in CANCER AND METASTASIS REVIEWS
  • 2010-03. miR-9, a MYC/MYCN-activated microRNA, regulates E-cadherin and cancer metastasis in NATURE CELL BIOLOGY
  • 2013-04. miRNA expression profiling of 51 human breast cancer cell lines reveals subtype and driver mutation-specific miRNAs in BREAST CANCER RESEARCH
  • 2002-01. Gene expression profiling predicts clinical outcome of breast cancer in NATURE
  • 2007-10-11. Tumour invasion and metastasis initiated by microRNA-10b in breast cancer in NATURE
  • 2005-05. NF-kB in development and progression of human cancer in VIRCHOWS ARCHIV
  • 2014-01. Prostaglandin E receptor EP4 is a therapeutic target in breast cancer cells with stem-like properties in BREAST CANCER RESEARCH AND TREATMENT
  • 2010-04. MicroRNA control of signal transduction in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 2013-12. Mir-655 up-regulation suppresses cell invasion by targeting pituitary tumor-transforming gene-1 in esophageal squamous cell carcinoma in JOURNAL OF TRANSLATIONAL MEDICINE
  • 2013-02. Re-expression of microRNA-375 reverses both tamoxifen resistance and accompanying EMT-like properties in breast cancer in ONCOGENE
  • 2006-12. Reduction in the risk of human breast cancer by selective cyclooxygenase-2 (COX-2) inhibitors in BMC CANCER
  • 2012-08. Targeting COX-2 and EP4 to control tumor growth, angiogenesis, lymphangiogenesis and metastasis to the lungs and lymph nodes in a breast cancer model in LABORATORY INVESTIGATION
  • 2014-08. MicroRNA-9 is associated with epithelial-mesenchymal transition, breast cancer stem cell phenotype, and tumor progression in breast cancer in BREAST CANCER RESEARCH AND TREATMENT
  • 2007-11. New concepts in breast cancer metastasis: tumor initiating cells and the microenvironment in CLINICAL & EXPERIMENTAL METASTASIS
  • 2006-04. COX-2-mediated stimulation of the lymphangiogenic factor VEGF-C in human breast cancer in BRITISH JOURNAL OF CANCER
  • 2005-06. MicroRNA expression profiles classify human cancers in NATURE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41598-017-18612-3

    DOI

    http://dx.doi.org/10.1038/s41598-017-18612-3

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1100203153

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/29321644


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Oncology and Carcinogenesis", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Brandon University", 
              "id": "https://www.grid.ac/institutes/grid.253269.9", 
              "name": [
                "Department of Biology, Brandon University, Brandon, Manitoba, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Majumder", 
            "givenName": "Mousumi", 
            "id": "sg:person.01366714052.18", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01366714052.18"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Western University", 
              "id": "https://www.grid.ac/institutes/grid.39381.30", 
              "name": [
                "Department of Anatomy and Cell Biology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Dunn", 
            "givenName": "Leanna", 
            "id": "sg:person.016003517072.56", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016003517072.56"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Western University", 
              "id": "https://www.grid.ac/institutes/grid.39381.30", 
              "name": [
                "Department of Anatomy and Cell Biology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Liu", 
            "givenName": "Ling", 
            "id": "sg:person.01103124600.35", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01103124600.35"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Western University", 
              "id": "https://www.grid.ac/institutes/grid.39381.30", 
              "name": [
                "Department of Anatomy and Cell Biology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hasan", 
            "givenName": "Asma", 
            "id": "sg:person.012535160563.92", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012535160563.92"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Alberta", 
              "id": "https://www.grid.ac/institutes/grid.17089.37", 
              "name": [
                "Department of Anatomy and Cell Biology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada", 
                "Department of Oncology, University of Alberta, Edmonton, Alberta, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Vincent", 
            "givenName": "Krista", 
            "id": "sg:person.0671340367.39", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0671340367.39"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Lawson Health Research Institute", 
              "id": "https://www.grid.ac/institutes/grid.415847.b", 
              "name": [
                "Department of Oncology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada", 
                "Lawson Research Institute, London, Ontario, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Brackstone", 
            "givenName": "Muriel", 
            "id": "sg:person.01061024446.05", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01061024446.05"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Western University", 
              "id": "https://www.grid.ac/institutes/grid.39381.30", 
              "name": [
                "Physiology and Pharmacology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada", 
                "Robarts Research Institute, London, Ontario, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hess", 
            "givenName": "David", 
            "id": "sg:person.01063405157.37", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01063405157.37"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Western University", 
              "id": "https://www.grid.ac/institutes/grid.39381.30", 
              "name": [
                "Department of Anatomy and Cell Biology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada", 
                "Department of Oncology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lala", 
            "givenName": "Peeyush K.", 
            "id": "sg:person.0737043323.76", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0737043323.76"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1111/cas.12475", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003786706"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.1061803", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004107821"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.bjc.6603067", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006690528", 
              "https://doi.org/10.1038/sj.bjc.6603067"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.bjc.6603067", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006690528", 
              "https://doi.org/10.1038/sj.bjc.6603067"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1001/jama.296.13.jed60058", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007181020"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ccr.2009.06.013", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009102589"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/labinvest.2012.90", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009402805", 
              "https://doi.org/10.1038/labinvest.2012.90"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/jcp.2005.030098", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010310304"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0014-4827(03)00269-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011544407"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0014-4827(03)00269-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011544407"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m212665200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012135478"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/stem.2426", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012517366"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.biocel.2009.12.014", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012999042"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-2407-6-27", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013256115", 
              "https://doi.org/10.1186/1471-2407-6-27"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0062757", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013467716"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0041178", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013610200"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/cncr.11437", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013678114"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature06174", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014546686", 
              "https://doi.org/10.1038/nature06174"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrm2868", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017044226", 
              "https://doi.org/10.1038/nrm2868"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrm2868", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017044226", 
              "https://doi.org/10.1038/nrm2868"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncb2024", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020751102", 
              "https://doi.org/10.1038/ncb2024"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncb2024", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020751102", 
              "https://doi.org/10.1038/ncb2024"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0008-8749(86)90220-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021389545"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature03702", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024825726", 
              "https://doi.org/10.1038/nature03702"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature03702", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024825726", 
              "https://doi.org/10.1038/nature03702"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2009.07.011", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026731603"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2009.07.011", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026731603"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-05-1783", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027381088"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gr.166702.113", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028372492"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmp048288", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028957589"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00428-005-1264-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029598834", 
              "https://doi.org/10.1007/s00428-005-1264-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00428-005-1264-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029598834", 
              "https://doi.org/10.1007/s00428-005-1264-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1479-5876-11-301", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030039990", 
              "https://doi.org/10.1186/1479-5876-11-301"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-05-3153", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030275719"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1146/annurev.pharmtox.41.1.661", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030715235"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10549-013-2779-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031796182", 
              "https://doi.org/10.1007/s10549-013-2779-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10549-013-2779-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031796182", 
              "https://doi.org/10.1007/s10549-013-2779-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.prostaglandins.2006.10.005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032222836"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/embor.2008.74", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032429234"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10549-014-3069-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032760569", 
              "https://doi.org/10.1007/s10549-014-3069-5"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ijc.27799", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033853022"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1349-7006.2010.01647.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035338243"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1349-7006.2010.01647.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035338243"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/jcp.55.6.429", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035382092"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1541-7786.mcr-14-0543", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036281016"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/gutjnl-2011-301846", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036909369"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/bcr3415", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039106985", 
              "https://doi.org/10.1186/bcr3415"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ijc.1376", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039838854"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ccr.2006.10.008", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040586971"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/onc.2012.11", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041255349", 
              "https://doi.org/10.1038/onc.2012.11"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0035094", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041372189"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/jcmm.12770", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041726416"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4161/onci.22647", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042412559"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/415530a", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043001094", 
              "https://doi.org/10.1038/415530a"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/415530a", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043001094", 
              "https://doi.org/10.1038/415530a"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.stem.2007.08.014", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045510569"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.r600038200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045997111"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10585-007-9122-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046321145", 
              "https://doi.org/10.1007/s10585-007-9122-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10585-007-9122-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046321145", 
              "https://doi.org/10.1007/s10585-007-9122-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m313989200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048415299"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0307323101", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049808985"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/onc.2012.128", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050107557", 
              "https://doi.org/10.1038/onc.2012.128"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/carcin/bgn202", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050311191"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2007.10.054", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050608753"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0013735", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051824513"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10555-010-9265-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052669414", 
              "https://doi.org/10.1007/s10555-010-9265-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10555-010-9265-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052669414", 
              "https://doi.org/10.1007/s10555-010-9265-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2174/156802607780487740", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1069193494"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3892/ol.2012.916", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1071525858"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074993533", 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2018-12", 
        "datePublishedReg": "2018-12-01", 
        "description": "We show that Cyclooxygenase-2 over-expression induces an oncogenic microRNA miR655 in human breast cancer cells by activation of EP4. MiR655 expression positively correlated with COX-2 in genetically disparate breast cancer cell lines and increased in all cell lines when grown as spheroids, implicating its link with stem-like cells (SLCs). Ectopic miR655 over-expression in MCF7 and SKBR3 cells resulted in increased proliferation, migration, invasion, spheroid formation and Epithelial to Masenchymal transition (EMT). Conversely, knocking down miR655 in aggressive MCF7-COX2 and SKBR3-COX2 cells reverted these phenotypes. MCF7-miR655 cells displayed upregulated NOTCH/WNT genes; both pathway inhibitors abrogated miR655-induced spheroid formation, linking miR655 with SLC-related pathways. MiR655 expression was dependent on EP4 activity and EP4 downstream signaling pathways PI3K/AKT, ERK and NF-kB and led to TGF\u03b2 resistance for Smad3 phosphorylation. Tail vein injection of MCF7-miR655 and SKBR3-miR655 cells in NOD/SCID/GUSB-null mice revealed increased lung colony growth and micrometastases to liver and spleen. MiR655 expression was significantly high in human breast tumors (n\u2009=\u2009105) compared to non-tumor tissues (n\u2009=\u200920) and associated with reduced patient survival. Thus miR655 could serve as a prognostic breast cancer biomarker.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/s41598-017-18612-3", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isPartOf": [
          {
            "id": "sg:journal.1045337", 
            "issn": [
              "2045-2322"
            ], 
            "name": "Scientific Reports", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "1", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "8"
          }
        ], 
        "name": "COX-2 induces oncogenic micro RNA miR655 in human breast cancer", 
        "pagination": "327", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "ccb59856b1ecc9a0cc641a532eba533dde7cb7d7d0d0294f950abfdf4ad37629"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "29321644"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "101563288"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/s41598-017-18612-3"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1100203153"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/s41598-017-18612-3", 
          "https://app.dimensions.ai/details/publication/pub.1100203153"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-10T13:24", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8659_00000548.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://www.nature.com/articles/s41598-017-18612-3"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41598-017-18612-3'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41598-017-18612-3'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41598-017-18612-3'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41598-017-18612-3'


     

    This table displays all metadata directly associated to this object as RDF triples.

    321 TRIPLES      21 PREDICATES      87 URIs      21 LITERALS      9 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/s41598-017-18612-3 schema:about anzsrc-for:11
    2 anzsrc-for:1112
    3 schema:author N65943d9c4c934a74918bde7dd4dbeaf2
    4 schema:citation sg:pub.10.1007/s00428-005-1264-9
    5 sg:pub.10.1007/s10549-013-2779-4
    6 sg:pub.10.1007/s10549-014-3069-5
    7 sg:pub.10.1007/s10555-010-9265-9
    8 sg:pub.10.1007/s10585-007-9122-6
    9 sg:pub.10.1038/415530a
    10 sg:pub.10.1038/labinvest.2012.90
    11 sg:pub.10.1038/nature03702
    12 sg:pub.10.1038/nature06174
    13 sg:pub.10.1038/ncb2024
    14 sg:pub.10.1038/nrm2868
    15 sg:pub.10.1038/onc.2012.11
    16 sg:pub.10.1038/onc.2012.128
    17 sg:pub.10.1038/sj.bjc.6603067
    18 sg:pub.10.1186/1471-2407-6-27
    19 sg:pub.10.1186/1479-5876-11-301
    20 sg:pub.10.1186/bcr3415
    21 https://app.dimensions.ai/details/publication/pub.1074993533
    22 https://doi.org/10.1001/jama.296.13.jed60058
    23 https://doi.org/10.1002/cncr.11437
    24 https://doi.org/10.1002/ijc.1376
    25 https://doi.org/10.1002/ijc.27799
    26 https://doi.org/10.1002/stem.2426
    27 https://doi.org/10.1016/0008-8749(86)90220-0
    28 https://doi.org/10.1016/j.biocel.2009.12.014
    29 https://doi.org/10.1016/j.ccr.2006.10.008
    30 https://doi.org/10.1016/j.ccr.2009.06.013
    31 https://doi.org/10.1016/j.cell.2007.10.054
    32 https://doi.org/10.1016/j.cell.2009.07.011
    33 https://doi.org/10.1016/j.prostaglandins.2006.10.005
    34 https://doi.org/10.1016/j.stem.2007.08.014
    35 https://doi.org/10.1016/s0014-4827(03)00269-6
    36 https://doi.org/10.1038/embor.2008.74
    37 https://doi.org/10.1056/nejmp048288
    38 https://doi.org/10.1073/pnas.0307323101
    39 https://doi.org/10.1074/jbc.m212665200
    40 https://doi.org/10.1074/jbc.m313989200
    41 https://doi.org/10.1074/jbc.r600038200
    42 https://doi.org/10.1093/carcin/bgn202
    43 https://doi.org/10.1101/gad.1061803
    44 https://doi.org/10.1101/gr.166702.113
    45 https://doi.org/10.1111/cas.12475
    46 https://doi.org/10.1111/j.1349-7006.2010.01647.x
    47 https://doi.org/10.1111/jcmm.12770
    48 https://doi.org/10.1136/gutjnl-2011-301846
    49 https://doi.org/10.1136/jcp.2005.030098
    50 https://doi.org/10.1136/jcp.55.6.429
    51 https://doi.org/10.1146/annurev.pharmtox.41.1.661
    52 https://doi.org/10.1158/0008-5472.can-05-1783
    53 https://doi.org/10.1158/0008-5472.can-05-3153
    54 https://doi.org/10.1158/1541-7786.mcr-14-0543
    55 https://doi.org/10.1371/journal.pone.0013735
    56 https://doi.org/10.1371/journal.pone.0035094
    57 https://doi.org/10.1371/journal.pone.0041178
    58 https://doi.org/10.1371/journal.pone.0062757
    59 https://doi.org/10.2174/156802607780487740
    60 https://doi.org/10.3892/ol.2012.916
    61 https://doi.org/10.4161/onci.22647
    62 schema:datePublished 2018-12
    63 schema:datePublishedReg 2018-12-01
    64 schema:description We show that Cyclooxygenase-2 over-expression induces an oncogenic microRNA miR655 in human breast cancer cells by activation of EP4. MiR655 expression positively correlated with COX-2 in genetically disparate breast cancer cell lines and increased in all cell lines when grown as spheroids, implicating its link with stem-like cells (SLCs). Ectopic miR655 over-expression in MCF7 and SKBR3 cells resulted in increased proliferation, migration, invasion, spheroid formation and Epithelial to Masenchymal transition (EMT). Conversely, knocking down miR655 in aggressive MCF7-COX2 and SKBR3-COX2 cells reverted these phenotypes. MCF7-miR655 cells displayed upregulated NOTCH/WNT genes; both pathway inhibitors abrogated miR655-induced spheroid formation, linking miR655 with SLC-related pathways. MiR655 expression was dependent on EP4 activity and EP4 downstream signaling pathways PI3K/AKT, ERK and NF-kB and led to TGFβ resistance for Smad3 phosphorylation. Tail vein injection of MCF7-miR655 and SKBR3-miR655 cells in NOD/SCID/GUSB-null mice revealed increased lung colony growth and micrometastases to liver and spleen. MiR655 expression was significantly high in human breast tumors (n = 105) compared to non-tumor tissues (n = 20) and associated with reduced patient survival. Thus miR655 could serve as a prognostic breast cancer biomarker.
    65 schema:genre research_article
    66 schema:inLanguage en
    67 schema:isAccessibleForFree true
    68 schema:isPartOf N15833ee3f20a4afcbacfccff6b886a0a
    69 Nec67d02cbc8c4b479c0444f56a4f31c4
    70 sg:journal.1045337
    71 schema:name COX-2 induces oncogenic micro RNA miR655 in human breast cancer
    72 schema:pagination 327
    73 schema:productId N0e7ac142c2084a5392931a2c4edf6b30
    74 N10ca9b61883848ee827fda7656f7c72a
    75 N7ce62426828d414abaa5280080dcbf1b
    76 N8994f58d4ff547e580e01b5027eab499
    77 Na89dd9d593e44a25a65fb762fc4ef767
    78 schema:sameAs https://app.dimensions.ai/details/publication/pub.1100203153
    79 https://doi.org/10.1038/s41598-017-18612-3
    80 schema:sdDatePublished 2019-04-10T13:24
    81 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    82 schema:sdPublisher Nb691dd54e508476fb470ff231697eda6
    83 schema:url https://www.nature.com/articles/s41598-017-18612-3
    84 sgo:license sg:explorer/license/
    85 sgo:sdDataset articles
    86 rdf:type schema:ScholarlyArticle
    87 N0e7ac142c2084a5392931a2c4edf6b30 schema:name pubmed_id
    88 schema:value 29321644
    89 rdf:type schema:PropertyValue
    90 N10ca9b61883848ee827fda7656f7c72a schema:name nlm_unique_id
    91 schema:value 101563288
    92 rdf:type schema:PropertyValue
    93 N15833ee3f20a4afcbacfccff6b886a0a schema:issueNumber 1
    94 rdf:type schema:PublicationIssue
    95 N36808fc01f7645b6a1c96cc316e53759 rdf:first sg:person.01103124600.35
    96 rdf:rest N38fc0177b2ed4451a9de365492d3cedd
    97 N38fc0177b2ed4451a9de365492d3cedd rdf:first sg:person.012535160563.92
    98 rdf:rest N6c2b05df2ad34185a5fcfa5aad758fb8
    99 N530cc99415224731913145f86400fea3 rdf:first sg:person.01061024446.05
    100 rdf:rest N8867e59acf9e4acfb1365045f0eb82b7
    101 N65943d9c4c934a74918bde7dd4dbeaf2 rdf:first sg:person.01366714052.18
    102 rdf:rest Nc329ab8af305408d92f1fb00df83f253
    103 N6c2b05df2ad34185a5fcfa5aad758fb8 rdf:first sg:person.0671340367.39
    104 rdf:rest N530cc99415224731913145f86400fea3
    105 N7ce62426828d414abaa5280080dcbf1b schema:name dimensions_id
    106 schema:value pub.1100203153
    107 rdf:type schema:PropertyValue
    108 N8867e59acf9e4acfb1365045f0eb82b7 rdf:first sg:person.01063405157.37
    109 rdf:rest Nffad96dd2e7d420a999e6a84fe04adbb
    110 N8994f58d4ff547e580e01b5027eab499 schema:name doi
    111 schema:value 10.1038/s41598-017-18612-3
    112 rdf:type schema:PropertyValue
    113 Na89dd9d593e44a25a65fb762fc4ef767 schema:name readcube_id
    114 schema:value ccb59856b1ecc9a0cc641a532eba533dde7cb7d7d0d0294f950abfdf4ad37629
    115 rdf:type schema:PropertyValue
    116 Nb691dd54e508476fb470ff231697eda6 schema:name Springer Nature - SN SciGraph project
    117 rdf:type schema:Organization
    118 Nc329ab8af305408d92f1fb00df83f253 rdf:first sg:person.016003517072.56
    119 rdf:rest N36808fc01f7645b6a1c96cc316e53759
    120 Nec67d02cbc8c4b479c0444f56a4f31c4 schema:volumeNumber 8
    121 rdf:type schema:PublicationVolume
    122 Nffad96dd2e7d420a999e6a84fe04adbb rdf:first sg:person.0737043323.76
    123 rdf:rest rdf:nil
    124 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    125 schema:name Medical and Health Sciences
    126 rdf:type schema:DefinedTerm
    127 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
    128 schema:name Oncology and Carcinogenesis
    129 rdf:type schema:DefinedTerm
    130 sg:journal.1045337 schema:issn 2045-2322
    131 schema:name Scientific Reports
    132 rdf:type schema:Periodical
    133 sg:person.01061024446.05 schema:affiliation https://www.grid.ac/institutes/grid.415847.b
    134 schema:familyName Brackstone
    135 schema:givenName Muriel
    136 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01061024446.05
    137 rdf:type schema:Person
    138 sg:person.01063405157.37 schema:affiliation https://www.grid.ac/institutes/grid.39381.30
    139 schema:familyName Hess
    140 schema:givenName David
    141 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01063405157.37
    142 rdf:type schema:Person
    143 sg:person.01103124600.35 schema:affiliation https://www.grid.ac/institutes/grid.39381.30
    144 schema:familyName Liu
    145 schema:givenName Ling
    146 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01103124600.35
    147 rdf:type schema:Person
    148 sg:person.012535160563.92 schema:affiliation https://www.grid.ac/institutes/grid.39381.30
    149 schema:familyName Hasan
    150 schema:givenName Asma
    151 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012535160563.92
    152 rdf:type schema:Person
    153 sg:person.01366714052.18 schema:affiliation https://www.grid.ac/institutes/grid.253269.9
    154 schema:familyName Majumder
    155 schema:givenName Mousumi
    156 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01366714052.18
    157 rdf:type schema:Person
    158 sg:person.016003517072.56 schema:affiliation https://www.grid.ac/institutes/grid.39381.30
    159 schema:familyName Dunn
    160 schema:givenName Leanna
    161 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016003517072.56
    162 rdf:type schema:Person
    163 sg:person.0671340367.39 schema:affiliation https://www.grid.ac/institutes/grid.17089.37
    164 schema:familyName Vincent
    165 schema:givenName Krista
    166 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0671340367.39
    167 rdf:type schema:Person
    168 sg:person.0737043323.76 schema:affiliation https://www.grid.ac/institutes/grid.39381.30
    169 schema:familyName Lala
    170 schema:givenName Peeyush K.
    171 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0737043323.76
    172 rdf:type schema:Person
    173 sg:pub.10.1007/s00428-005-1264-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029598834
    174 https://doi.org/10.1007/s00428-005-1264-9
    175 rdf:type schema:CreativeWork
    176 sg:pub.10.1007/s10549-013-2779-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031796182
    177 https://doi.org/10.1007/s10549-013-2779-4
    178 rdf:type schema:CreativeWork
    179 sg:pub.10.1007/s10549-014-3069-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032760569
    180 https://doi.org/10.1007/s10549-014-3069-5
    181 rdf:type schema:CreativeWork
    182 sg:pub.10.1007/s10555-010-9265-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052669414
    183 https://doi.org/10.1007/s10555-010-9265-9
    184 rdf:type schema:CreativeWork
    185 sg:pub.10.1007/s10585-007-9122-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046321145
    186 https://doi.org/10.1007/s10585-007-9122-6
    187 rdf:type schema:CreativeWork
    188 sg:pub.10.1038/415530a schema:sameAs https://app.dimensions.ai/details/publication/pub.1043001094
    189 https://doi.org/10.1038/415530a
    190 rdf:type schema:CreativeWork
    191 sg:pub.10.1038/labinvest.2012.90 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009402805
    192 https://doi.org/10.1038/labinvest.2012.90
    193 rdf:type schema:CreativeWork
    194 sg:pub.10.1038/nature03702 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024825726
    195 https://doi.org/10.1038/nature03702
    196 rdf:type schema:CreativeWork
    197 sg:pub.10.1038/nature06174 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014546686
    198 https://doi.org/10.1038/nature06174
    199 rdf:type schema:CreativeWork
    200 sg:pub.10.1038/ncb2024 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020751102
    201 https://doi.org/10.1038/ncb2024
    202 rdf:type schema:CreativeWork
    203 sg:pub.10.1038/nrm2868 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017044226
    204 https://doi.org/10.1038/nrm2868
    205 rdf:type schema:CreativeWork
    206 sg:pub.10.1038/onc.2012.11 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041255349
    207 https://doi.org/10.1038/onc.2012.11
    208 rdf:type schema:CreativeWork
    209 sg:pub.10.1038/onc.2012.128 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050107557
    210 https://doi.org/10.1038/onc.2012.128
    211 rdf:type schema:CreativeWork
    212 sg:pub.10.1038/sj.bjc.6603067 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006690528
    213 https://doi.org/10.1038/sj.bjc.6603067
    214 rdf:type schema:CreativeWork
    215 sg:pub.10.1186/1471-2407-6-27 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013256115
    216 https://doi.org/10.1186/1471-2407-6-27
    217 rdf:type schema:CreativeWork
    218 sg:pub.10.1186/1479-5876-11-301 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030039990
    219 https://doi.org/10.1186/1479-5876-11-301
    220 rdf:type schema:CreativeWork
    221 sg:pub.10.1186/bcr3415 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039106985
    222 https://doi.org/10.1186/bcr3415
    223 rdf:type schema:CreativeWork
    224 https://app.dimensions.ai/details/publication/pub.1074993533 schema:CreativeWork
    225 https://doi.org/10.1001/jama.296.13.jed60058 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007181020
    226 rdf:type schema:CreativeWork
    227 https://doi.org/10.1002/cncr.11437 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013678114
    228 rdf:type schema:CreativeWork
    229 https://doi.org/10.1002/ijc.1376 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039838854
    230 rdf:type schema:CreativeWork
    231 https://doi.org/10.1002/ijc.27799 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033853022
    232 rdf:type schema:CreativeWork
    233 https://doi.org/10.1002/stem.2426 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012517366
    234 rdf:type schema:CreativeWork
    235 https://doi.org/10.1016/0008-8749(86)90220-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021389545
    236 rdf:type schema:CreativeWork
    237 https://doi.org/10.1016/j.biocel.2009.12.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012999042
    238 rdf:type schema:CreativeWork
    239 https://doi.org/10.1016/j.ccr.2006.10.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040586971
    240 rdf:type schema:CreativeWork
    241 https://doi.org/10.1016/j.ccr.2009.06.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009102589
    242 rdf:type schema:CreativeWork
    243 https://doi.org/10.1016/j.cell.2007.10.054 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050608753
    244 rdf:type schema:CreativeWork
    245 https://doi.org/10.1016/j.cell.2009.07.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026731603
    246 rdf:type schema:CreativeWork
    247 https://doi.org/10.1016/j.prostaglandins.2006.10.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032222836
    248 rdf:type schema:CreativeWork
    249 https://doi.org/10.1016/j.stem.2007.08.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045510569
    250 rdf:type schema:CreativeWork
    251 https://doi.org/10.1016/s0014-4827(03)00269-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011544407
    252 rdf:type schema:CreativeWork
    253 https://doi.org/10.1038/embor.2008.74 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032429234
    254 rdf:type schema:CreativeWork
    255 https://doi.org/10.1056/nejmp048288 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028957589
    256 rdf:type schema:CreativeWork
    257 https://doi.org/10.1073/pnas.0307323101 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049808985
    258 rdf:type schema:CreativeWork
    259 https://doi.org/10.1074/jbc.m212665200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012135478
    260 rdf:type schema:CreativeWork
    261 https://doi.org/10.1074/jbc.m313989200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048415299
    262 rdf:type schema:CreativeWork
    263 https://doi.org/10.1074/jbc.r600038200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045997111
    264 rdf:type schema:CreativeWork
    265 https://doi.org/10.1093/carcin/bgn202 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050311191
    266 rdf:type schema:CreativeWork
    267 https://doi.org/10.1101/gad.1061803 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004107821
    268 rdf:type schema:CreativeWork
    269 https://doi.org/10.1101/gr.166702.113 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028372492
    270 rdf:type schema:CreativeWork
    271 https://doi.org/10.1111/cas.12475 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003786706
    272 rdf:type schema:CreativeWork
    273 https://doi.org/10.1111/j.1349-7006.2010.01647.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1035338243
    274 rdf:type schema:CreativeWork
    275 https://doi.org/10.1111/jcmm.12770 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041726416
    276 rdf:type schema:CreativeWork
    277 https://doi.org/10.1136/gutjnl-2011-301846 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036909369
    278 rdf:type schema:CreativeWork
    279 https://doi.org/10.1136/jcp.2005.030098 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010310304
    280 rdf:type schema:CreativeWork
    281 https://doi.org/10.1136/jcp.55.6.429 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035382092
    282 rdf:type schema:CreativeWork
    283 https://doi.org/10.1146/annurev.pharmtox.41.1.661 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030715235
    284 rdf:type schema:CreativeWork
    285 https://doi.org/10.1158/0008-5472.can-05-1783 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027381088
    286 rdf:type schema:CreativeWork
    287 https://doi.org/10.1158/0008-5472.can-05-3153 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030275719
    288 rdf:type schema:CreativeWork
    289 https://doi.org/10.1158/1541-7786.mcr-14-0543 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036281016
    290 rdf:type schema:CreativeWork
    291 https://doi.org/10.1371/journal.pone.0013735 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051824513
    292 rdf:type schema:CreativeWork
    293 https://doi.org/10.1371/journal.pone.0035094 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041372189
    294 rdf:type schema:CreativeWork
    295 https://doi.org/10.1371/journal.pone.0041178 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013610200
    296 rdf:type schema:CreativeWork
    297 https://doi.org/10.1371/journal.pone.0062757 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013467716
    298 rdf:type schema:CreativeWork
    299 https://doi.org/10.2174/156802607780487740 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069193494
    300 rdf:type schema:CreativeWork
    301 https://doi.org/10.3892/ol.2012.916 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071525858
    302 rdf:type schema:CreativeWork
    303 https://doi.org/10.4161/onci.22647 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042412559
    304 rdf:type schema:CreativeWork
    305 https://www.grid.ac/institutes/grid.17089.37 schema:alternateName University of Alberta
    306 schema:name Department of Anatomy and Cell Biology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada
    307 Department of Oncology, University of Alberta, Edmonton, Alberta, Canada
    308 rdf:type schema:Organization
    309 https://www.grid.ac/institutes/grid.253269.9 schema:alternateName Brandon University
    310 schema:name Department of Biology, Brandon University, Brandon, Manitoba, Canada
    311 rdf:type schema:Organization
    312 https://www.grid.ac/institutes/grid.39381.30 schema:alternateName Western University
    313 schema:name Department of Anatomy and Cell Biology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada
    314 Department of Oncology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada
    315 Physiology and Pharmacology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada
    316 Robarts Research Institute, London, Ontario, Canada
    317 rdf:type schema:Organization
    318 https://www.grid.ac/institutes/grid.415847.b schema:alternateName Lawson Health Research Institute
    319 schema:name Department of Oncology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada
    320 Lawson Research Institute, London, Ontario, Canada
    321 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...