N-domain of angiotensin-converting enzyme hydrolyzes human and rat amyloid-β(1-16) peptides as arginine specific endopeptidase potentially enhancing risk of Alzheimer’s disease View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-12

AUTHORS

Elena V. Kugaevskaya, Alexander V. Veselovsky, Maria I. Indeykina, Nina I. Solovyeva, Maria S. Zharkova, Igor A. Popov, Eugene N. Nikolaev, Alexey B. Mantsyzov, Alexander A. Makarov, Sergey A. Kozin

ABSTRACT

Alzheimer's disease (AD) is a multifactorial neurodegenerative disorder. Amyloid-β (Aβ) aggregation is likely to be the major cause of AD. In contrast to humans and other mammals, that share the same Aβ sequence, rats and mice are invulnerable to AD-like neurodegenerative pathologies, and Aβ of these rodents (ratAβ) has three amino acid substitutions in the metal-binding domain 1-16 (MBD). Angiotensin-converting enzyme (ACE) cleaves Aβ-derived peptide substrates, however, there are contradictions concerning the localization of the cleavage sites within Aβ and the roles of each of the two ACE catalytically active domains in the hydrolysis. In the current study by using mass spectrometry and molecular modelling we have tested a set of peptides corresponding to MBDs of Aβ and ratAβ to get insights on the interactions between ACE and these Aβ species. It has been shown that the N-domain of ACE (N-ACE) acts as an arginine specific endopeptidase on the Aβ and ratAβ MBDs with C-amidated termini, thus assuming that full-length Aβ and ratAβ can be hydrolyzed by N-ACE in the same endopeptidase mode. Taken together with the recent data on the molecular mechanism of zinc-dependent oligomerization of Aβ, our results suggest a modulating role of N-ACE in AD pathogenesis. More... »

PAGES

298

References to SciGraph publications

  • 2016-05. Cerebrovascular disease in ageing and Alzheimer’s disease in ACTA NEUROPATHOLOGICA
  • 2015-06. Three dimensions of the amyloid hypothesis: time, space and 'wingmen' in NATURE NEUROSCIENCE
  • 1992-04. Arginine specific endopeptidases modify the aggregation properties of a synthetic peptide derived from Alzheimer β/A4 amyloid in NEUROCHEMICAL RESEARCH
  • 2012-12. Molecular recognition and regulation of human angiotensin-I converting enzyme (ACE) activity by natural inhibitory peptides in SCIENTIFIC REPORTS
  • 2003-01. Crystal structure of the human angiotensin-converting enzyme–lisinopril complex in NATURE
  • 2013-05. ESI-MS identification of the minimal zinc-binding center in natural isoforms of β-amyloid domain 1–16 in MOLECULAR BIOLOGY
  • 2016-04. Interplay of histidine residues of the Alzheimer’s disease Aβ peptide governs its Zn-induced oligomerization in SCIENTIFIC REPORTS
  • 2015-02. Amyloid β oligomers in Alzheimer’s disease pathogenesis, treatment, and diagnosis in ACTA NEUROPATHOLOGICA
  • 2004-11. What’s new in the renin-angiotensin system? in CELLULAR AND MOLECULAR LIFE SCIENCES
  • 2013-09. Self-propagation of pathogenic protein aggregates in neurodegenerative diseases in NATURE
  • 2003-11. Ace revisited: A new target for structure-based drug design in NATURE REVIEWS DRUG DISCOVERY
  • 2016-05. Intracerebral Injection of Metal-Binding Domain of Aβ Comprising the Isomerized Asp7 Increases the Amyloid Burden in Transgenic Mice in NEUROTOXICITY RESEARCH
  • 1999-01. Variation in DCP1, encoding ACE, is associated with susceptibility to Alzheimer disease in NATURE GENETICS
  • 2013-10. Peripherally Applied Synthetic Peptide isoAsp7-Aβ(1-42) Triggers Cerebral β-Amyloidosis in NEUROTOXICITY RESEARCH
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41598-017-18567-5

    DOI

    http://dx.doi.org/10.1038/s41598-017-18567-5

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1100203138

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/29321566


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biochemistry and Cell Biology", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biological Sciences", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Institute of Biomedical Chemistry", 
              "id": "https://www.grid.ac/institutes/grid.418846.7", 
              "name": [
                "Institute of Biomedical Chemistry, Moscow, Russia"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kugaevskaya", 
            "givenName": "Elena V.", 
            "id": "sg:person.01344604656.34", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01344604656.34"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Institute of Biomedical Chemistry", 
              "id": "https://www.grid.ac/institutes/grid.418846.7", 
              "name": [
                "Institute of Biomedical Chemistry, Moscow, Russia"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Veselovsky", 
            "givenName": "Alexander V.", 
            "id": "sg:person.0605460064.10", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0605460064.10"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Moscow Institute of Physics and Technology", 
              "id": "https://www.grid.ac/institutes/grid.18763.3b", 
              "name": [
                "Engelhardt Institute of Molecular Biology of the Russian Academy of Sciences, Moscow, Russia", 
                "Emanuel Institute of Biochemical Physics of the Russian Academy of Sciences, Moscow, Russia", 
                "Moscow Institute of Physics and Technology, Dolgoprudnyi, Moscow Region, Russia"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Indeykina", 
            "givenName": "Maria I.", 
            "id": "sg:person.01273442237.70", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01273442237.70"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Institute of Biomedical Chemistry", 
              "id": "https://www.grid.ac/institutes/grid.418846.7", 
              "name": [
                "Institute of Biomedical Chemistry, Moscow, Russia"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Solovyeva", 
            "givenName": "Nina I.", 
            "id": "sg:person.0616775031.21", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0616775031.21"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Institute of Biomedical Chemistry", 
              "id": "https://www.grid.ac/institutes/grid.418846.7", 
              "name": [
                "Institute of Biomedical Chemistry, Moscow, Russia"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Zharkova", 
            "givenName": "Maria S.", 
            "id": "sg:person.01100134450.52", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01100134450.52"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Moscow Institute of Physics and Technology", 
              "id": "https://www.grid.ac/institutes/grid.18763.3b", 
              "name": [
                "Engelhardt Institute of Molecular Biology of the Russian Academy of Sciences, Moscow, Russia", 
                "Emanuel Institute of Biochemical Physics of the Russian Academy of Sciences, Moscow, Russia", 
                "Moscow Institute of Physics and Technology, Dolgoprudnyi, Moscow Region, Russia"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Popov", 
            "givenName": "Igor A.", 
            "id": "sg:person.01245132317.31", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01245132317.31"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Skolkovo Institute of Science and Technology", 
              "id": "https://www.grid.ac/institutes/grid.454320.4", 
              "name": [
                "Emanuel Institute of Biochemical Physics of the Russian Academy of Sciences, Moscow, Russia", 
                "Moscow Institute of Physics and Technology, Dolgoprudnyi, Moscow Region, Russia", 
                "Skolkovo Institute of Science and technology, Moscow, Russia"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Nikolaev", 
            "givenName": "Eugene N.", 
            "id": "sg:person.01361360717.33", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01361360717.33"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Moscow State University", 
              "id": "https://www.grid.ac/institutes/grid.14476.30", 
              "name": [
                "Faculty of Fundamental Medicine, Lomonosov Moscow State University, Moscow, Russia"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Mantsyzov", 
            "givenName": "Alexey B.", 
            "id": "sg:person.01222403363.21", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01222403363.21"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Engelhardt Institute of Molecular Biology", 
              "id": "https://www.grid.ac/institutes/grid.418899.5", 
              "name": [
                "Engelhardt Institute of Molecular Biology of the Russian Academy of Sciences, Moscow, Russia"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Makarov", 
            "givenName": "Alexander A.", 
            "id": "sg:person.0726261631.01", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0726261631.01"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Engelhardt Institute of Molecular Biology", 
              "id": "https://www.grid.ac/institutes/grid.418899.5", 
              "name": [
                "Engelhardt Institute of Molecular Biology of the Russian Academy of Sciences, Moscow, Russia"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kozin", 
            "givenName": "Sergey A.", 
            "id": "sg:person.01163230705.37", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01163230705.37"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1021/cr500638n", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000332267"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.bpj.2011.11.4006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000884713"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.brainres.2010.07.006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002274879"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1365-2990.2007.00885.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003637994"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ejphar.2008.03.058", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003647229"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmra040223", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004006233"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1134/s002689331302012x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007351211", 
              "https://doi.org/10.1134/s002689331302012x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0913114107", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007652405"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/jcc.20084", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008225564"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/srep00717", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008334165", 
              "https://doi.org/10.1038/srep00717"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00974579", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008715855", 
              "https://doi.org/10.1007/bf00974579"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3390/ijms140816917", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008978463"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3233/jad-150831", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011381806"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/prot.24312", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012943839"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/5009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013386602", 
              "https://doi.org/10.1038/5009"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/5009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013386602", 
              "https://doi.org/10.1038/5009"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00018-004-4239-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013660985", 
              "https://doi.org/10.1007/s00018-004-4239-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/jcc.20291", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013759612"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/jcc.20291", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013759612"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s12640-013-9399-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015186144", 
              "https://doi.org/10.1007/s12640-013-9399-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/srep21734", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015726290", 
              "https://doi.org/10.1038/srep21734"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1471-4159.1982.tb07930.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015810058"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3109/10641968709164184", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015828630"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/aje/kwi202", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016011757"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/aje/kwi202", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016011757"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m605827200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017347265"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s12640-016-9603-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019267721", 
              "https://doi.org/10.1007/s12640-016-9603-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m504454200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019761482"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m504454200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019761482"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/(sici)1097-461x(1996)60:7<1271::aid-qua8>3.0.co;2-w", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020764767"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1357-2725(02)00262-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024296727"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/hjh.0b013e3283603f53", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024597422"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/hjh.0b013e3283603f53", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024597422"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0304-3940(99)00827-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026068961"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/(sici)1096-987x(199709)18:12<1463::aid-jcc4>3.0.co;2-h", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027230962"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1159/000285518", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028660641"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/prot.22711", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028712683"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/prot.22711", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028712683"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/febs.13647", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030548895"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/1097-0231(20000730)14:14<1226::aid-rcm14>3.0.co;2-v", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031031921"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/bmjopen-2013-002881", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031353990"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m508460200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032242477"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m508460200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032242477"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.85.24.9386", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032251443"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.arr.2010.04.002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033980788"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.mencom.2016.07.001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034072294"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00401-015-1522-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036914105", 
              "https://doi.org/10.1007/s00401-015-1522-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00401-015-1522-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036914105", 
              "https://doi.org/10.1007/s00401-015-1522-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1179/016164106x130506", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037682766"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00401-015-1386-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038976805", 
              "https://doi.org/10.1007/s00401-015-1386-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1460-9568.2005.03912.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039546961"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrd1227", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040165721", 
              "https://doi.org/10.1038/nrd1227"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrd1227", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040165721", 
              "https://doi.org/10.1038/nrd1227"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrd1227", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040165721", 
              "https://doi.org/10.1038/nrd1227"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1080/07391102.2015.1113890", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040827099"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0506723102", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040923915"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0506723102", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040923915"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nn.4018", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041370090", 
              "https://doi.org/10.1038/nn.4018"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1471-4159.2011.07510.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041459571"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jmb.2006.01.048", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041672740"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/rcm.3357", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042043412"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1753-4887.2010.00352.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044787060"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1753-4887.2010.00352.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044787060"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/ede.0b013e31822708b5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047775347"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/ede.0b013e31822708b5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047775347"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature12481", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047908684", 
              "https://doi.org/10.1038/nature12481"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1006/bbrc.2001.5284", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049034346"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature01370", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050991777", 
              "https://doi.org/10.1038/nature01370"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature01370", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050991777", 
              "https://doi.org/10.1038/nature01370"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1096/fj.11-182873", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051809509"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1072994", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052597019"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/ac035389y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1054995560"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/ac035389y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1054995560"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/ac103213j", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055001266"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/ac103213j", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055001266"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/acs.jcim.5b00674", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055098278"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/ci200083f", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055402618"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/ci200083f", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055402618"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/ct1002626", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055423535"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/ct1002626", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055423535"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/j100142a004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055654695"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/jp400974n", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1056093910"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1063/1.445869", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1058023889"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1063/1.464397", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1058042407"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1131864", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062454675"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/1533317507309803", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064038502"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/1533317507309803", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064038502"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1212/01.wnl.0000140705.23869.e9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064346397"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1212/01.wnl.0000140705.23869.e9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064346397"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1212/01.wnl.0000140705.23869.e9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064346397"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.7868/s0026898413020122", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1074093622"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1152/physrev.2001.81.2.741", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1074791168"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m104068200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1074895274"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1077991217", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1078312836", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3233/jad-2011-110347", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1078416136"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3233/jad-131694", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1078851757"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/j.1460-2075.1988.tb02952.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1079445808"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/j.1460-2075.1995.tb00176.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1082425663"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082464323", 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2018-12", 
        "datePublishedReg": "2018-12-01", 
        "description": "Alzheimer's disease (AD) is a multifactorial neurodegenerative disorder. Amyloid-\u03b2 (A\u03b2) aggregation is likely to be the major cause of AD. In contrast to humans and other mammals, that share the same A\u03b2 sequence, rats and mice are invulnerable to AD-like neurodegenerative pathologies, and A\u03b2 of these rodents (ratA\u03b2) has three amino acid substitutions in the metal-binding domain 1-16 (MBD). Angiotensin-converting enzyme (ACE) cleaves A\u03b2-derived peptide substrates, however, there are contradictions concerning the localization of the cleavage sites within A\u03b2 and the roles of each of the two ACE catalytically active domains in the hydrolysis. In the current study by using mass spectrometry and molecular modelling we have tested a set of peptides corresponding to MBDs of A\u03b2 and ratA\u03b2 to get insights on the interactions between ACE and these A\u03b2 species. It has been shown that the N-domain of ACE (N-ACE) acts as an arginine specific endopeptidase on the A\u03b2 and ratA\u03b2 MBDs with C-amidated termini, thus assuming that full-length A\u03b2 and ratA\u03b2 can be hydrolyzed by N-ACE in the same endopeptidase mode. Taken together with the recent data on the molecular mechanism of zinc-dependent oligomerization of A\u03b2, our results suggest a modulating role of N-ACE in AD pathogenesis.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/s41598-017-18567-5", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.4896000", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.4896903", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1045337", 
            "issn": [
              "2045-2322"
            ], 
            "name": "Scientific Reports", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "1", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "8"
          }
        ], 
        "name": "N-domain of angiotensin-converting enzyme hydrolyzes human and rat amyloid-\u03b2(1-16) peptides as arginine specific endopeptidase potentially enhancing risk of Alzheimer\u2019s disease", 
        "pagination": "298", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "4d1627dfe73876884af395add5d4adb1c3c99ecac2768601c6219b9fadb4a98a"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "29321566"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "101563288"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/s41598-017-18567-5"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1100203138"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/s41598-017-18567-5", 
          "https://app.dimensions.ai/details/publication/pub.1100203138"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-10T17:37", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8672_00000548.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://www.nature.com/articles/s41598-017-18567-5"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41598-017-18567-5'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41598-017-18567-5'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41598-017-18567-5'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41598-017-18567-5'


     

    This table displays all metadata directly associated to this object as RDF triples.

    399 TRIPLES      21 PREDICATES      108 URIs      21 LITERALS      9 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/s41598-017-18567-5 schema:about anzsrc-for:06
    2 anzsrc-for:0601
    3 schema:author N019d4a4a369145658317abd927eedf59
    4 schema:citation sg:pub.10.1007/bf00974579
    5 sg:pub.10.1007/s00018-004-4239-0
    6 sg:pub.10.1007/s00401-015-1386-3
    7 sg:pub.10.1007/s00401-015-1522-0
    8 sg:pub.10.1007/s12640-013-9399-y
    9 sg:pub.10.1007/s12640-016-9603-y
    10 sg:pub.10.1038/5009
    11 sg:pub.10.1038/nature01370
    12 sg:pub.10.1038/nature12481
    13 sg:pub.10.1038/nn.4018
    14 sg:pub.10.1038/nrd1227
    15 sg:pub.10.1038/srep00717
    16 sg:pub.10.1038/srep21734
    17 sg:pub.10.1134/s002689331302012x
    18 https://app.dimensions.ai/details/publication/pub.1077991217
    19 https://app.dimensions.ai/details/publication/pub.1078312836
    20 https://app.dimensions.ai/details/publication/pub.1082464323
    21 https://doi.org/10.1002/(sici)1096-987x(199709)18:12<1463::aid-jcc4>3.0.co;2-h
    22 https://doi.org/10.1002/(sici)1097-461x(1996)60:7<1271::aid-qua8>3.0.co;2-w
    23 https://doi.org/10.1002/1097-0231(20000730)14:14<1226::aid-rcm14>3.0.co;2-v
    24 https://doi.org/10.1002/j.1460-2075.1988.tb02952.x
    25 https://doi.org/10.1002/j.1460-2075.1995.tb00176.x
    26 https://doi.org/10.1002/jcc.20084
    27 https://doi.org/10.1002/jcc.20291
    28 https://doi.org/10.1002/prot.22711
    29 https://doi.org/10.1002/prot.24312
    30 https://doi.org/10.1002/rcm.3357
    31 https://doi.org/10.1006/bbrc.2001.5284
    32 https://doi.org/10.1016/j.arr.2010.04.002
    33 https://doi.org/10.1016/j.bpj.2011.11.4006
    34 https://doi.org/10.1016/j.brainres.2010.07.006
    35 https://doi.org/10.1016/j.ejphar.2008.03.058
    36 https://doi.org/10.1016/j.jmb.2006.01.048
    37 https://doi.org/10.1016/j.mencom.2016.07.001
    38 https://doi.org/10.1016/s0304-3940(99)00827-7
    39 https://doi.org/10.1016/s1357-2725(02)00262-5
    40 https://doi.org/10.1021/ac035389y
    41 https://doi.org/10.1021/ac103213j
    42 https://doi.org/10.1021/acs.jcim.5b00674
    43 https://doi.org/10.1021/ci200083f
    44 https://doi.org/10.1021/cr500638n
    45 https://doi.org/10.1021/ct1002626
    46 https://doi.org/10.1021/j100142a004
    47 https://doi.org/10.1021/jp400974n
    48 https://doi.org/10.1056/nejmra040223
    49 https://doi.org/10.1063/1.445869
    50 https://doi.org/10.1063/1.464397
    51 https://doi.org/10.1073/pnas.0506723102
    52 https://doi.org/10.1073/pnas.0913114107
    53 https://doi.org/10.1073/pnas.85.24.9386
    54 https://doi.org/10.1074/jbc.m104068200
    55 https://doi.org/10.1074/jbc.m504454200
    56 https://doi.org/10.1074/jbc.m508460200
    57 https://doi.org/10.1074/jbc.m605827200
    58 https://doi.org/10.1080/07391102.2015.1113890
    59 https://doi.org/10.1093/aje/kwi202
    60 https://doi.org/10.1096/fj.11-182873
    61 https://doi.org/10.1097/ede.0b013e31822708b5
    62 https://doi.org/10.1097/hjh.0b013e3283603f53
    63 https://doi.org/10.1111/febs.13647
    64 https://doi.org/10.1111/j.1365-2990.2007.00885.x
    65 https://doi.org/10.1111/j.1460-9568.2005.03912.x
    66 https://doi.org/10.1111/j.1471-4159.1982.tb07930.x
    67 https://doi.org/10.1111/j.1471-4159.2011.07510.x
    68 https://doi.org/10.1111/j.1753-4887.2010.00352.x
    69 https://doi.org/10.1126/science.1072994
    70 https://doi.org/10.1126/science.1131864
    71 https://doi.org/10.1136/bmjopen-2013-002881
    72 https://doi.org/10.1152/physrev.2001.81.2.741
    73 https://doi.org/10.1159/000285518
    74 https://doi.org/10.1177/1533317507309803
    75 https://doi.org/10.1179/016164106x130506
    76 https://doi.org/10.1212/01.wnl.0000140705.23869.e9
    77 https://doi.org/10.3109/10641968709164184
    78 https://doi.org/10.3233/jad-131694
    79 https://doi.org/10.3233/jad-150831
    80 https://doi.org/10.3233/jad-2011-110347
    81 https://doi.org/10.3390/ijms140816917
    82 https://doi.org/10.7868/s0026898413020122
    83 schema:datePublished 2018-12
    84 schema:datePublishedReg 2018-12-01
    85 schema:description Alzheimer's disease (AD) is a multifactorial neurodegenerative disorder. Amyloid-β (Aβ) aggregation is likely to be the major cause of AD. In contrast to humans and other mammals, that share the same Aβ sequence, rats and mice are invulnerable to AD-like neurodegenerative pathologies, and Aβ of these rodents (ratAβ) has three amino acid substitutions in the metal-binding domain 1-16 (MBD). Angiotensin-converting enzyme (ACE) cleaves Aβ-derived peptide substrates, however, there are contradictions concerning the localization of the cleavage sites within Aβ and the roles of each of the two ACE catalytically active domains in the hydrolysis. In the current study by using mass spectrometry and molecular modelling we have tested a set of peptides corresponding to MBDs of Aβ and ratAβ to get insights on the interactions between ACE and these Aβ species. It has been shown that the N-domain of ACE (N-ACE) acts as an arginine specific endopeptidase on the Aβ and ratAβ MBDs with C-amidated termini, thus assuming that full-length Aβ and ratAβ can be hydrolyzed by N-ACE in the same endopeptidase mode. Taken together with the recent data on the molecular mechanism of zinc-dependent oligomerization of Aβ, our results suggest a modulating role of N-ACE in AD pathogenesis.
    86 schema:genre research_article
    87 schema:inLanguage en
    88 schema:isAccessibleForFree true
    89 schema:isPartOf N20cb4e7800b64ae2b2f3568411884dce
    90 N355fd20434ee492faf0992ea2ed0198d
    91 sg:journal.1045337
    92 schema:name N-domain of angiotensin-converting enzyme hydrolyzes human and rat amyloid-β(1-16) peptides as arginine specific endopeptidase potentially enhancing risk of Alzheimer’s disease
    93 schema:pagination 298
    94 schema:productId N0624ab3150e54d0f8637913db95b32fc
    95 N6df1fd3174e34281a05ca907c2bde03c
    96 N74a4ae2aff6a462c8d36b8ca732d684a
    97 N909523fa485c4c7cbbb9079bdb797485
    98 Ne75dcbfa351044429b9159abc875b91c
    99 schema:sameAs https://app.dimensions.ai/details/publication/pub.1100203138
    100 https://doi.org/10.1038/s41598-017-18567-5
    101 schema:sdDatePublished 2019-04-10T17:37
    102 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    103 schema:sdPublisher Na80947e7202f49fea3c7a7f4ee6e6983
    104 schema:url https://www.nature.com/articles/s41598-017-18567-5
    105 sgo:license sg:explorer/license/
    106 sgo:sdDataset articles
    107 rdf:type schema:ScholarlyArticle
    108 N019d4a4a369145658317abd927eedf59 rdf:first sg:person.01344604656.34
    109 rdf:rest Ncdcd44a853a74057afe878a240a06ffb
    110 N0624ab3150e54d0f8637913db95b32fc schema:name doi
    111 schema:value 10.1038/s41598-017-18567-5
    112 rdf:type schema:PropertyValue
    113 N20cb4e7800b64ae2b2f3568411884dce schema:issueNumber 1
    114 rdf:type schema:PublicationIssue
    115 N355fd20434ee492faf0992ea2ed0198d schema:volumeNumber 8
    116 rdf:type schema:PublicationVolume
    117 N47a170381fd742b2aa0ed3b660856d6a rdf:first sg:person.01361360717.33
    118 rdf:rest N587487cabde6424289d9dbddf2c9ee7a
    119 N4985bc8be9634298add1cc62be3d7534 rdf:first sg:person.01163230705.37
    120 rdf:rest rdf:nil
    121 N587487cabde6424289d9dbddf2c9ee7a rdf:first sg:person.01222403363.21
    122 rdf:rest N807fc8f17cfb499e8c817fe5e1ad9989
    123 N655bb600e0994dde912d6d3971249a36 rdf:first sg:person.0616775031.21
    124 rdf:rest Nab32bfcc1f594340b4f7252b0bf61454
    125 N6df1fd3174e34281a05ca907c2bde03c schema:name pubmed_id
    126 schema:value 29321566
    127 rdf:type schema:PropertyValue
    128 N74a4ae2aff6a462c8d36b8ca732d684a schema:name dimensions_id
    129 schema:value pub.1100203138
    130 rdf:type schema:PropertyValue
    131 N807fc8f17cfb499e8c817fe5e1ad9989 rdf:first sg:person.0726261631.01
    132 rdf:rest N4985bc8be9634298add1cc62be3d7534
    133 N909523fa485c4c7cbbb9079bdb797485 schema:name nlm_unique_id
    134 schema:value 101563288
    135 rdf:type schema:PropertyValue
    136 Na80947e7202f49fea3c7a7f4ee6e6983 schema:name Springer Nature - SN SciGraph project
    137 rdf:type schema:Organization
    138 Nab32bfcc1f594340b4f7252b0bf61454 rdf:first sg:person.01100134450.52
    139 rdf:rest Nba12bd631dae45a6bf05f51c04347ba4
    140 Nba12bd631dae45a6bf05f51c04347ba4 rdf:first sg:person.01245132317.31
    141 rdf:rest N47a170381fd742b2aa0ed3b660856d6a
    142 Nbf19890b9ecd4e3f911a8e3ec181d395 rdf:first sg:person.01273442237.70
    143 rdf:rest N655bb600e0994dde912d6d3971249a36
    144 Ncdcd44a853a74057afe878a240a06ffb rdf:first sg:person.0605460064.10
    145 rdf:rest Nbf19890b9ecd4e3f911a8e3ec181d395
    146 Ne75dcbfa351044429b9159abc875b91c schema:name readcube_id
    147 schema:value 4d1627dfe73876884af395add5d4adb1c3c99ecac2768601c6219b9fadb4a98a
    148 rdf:type schema:PropertyValue
    149 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    150 schema:name Biological Sciences
    151 rdf:type schema:DefinedTerm
    152 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
    153 schema:name Biochemistry and Cell Biology
    154 rdf:type schema:DefinedTerm
    155 sg:grant.4896000 http://pending.schema.org/fundedItem sg:pub.10.1038/s41598-017-18567-5
    156 rdf:type schema:MonetaryGrant
    157 sg:grant.4896903 http://pending.schema.org/fundedItem sg:pub.10.1038/s41598-017-18567-5
    158 rdf:type schema:MonetaryGrant
    159 sg:journal.1045337 schema:issn 2045-2322
    160 schema:name Scientific Reports
    161 rdf:type schema:Periodical
    162 sg:person.01100134450.52 schema:affiliation https://www.grid.ac/institutes/grid.418846.7
    163 schema:familyName Zharkova
    164 schema:givenName Maria S.
    165 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01100134450.52
    166 rdf:type schema:Person
    167 sg:person.01163230705.37 schema:affiliation https://www.grid.ac/institutes/grid.418899.5
    168 schema:familyName Kozin
    169 schema:givenName Sergey A.
    170 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01163230705.37
    171 rdf:type schema:Person
    172 sg:person.01222403363.21 schema:affiliation https://www.grid.ac/institutes/grid.14476.30
    173 schema:familyName Mantsyzov
    174 schema:givenName Alexey B.
    175 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01222403363.21
    176 rdf:type schema:Person
    177 sg:person.01245132317.31 schema:affiliation https://www.grid.ac/institutes/grid.18763.3b
    178 schema:familyName Popov
    179 schema:givenName Igor A.
    180 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01245132317.31
    181 rdf:type schema:Person
    182 sg:person.01273442237.70 schema:affiliation https://www.grid.ac/institutes/grid.18763.3b
    183 schema:familyName Indeykina
    184 schema:givenName Maria I.
    185 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01273442237.70
    186 rdf:type schema:Person
    187 sg:person.01344604656.34 schema:affiliation https://www.grid.ac/institutes/grid.418846.7
    188 schema:familyName Kugaevskaya
    189 schema:givenName Elena V.
    190 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01344604656.34
    191 rdf:type schema:Person
    192 sg:person.01361360717.33 schema:affiliation https://www.grid.ac/institutes/grid.454320.4
    193 schema:familyName Nikolaev
    194 schema:givenName Eugene N.
    195 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01361360717.33
    196 rdf:type schema:Person
    197 sg:person.0605460064.10 schema:affiliation https://www.grid.ac/institutes/grid.418846.7
    198 schema:familyName Veselovsky
    199 schema:givenName Alexander V.
    200 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0605460064.10
    201 rdf:type schema:Person
    202 sg:person.0616775031.21 schema:affiliation https://www.grid.ac/institutes/grid.418846.7
    203 schema:familyName Solovyeva
    204 schema:givenName Nina I.
    205 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0616775031.21
    206 rdf:type schema:Person
    207 sg:person.0726261631.01 schema:affiliation https://www.grid.ac/institutes/grid.418899.5
    208 schema:familyName Makarov
    209 schema:givenName Alexander A.
    210 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0726261631.01
    211 rdf:type schema:Person
    212 sg:pub.10.1007/bf00974579 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008715855
    213 https://doi.org/10.1007/bf00974579
    214 rdf:type schema:CreativeWork
    215 sg:pub.10.1007/s00018-004-4239-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013660985
    216 https://doi.org/10.1007/s00018-004-4239-0
    217 rdf:type schema:CreativeWork
    218 sg:pub.10.1007/s00401-015-1386-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038976805
    219 https://doi.org/10.1007/s00401-015-1386-3
    220 rdf:type schema:CreativeWork
    221 sg:pub.10.1007/s00401-015-1522-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036914105
    222 https://doi.org/10.1007/s00401-015-1522-0
    223 rdf:type schema:CreativeWork
    224 sg:pub.10.1007/s12640-013-9399-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1015186144
    225 https://doi.org/10.1007/s12640-013-9399-y
    226 rdf:type schema:CreativeWork
    227 sg:pub.10.1007/s12640-016-9603-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1019267721
    228 https://doi.org/10.1007/s12640-016-9603-y
    229 rdf:type schema:CreativeWork
    230 sg:pub.10.1038/5009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013386602
    231 https://doi.org/10.1038/5009
    232 rdf:type schema:CreativeWork
    233 sg:pub.10.1038/nature01370 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050991777
    234 https://doi.org/10.1038/nature01370
    235 rdf:type schema:CreativeWork
    236 sg:pub.10.1038/nature12481 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047908684
    237 https://doi.org/10.1038/nature12481
    238 rdf:type schema:CreativeWork
    239 sg:pub.10.1038/nn.4018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041370090
    240 https://doi.org/10.1038/nn.4018
    241 rdf:type schema:CreativeWork
    242 sg:pub.10.1038/nrd1227 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040165721
    243 https://doi.org/10.1038/nrd1227
    244 rdf:type schema:CreativeWork
    245 sg:pub.10.1038/srep00717 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008334165
    246 https://doi.org/10.1038/srep00717
    247 rdf:type schema:CreativeWork
    248 sg:pub.10.1038/srep21734 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015726290
    249 https://doi.org/10.1038/srep21734
    250 rdf:type schema:CreativeWork
    251 sg:pub.10.1134/s002689331302012x schema:sameAs https://app.dimensions.ai/details/publication/pub.1007351211
    252 https://doi.org/10.1134/s002689331302012x
    253 rdf:type schema:CreativeWork
    254 https://app.dimensions.ai/details/publication/pub.1077991217 schema:CreativeWork
    255 https://app.dimensions.ai/details/publication/pub.1078312836 schema:CreativeWork
    256 https://app.dimensions.ai/details/publication/pub.1082464323 schema:CreativeWork
    257 https://doi.org/10.1002/(sici)1096-987x(199709)18:12<1463::aid-jcc4>3.0.co;2-h schema:sameAs https://app.dimensions.ai/details/publication/pub.1027230962
    258 rdf:type schema:CreativeWork
    259 https://doi.org/10.1002/(sici)1097-461x(1996)60:7<1271::aid-qua8>3.0.co;2-w schema:sameAs https://app.dimensions.ai/details/publication/pub.1020764767
    260 rdf:type schema:CreativeWork
    261 https://doi.org/10.1002/1097-0231(20000730)14:14<1226::aid-rcm14>3.0.co;2-v schema:sameAs https://app.dimensions.ai/details/publication/pub.1031031921
    262 rdf:type schema:CreativeWork
    263 https://doi.org/10.1002/j.1460-2075.1988.tb02952.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1079445808
    264 rdf:type schema:CreativeWork
    265 https://doi.org/10.1002/j.1460-2075.1995.tb00176.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1082425663
    266 rdf:type schema:CreativeWork
    267 https://doi.org/10.1002/jcc.20084 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008225564
    268 rdf:type schema:CreativeWork
    269 https://doi.org/10.1002/jcc.20291 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013759612
    270 rdf:type schema:CreativeWork
    271 https://doi.org/10.1002/prot.22711 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028712683
    272 rdf:type schema:CreativeWork
    273 https://doi.org/10.1002/prot.24312 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012943839
    274 rdf:type schema:CreativeWork
    275 https://doi.org/10.1002/rcm.3357 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042043412
    276 rdf:type schema:CreativeWork
    277 https://doi.org/10.1006/bbrc.2001.5284 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049034346
    278 rdf:type schema:CreativeWork
    279 https://doi.org/10.1016/j.arr.2010.04.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033980788
    280 rdf:type schema:CreativeWork
    281 https://doi.org/10.1016/j.bpj.2011.11.4006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000884713
    282 rdf:type schema:CreativeWork
    283 https://doi.org/10.1016/j.brainres.2010.07.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002274879
    284 rdf:type schema:CreativeWork
    285 https://doi.org/10.1016/j.ejphar.2008.03.058 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003647229
    286 rdf:type schema:CreativeWork
    287 https://doi.org/10.1016/j.jmb.2006.01.048 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041672740
    288 rdf:type schema:CreativeWork
    289 https://doi.org/10.1016/j.mencom.2016.07.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034072294
    290 rdf:type schema:CreativeWork
    291 https://doi.org/10.1016/s0304-3940(99)00827-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026068961
    292 rdf:type schema:CreativeWork
    293 https://doi.org/10.1016/s1357-2725(02)00262-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024296727
    294 rdf:type schema:CreativeWork
    295 https://doi.org/10.1021/ac035389y schema:sameAs https://app.dimensions.ai/details/publication/pub.1054995560
    296 rdf:type schema:CreativeWork
    297 https://doi.org/10.1021/ac103213j schema:sameAs https://app.dimensions.ai/details/publication/pub.1055001266
    298 rdf:type schema:CreativeWork
    299 https://doi.org/10.1021/acs.jcim.5b00674 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055098278
    300 rdf:type schema:CreativeWork
    301 https://doi.org/10.1021/ci200083f schema:sameAs https://app.dimensions.ai/details/publication/pub.1055402618
    302 rdf:type schema:CreativeWork
    303 https://doi.org/10.1021/cr500638n schema:sameAs https://app.dimensions.ai/details/publication/pub.1000332267
    304 rdf:type schema:CreativeWork
    305 https://doi.org/10.1021/ct1002626 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055423535
    306 rdf:type schema:CreativeWork
    307 https://doi.org/10.1021/j100142a004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055654695
    308 rdf:type schema:CreativeWork
    309 https://doi.org/10.1021/jp400974n schema:sameAs https://app.dimensions.ai/details/publication/pub.1056093910
    310 rdf:type schema:CreativeWork
    311 https://doi.org/10.1056/nejmra040223 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004006233
    312 rdf:type schema:CreativeWork
    313 https://doi.org/10.1063/1.445869 schema:sameAs https://app.dimensions.ai/details/publication/pub.1058023889
    314 rdf:type schema:CreativeWork
    315 https://doi.org/10.1063/1.464397 schema:sameAs https://app.dimensions.ai/details/publication/pub.1058042407
    316 rdf:type schema:CreativeWork
    317 https://doi.org/10.1073/pnas.0506723102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040923915
    318 rdf:type schema:CreativeWork
    319 https://doi.org/10.1073/pnas.0913114107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007652405
    320 rdf:type schema:CreativeWork
    321 https://doi.org/10.1073/pnas.85.24.9386 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032251443
    322 rdf:type schema:CreativeWork
    323 https://doi.org/10.1074/jbc.m104068200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074895274
    324 rdf:type schema:CreativeWork
    325 https://doi.org/10.1074/jbc.m504454200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019761482
    326 rdf:type schema:CreativeWork
    327 https://doi.org/10.1074/jbc.m508460200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032242477
    328 rdf:type schema:CreativeWork
    329 https://doi.org/10.1074/jbc.m605827200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017347265
    330 rdf:type schema:CreativeWork
    331 https://doi.org/10.1080/07391102.2015.1113890 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040827099
    332 rdf:type schema:CreativeWork
    333 https://doi.org/10.1093/aje/kwi202 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016011757
    334 rdf:type schema:CreativeWork
    335 https://doi.org/10.1096/fj.11-182873 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051809509
    336 rdf:type schema:CreativeWork
    337 https://doi.org/10.1097/ede.0b013e31822708b5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047775347
    338 rdf:type schema:CreativeWork
    339 https://doi.org/10.1097/hjh.0b013e3283603f53 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024597422
    340 rdf:type schema:CreativeWork
    341 https://doi.org/10.1111/febs.13647 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030548895
    342 rdf:type schema:CreativeWork
    343 https://doi.org/10.1111/j.1365-2990.2007.00885.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1003637994
    344 rdf:type schema:CreativeWork
    345 https://doi.org/10.1111/j.1460-9568.2005.03912.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1039546961
    346 rdf:type schema:CreativeWork
    347 https://doi.org/10.1111/j.1471-4159.1982.tb07930.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1015810058
    348 rdf:type schema:CreativeWork
    349 https://doi.org/10.1111/j.1471-4159.2011.07510.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1041459571
    350 rdf:type schema:CreativeWork
    351 https://doi.org/10.1111/j.1753-4887.2010.00352.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1044787060
    352 rdf:type schema:CreativeWork
    353 https://doi.org/10.1126/science.1072994 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052597019
    354 rdf:type schema:CreativeWork
    355 https://doi.org/10.1126/science.1131864 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062454675
    356 rdf:type schema:CreativeWork
    357 https://doi.org/10.1136/bmjopen-2013-002881 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031353990
    358 rdf:type schema:CreativeWork
    359 https://doi.org/10.1152/physrev.2001.81.2.741 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074791168
    360 rdf:type schema:CreativeWork
    361 https://doi.org/10.1159/000285518 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028660641
    362 rdf:type schema:CreativeWork
    363 https://doi.org/10.1177/1533317507309803 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064038502
    364 rdf:type schema:CreativeWork
    365 https://doi.org/10.1179/016164106x130506 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037682766
    366 rdf:type schema:CreativeWork
    367 https://doi.org/10.1212/01.wnl.0000140705.23869.e9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064346397
    368 rdf:type schema:CreativeWork
    369 https://doi.org/10.3109/10641968709164184 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015828630
    370 rdf:type schema:CreativeWork
    371 https://doi.org/10.3233/jad-131694 schema:sameAs https://app.dimensions.ai/details/publication/pub.1078851757
    372 rdf:type schema:CreativeWork
    373 https://doi.org/10.3233/jad-150831 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011381806
    374 rdf:type schema:CreativeWork
    375 https://doi.org/10.3233/jad-2011-110347 schema:sameAs https://app.dimensions.ai/details/publication/pub.1078416136
    376 rdf:type schema:CreativeWork
    377 https://doi.org/10.3390/ijms140816917 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008978463
    378 rdf:type schema:CreativeWork
    379 https://doi.org/10.7868/s0026898413020122 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074093622
    380 rdf:type schema:CreativeWork
    381 https://www.grid.ac/institutes/grid.14476.30 schema:alternateName Moscow State University
    382 schema:name Faculty of Fundamental Medicine, Lomonosov Moscow State University, Moscow, Russia
    383 rdf:type schema:Organization
    384 https://www.grid.ac/institutes/grid.18763.3b schema:alternateName Moscow Institute of Physics and Technology
    385 schema:name Emanuel Institute of Biochemical Physics of the Russian Academy of Sciences, Moscow, Russia
    386 Engelhardt Institute of Molecular Biology of the Russian Academy of Sciences, Moscow, Russia
    387 Moscow Institute of Physics and Technology, Dolgoprudnyi, Moscow Region, Russia
    388 rdf:type schema:Organization
    389 https://www.grid.ac/institutes/grid.418846.7 schema:alternateName Institute of Biomedical Chemistry
    390 schema:name Institute of Biomedical Chemistry, Moscow, Russia
    391 rdf:type schema:Organization
    392 https://www.grid.ac/institutes/grid.418899.5 schema:alternateName Engelhardt Institute of Molecular Biology
    393 schema:name Engelhardt Institute of Molecular Biology of the Russian Academy of Sciences, Moscow, Russia
    394 rdf:type schema:Organization
    395 https://www.grid.ac/institutes/grid.454320.4 schema:alternateName Skolkovo Institute of Science and Technology
    396 schema:name Emanuel Institute of Biochemical Physics of the Russian Academy of Sciences, Moscow, Russia
    397 Moscow Institute of Physics and Technology, Dolgoprudnyi, Moscow Region, Russia
    398 Skolkovo Institute of Science and technology, Moscow, Russia
    399 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...