Clinical Outcome of Eosinophilic Airway Inflammation in Chronic Airway Diseases Including Nonasthmatic Eosinophilic Bronchitis View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-12

AUTHORS

Jaeyoung Cho, Sun Mi Choi, Jinwoo Lee, Young Sik Park, Sang-Min Lee, Chul-Gyu Yoo, Young Whan Kim, Sung Koo Han, Chang-Hoon Lee

ABSTRACT

We enrolled patients with confirmed sputum eosinophilia who had visited our tertiary referral hospital between 2012 and 2015. We evaluated the incidence and predictors of exacerbations in patients with nonasthmatic eosinophilic bronchitis (NAEB), and investigated predictors of improvement in eosinophilic inflammation in chronic airway diseases with or without persistent airflow limitation. In total, 398 patients with sputum eosinophilia were enrolled. Of these, 152 (38.2%) had NAEB. The incidence rate of exacerbations requiring treatment with antibiotics, systemic corticosteroids, or hospital admission was 0.13 per patient-year (95% CI, 0.06-0.19) in NAEB. Inhaled corticosteroid (ICS) did not affect the risk of exacerbations, even in an analysis of propensity score. One hundred seventy-six patients had chronic airway diseases; in 37 of these (21.0%), sputum eosinophilia had improved at the 1-year follow-up. Patients who had persistent airflow limitation were less likely to show an improvement in eosinophilic inflammation (aOR, 0.26; 95% CI, 0.09-0.77) when they were treated with ICSs for less than 75% of the follow-up days. Exacerbations requiring systemic corticosteroids, antibiotics, or hospitalization did occur, although infrequently, in NAEB patients. Among patients with chronic airway diseases, those with persistent airflow limitation were less likely to show an improvement in eosinophilic airway inflammation. More... »

PAGES

146

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41598-017-18265-2

DOI

http://dx.doi.org/10.1038/s41598-017-18265-2

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1100179059

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29317659


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1102", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Cardiorespiratory Medicine and Haematology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Seoul National University", 
          "id": "https://www.grid.ac/institutes/grid.31501.36", 
          "name": [
            "Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University Hospital, Seoul, Republic of Korea", 
            "Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cho", 
        "givenName": "Jaeyoung", 
        "id": "sg:person.01370713203.01", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01370713203.01"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Seoul National University", 
          "id": "https://www.grid.ac/institutes/grid.31501.36", 
          "name": [
            "Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University Hospital, Seoul, Republic of Korea", 
            "Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Choi", 
        "givenName": "Sun Mi", 
        "id": "sg:person.01067024644.46", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01067024644.46"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Seoul National University", 
          "id": "https://www.grid.ac/institutes/grid.31501.36", 
          "name": [
            "Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University Hospital, Seoul, Republic of Korea", 
            "Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lee", 
        "givenName": "Jinwoo", 
        "id": "sg:person.015277664420.19", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015277664420.19"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Seoul National University", 
          "id": "https://www.grid.ac/institutes/grid.31501.36", 
          "name": [
            "Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University Hospital, Seoul, Republic of Korea", 
            "Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Park", 
        "givenName": "Young Sik", 
        "id": "sg:person.013145366724.20", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013145366724.20"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Seoul National University", 
          "id": "https://www.grid.ac/institutes/grid.31501.36", 
          "name": [
            "Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University Hospital, Seoul, Republic of Korea", 
            "Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lee", 
        "givenName": "Sang-Min", 
        "id": "sg:person.01315300754.59", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01315300754.59"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Seoul National University", 
          "id": "https://www.grid.ac/institutes/grid.31501.36", 
          "name": [
            "Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University Hospital, Seoul, Republic of Korea", 
            "Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yoo", 
        "givenName": "Chul-Gyu", 
        "id": "sg:person.01355161055.28", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01355161055.28"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Seoul National University", 
          "id": "https://www.grid.ac/institutes/grid.31501.36", 
          "name": [
            "Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University Hospital, Seoul, Republic of Korea", 
            "Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kim", 
        "givenName": "Young Whan", 
        "id": "sg:person.01210676453.82", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01210676453.82"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Seoul National University", 
          "id": "https://www.grid.ac/institutes/grid.31501.36", 
          "name": [
            "Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University Hospital, Seoul, Republic of Korea", 
            "Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Han", 
        "givenName": "Sung Koo", 
        "id": "sg:person.01237102766.14", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01237102766.14"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Seoul National University Hospital", 
          "id": "https://www.grid.ac/institutes/grid.412484.f", 
          "name": [
            "Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University Hospital, Seoul, Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lee", 
        "givenName": "Chang-Hoon", 
        "id": "sg:person.0743464132.81", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0743464132.81"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1111/cea.12652", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001033220"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(89)92801-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001202450"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jaci.2009.06.028", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002177496"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/thorax.57.2.178", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004005079"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/thorax.57.2.178", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004005079"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1378/chest.129.1_suppl.116s", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004893681"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2222.2005.02222.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008270926"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2222.2005.02222.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008270926"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa1505971", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011976519"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1183/09031936.06.00072105", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013138392"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1378/chest.15-1055", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015208810"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.arbr.2012.06.017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015365523"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3346/jkms.2015.30.6.737", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016948198"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1164/ajrccm.161.1.ats11-99", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017651982"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s2213-2600(15)00106-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018402324"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jaci.2003.09.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018476854"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1378/chest.12-0441", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019182011"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(00)02872-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019514585"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.arbres.2011.12.009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020501249"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1378/chest.14-2351", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021896760"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev.physiol.010908.163257", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022813465"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmra1411863", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024058106"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1164/ajrccm.160.2.9810100", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024372439"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa041892", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025266149"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa041892", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025266149"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1164/ajrccm.158.5.9804028", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026877267"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1183/09031936.00102509", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028567252"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1183/13993003.00436-2016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029757088"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1183/13993003.00436-2016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029757088"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1183/13993003.00436-2016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029757088"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1440-1843.2000.00226.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031938447"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1164/rccm.201502-0235le", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036820606"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/thx.2004.032516", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036872212"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/rmed.2003.1503", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037745124"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/rmed.2003.1503", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037745124"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1378/chest.125.6.1998", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042989252"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1034/j.1399-3003.2000.15d10.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050262900"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1183/09031936.00.16582400", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064123577"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.7326/0003-4819-151-8-200910200-00004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1073711084"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2018-12", 
    "datePublishedReg": "2018-12-01", 
    "description": "We enrolled patients with confirmed sputum eosinophilia who had visited our tertiary referral hospital between 2012 and 2015. We evaluated the incidence and predictors of exacerbations in patients with nonasthmatic eosinophilic bronchitis (NAEB), and investigated predictors of improvement in eosinophilic inflammation in chronic airway diseases with or without persistent airflow limitation. In total, 398 patients with sputum eosinophilia were enrolled. Of these, 152 (38.2%) had NAEB. The incidence rate of exacerbations requiring treatment with antibiotics, systemic corticosteroids, or hospital admission was 0.13 per patient-year (95% CI, 0.06-0.19) in NAEB. Inhaled corticosteroid (ICS) did not affect the risk of exacerbations, even in an analysis of propensity score. One hundred seventy-six patients had chronic airway diseases; in 37 of these (21.0%), sputum eosinophilia had improved at the 1-year follow-up. Patients who had persistent airflow limitation were less likely to show an improvement in eosinophilic inflammation (aOR, 0.26; 95% CI, 0.09-0.77) when they were treated with ICSs for less than 75% of the follow-up days. Exacerbations requiring systemic corticosteroids, antibiotics, or hospitalization did occur, although infrequently, in NAEB patients. Among patients with chronic airway diseases, those with persistent airflow limitation were less likely to show an improvement in eosinophilic airway inflammation.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/s41598-017-18265-2", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1045337", 
        "issn": [
          "2045-2322"
        ], 
        "name": "Scientific Reports", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "8"
      }
    ], 
    "name": "Clinical Outcome of Eosinophilic Airway Inflammation in Chronic Airway Diseases Including Nonasthmatic Eosinophilic Bronchitis", 
    "pagination": "146", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "d7631e958e6a999371ceb5748fb303cc7941b88b9f7da196e77c5de7db2ff51e"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "29317659"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101563288"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/s41598-017-18265-2"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1100179059"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/s41598-017-18265-2", 
      "https://app.dimensions.ai/details/publication/pub.1100179059"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T02:18", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8700_00000545.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/s41598-017-18265-2"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41598-017-18265-2'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41598-017-18265-2'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41598-017-18265-2'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41598-017-18265-2'


 

This table displays all metadata directly associated to this object as RDF triples.

227 TRIPLES      21 PREDICATES      62 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/s41598-017-18265-2 schema:about anzsrc-for:11
2 anzsrc-for:1102
3 schema:author Nba2bf22fc39f4f13b98071fd5bb4e527
4 schema:citation https://doi.org/10.1016/j.arbr.2012.06.017
5 https://doi.org/10.1016/j.arbres.2011.12.009
6 https://doi.org/10.1016/j.jaci.2003.09.008
7 https://doi.org/10.1016/j.jaci.2009.06.028
8 https://doi.org/10.1016/s0140-6736(00)02872-5
9 https://doi.org/10.1016/s0140-6736(89)92801-8
10 https://doi.org/10.1016/s2213-2600(15)00106-x
11 https://doi.org/10.1034/j.1399-3003.2000.15d10.x
12 https://doi.org/10.1046/j.1440-1843.2000.00226.x
13 https://doi.org/10.1053/rmed.2003.1503
14 https://doi.org/10.1056/nejmoa041892
15 https://doi.org/10.1056/nejmoa1505971
16 https://doi.org/10.1056/nejmra1411863
17 https://doi.org/10.1111/cea.12652
18 https://doi.org/10.1111/j.1365-2222.2005.02222.x
19 https://doi.org/10.1136/thorax.57.2.178
20 https://doi.org/10.1136/thx.2004.032516
21 https://doi.org/10.1146/annurev.physiol.010908.163257
22 https://doi.org/10.1164/ajrccm.158.5.9804028
23 https://doi.org/10.1164/ajrccm.160.2.9810100
24 https://doi.org/10.1164/ajrccm.161.1.ats11-99
25 https://doi.org/10.1164/rccm.201502-0235le
26 https://doi.org/10.1183/09031936.00.16582400
27 https://doi.org/10.1183/09031936.00102509
28 https://doi.org/10.1183/09031936.06.00072105
29 https://doi.org/10.1183/13993003.00436-2016
30 https://doi.org/10.1378/chest.12-0441
31 https://doi.org/10.1378/chest.125.6.1998
32 https://doi.org/10.1378/chest.129.1_suppl.116s
33 https://doi.org/10.1378/chest.14-2351
34 https://doi.org/10.1378/chest.15-1055
35 https://doi.org/10.3346/jkms.2015.30.6.737
36 https://doi.org/10.7326/0003-4819-151-8-200910200-00004
37 schema:datePublished 2018-12
38 schema:datePublishedReg 2018-12-01
39 schema:description We enrolled patients with confirmed sputum eosinophilia who had visited our tertiary referral hospital between 2012 and 2015. We evaluated the incidence and predictors of exacerbations in patients with nonasthmatic eosinophilic bronchitis (NAEB), and investigated predictors of improvement in eosinophilic inflammation in chronic airway diseases with or without persistent airflow limitation. In total, 398 patients with sputum eosinophilia were enrolled. Of these, 152 (38.2%) had NAEB. The incidence rate of exacerbations requiring treatment with antibiotics, systemic corticosteroids, or hospital admission was 0.13 per patient-year (95% CI, 0.06-0.19) in NAEB. Inhaled corticosteroid (ICS) did not affect the risk of exacerbations, even in an analysis of propensity score. One hundred seventy-six patients had chronic airway diseases; in 37 of these (21.0%), sputum eosinophilia had improved at the 1-year follow-up. Patients who had persistent airflow limitation were less likely to show an improvement in eosinophilic inflammation (aOR, 0.26; 95% CI, 0.09-0.77) when they were treated with ICSs for less than 75% of the follow-up days. Exacerbations requiring systemic corticosteroids, antibiotics, or hospitalization did occur, although infrequently, in NAEB patients. Among patients with chronic airway diseases, those with persistent airflow limitation were less likely to show an improvement in eosinophilic airway inflammation.
40 schema:genre research_article
41 schema:inLanguage en
42 schema:isAccessibleForFree true
43 schema:isPartOf N1293e7eb492d42fc943af67d3525e0e2
44 N41d7612c27374585879e19a3f283985b
45 sg:journal.1045337
46 schema:name Clinical Outcome of Eosinophilic Airway Inflammation in Chronic Airway Diseases Including Nonasthmatic Eosinophilic Bronchitis
47 schema:pagination 146
48 schema:productId N0139d9ec2c3240289675808570974483
49 N077c0bc356a44a81b4e2322930e5f222
50 N1400c350b99344b180903b94723ac6ee
51 N2a286cc7d7404a29b248f9ff8a641fb6
52 Nf7c6b8c1e8614609ac1ff513f28f5543
53 schema:sameAs https://app.dimensions.ai/details/publication/pub.1100179059
54 https://doi.org/10.1038/s41598-017-18265-2
55 schema:sdDatePublished 2019-04-11T02:18
56 schema:sdLicense https://scigraph.springernature.com/explorer/license/
57 schema:sdPublisher N09b9e5242c5c42409fe20ceeff6f8e88
58 schema:url https://www.nature.com/articles/s41598-017-18265-2
59 sgo:license sg:explorer/license/
60 sgo:sdDataset articles
61 rdf:type schema:ScholarlyArticle
62 N0139d9ec2c3240289675808570974483 schema:name doi
63 schema:value 10.1038/s41598-017-18265-2
64 rdf:type schema:PropertyValue
65 N077c0bc356a44a81b4e2322930e5f222 schema:name nlm_unique_id
66 schema:value 101563288
67 rdf:type schema:PropertyValue
68 N09b9e5242c5c42409fe20ceeff6f8e88 schema:name Springer Nature - SN SciGraph project
69 rdf:type schema:Organization
70 N1293e7eb492d42fc943af67d3525e0e2 schema:issueNumber 1
71 rdf:type schema:PublicationIssue
72 N1400c350b99344b180903b94723ac6ee schema:name pubmed_id
73 schema:value 29317659
74 rdf:type schema:PropertyValue
75 N14a77ea2323f46caaa4128ebbdb02a2e rdf:first sg:person.01237102766.14
76 rdf:rest N5ced1b2ca2a2468994f391fe08356069
77 N2a286cc7d7404a29b248f9ff8a641fb6 schema:name dimensions_id
78 schema:value pub.1100179059
79 rdf:type schema:PropertyValue
80 N34079166a9cf46f88ca09f002cfab65e rdf:first sg:person.015277664420.19
81 rdf:rest N8ae1e904a4f542009da381ab7c604750
82 N41d7612c27374585879e19a3f283985b schema:volumeNumber 8
83 rdf:type schema:PublicationVolume
84 N4d9c854dd17b4fbc8d828e148e3a24dc rdf:first sg:person.01355161055.28
85 rdf:rest N7dbd8f1e12b747c4abd286b0dd3b962e
86 N5ced1b2ca2a2468994f391fe08356069 rdf:first sg:person.0743464132.81
87 rdf:rest rdf:nil
88 N6c44daaab8664fb3bf1f33ba1824eb2c rdf:first sg:person.01067024644.46
89 rdf:rest N34079166a9cf46f88ca09f002cfab65e
90 N7af8543e093f46149f463a386a427147 rdf:first sg:person.01315300754.59
91 rdf:rest N4d9c854dd17b4fbc8d828e148e3a24dc
92 N7dbd8f1e12b747c4abd286b0dd3b962e rdf:first sg:person.01210676453.82
93 rdf:rest N14a77ea2323f46caaa4128ebbdb02a2e
94 N8ae1e904a4f542009da381ab7c604750 rdf:first sg:person.013145366724.20
95 rdf:rest N7af8543e093f46149f463a386a427147
96 Nba2bf22fc39f4f13b98071fd5bb4e527 rdf:first sg:person.01370713203.01
97 rdf:rest N6c44daaab8664fb3bf1f33ba1824eb2c
98 Nf7c6b8c1e8614609ac1ff513f28f5543 schema:name readcube_id
99 schema:value d7631e958e6a999371ceb5748fb303cc7941b88b9f7da196e77c5de7db2ff51e
100 rdf:type schema:PropertyValue
101 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
102 schema:name Medical and Health Sciences
103 rdf:type schema:DefinedTerm
104 anzsrc-for:1102 schema:inDefinedTermSet anzsrc-for:
105 schema:name Cardiorespiratory Medicine and Haematology
106 rdf:type schema:DefinedTerm
107 sg:journal.1045337 schema:issn 2045-2322
108 schema:name Scientific Reports
109 rdf:type schema:Periodical
110 sg:person.01067024644.46 schema:affiliation https://www.grid.ac/institutes/grid.31501.36
111 schema:familyName Choi
112 schema:givenName Sun Mi
113 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01067024644.46
114 rdf:type schema:Person
115 sg:person.01210676453.82 schema:affiliation https://www.grid.ac/institutes/grid.31501.36
116 schema:familyName Kim
117 schema:givenName Young Whan
118 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01210676453.82
119 rdf:type schema:Person
120 sg:person.01237102766.14 schema:affiliation https://www.grid.ac/institutes/grid.31501.36
121 schema:familyName Han
122 schema:givenName Sung Koo
123 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01237102766.14
124 rdf:type schema:Person
125 sg:person.013145366724.20 schema:affiliation https://www.grid.ac/institutes/grid.31501.36
126 schema:familyName Park
127 schema:givenName Young Sik
128 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013145366724.20
129 rdf:type schema:Person
130 sg:person.01315300754.59 schema:affiliation https://www.grid.ac/institutes/grid.31501.36
131 schema:familyName Lee
132 schema:givenName Sang-Min
133 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01315300754.59
134 rdf:type schema:Person
135 sg:person.01355161055.28 schema:affiliation https://www.grid.ac/institutes/grid.31501.36
136 schema:familyName Yoo
137 schema:givenName Chul-Gyu
138 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01355161055.28
139 rdf:type schema:Person
140 sg:person.01370713203.01 schema:affiliation https://www.grid.ac/institutes/grid.31501.36
141 schema:familyName Cho
142 schema:givenName Jaeyoung
143 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01370713203.01
144 rdf:type schema:Person
145 sg:person.015277664420.19 schema:affiliation https://www.grid.ac/institutes/grid.31501.36
146 schema:familyName Lee
147 schema:givenName Jinwoo
148 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015277664420.19
149 rdf:type schema:Person
150 sg:person.0743464132.81 schema:affiliation https://www.grid.ac/institutes/grid.412484.f
151 schema:familyName Lee
152 schema:givenName Chang-Hoon
153 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0743464132.81
154 rdf:type schema:Person
155 https://doi.org/10.1016/j.arbr.2012.06.017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015365523
156 rdf:type schema:CreativeWork
157 https://doi.org/10.1016/j.arbres.2011.12.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020501249
158 rdf:type schema:CreativeWork
159 https://doi.org/10.1016/j.jaci.2003.09.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018476854
160 rdf:type schema:CreativeWork
161 https://doi.org/10.1016/j.jaci.2009.06.028 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002177496
162 rdf:type schema:CreativeWork
163 https://doi.org/10.1016/s0140-6736(00)02872-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019514585
164 rdf:type schema:CreativeWork
165 https://doi.org/10.1016/s0140-6736(89)92801-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001202450
166 rdf:type schema:CreativeWork
167 https://doi.org/10.1016/s2213-2600(15)00106-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1018402324
168 rdf:type schema:CreativeWork
169 https://doi.org/10.1034/j.1399-3003.2000.15d10.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1050262900
170 rdf:type schema:CreativeWork
171 https://doi.org/10.1046/j.1440-1843.2000.00226.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1031938447
172 rdf:type schema:CreativeWork
173 https://doi.org/10.1053/rmed.2003.1503 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037745124
174 rdf:type schema:CreativeWork
175 https://doi.org/10.1056/nejmoa041892 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025266149
176 rdf:type schema:CreativeWork
177 https://doi.org/10.1056/nejmoa1505971 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011976519
178 rdf:type schema:CreativeWork
179 https://doi.org/10.1056/nejmra1411863 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024058106
180 rdf:type schema:CreativeWork
181 https://doi.org/10.1111/cea.12652 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001033220
182 rdf:type schema:CreativeWork
183 https://doi.org/10.1111/j.1365-2222.2005.02222.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1008270926
184 rdf:type schema:CreativeWork
185 https://doi.org/10.1136/thorax.57.2.178 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004005079
186 rdf:type schema:CreativeWork
187 https://doi.org/10.1136/thx.2004.032516 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036872212
188 rdf:type schema:CreativeWork
189 https://doi.org/10.1146/annurev.physiol.010908.163257 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022813465
190 rdf:type schema:CreativeWork
191 https://doi.org/10.1164/ajrccm.158.5.9804028 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026877267
192 rdf:type schema:CreativeWork
193 https://doi.org/10.1164/ajrccm.160.2.9810100 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024372439
194 rdf:type schema:CreativeWork
195 https://doi.org/10.1164/ajrccm.161.1.ats11-99 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017651982
196 rdf:type schema:CreativeWork
197 https://doi.org/10.1164/rccm.201502-0235le schema:sameAs https://app.dimensions.ai/details/publication/pub.1036820606
198 rdf:type schema:CreativeWork
199 https://doi.org/10.1183/09031936.00.16582400 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064123577
200 rdf:type schema:CreativeWork
201 https://doi.org/10.1183/09031936.00102509 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028567252
202 rdf:type schema:CreativeWork
203 https://doi.org/10.1183/09031936.06.00072105 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013138392
204 rdf:type schema:CreativeWork
205 https://doi.org/10.1183/13993003.00436-2016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029757088
206 rdf:type schema:CreativeWork
207 https://doi.org/10.1378/chest.12-0441 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019182011
208 rdf:type schema:CreativeWork
209 https://doi.org/10.1378/chest.125.6.1998 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042989252
210 rdf:type schema:CreativeWork
211 https://doi.org/10.1378/chest.129.1_suppl.116s schema:sameAs https://app.dimensions.ai/details/publication/pub.1004893681
212 rdf:type schema:CreativeWork
213 https://doi.org/10.1378/chest.14-2351 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021896760
214 rdf:type schema:CreativeWork
215 https://doi.org/10.1378/chest.15-1055 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015208810
216 rdf:type schema:CreativeWork
217 https://doi.org/10.3346/jkms.2015.30.6.737 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016948198
218 rdf:type schema:CreativeWork
219 https://doi.org/10.7326/0003-4819-151-8-200910200-00004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1073711084
220 rdf:type schema:CreativeWork
221 https://www.grid.ac/institutes/grid.31501.36 schema:alternateName Seoul National University
222 schema:name Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea
223 Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University Hospital, Seoul, Republic of Korea
224 rdf:type schema:Organization
225 https://www.grid.ac/institutes/grid.412484.f schema:alternateName Seoul National University Hospital
226 schema:name Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University Hospital, Seoul, Republic of Korea
227 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...