Inhaled bronchodilators and acute myocardial infarction: a nested case-control study View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-12

AUTHORS

Chang-Hoon Lee, Seongmi Choi, Eun Jin Jang, Han-Mo Yang, Ho Il Yoon, Yun Jung Kim, Jimin Kim, Jae-Joon Yim, Deog Kyeom Kim

ABSTRACT

We investigated the association between the use of inhaled bronchodilators and the risk of AMI. A nested case-control study using the nationwide insurance claims database was conducted. Overall, 11,054 AMI cases and 47,815 matched (up to 1:5) controls were identified from 1,036,119 subjects without acute major cardiovascular events in the past year. Long-acting and short-acting β-agonists (LABAs and SABAs) were associated with increase in the risk of AMI, although an inhaled corticosteroid combined with a long-acting β-agonist was not. Long-acting muscarinic antagonists (LAMAs) in a dry powder inhaler (DPI) were significantly associated with reduced risk of AMI, while LAMAs in a soft mist inhaler (SMI) didn't decrease the risk of it. In hypertensive or diabetic patients, LAMAs in a DPI were associated with reduced risk of AMI, but LABAs were associated with increased risk. Among the β-blocker users, the reduction of AMI risk by LAMAs was the most significant. In conclusions, inhaled β-agonists were associated with increase in the risk of AMI, while LABAs accompanied by ICSs were not associated with increase in the risk of AMI. LAMAs in a DPI use were associated with lower risk of AMI. More... »

PAGES

17915

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41598-017-17890-1

DOI

http://dx.doi.org/10.1038/s41598-017-17890-1

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1099719595

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29263396


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