Altered resting-state brain activity in Parkinson’s disease patients with freezing of gait View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-12-01

AUTHORS

Tao-Mian Mi, Shan-Shan Mei, Pei-Peng Liang, Lin-Lin Gao, Kun-Cheng Li, Tao Wu, Piu Chan

ABSTRACT

Freezing of gait (FOG) is a common and debilitating symptom in Parkinson’s disease (PD). The current study investigated alterations of resting-state spontaneous brain activity in PD patients with FOG. A total of 29 patients with FOG, 28 patients without FOG and 31 controls were included. All subjects underwent resting-state functional MRI, and the amplitude of low-frequency fluctuation (ALFF) was calculated to measure the spontaneous brain activity. Between-group differences and correlations with FOG severity (both subjective and objective measures) were analyzed. Compared to those without FOG, patients with FOG showed increased ALFF in right anterior cingulate cortex (ACC) and left inferior parietal lobule (IPL), as well as decreased ALFF in right superior frontal gyrus (SFG), bilateral cerebellum and left thalamus. Correlation analyses demonstrated that ALFF within the right SFG, right ACC and bilateral pallidum were positively correlated with FOG; while ALFF within the thalamus, putamen, cerebellum and sensorimotor regions were negatively correlated. Our results indicate that FOG is associated with dysfunction within frontal-parietal regions, along with increased inhibitory outputs from basal ganglia. Additionally, altered activity of cerebellum implicates its role in the pathophysiology of FOG. These findings provide further insight into the underlying neural mechanisms of FOG in PD patients. More... »

PAGES

16711

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41598-017-16922-0

DOI

http://dx.doi.org/10.1038/s41598-017-16922-0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1093031947

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29196699


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1109", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Neurosciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Brain", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Brain Mapping", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Case-Control Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gait", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gait Disorders, Neurologic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Magnetic Resonance Imaging", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Parkinson Disease", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rest", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Neurology, Neurobiology and Geriatrics, Xuanwu Hospital of Capital Medical University, Beijing Institute of Brain Disorders, 100053, Beijing, China", 
          "id": "http://www.grid.ac/institutes/grid.413259.8", 
          "name": [
            "Department of Neurology, Neurobiology and Geriatrics, Xuanwu Hospital of Capital Medical University, Beijing Institute of Brain Disorders, 100053, Beijing, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mi", 
        "givenName": "Tao-Mian", 
        "id": "sg:person.01000423222.93", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01000423222.93"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Neurology, Neurobiology and Geriatrics, Xuanwu Hospital of Capital Medical University, Beijing Institute of Brain Disorders, 100053, Beijing, China", 
          "id": "http://www.grid.ac/institutes/grid.413259.8", 
          "name": [
            "Department of Neurology, Neurobiology and Geriatrics, Xuanwu Hospital of Capital Medical University, Beijing Institute of Brain Disorders, 100053, Beijing, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mei", 
        "givenName": "Shan-Shan", 
        "id": "sg:person.01265623264.32", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01265623264.32"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Beijing Key Laboratory of MRI and Brain Informatics, 100053, Beijing, China", 
          "id": "http://www.grid.ac/institutes/grid.413259.8", 
          "name": [
            "Department of Radiology, Xuanwu Hospital of Capital Medical University, 100053, Beijing, China", 
            "Beijing Key Laboratory of MRI and Brain Informatics, 100053, Beijing, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Liang", 
        "givenName": "Pei-Peng", 
        "id": "sg:person.0722540505.81", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0722540505.81"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Neurology, Neurobiology and Geriatrics, Xuanwu Hospital of Capital Medical University, Beijing Institute of Brain Disorders, 100053, Beijing, China", 
          "id": "http://www.grid.ac/institutes/grid.413259.8", 
          "name": [
            "Department of Neurology, Neurobiology and Geriatrics, Xuanwu Hospital of Capital Medical University, Beijing Institute of Brain Disorders, 100053, Beijing, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gao", 
        "givenName": "Lin-Lin", 
        "id": "sg:person.011644646625.29", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011644646625.29"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Beijing Key Laboratory of MRI and Brain Informatics, 100053, Beijing, China", 
          "id": "http://www.grid.ac/institutes/grid.413259.8", 
          "name": [
            "Department of Radiology, Xuanwu Hospital of Capital Medical University, 100053, Beijing, China", 
            "Beijing Key Laboratory of MRI and Brain Informatics, 100053, Beijing, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Li", 
        "givenName": "Kun-Cheng", 
        "id": "sg:person.01326527402.59", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01326527402.59"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Clinical Research Center for Geriatric Disorders, 100053, Beijing, China", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Department of Neurology, Neurobiology and Geriatrics, Xuanwu Hospital of Capital Medical University, Beijing Institute of Brain Disorders, 100053, Beijing, China", 
            "Clinical Center for Parkinson\u2019s Disease, Capital Medical University, 100053, Beijing, China", 
            "Key Laboratory for Neurodegenerative Disease of the Ministry of Education, Beijing Key Laboratory for Parkinson\u2019s Disease, 100053, Beijing, China", 
            "National Clinical Research Center for Geriatric Disorders, 100053, Beijing, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wu", 
        "givenName": "Tao", 
        "id": "sg:person.01232607200.16", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01232607200.16"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Clinical Research Center for Geriatric Disorders, 100053, Beijing, China", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Department of Neurology, Neurobiology and Geriatrics, Xuanwu Hospital of Capital Medical University, Beijing Institute of Brain Disorders, 100053, Beijing, China", 
            "Clinical Center for Parkinson\u2019s Disease, Capital Medical University, 100053, Beijing, China", 
            "Key Laboratory for Neurodegenerative Disease of the Ministry of Education, Beijing Key Laboratory for Parkinson\u2019s Disease, 100053, Beijing, China", 
            "National Clinical Research Center for Geriatric Disorders, 100053, Beijing, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chan", 
        "givenName": "Piu", 
        "id": "sg:person.01006027315.73", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01006027315.73"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/s00221-002-1354-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009525753", 
          "https://doi.org/10.1007/s00221-002-1354-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1080/14734220601169707", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021697120", 
          "https://doi.org/10.1080/14734220601169707"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11434-016-1205-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020175821", 
          "https://doi.org/10.1007/s11434-016-1205-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s40673-017-0071-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1090916251", 
          "https://doi.org/10.1186/s40673-017-0071-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00221-008-1520-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004762905", 
          "https://doi.org/10.1007/s00221-008-1520-8"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2017-12-01", 
    "datePublishedReg": "2017-12-01", 
    "description": "Freezing of gait (FOG) is a common and debilitating symptom in Parkinson\u2019s disease (PD). The current study investigated alterations of resting-state spontaneous brain activity in PD patients with FOG. A total of 29 patients with FOG, 28 patients without FOG and 31 controls were included. All subjects underwent resting-state functional MRI, and the amplitude of low-frequency fluctuation (ALFF) was calculated to measure the spontaneous brain activity. Between-group differences and correlations with FOG severity (both subjective and objective measures) were analyzed. Compared to those without FOG, patients with FOG showed increased ALFF in right anterior cingulate cortex (ACC) and left inferior parietal lobule (IPL), as well as decreased ALFF in right superior frontal gyrus (SFG), bilateral cerebellum and left thalamus. Correlation analyses demonstrated that ALFF within the right SFG, right ACC and bilateral pallidum were positively correlated with FOG; while ALFF within the thalamus, putamen, cerebellum and sensorimotor regions were negatively correlated. Our results indicate that FOG is associated with dysfunction within frontal-parietal regions, along with increased inhibitory outputs from basal ganglia. Additionally, altered activity of cerebellum implicates its role in the pathophysiology of FOG. These findings provide further insight into the underlying neural mechanisms of FOG in PD patients.", 
    "genre": "article", 
    "id": "sg:pub.10.1038/s41598-017-16922-0", 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.8298220", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1045337", 
        "issn": [
          "2045-2322"
        ], 
        "name": "Scientific Reports", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "7"
      }
    ], 
    "keywords": [
      "right anterior cingulate cortex", 
      "anterior cingulate cortex", 
      "superior frontal gyrus", 
      "right superior frontal gyrus", 
      "spontaneous brain activity", 
      "inferior parietal lobule", 
      "PD patients", 
      "disease patients", 
      "Parkinson's disease", 
      "resting-state spontaneous brain activity", 
      "altered resting-state brain activity", 
      "brain activity", 
      "resting-state functional MRI", 
      "pathophysiology of FOG", 
      "resting-state brain activity", 
      "freezing of gait", 
      "Parkinson's disease patients", 
      "frontal-parietal regions", 
      "FOG severity", 
      "basal ganglia", 
      "bilateral cerebellum", 
      "inhibitory output", 
      "patients", 
      "bilateral pallidum", 
      "sensorimotor regions", 
      "underlying neural mechanisms", 
      "cingulate cortex", 
      "functional MRI", 
      "parietal lobule", 
      "ALFF", 
      "frontal gyrus", 
      "low-frequency fluctuations", 
      "cerebellum", 
      "group differences", 
      "thalamus", 
      "neural mechanisms", 
      "disease", 
      "gait", 
      "current study", 
      "putamen", 
      "dysfunction", 
      "ganglia", 
      "pathophysiology", 
      "symptoms", 
      "activity", 
      "cortex", 
      "gyrus", 
      "MRI", 
      "pallidum", 
      "severity", 
      "lobule", 
      "correlation analysis", 
      "total", 
      "alterations", 
      "subjects", 
      "further insight", 
      "findings", 
      "differences", 
      "control", 
      "study", 
      "role", 
      "correlation", 
      "mechanism", 
      "region", 
      "analysis", 
      "results", 
      "amplitude", 
      "insights", 
      "freezing", 
      "output", 
      "fog", 
      "fluctuations"
    ], 
    "name": "Altered resting-state brain activity in Parkinson\u2019s disease patients with freezing of gait", 
    "pagination": "16711", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1093031947"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/s41598-017-16922-0"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "29196699"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/s41598-017-16922-0", 
      "https://app.dimensions.ai/details/publication/pub.1093031947"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-10-01T06:43", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20221001/entities/gbq_results/article/article_731.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1038/s41598-017-16922-0"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41598-017-16922-0'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41598-017-16922-0'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41598-017-16922-0'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41598-017-16922-0'


 

This table displays all metadata directly associated to this object as RDF triples.

257 TRIPLES      21 PREDICATES      115 URIs      102 LITERALS      20 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/s41598-017-16922-0 schema:about N0175e92c3e5249dc8809154b436471af
2 N064cabf7444b4bfa808600bc0b9b6e99
3 N168e450e9a51430898000922bdb7a5ba
4 N2e1947c4d63142c3b8464ab4e548e70c
5 N56bb65a6a7d544bba832821625697493
6 N89a67cae28d54b95aa3bf689febad305
7 N93c2b5f2ec734b449dfbae0b3ef02a28
8 N98d20ff3b32b42beb8507392c3ae1dd7
9 Nc793076fc4ba40a28450f38c96aacb5d
10 Ncb56e730ea2847f9bb6ef82b3bfc97e2
11 Nd3c64da9bb0449999eac5646739549e3
12 Nd98f951ff0d246a2a592a4cef4a93bad
13 Nf79d6b6436214a68ac096cb6d47a45f0
14 anzsrc-for:11
15 anzsrc-for:1109
16 schema:author N3614611f228144d080f6effb5a866b4b
17 schema:citation sg:pub.10.1007/s00221-002-1354-8
18 sg:pub.10.1007/s00221-008-1520-8
19 sg:pub.10.1007/s11434-016-1205-9
20 sg:pub.10.1080/14734220601169707
21 sg:pub.10.1186/s40673-017-0071-9
22 schema:datePublished 2017-12-01
23 schema:datePublishedReg 2017-12-01
24 schema:description Freezing of gait (FOG) is a common and debilitating symptom in Parkinson’s disease (PD). The current study investigated alterations of resting-state spontaneous brain activity in PD patients with FOG. A total of 29 patients with FOG, 28 patients without FOG and 31 controls were included. All subjects underwent resting-state functional MRI, and the amplitude of low-frequency fluctuation (ALFF) was calculated to measure the spontaneous brain activity. Between-group differences and correlations with FOG severity (both subjective and objective measures) were analyzed. Compared to those without FOG, patients with FOG showed increased ALFF in right anterior cingulate cortex (ACC) and left inferior parietal lobule (IPL), as well as decreased ALFF in right superior frontal gyrus (SFG), bilateral cerebellum and left thalamus. Correlation analyses demonstrated that ALFF within the right SFG, right ACC and bilateral pallidum were positively correlated with FOG; while ALFF within the thalamus, putamen, cerebellum and sensorimotor regions were negatively correlated. Our results indicate that FOG is associated with dysfunction within frontal-parietal regions, along with increased inhibitory outputs from basal ganglia. Additionally, altered activity of cerebellum implicates its role in the pathophysiology of FOG. These findings provide further insight into the underlying neural mechanisms of FOG in PD patients.
25 schema:genre article
26 schema:isAccessibleForFree true
27 schema:isPartOf Nbb46a82e39df4a9d9db1aaf08d8e4d2c
28 Nd357c25a5c8242848e03d1d4d50f939c
29 sg:journal.1045337
30 schema:keywords ALFF
31 FOG severity
32 MRI
33 PD patients
34 Parkinson's disease
35 Parkinson's disease patients
36 activity
37 alterations
38 altered resting-state brain activity
39 amplitude
40 analysis
41 anterior cingulate cortex
42 basal ganglia
43 bilateral cerebellum
44 bilateral pallidum
45 brain activity
46 cerebellum
47 cingulate cortex
48 control
49 correlation
50 correlation analysis
51 cortex
52 current study
53 differences
54 disease
55 disease patients
56 dysfunction
57 findings
58 fluctuations
59 fog
60 freezing
61 freezing of gait
62 frontal gyrus
63 frontal-parietal regions
64 functional MRI
65 further insight
66 gait
67 ganglia
68 group differences
69 gyrus
70 inferior parietal lobule
71 inhibitory output
72 insights
73 lobule
74 low-frequency fluctuations
75 mechanism
76 neural mechanisms
77 output
78 pallidum
79 parietal lobule
80 pathophysiology
81 pathophysiology of FOG
82 patients
83 putamen
84 region
85 resting-state brain activity
86 resting-state functional MRI
87 resting-state spontaneous brain activity
88 results
89 right anterior cingulate cortex
90 right superior frontal gyrus
91 role
92 sensorimotor regions
93 severity
94 spontaneous brain activity
95 study
96 subjects
97 superior frontal gyrus
98 symptoms
99 thalamus
100 total
101 underlying neural mechanisms
102 schema:name Altered resting-state brain activity in Parkinson’s disease patients with freezing of gait
103 schema:pagination 16711
104 schema:productId N9e027f8215044d628b227fd0d03c5ab6
105 Na191cb916bb74775b4d4af14ad126b96
106 Nc9760401b1f141d2808a9db860f9b8e3
107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1093031947
108 https://doi.org/10.1038/s41598-017-16922-0
109 schema:sdDatePublished 2022-10-01T06:43
110 schema:sdLicense https://scigraph.springernature.com/explorer/license/
111 schema:sdPublisher N13c898547c3e4f82bf52948c7c4e6bff
112 schema:url https://doi.org/10.1038/s41598-017-16922-0
113 sgo:license sg:explorer/license/
114 sgo:sdDataset articles
115 rdf:type schema:ScholarlyArticle
116 N0175e92c3e5249dc8809154b436471af schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
117 schema:name Magnetic Resonance Imaging
118 rdf:type schema:DefinedTerm
119 N064cabf7444b4bfa808600bc0b9b6e99 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name Humans
121 rdf:type schema:DefinedTerm
122 N13c898547c3e4f82bf52948c7c4e6bff schema:name Springer Nature - SN SciGraph project
123 rdf:type schema:Organization
124 N168e450e9a51430898000922bdb7a5ba schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name Gait Disorders, Neurologic
126 rdf:type schema:DefinedTerm
127 N2e1947c4d63142c3b8464ab4e548e70c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
128 schema:name Gait
129 rdf:type schema:DefinedTerm
130 N30af193d2b36413ab689eb8d2a64830b rdf:first sg:person.01006027315.73
131 rdf:rest rdf:nil
132 N3614611f228144d080f6effb5a866b4b rdf:first sg:person.01000423222.93
133 rdf:rest N93bb65af5b5343ddb7946ee22aee7520
134 N4f4561f7e95646e5b4ceb5b3616a48b2 rdf:first sg:person.0722540505.81
135 rdf:rest Nab251f076b2546a3b56bb6638647710a
136 N56bb65a6a7d544bba832821625697493 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name Rest
138 rdf:type schema:DefinedTerm
139 N82918e7eeb114da2978a8abf58d33824 rdf:first sg:person.01326527402.59
140 rdf:rest N9d1a6b64e3164d34a3262ae5b89d88b6
141 N89a67cae28d54b95aa3bf689febad305 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
142 schema:name Aged
143 rdf:type schema:DefinedTerm
144 N93bb65af5b5343ddb7946ee22aee7520 rdf:first sg:person.01265623264.32
145 rdf:rest N4f4561f7e95646e5b4ceb5b3616a48b2
146 N93c2b5f2ec734b449dfbae0b3ef02a28 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
147 schema:name Brain
148 rdf:type schema:DefinedTerm
149 N98d20ff3b32b42beb8507392c3ae1dd7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name Male
151 rdf:type schema:DefinedTerm
152 N9d1a6b64e3164d34a3262ae5b89d88b6 rdf:first sg:person.01232607200.16
153 rdf:rest N30af193d2b36413ab689eb8d2a64830b
154 N9e027f8215044d628b227fd0d03c5ab6 schema:name dimensions_id
155 schema:value pub.1093031947
156 rdf:type schema:PropertyValue
157 Na191cb916bb74775b4d4af14ad126b96 schema:name pubmed_id
158 schema:value 29196699
159 rdf:type schema:PropertyValue
160 Nab251f076b2546a3b56bb6638647710a rdf:first sg:person.011644646625.29
161 rdf:rest N82918e7eeb114da2978a8abf58d33824
162 Nbb46a82e39df4a9d9db1aaf08d8e4d2c schema:issueNumber 1
163 rdf:type schema:PublicationIssue
164 Nc793076fc4ba40a28450f38c96aacb5d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
165 schema:name Female
166 rdf:type schema:DefinedTerm
167 Nc9760401b1f141d2808a9db860f9b8e3 schema:name doi
168 schema:value 10.1038/s41598-017-16922-0
169 rdf:type schema:PropertyValue
170 Ncb56e730ea2847f9bb6ef82b3bfc97e2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
171 schema:name Middle Aged
172 rdf:type schema:DefinedTerm
173 Nd357c25a5c8242848e03d1d4d50f939c schema:volumeNumber 7
174 rdf:type schema:PublicationVolume
175 Nd3c64da9bb0449999eac5646739549e3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
176 schema:name Parkinson Disease
177 rdf:type schema:DefinedTerm
178 Nd98f951ff0d246a2a592a4cef4a93bad schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
179 schema:name Case-Control Studies
180 rdf:type schema:DefinedTerm
181 Nf79d6b6436214a68ac096cb6d47a45f0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
182 schema:name Brain Mapping
183 rdf:type schema:DefinedTerm
184 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
185 schema:name Medical and Health Sciences
186 rdf:type schema:DefinedTerm
187 anzsrc-for:1109 schema:inDefinedTermSet anzsrc-for:
188 schema:name Neurosciences
189 rdf:type schema:DefinedTerm
190 sg:grant.8298220 http://pending.schema.org/fundedItem sg:pub.10.1038/s41598-017-16922-0
191 rdf:type schema:MonetaryGrant
192 sg:journal.1045337 schema:issn 2045-2322
193 schema:name Scientific Reports
194 schema:publisher Springer Nature
195 rdf:type schema:Periodical
196 sg:person.01000423222.93 schema:affiliation grid-institutes:grid.413259.8
197 schema:familyName Mi
198 schema:givenName Tao-Mian
199 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01000423222.93
200 rdf:type schema:Person
201 sg:person.01006027315.73 schema:affiliation grid-institutes:None
202 schema:familyName Chan
203 schema:givenName Piu
204 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01006027315.73
205 rdf:type schema:Person
206 sg:person.011644646625.29 schema:affiliation grid-institutes:grid.413259.8
207 schema:familyName Gao
208 schema:givenName Lin-Lin
209 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011644646625.29
210 rdf:type schema:Person
211 sg:person.01232607200.16 schema:affiliation grid-institutes:None
212 schema:familyName Wu
213 schema:givenName Tao
214 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01232607200.16
215 rdf:type schema:Person
216 sg:person.01265623264.32 schema:affiliation grid-institutes:grid.413259.8
217 schema:familyName Mei
218 schema:givenName Shan-Shan
219 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01265623264.32
220 rdf:type schema:Person
221 sg:person.01326527402.59 schema:affiliation grid-institutes:grid.413259.8
222 schema:familyName Li
223 schema:givenName Kun-Cheng
224 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01326527402.59
225 rdf:type schema:Person
226 sg:person.0722540505.81 schema:affiliation grid-institutes:grid.413259.8
227 schema:familyName Liang
228 schema:givenName Pei-Peng
229 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0722540505.81
230 rdf:type schema:Person
231 sg:pub.10.1007/s00221-002-1354-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009525753
232 https://doi.org/10.1007/s00221-002-1354-8
233 rdf:type schema:CreativeWork
234 sg:pub.10.1007/s00221-008-1520-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004762905
235 https://doi.org/10.1007/s00221-008-1520-8
236 rdf:type schema:CreativeWork
237 sg:pub.10.1007/s11434-016-1205-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020175821
238 https://doi.org/10.1007/s11434-016-1205-9
239 rdf:type schema:CreativeWork
240 sg:pub.10.1080/14734220601169707 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021697120
241 https://doi.org/10.1080/14734220601169707
242 rdf:type schema:CreativeWork
243 sg:pub.10.1186/s40673-017-0071-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1090916251
244 https://doi.org/10.1186/s40673-017-0071-9
245 rdf:type schema:CreativeWork
246 grid-institutes:None schema:alternateName National Clinical Research Center for Geriatric Disorders, 100053, Beijing, China
247 schema:name Clinical Center for Parkinson’s Disease, Capital Medical University, 100053, Beijing, China
248 Department of Neurology, Neurobiology and Geriatrics, Xuanwu Hospital of Capital Medical University, Beijing Institute of Brain Disorders, 100053, Beijing, China
249 Key Laboratory for Neurodegenerative Disease of the Ministry of Education, Beijing Key Laboratory for Parkinson’s Disease, 100053, Beijing, China
250 National Clinical Research Center for Geriatric Disorders, 100053, Beijing, China
251 rdf:type schema:Organization
252 grid-institutes:grid.413259.8 schema:alternateName Beijing Key Laboratory of MRI and Brain Informatics, 100053, Beijing, China
253 Department of Neurology, Neurobiology and Geriatrics, Xuanwu Hospital of Capital Medical University, Beijing Institute of Brain Disorders, 100053, Beijing, China
254 schema:name Beijing Key Laboratory of MRI and Brain Informatics, 100053, Beijing, China
255 Department of Neurology, Neurobiology and Geriatrics, Xuanwu Hospital of Capital Medical University, Beijing Institute of Brain Disorders, 100053, Beijing, China
256 Department of Radiology, Xuanwu Hospital of Capital Medical University, 100053, Beijing, China
257 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...