Altered resting-state brain activity in Parkinson’s disease patients with freezing of gait View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-12-01

AUTHORS

Tao-Mian Mi, Shan-Shan Mei, Pei-Peng Liang, Lin-Lin Gao, Kun-Cheng Li, Tao Wu, Piu Chan

ABSTRACT

Freezing of gait (FOG) is a common and debilitating symptom in Parkinson’s disease (PD). The current study investigated alterations of resting-state spontaneous brain activity in PD patients with FOG. A total of 29 patients with FOG, 28 patients without FOG and 31 controls were included. All subjects underwent resting-state functional MRI, and the amplitude of low-frequency fluctuation (ALFF) was calculated to measure the spontaneous brain activity. Between-group differences and correlations with FOG severity (both subjective and objective measures) were analyzed. Compared to those without FOG, patients with FOG showed increased ALFF in right anterior cingulate cortex (ACC) and left inferior parietal lobule (IPL), as well as decreased ALFF in right superior frontal gyrus (SFG), bilateral cerebellum and left thalamus. Correlation analyses demonstrated that ALFF within the right SFG, right ACC and bilateral pallidum were positively correlated with FOG; while ALFF within the thalamus, putamen, cerebellum and sensorimotor regions were negatively correlated. Our results indicate that FOG is associated with dysfunction within frontal-parietal regions, along with increased inhibitory outputs from basal ganglia. Additionally, altered activity of cerebellum implicates its role in the pathophysiology of FOG. These findings provide further insight into the underlying neural mechanisms of FOG in PD patients. More... »

PAGES

16711

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41598-017-16922-0

DOI

http://dx.doi.org/10.1038/s41598-017-16922-0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1093031947

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29196699


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1109", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Neurosciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Brain", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Brain Mapping", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Case-Control Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gait", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gait Disorders, Neurologic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Magnetic Resonance Imaging", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Parkinson Disease", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rest", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Neurology, Neurobiology and Geriatrics, Xuanwu Hospital of Capital Medical University, Beijing Institute of Brain Disorders, 100053, Beijing, China", 
          "id": "http://www.grid.ac/institutes/grid.413259.8", 
          "name": [
            "Department of Neurology, Neurobiology and Geriatrics, Xuanwu Hospital of Capital Medical University, Beijing Institute of Brain Disorders, 100053, Beijing, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mi", 
        "givenName": "Tao-Mian", 
        "id": "sg:person.01000423222.93", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01000423222.93"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Neurology, Neurobiology and Geriatrics, Xuanwu Hospital of Capital Medical University, Beijing Institute of Brain Disorders, 100053, Beijing, China", 
          "id": "http://www.grid.ac/institutes/grid.413259.8", 
          "name": [
            "Department of Neurology, Neurobiology and Geriatrics, Xuanwu Hospital of Capital Medical University, Beijing Institute of Brain Disorders, 100053, Beijing, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mei", 
        "givenName": "Shan-Shan", 
        "id": "sg:person.01265623264.32", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01265623264.32"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Beijing Key Laboratory of MRI and Brain Informatics, 100053, Beijing, China", 
          "id": "http://www.grid.ac/institutes/grid.413259.8", 
          "name": [
            "Department of Radiology, Xuanwu Hospital of Capital Medical University, 100053, Beijing, China", 
            "Beijing Key Laboratory of MRI and Brain Informatics, 100053, Beijing, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Liang", 
        "givenName": "Pei-Peng", 
        "id": "sg:person.0722540505.81", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0722540505.81"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Neurology, Neurobiology and Geriatrics, Xuanwu Hospital of Capital Medical University, Beijing Institute of Brain Disorders, 100053, Beijing, China", 
          "id": "http://www.grid.ac/institutes/grid.413259.8", 
          "name": [
            "Department of Neurology, Neurobiology and Geriatrics, Xuanwu Hospital of Capital Medical University, Beijing Institute of Brain Disorders, 100053, Beijing, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gao", 
        "givenName": "Lin-Lin", 
        "id": "sg:person.011644646625.29", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011644646625.29"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Beijing Key Laboratory of MRI and Brain Informatics, 100053, Beijing, China", 
          "id": "http://www.grid.ac/institutes/grid.413259.8", 
          "name": [
            "Department of Radiology, Xuanwu Hospital of Capital Medical University, 100053, Beijing, China", 
            "Beijing Key Laboratory of MRI and Brain Informatics, 100053, Beijing, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Li", 
        "givenName": "Kun-Cheng", 
        "id": "sg:person.01326527402.59", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01326527402.59"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Clinical Research Center for Geriatric Disorders, 100053, Beijing, China", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Department of Neurology, Neurobiology and Geriatrics, Xuanwu Hospital of Capital Medical University, Beijing Institute of Brain Disorders, 100053, Beijing, China", 
            "Clinical Center for Parkinson\u2019s Disease, Capital Medical University, 100053, Beijing, China", 
            "Key Laboratory for Neurodegenerative Disease of the Ministry of Education, Beijing Key Laboratory for Parkinson\u2019s Disease, 100053, Beijing, China", 
            "National Clinical Research Center for Geriatric Disorders, 100053, Beijing, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wu", 
        "givenName": "Tao", 
        "id": "sg:person.01232607200.16", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01232607200.16"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Clinical Research Center for Geriatric Disorders, 100053, Beijing, China", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Department of Neurology, Neurobiology and Geriatrics, Xuanwu Hospital of Capital Medical University, Beijing Institute of Brain Disorders, 100053, Beijing, China", 
            "Clinical Center for Parkinson\u2019s Disease, Capital Medical University, 100053, Beijing, China", 
            "Key Laboratory for Neurodegenerative Disease of the Ministry of Education, Beijing Key Laboratory for Parkinson\u2019s Disease, 100053, Beijing, China", 
            "National Clinical Research Center for Geriatric Disorders, 100053, Beijing, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chan", 
        "givenName": "Piu", 
        "id": "sg:person.01006027315.73", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01006027315.73"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/s11434-016-1205-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020175821", 
          "https://doi.org/10.1007/s11434-016-1205-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00221-008-1520-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004762905", 
          "https://doi.org/10.1007/s00221-008-1520-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00221-002-1354-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009525753", 
          "https://doi.org/10.1007/s00221-002-1354-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1080/14734220601169707", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021697120", 
          "https://doi.org/10.1080/14734220601169707"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s40673-017-0071-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1090916251", 
          "https://doi.org/10.1186/s40673-017-0071-9"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2017-12-01", 
    "datePublishedReg": "2017-12-01", 
    "description": "Freezing of gait (FOG) is a common and debilitating symptom in Parkinson\u2019s disease (PD). The current study investigated alterations of resting-state spontaneous brain activity in PD patients with FOG. A total of 29 patients with FOG, 28 patients without FOG and 31 controls were included. All subjects underwent resting-state functional MRI, and the amplitude of low-frequency fluctuation (ALFF) was calculated to measure the spontaneous brain activity. Between-group differences and correlations with FOG severity (both subjective and objective measures) were analyzed. Compared to those without FOG, patients with FOG showed increased ALFF in right anterior cingulate cortex (ACC) and left inferior parietal lobule (IPL), as well as decreased ALFF in right superior frontal gyrus (SFG), bilateral cerebellum and left thalamus. Correlation analyses demonstrated that ALFF within the right SFG, right ACC and bilateral pallidum were positively correlated with FOG; while ALFF within the thalamus, putamen, cerebellum and sensorimotor regions were negatively correlated. Our results indicate that FOG is associated with dysfunction within frontal-parietal regions, along with increased inhibitory outputs from basal ganglia. Additionally, altered activity of cerebellum implicates its role in the pathophysiology of FOG. These findings provide further insight into the underlying neural mechanisms of FOG in PD patients.", 
    "genre": "article", 
    "id": "sg:pub.10.1038/s41598-017-16922-0", 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.8298220", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1045337", 
        "issn": [
          "2045-2322"
        ], 
        "name": "Scientific Reports", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "7"
      }
    ], 
    "keywords": [
      "right anterior cingulate cortex", 
      "anterior cingulate cortex", 
      "superior frontal gyrus", 
      "right superior frontal gyrus", 
      "spontaneous brain activity", 
      "inferior parietal lobule", 
      "PD patients", 
      "disease patients", 
      "Parkinson's disease", 
      "resting-state spontaneous brain activity", 
      "altered resting-state brain activity", 
      "brain activity", 
      "resting-state functional MRI", 
      "pathophysiology of FOG", 
      "resting-state brain activity", 
      "freezing of gait", 
      "Parkinson's disease patients", 
      "frontal-parietal regions", 
      "FOG severity", 
      "basal ganglia", 
      "bilateral cerebellum", 
      "inhibitory output", 
      "patients", 
      "bilateral pallidum", 
      "sensorimotor regions", 
      "underlying neural mechanisms", 
      "cingulate cortex", 
      "functional MRI", 
      "parietal lobule", 
      "ALFF", 
      "frontal gyrus", 
      "low-frequency fluctuations", 
      "cerebellum", 
      "group differences", 
      "thalamus", 
      "neural mechanisms", 
      "disease", 
      "gait", 
      "current study", 
      "putamen", 
      "dysfunction", 
      "ganglia", 
      "pathophysiology", 
      "symptoms", 
      "activity", 
      "cortex", 
      "gyrus", 
      "MRI", 
      "pallidum", 
      "severity", 
      "lobule", 
      "correlation analysis", 
      "total", 
      "alterations", 
      "subjects", 
      "further insight", 
      "findings", 
      "differences", 
      "control", 
      "study", 
      "role", 
      "correlation", 
      "mechanism", 
      "region", 
      "analysis", 
      "results", 
      "amplitude", 
      "insights", 
      "freezing", 
      "output", 
      "fog", 
      "fluctuations"
    ], 
    "name": "Altered resting-state brain activity in Parkinson\u2019s disease patients with freezing of gait", 
    "pagination": "16711", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1093031947"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/s41598-017-16922-0"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "29196699"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/s41598-017-16922-0", 
      "https://app.dimensions.ai/details/publication/pub.1093031947"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-12-01T06:36", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20221201/entities/gbq_results/article/article_741.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1038/s41598-017-16922-0"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41598-017-16922-0'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41598-017-16922-0'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41598-017-16922-0'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41598-017-16922-0'


 

This table displays all metadata directly associated to this object as RDF triples.

257 TRIPLES      21 PREDICATES      115 URIs      102 LITERALS      20 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/s41598-017-16922-0 schema:about N23b146737cd64f6a87b1335259f79b95
2 N3fcd4cdbe17042f7b323a09598103c46
3 N476cd66c3aa24616bf061155bcc75ab2
4 N5860703b2ea64465a563c491d79aed62
5 N5c9994bb95b24b309d9d766582827b6c
6 N734e4e7d12914e3cae4d50cdad7db259
7 N7f9835f065674417b442a8bf6459c0de
8 Nb0fca80f141c489ba7963fa3f9921747
9 Nbd4313a30e8d4b02b1930481fc7103bc
10 Ncf3e3fa6ccef4d30a1976de16b12adae
11 Ne35b502030284fafa835c1512bdb8529
12 Nf2a3d9b32fce44e3a4806fa333abbf5d
13 Nf60bc0e7581f4721b16cb86a6fd9a2fc
14 anzsrc-for:11
15 anzsrc-for:1109
16 schema:author Nf531d30c20634494b9751187e67c1798
17 schema:citation sg:pub.10.1007/s00221-002-1354-8
18 sg:pub.10.1007/s00221-008-1520-8
19 sg:pub.10.1007/s11434-016-1205-9
20 sg:pub.10.1080/14734220601169707
21 sg:pub.10.1186/s40673-017-0071-9
22 schema:datePublished 2017-12-01
23 schema:datePublishedReg 2017-12-01
24 schema:description Freezing of gait (FOG) is a common and debilitating symptom in Parkinson’s disease (PD). The current study investigated alterations of resting-state spontaneous brain activity in PD patients with FOG. A total of 29 patients with FOG, 28 patients without FOG and 31 controls were included. All subjects underwent resting-state functional MRI, and the amplitude of low-frequency fluctuation (ALFF) was calculated to measure the spontaneous brain activity. Between-group differences and correlations with FOG severity (both subjective and objective measures) were analyzed. Compared to those without FOG, patients with FOG showed increased ALFF in right anterior cingulate cortex (ACC) and left inferior parietal lobule (IPL), as well as decreased ALFF in right superior frontal gyrus (SFG), bilateral cerebellum and left thalamus. Correlation analyses demonstrated that ALFF within the right SFG, right ACC and bilateral pallidum were positively correlated with FOG; while ALFF within the thalamus, putamen, cerebellum and sensorimotor regions were negatively correlated. Our results indicate that FOG is associated with dysfunction within frontal-parietal regions, along with increased inhibitory outputs from basal ganglia. Additionally, altered activity of cerebellum implicates its role in the pathophysiology of FOG. These findings provide further insight into the underlying neural mechanisms of FOG in PD patients.
25 schema:genre article
26 schema:isAccessibleForFree true
27 schema:isPartOf N577fcc7c7f7a49d49e7a4d8ac7bac024
28 N8655cfdb3e884afc8cd265d295860320
29 sg:journal.1045337
30 schema:keywords ALFF
31 FOG severity
32 MRI
33 PD patients
34 Parkinson's disease
35 Parkinson's disease patients
36 activity
37 alterations
38 altered resting-state brain activity
39 amplitude
40 analysis
41 anterior cingulate cortex
42 basal ganglia
43 bilateral cerebellum
44 bilateral pallidum
45 brain activity
46 cerebellum
47 cingulate cortex
48 control
49 correlation
50 correlation analysis
51 cortex
52 current study
53 differences
54 disease
55 disease patients
56 dysfunction
57 findings
58 fluctuations
59 fog
60 freezing
61 freezing of gait
62 frontal gyrus
63 frontal-parietal regions
64 functional MRI
65 further insight
66 gait
67 ganglia
68 group differences
69 gyrus
70 inferior parietal lobule
71 inhibitory output
72 insights
73 lobule
74 low-frequency fluctuations
75 mechanism
76 neural mechanisms
77 output
78 pallidum
79 parietal lobule
80 pathophysiology
81 pathophysiology of FOG
82 patients
83 putamen
84 region
85 resting-state brain activity
86 resting-state functional MRI
87 resting-state spontaneous brain activity
88 results
89 right anterior cingulate cortex
90 right superior frontal gyrus
91 role
92 sensorimotor regions
93 severity
94 spontaneous brain activity
95 study
96 subjects
97 superior frontal gyrus
98 symptoms
99 thalamus
100 total
101 underlying neural mechanisms
102 schema:name Altered resting-state brain activity in Parkinson’s disease patients with freezing of gait
103 schema:pagination 16711
104 schema:productId N054ee86c69934bda95b8a5cc6b60e4cc
105 N82db5f2338e44df1966903e4e2374fb7
106 Ndccdb0e76db94d06bfbb746fb8e4a493
107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1093031947
108 https://doi.org/10.1038/s41598-017-16922-0
109 schema:sdDatePublished 2022-12-01T06:36
110 schema:sdLicense https://scigraph.springernature.com/explorer/license/
111 schema:sdPublisher N9b8489c1a6f5452c994e276e019faecd
112 schema:url https://doi.org/10.1038/s41598-017-16922-0
113 sgo:license sg:explorer/license/
114 sgo:sdDataset articles
115 rdf:type schema:ScholarlyArticle
116 N054ee86c69934bda95b8a5cc6b60e4cc schema:name dimensions_id
117 schema:value pub.1093031947
118 rdf:type schema:PropertyValue
119 N23b146737cd64f6a87b1335259f79b95 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name Gait Disorders, Neurologic
121 rdf:type schema:DefinedTerm
122 N3b6b3063e4d74db79adcd42af169a527 rdf:first sg:person.01265623264.32
123 rdf:rest N7b2b4983062e445bb51c05ff37494cab
124 N3fcd4cdbe17042f7b323a09598103c46 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name Aged
126 rdf:type schema:DefinedTerm
127 N476cd66c3aa24616bf061155bcc75ab2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
128 schema:name Female
129 rdf:type schema:DefinedTerm
130 N577fcc7c7f7a49d49e7a4d8ac7bac024 schema:issueNumber 1
131 rdf:type schema:PublicationIssue
132 N5860703b2ea64465a563c491d79aed62 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name Rest
134 rdf:type schema:DefinedTerm
135 N5c9994bb95b24b309d9d766582827b6c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name Magnetic Resonance Imaging
137 rdf:type schema:DefinedTerm
138 N734e4e7d12914e3cae4d50cdad7db259 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
139 schema:name Humans
140 rdf:type schema:DefinedTerm
141 N7b2b4983062e445bb51c05ff37494cab rdf:first sg:person.0722540505.81
142 rdf:rest Nbb7f531f5d9143e28f60f9e1e2960d78
143 N7f9835f065674417b442a8bf6459c0de schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
144 schema:name Male
145 rdf:type schema:DefinedTerm
146 N82db5f2338e44df1966903e4e2374fb7 schema:name doi
147 schema:value 10.1038/s41598-017-16922-0
148 rdf:type schema:PropertyValue
149 N8655cfdb3e884afc8cd265d295860320 schema:volumeNumber 7
150 rdf:type schema:PublicationVolume
151 N9b26ee96e1a148d6b48f231df2b6807f rdf:first sg:person.01006027315.73
152 rdf:rest rdf:nil
153 N9b8489c1a6f5452c994e276e019faecd schema:name Springer Nature - SN SciGraph project
154 rdf:type schema:Organization
155 Nb0fca80f141c489ba7963fa3f9921747 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
156 schema:name Case-Control Studies
157 rdf:type schema:DefinedTerm
158 Nbb7f531f5d9143e28f60f9e1e2960d78 rdf:first sg:person.011644646625.29
159 rdf:rest Nc2affddd3aab44dcb458243ba17b8ebd
160 Nbd4313a30e8d4b02b1930481fc7103bc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
161 schema:name Brain
162 rdf:type schema:DefinedTerm
163 Nc2affddd3aab44dcb458243ba17b8ebd rdf:first sg:person.01326527402.59
164 rdf:rest Ndec9735e011647f69a1f370de9355c92
165 Ncf3e3fa6ccef4d30a1976de16b12adae schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
166 schema:name Parkinson Disease
167 rdf:type schema:DefinedTerm
168 Ndccdb0e76db94d06bfbb746fb8e4a493 schema:name pubmed_id
169 schema:value 29196699
170 rdf:type schema:PropertyValue
171 Ndec9735e011647f69a1f370de9355c92 rdf:first sg:person.01232607200.16
172 rdf:rest N9b26ee96e1a148d6b48f231df2b6807f
173 Ne35b502030284fafa835c1512bdb8529 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
174 schema:name Gait
175 rdf:type schema:DefinedTerm
176 Nf2a3d9b32fce44e3a4806fa333abbf5d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
177 schema:name Middle Aged
178 rdf:type schema:DefinedTerm
179 Nf531d30c20634494b9751187e67c1798 rdf:first sg:person.01000423222.93
180 rdf:rest N3b6b3063e4d74db79adcd42af169a527
181 Nf60bc0e7581f4721b16cb86a6fd9a2fc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
182 schema:name Brain Mapping
183 rdf:type schema:DefinedTerm
184 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
185 schema:name Medical and Health Sciences
186 rdf:type schema:DefinedTerm
187 anzsrc-for:1109 schema:inDefinedTermSet anzsrc-for:
188 schema:name Neurosciences
189 rdf:type schema:DefinedTerm
190 sg:grant.8298220 http://pending.schema.org/fundedItem sg:pub.10.1038/s41598-017-16922-0
191 rdf:type schema:MonetaryGrant
192 sg:journal.1045337 schema:issn 2045-2322
193 schema:name Scientific Reports
194 schema:publisher Springer Nature
195 rdf:type schema:Periodical
196 sg:person.01000423222.93 schema:affiliation grid-institutes:grid.413259.8
197 schema:familyName Mi
198 schema:givenName Tao-Mian
199 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01000423222.93
200 rdf:type schema:Person
201 sg:person.01006027315.73 schema:affiliation grid-institutes:None
202 schema:familyName Chan
203 schema:givenName Piu
204 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01006027315.73
205 rdf:type schema:Person
206 sg:person.011644646625.29 schema:affiliation grid-institutes:grid.413259.8
207 schema:familyName Gao
208 schema:givenName Lin-Lin
209 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011644646625.29
210 rdf:type schema:Person
211 sg:person.01232607200.16 schema:affiliation grid-institutes:None
212 schema:familyName Wu
213 schema:givenName Tao
214 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01232607200.16
215 rdf:type schema:Person
216 sg:person.01265623264.32 schema:affiliation grid-institutes:grid.413259.8
217 schema:familyName Mei
218 schema:givenName Shan-Shan
219 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01265623264.32
220 rdf:type schema:Person
221 sg:person.01326527402.59 schema:affiliation grid-institutes:grid.413259.8
222 schema:familyName Li
223 schema:givenName Kun-Cheng
224 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01326527402.59
225 rdf:type schema:Person
226 sg:person.0722540505.81 schema:affiliation grid-institutes:grid.413259.8
227 schema:familyName Liang
228 schema:givenName Pei-Peng
229 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0722540505.81
230 rdf:type schema:Person
231 sg:pub.10.1007/s00221-002-1354-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009525753
232 https://doi.org/10.1007/s00221-002-1354-8
233 rdf:type schema:CreativeWork
234 sg:pub.10.1007/s00221-008-1520-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004762905
235 https://doi.org/10.1007/s00221-008-1520-8
236 rdf:type schema:CreativeWork
237 sg:pub.10.1007/s11434-016-1205-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020175821
238 https://doi.org/10.1007/s11434-016-1205-9
239 rdf:type schema:CreativeWork
240 sg:pub.10.1080/14734220601169707 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021697120
241 https://doi.org/10.1080/14734220601169707
242 rdf:type schema:CreativeWork
243 sg:pub.10.1186/s40673-017-0071-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1090916251
244 https://doi.org/10.1186/s40673-017-0071-9
245 rdf:type schema:CreativeWork
246 grid-institutes:None schema:alternateName National Clinical Research Center for Geriatric Disorders, 100053, Beijing, China
247 schema:name Clinical Center for Parkinson’s Disease, Capital Medical University, 100053, Beijing, China
248 Department of Neurology, Neurobiology and Geriatrics, Xuanwu Hospital of Capital Medical University, Beijing Institute of Brain Disorders, 100053, Beijing, China
249 Key Laboratory for Neurodegenerative Disease of the Ministry of Education, Beijing Key Laboratory for Parkinson’s Disease, 100053, Beijing, China
250 National Clinical Research Center for Geriatric Disorders, 100053, Beijing, China
251 rdf:type schema:Organization
252 grid-institutes:grid.413259.8 schema:alternateName Beijing Key Laboratory of MRI and Brain Informatics, 100053, Beijing, China
253 Department of Neurology, Neurobiology and Geriatrics, Xuanwu Hospital of Capital Medical University, Beijing Institute of Brain Disorders, 100053, Beijing, China
254 schema:name Beijing Key Laboratory of MRI and Brain Informatics, 100053, Beijing, China
255 Department of Neurology, Neurobiology and Geriatrics, Xuanwu Hospital of Capital Medical University, Beijing Institute of Brain Disorders, 100053, Beijing, China
256 Department of Radiology, Xuanwu Hospital of Capital Medical University, 100053, Beijing, China
257 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...