Kidney Androgen-Regulated Protein (KAP) Transgenic Mice Are Protected Against High-Fat Diet Induced Metabolic Syndrome View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-12

AUTHORS

Beatriz Bardaji de Quixano, Josep A. Villena, Miguel Aranda, Gemma Brils, Antoni Cuevas, Théana Hespel, Haizea Lekuona, Cristina Súarez, Olga Tornavaca, Anna Meseguer

ABSTRACT

Metabolic Syndrome (MS) is reaching epidemic proportions with significant social and economical burden worldwide. Since the molecular basis of MS remains poorly defined, we investigated the impact of KAP, a kidney specific androgen-regulated gene, in the development of high fat-diet (hfd)-induced MS. Tg mice overexpressing KAP specifically in proximal tubule cells of the kidney exhibited reduced body weight and lower liver and adipose tissue weight compared to control littermates when fed a hfd. KAP Tg mice showed diminished adipocyte hypertrophy and reduced hepatic steatosis, significantly correlating with expression of relevant molecular markers and lower lipid content in liver. KAP transgenic were protected from hfd-induced insulin resistance, increased blood pressure and exhibited lower IL-6 serum levels and diminished expression of inflammatory markers in the adipose. Moreover, KAP was localized in the secretory pathway of proximal tubule cells and it is released to the extracellular media, preventing IL-6 induction and STAT-3 activation upon TNFα stimulation. We conclude that KAP, which might act as a hormone-like product in extra-renal tissues, protects Tg mice against hfd-induced MS by preventing inflammatory related events that are mediated, in part, through the IL-6 pathway. More... »

PAGES

16102

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41598-017-16487-y

DOI

http://dx.doi.org/10.1038/s41598-017-16487-y

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1092756238

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29170528


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