Coordinated response of the Desulfovibrio desulfuricans 27774 transcriptome to nitrate, nitrite and nitric oxide View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-11-24

AUTHORS

Ian T. Cadby, Matthew Faulkner, Jeanne Cheneby, Justine Long, Jacques van Helden, Alain Dolla, Jeffrey A. Cole

ABSTRACT

The sulfate reducing bacterium Desulfovibrio desulfuricans inhabits both the human gut and external environments. It can reduce nitrate and nitrite as alternative electron acceptors to sulfate to support growth. Like other sulphate reducing bacteria, it can also protect itself against nitrosative stress caused by NO generated when nitrite accumulates. By combining in vitro experiments with bioinformatic and RNA-seq data, metabolic responses to nitrate or NO and how nitrate and nitrite reduction are coordinated with the response to nitrosative stress were revealed. Although nitrate and nitrite reduction are tightly regulated in response to substrate availability, the global responses to nitrate or NO were largely regulated independently. Multiple NADH dehydrogenases, transcription factors of unknown function and genes for iron uptake were differentially expressed in response to electron acceptor availability or nitrosative stress. Amongst many fascinating problems for future research, the data revealed a YtfE orthologue, Ddes_1165, that is implicated in the repair of nitrosative damage. The combined data suggest that three transcription factors coordinate this regulation in which NrfS-NrfR coordinates nitrate and nitrite reduction to minimize toxicity due to nitrite accumulation, HcpR1 serves a global role in regulating the response to nitrate, and HcpR2 regulates the response to nitrosative stress. More... »

PAGES

16228

References to SciGraph publications

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  • 1982-06. Studies on dissimilatory sulfate-reducing bacteria that decompose fatty acids II. Incomplete oxidation of propionate by Desulfobulbus propionicus gen. nov., sp. nov. in ARCHIVES OF MICROBIOLOGY
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  • 2006-05-06. Oxidative stress and heat-shock responses in Desulfovibrio vulgaris by genome-wide transcriptomic analysis in ANTONIE VAN LEEUWENHOEK
  • 1983-09. Respiratory nitrate reduction by Desulfovibrio sp. in ARCHIVES OF MICROBIOLOGY
  • 2002-12-19. A novel iron centre in the split-Soret cytochrome c from Desulfovibrio desulfuricans ATCC 27774 in JBIC JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY
  • 2003-05-01. Reduced hybrid cluster proteins (HCP) from Desulfovibrio desulfuricans ATCC 27774 and Desulfovibrio vulgaris (Hildenborough): X-ray structures at high resolution using synchrotron radiation in JBIC JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY
  • 2009-01-13. Di-iron proteins of the Ric family are involved in iron–sulfur cluster repair in BIOMETALS
  • 1986-10. Chemolithotrophic growth ofDesulfovibrio desulfuricans with hydrogen coupled to ammonification of nitrate or nitrite in ARCHIVES OF MICROBIOLOGY
  • 2006-02. Global transcriptomic analysis of Desulfovibrio vulgaris on different electron donors in ANTONIE VAN LEEUWENHOEK
  • 2004-10-22. Reconstruction of regulatory and metabolic pathways in metal-reducing δ-proteobacteria in GENOME BIOLOGY
  • 1986-02. Distribution and regulation of nitrate and nitrite reduction by Desulfovibrio and Desulfotomaculum species in ARCHIVES OF MICROBIOLOGY
  • 2012-03-04. Fast gapped-read alignment with Bowtie 2 in NATURE METHODS
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41598-017-16403-4

    DOI

    http://dx.doi.org/10.1038/s41598-017-16403-4

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1092832113

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/29176637


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    84 problem
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    87 repair
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