Identification of microRNAs as potential cellular monocytic biomarkers in the early phase of myocardial infarction: a pilot study View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-11-21

AUTHORS

Mariana S. Parahuleva, Gerhild Euler, Amar Mardini, Behnoush Parviz, Bernhard Schieffer, Rainer Schulz, Muhammad Aslam

ABSTRACT

MicroRNA has been increasingly suggested to be involved in vascular inflammation. The aim of this study was to assess the expression profile of miRs as possible novel cellular biomarkers in circulating monocytes in patients with ST-segment elevation myocardial infarction (STEMI). Microarray techniques and TaqMan polymerase chain reaction were used to analyse the global expression of 352 miRNAs in peripheral blood monocytes from healthy donors (n = 20) and patients (n = 24) with acute STEMI. The expression level of miR-143 in monocytes from STEMI patients compared to healthy controls was increased, whereas the expression of miR-1, -92a, -99a, and -223 was reduced significantly. During 3.5 ± 1.5 months of follow-up miR-1 and -223 were back to baseline, whereas miR-92a and -99a return to normal levels over 3 months, but remained lower than healthy controls. Furthermore, monocytic expression of miR-143 was positively correlated with hs-CRP (R2 = 0.338; P < 0.031), but not with cTnT. Importantly, treatment of monocytes isolated from healthy individuals with INFγ, but not LPS or TNFα caused an upregulation of miR-143 and downregulation of miR-1. Our findings identify circulating monocytes as putative biomarkers and as novel carriers for the cell-specific transfer of miRs in the early phase of myocardial infarction. More... »

PAGES

15974

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41598-017-16263-y

DOI

http://dx.doi.org/10.1038/s41598-017-16263-y

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1092715045

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29162889


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Biomarkers", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Case-Control Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Down-Regulation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Interferon-gamma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Linear Models", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "MicroRNAs", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Monocytes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Myocardial Infarction", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pilot Projects", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Up-Regulation", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Internal Medicine I/Cardiology and Angiology, University Hospital of Giessen and Marburg, Giessen, Germany", 
          "id": "http://www.grid.ac/institutes/grid.411067.5", 
          "name": [
            "Internal Medicine/Cardiology and Angiology, University Hospital of Giessen and Marburg, Marburg, Germany", 
            "Internal Medicine I/Cardiology and Angiology, University Hospital of Giessen and Marburg, Giessen, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Parahuleva", 
        "givenName": "Mariana S.", 
        "id": "sg:person.01107017110.51", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01107017110.51"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute of Physiology, Justus Liebig University, Giessen, Germany", 
          "id": "http://www.grid.ac/institutes/grid.8664.c", 
          "name": [
            "Institute of Physiology, Justus Liebig University, Giessen, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Euler", 
        "givenName": "Gerhild", 
        "id": "sg:person.01022547142.56", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01022547142.56"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Internal Medicine/Cardiology and Angiology, University Hospital of Giessen and Marburg, Marburg, Germany", 
          "id": "http://www.grid.ac/institutes/grid.411067.5", 
          "name": [
            "Internal Medicine/Cardiology and Angiology, University Hospital of Giessen and Marburg, Marburg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mardini", 
        "givenName": "Amar", 
        "id": "sg:person.016112564000.18", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016112564000.18"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Internal Medicine I/Cardiology and Angiology, University Hospital of Giessen and Marburg, Giessen, Germany", 
          "id": "http://www.grid.ac/institutes/grid.411067.5", 
          "name": [
            "Internal Medicine I/Cardiology and Angiology, University Hospital of Giessen and Marburg, Giessen, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Parviz", 
        "givenName": "Behnoush", 
        "id": "sg:person.01165366436.38", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01165366436.38"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Internal Medicine/Cardiology and Angiology, University Hospital of Giessen and Marburg, Marburg, Germany", 
          "id": "http://www.grid.ac/institutes/grid.411067.5", 
          "name": [
            "Internal Medicine/Cardiology and Angiology, University Hospital of Giessen and Marburg, Marburg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Schieffer", 
        "givenName": "Bernhard", 
        "id": "sg:person.01075113266.30", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01075113266.30"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute of Physiology, Justus Liebig University, Giessen, Germany", 
          "id": "http://www.grid.ac/institutes/grid.8664.c", 
          "name": [
            "Institute of Physiology, Justus Liebig University, Giessen, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Schulz", 
        "givenName": "Rainer", 
        "id": "sg:person.0751067321.69", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0751067321.69"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Internal Medicine I/Cardiology and Angiology, University Hospital of Giessen and Marburg, Giessen, Germany", 
          "id": "http://www.grid.ac/institutes/grid.411067.5", 
          "name": [
            "Internal Medicine I/Cardiology and Angiology, University Hospital of Giessen and Marburg, Giessen, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Aslam", 
        "givenName": "Muhammad", 
        "id": "sg:person.01204300150.50", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01204300150.50"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/ncb2441", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015629495", 
          "https://doi.org/10.1038/ncb2441"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00059-015-4341-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000083001", 
          "https://doi.org/10.1007/s00059-015-4341-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s12265-010-9173-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037791397", 
          "https://doi.org/10.1007/s12265-010-9173-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/s41598-017-01695-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085210859", 
          "https://doi.org/10.1038/s41598-017-01695-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1471-2261-10-11", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003428909", 
          "https://doi.org/10.1186/1471-2261-10-11"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2017-11-21", 
    "datePublishedReg": "2017-11-21", 
    "description": "MicroRNA has been increasingly suggested to be involved in vascular inflammation. The aim of this study was to assess the expression profile of miRs as possible novel cellular biomarkers in circulating monocytes in patients with ST-segment elevation myocardial infarction (STEMI). Microarray techniques and TaqMan polymerase chain reaction were used to analyse the global expression of 352 miRNAs in peripheral blood monocytes from healthy donors (n\u2009=\u200920) and patients (n\u2009=\u200924) with acute STEMI. The expression level of miR-143 in monocytes from STEMI patients compared to healthy controls was increased, whereas the expression of miR-1, -92a, -99a, and -223 was reduced significantly. During 3.5\u2009\u00b1\u20091.5 months of follow-up miR-1 and -223 were back to baseline, whereas miR-92a and -99a return to normal levels over 3 months, but remained lower than healthy controls. Furthermore, monocytic expression of miR-143 was positively correlated with hs-CRP (R2\u2009=\u20090.338; P\u2009<\u20090.031), but not with cTnT. Importantly, treatment of monocytes isolated from healthy individuals with INF\u03b3, but not LPS or TNF\u03b1 caused an upregulation of miR-143 and downregulation of miR-1. Our findings identify circulating monocytes as putative biomarkers and as novel carriers for the cell-specific transfer of miRs in the early phase of myocardial infarction.", 
    "genre": "article", 
    "id": "sg:pub.10.1038/s41598-017-16263-y", 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1045337", 
        "issn": [
          "2045-2322"
        ], 
        "name": "Scientific Reports", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "7"
      }
    ], 
    "keywords": [
      "ST-segment elevation myocardial infarction", 
      "myocardial infarction", 
      "healthy controls", 
      "miR-143", 
      "acute ST-segment elevation myocardial infarction", 
      "miR-1", 
      "elevation myocardial infarction", 
      "peripheral blood monocytes", 
      "TaqMan polymerase chain reaction", 
      "treatment of monocytes", 
      "early phase", 
      "STEMI patients", 
      "hs-CRP", 
      "vascular inflammation", 
      "monocytic expression", 
      "polymerase chain reaction", 
      "healthy donors", 
      "blood monocytes", 
      "healthy individuals", 
      "monocytes", 
      "normal levels", 
      "infarction", 
      "miR-92a", 
      "patients", 
      "putative biomarkers", 
      "novel cellular biomarkers", 
      "pilot study", 
      "chain reaction", 
      "biomarkers", 
      "cellular biomarkers", 
      "expression levels", 
      "months", 
      "microarray technique", 
      "expression profiles", 
      "miR", 
      "expression", 
      "microRNAs", 
      "inflammation", 
      "INF\u03b3", 
      "TNF\u03b1", 
      "LPS", 
      "cTnT.", 
      "baseline", 
      "Identification of microRNAs", 
      "upregulation", 
      "downregulation", 
      "global expression", 
      "levels", 
      "treatment", 
      "control", 
      "novel carrier", 
      "study", 
      "aim", 
      "donors", 
      "findings", 
      "miRNAs", 
      "individuals", 
      "profile", 
      "identification", 
      "carriers", 
      "phase", 
      "reaction", 
      "technique", 
      "transfer"
    ], 
    "name": "Identification of microRNAs as potential cellular monocytic biomarkers in the early phase of myocardial infarction: a pilot study", 
    "pagination": "15974", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1092715045"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/s41598-017-16263-y"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "29162889"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/s41598-017-16263-y", 
      "https://app.dimensions.ai/details/publication/pub.1092715045"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-09-02T16:01", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220902/entities/gbq_results/article/article_753.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1038/s41598-017-16263-y"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41598-017-16263-y'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41598-017-16263-y'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41598-017-16263-y'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41598-017-16263-y'


 

This table displays all metadata directly associated to this object as RDF triples.

247 TRIPLES      21 PREDICATES      108 URIs      95 LITERALS      21 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/s41598-017-16263-y schema:about N01c2c5e16ff14ab2b2affe7e92c13855
2 N09657799afdd488c96b638a8daa6e494
3 N4878ad789b424589a14a0f5dcb0f0215
4 N63c0facfba0241f482139af69c3787ae
5 N79e6bbf6e18b4baeb045034bbd4231f0
6 N82838afbfb5f47acbfce61977c28ad1d
7 N97db0665b60b4c65a36160ced3184c66
8 N9e849a5acb7d4d68bad775c0168f93b9
9 Na342dd1d946c473fa7219b710f3be3c0
10 Nbe16e52993234222ac2319f582d0f6b5
11 Nc28089cf9dd444e18ebaf2fffa6c92fa
12 Nc467efca446c43a688c66c04951d489b
13 Nd2f810c68dcd4a5abb88763c875f75e2
14 Ndf22176b49b44c349140abb7c45dce4d
15 anzsrc-for:11
16 anzsrc-for:1103
17 schema:author Nb25a9ceb54af4137a36b6cb784f76687
18 schema:citation sg:pub.10.1007/s00059-015-4341-0
19 sg:pub.10.1007/s12265-010-9173-y
20 sg:pub.10.1038/ncb2441
21 sg:pub.10.1038/s41598-017-01695-3
22 sg:pub.10.1186/1471-2261-10-11
23 schema:datePublished 2017-11-21
24 schema:datePublishedReg 2017-11-21
25 schema:description MicroRNA has been increasingly suggested to be involved in vascular inflammation. The aim of this study was to assess the expression profile of miRs as possible novel cellular biomarkers in circulating monocytes in patients with ST-segment elevation myocardial infarction (STEMI). Microarray techniques and TaqMan polymerase chain reaction were used to analyse the global expression of 352 miRNAs in peripheral blood monocytes from healthy donors (n = 20) and patients (n = 24) with acute STEMI. The expression level of miR-143 in monocytes from STEMI patients compared to healthy controls was increased, whereas the expression of miR-1, -92a, -99a, and -223 was reduced significantly. During 3.5 ± 1.5 months of follow-up miR-1 and -223 were back to baseline, whereas miR-92a and -99a return to normal levels over 3 months, but remained lower than healthy controls. Furthermore, monocytic expression of miR-143 was positively correlated with hs-CRP (R2 = 0.338; P < 0.031), but not with cTnT. Importantly, treatment of monocytes isolated from healthy individuals with INFγ, but not LPS or TNFα caused an upregulation of miR-143 and downregulation of miR-1. Our findings identify circulating monocytes as putative biomarkers and as novel carriers for the cell-specific transfer of miRs in the early phase of myocardial infarction.
26 schema:genre article
27 schema:isAccessibleForFree true
28 schema:isPartOf N1156ab3321f043c2abdc74d61bfba347
29 N9f54f7e369dd4361929d84c6576d3610
30 sg:journal.1045337
31 schema:keywords INFγ
32 Identification of microRNAs
33 LPS
34 ST-segment elevation myocardial infarction
35 STEMI patients
36 TNFα
37 TaqMan polymerase chain reaction
38 acute ST-segment elevation myocardial infarction
39 aim
40 baseline
41 biomarkers
42 blood monocytes
43 cTnT.
44 carriers
45 cellular biomarkers
46 chain reaction
47 control
48 donors
49 downregulation
50 early phase
51 elevation myocardial infarction
52 expression
53 expression levels
54 expression profiles
55 findings
56 global expression
57 healthy controls
58 healthy donors
59 healthy individuals
60 hs-CRP
61 identification
62 individuals
63 infarction
64 inflammation
65 levels
66 miR
67 miR-1
68 miR-143
69 miR-92a
70 miRNAs
71 microRNAs
72 microarray technique
73 monocytes
74 monocytic expression
75 months
76 myocardial infarction
77 normal levels
78 novel carrier
79 novel cellular biomarkers
80 patients
81 peripheral blood monocytes
82 phase
83 pilot study
84 polymerase chain reaction
85 profile
86 putative biomarkers
87 reaction
88 study
89 technique
90 transfer
91 treatment
92 treatment of monocytes
93 upregulation
94 vascular inflammation
95 schema:name Identification of microRNAs as potential cellular monocytic biomarkers in the early phase of myocardial infarction: a pilot study
96 schema:pagination 15974
97 schema:productId N0b717415364c490f951e8fbefc79d8c3
98 N70ee8457b9054ea4bfc977a451f2f003
99 N8dd5dc6acb254fa3a8be66545fb90f3f
100 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092715045
101 https://doi.org/10.1038/s41598-017-16263-y
102 schema:sdDatePublished 2022-09-02T16:01
103 schema:sdLicense https://scigraph.springernature.com/explorer/license/
104 schema:sdPublisher Nbf42417588814241b1c052b70fdfadbd
105 schema:url https://doi.org/10.1038/s41598-017-16263-y
106 sgo:license sg:explorer/license/
107 sgo:sdDataset articles
108 rdf:type schema:ScholarlyArticle
109 N01c2c5e16ff14ab2b2affe7e92c13855 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name Case-Control Studies
111 rdf:type schema:DefinedTerm
112 N09657799afdd488c96b638a8daa6e494 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
113 schema:name Up-Regulation
114 rdf:type schema:DefinedTerm
115 N0b717415364c490f951e8fbefc79d8c3 schema:name pubmed_id
116 schema:value 29162889
117 rdf:type schema:PropertyValue
118 N1156ab3321f043c2abdc74d61bfba347 schema:issueNumber 1
119 rdf:type schema:PublicationIssue
120 N155eae5379e842b3883cd8735e56fb65 rdf:first sg:person.0751067321.69
121 rdf:rest N8af7b773b86f496e8f7196724c00ce5b
122 N4878ad789b424589a14a0f5dcb0f0215 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
123 schema:name Down-Regulation
124 rdf:type schema:DefinedTerm
125 N63c0facfba0241f482139af69c3787ae schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name MicroRNAs
127 rdf:type schema:DefinedTerm
128 N6413fe2f746646d7b948b50bbfd9f6ff rdf:first sg:person.01165366436.38
129 rdf:rest N6dd56bea91094c65a064605a1c98c29a
130 N6dd56bea91094c65a064605a1c98c29a rdf:first sg:person.01075113266.30
131 rdf:rest N155eae5379e842b3883cd8735e56fb65
132 N70ee8457b9054ea4bfc977a451f2f003 schema:name dimensions_id
133 schema:value pub.1092715045
134 rdf:type schema:PropertyValue
135 N79e6bbf6e18b4baeb045034bbd4231f0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name Male
137 rdf:type schema:DefinedTerm
138 N82838afbfb5f47acbfce61977c28ad1d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
139 schema:name Monocytes
140 rdf:type schema:DefinedTerm
141 N8af7b773b86f496e8f7196724c00ce5b rdf:first sg:person.01204300150.50
142 rdf:rest rdf:nil
143 N8dd5dc6acb254fa3a8be66545fb90f3f schema:name doi
144 schema:value 10.1038/s41598-017-16263-y
145 rdf:type schema:PropertyValue
146 N97db0665b60b4c65a36160ced3184c66 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
147 schema:name Pilot Projects
148 rdf:type schema:DefinedTerm
149 N98d7ace80d0740b3923290effe622613 rdf:first sg:person.016112564000.18
150 rdf:rest N6413fe2f746646d7b948b50bbfd9f6ff
151 N9e849a5acb7d4d68bad775c0168f93b9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
152 schema:name Biomarkers
153 rdf:type schema:DefinedTerm
154 N9f54f7e369dd4361929d84c6576d3610 schema:volumeNumber 7
155 rdf:type schema:PublicationVolume
156 Na342dd1d946c473fa7219b710f3be3c0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
157 schema:name Middle Aged
158 rdf:type schema:DefinedTerm
159 Nb25a9ceb54af4137a36b6cb784f76687 rdf:first sg:person.01107017110.51
160 rdf:rest Ne6e4af60afd04ff4814f5593a82e803c
161 Nbe16e52993234222ac2319f582d0f6b5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
162 schema:name Humans
163 rdf:type schema:DefinedTerm
164 Nbf42417588814241b1c052b70fdfadbd schema:name Springer Nature - SN SciGraph project
165 rdf:type schema:Organization
166 Nc28089cf9dd444e18ebaf2fffa6c92fa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
167 schema:name Female
168 rdf:type schema:DefinedTerm
169 Nc467efca446c43a688c66c04951d489b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
170 schema:name Interferon-gamma
171 rdf:type schema:DefinedTerm
172 Nd2f810c68dcd4a5abb88763c875f75e2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
173 schema:name Linear Models
174 rdf:type schema:DefinedTerm
175 Ndf22176b49b44c349140abb7c45dce4d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
176 schema:name Myocardial Infarction
177 rdf:type schema:DefinedTerm
178 Ne6e4af60afd04ff4814f5593a82e803c rdf:first sg:person.01022547142.56
179 rdf:rest N98d7ace80d0740b3923290effe622613
180 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
181 schema:name Medical and Health Sciences
182 rdf:type schema:DefinedTerm
183 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
184 schema:name Clinical Sciences
185 rdf:type schema:DefinedTerm
186 sg:journal.1045337 schema:issn 2045-2322
187 schema:name Scientific Reports
188 schema:publisher Springer Nature
189 rdf:type schema:Periodical
190 sg:person.01022547142.56 schema:affiliation grid-institutes:grid.8664.c
191 schema:familyName Euler
192 schema:givenName Gerhild
193 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01022547142.56
194 rdf:type schema:Person
195 sg:person.01075113266.30 schema:affiliation grid-institutes:grid.411067.5
196 schema:familyName Schieffer
197 schema:givenName Bernhard
198 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01075113266.30
199 rdf:type schema:Person
200 sg:person.01107017110.51 schema:affiliation grid-institutes:grid.411067.5
201 schema:familyName Parahuleva
202 schema:givenName Mariana S.
203 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01107017110.51
204 rdf:type schema:Person
205 sg:person.01165366436.38 schema:affiliation grid-institutes:grid.411067.5
206 schema:familyName Parviz
207 schema:givenName Behnoush
208 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01165366436.38
209 rdf:type schema:Person
210 sg:person.01204300150.50 schema:affiliation grid-institutes:grid.411067.5
211 schema:familyName Aslam
212 schema:givenName Muhammad
213 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01204300150.50
214 rdf:type schema:Person
215 sg:person.016112564000.18 schema:affiliation grid-institutes:grid.411067.5
216 schema:familyName Mardini
217 schema:givenName Amar
218 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016112564000.18
219 rdf:type schema:Person
220 sg:person.0751067321.69 schema:affiliation grid-institutes:grid.8664.c
221 schema:familyName Schulz
222 schema:givenName Rainer
223 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0751067321.69
224 rdf:type schema:Person
225 sg:pub.10.1007/s00059-015-4341-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000083001
226 https://doi.org/10.1007/s00059-015-4341-0
227 rdf:type schema:CreativeWork
228 sg:pub.10.1007/s12265-010-9173-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1037791397
229 https://doi.org/10.1007/s12265-010-9173-y
230 rdf:type schema:CreativeWork
231 sg:pub.10.1038/ncb2441 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015629495
232 https://doi.org/10.1038/ncb2441
233 rdf:type schema:CreativeWork
234 sg:pub.10.1038/s41598-017-01695-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085210859
235 https://doi.org/10.1038/s41598-017-01695-3
236 rdf:type schema:CreativeWork
237 sg:pub.10.1186/1471-2261-10-11 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003428909
238 https://doi.org/10.1186/1471-2261-10-11
239 rdf:type schema:CreativeWork
240 grid-institutes:grid.411067.5 schema:alternateName Internal Medicine I/Cardiology and Angiology, University Hospital of Giessen and Marburg, Giessen, Germany
241 Internal Medicine/Cardiology and Angiology, University Hospital of Giessen and Marburg, Marburg, Germany
242 schema:name Internal Medicine I/Cardiology and Angiology, University Hospital of Giessen and Marburg, Giessen, Germany
243 Internal Medicine/Cardiology and Angiology, University Hospital of Giessen and Marburg, Marburg, Germany
244 rdf:type schema:Organization
245 grid-institutes:grid.8664.c schema:alternateName Institute of Physiology, Justus Liebig University, Giessen, Germany
246 schema:name Institute of Physiology, Justus Liebig University, Giessen, Germany
247 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...