Dengue fatal cases present virus-specific HMGB1 response in peripheral organs View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-12

AUTHORS

Edson R. A. Oliveira, Tiago F. Póvoa, Gerard J. Nuovo, Diego Allonso, Natália G. Salomão, Carlos A. Basílio-de-Oliveira, Luiz H. M. Geraldo, Celina G. Fonseca, Flávia R. S. Lima, Ronaldo Mohana-Borges, Marciano V. Paes

ABSTRACT

Dengue is an important infectious disease that presents high incidence and yields a relevant number of fatal cases (about 20,000) every year worldwide. Despite its epidemiological relevance, there are many knowledge gaps concerning dengue pathogenesis, especially with regards to the circumstances that drive a mild clinical course to a severe disease. In this work, we investigated the participation of high mobility group box 1 (HMGB1), an important modulator of inflammation, in dengue fatal cases. Histopathological and ultrastructural analyses revealed that liver, lung and heart post-mortem samples were marked by tissue abnormalities, such as necrosis and apoptotic cell death. These observations go in line with an HMGB1-mediated response and raised concerns regarding the participation of this cytokine in promoting/perpetuating inflammation in severe dengue. Further experiments of immunohistochemistry (IHC) showed increased expression of cytoplasmic HMGB1 in dengue-extracted tissues when compared to non-dengue controls. Co-staining of DENV RNA and HMGB1 in the host cell cytoplasm, as found by in situ hybridization and IHC, confirmed the virus specific induction of the HMGB1-mediated response in these peripheral tissues. This report brings the first in-situ evidence of the participation of HMGB1 in severe dengue and highlights novel considerations in the development of dengue immunopathogenesis. More... »

PAGES

16011

References to SciGraph publications

  • 2012-04. HMGB1: A multifunctional alarmin driving autoimmune and inflammatory disease in NATURE REVIEWS RHEUMATOLOGY
  • 2007-01. Of cascades and perfect storms: the immunopathogenesis of dengue haemorrhagic fever-dengue shock syndrome (DHF/DSS) in IMMUNOLOGY AND CELL BIOLOGY
  • 2004-12. Immune response to SARS sets up puzzling paradox in NATURE MEDICINE
  • 2000-09. DNA fragmentation in apoptosis in CELL RESEARCH
  • 2003-07. Original antigenic sin and apoptosis in the pathogenesis of dengue hemorrhagic fever in NATURE MEDICINE
  • 2013. RAGE-Mediated Cell Signaling in CALCIUM-BINDING PROTEINS AND RAGE
  • 2010. Markers of Dengue Disease Severity in DENGUE VIRUS
  • 2010. Cellular Immunology of Sequential Dengue Virus Infection and its Role in Disease Pathogenesis in DENGUE VIRUS
  • 2011-08. Immunity to dengue virus: a tale of original antigenic sin and tropical cytokine storms in NATURE REVIEWS IMMUNOLOGY
  • 2013-01. PDZK1 Is a Novel Factor in Breast Cancer That Is Indirectly Regulated by Estrogen through IGF-1R and Promotes Estrogen-Mediated Growth in MOLECULAR MEDICINE
  • 2016-12. Slow resolution of inflammation in severe adult dengue patients in BMC INFECTIOUS DISEASES
  • 2013-04-07. The global distribution and burden of dengue in NATURE
  • 2009-10. Hepatic damage associated with dengue-2 virus replication in liver cells of BALB/c mice in LABORATORY INVESTIGATION
  • 2017-12. Salidroside ameliorates sepsis-induced acute lung injury and mortality via downregulating NF-κB and HMGB1 pathways through the upregulation of SIRT1 in SCIENTIFIC REPORTS
  • 2013-01. Signaling of High Mobility Group Box 1 (HMGB1) through Toll-like Receptor 4 in Macrophages Requires CD14 in MOLECULAR MEDICINE
  • 2012-02. HMGB1 Increases Permeability of the Endothelial Cell Monolayer via RAGE and Src Family Tyrosine Kinase Pathways in INFLAMMATION
  • 2013-01. Effects of Metformin on Burn-Induced Hepatic Endoplasmic Reticulum Stress in Male Rats in MOLECULAR MEDICINE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41598-017-16197-5

    DOI

    http://dx.doi.org/10.1038/s41598-017-16197-5

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1092730399

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/29167501


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1108", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical Microbiology", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Federal University of Rio de Janeiro", 
              "id": "https://www.grid.ac/institutes/grid.8536.8", 
              "name": [
                "Laborat\u00f3io de Modelagem Molecular, Instituto de Qu\u00edmica Org\u00e2nica, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Oliveira", 
            "givenName": "Edson R. A.", 
            "id": "sg:person.01234076673.32", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01234076673.32"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Instituto de Criminal\u00edstica, Tocantins, Brazil"
              ], 
              "type": "Organization"
            }, 
            "familyName": "P\u00f3voa", 
            "givenName": "Tiago F.", 
            "id": "sg:person.01242156230.54", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01242156230.54"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Phylogeny (United States)", 
              "id": "https://www.grid.ac/institutes/grid.430298.4", 
              "name": [
                "Ohio State University Comprehensive Cancer Center, Columbus, Ohio, United States of America", 
                "Phylogeny Inc, Powell, Ohio, United States of America"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Nuovo", 
            "givenName": "Gerard J.", 
            "id": "sg:person.01207205631.89", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01207205631.89"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Federal University of Rio de Janeiro", 
              "id": "https://www.grid.ac/institutes/grid.8536.8", 
              "name": [
                "Laborat\u00f3rio de Gen\u00f4mica Estrutural, Instituto de Biof\u00edsica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Allonso", 
            "givenName": "Diego", 
            "id": "sg:person.0655621461.30", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0655621461.30"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Oswaldo Cruz Foundation", 
              "id": "https://www.grid.ac/institutes/grid.418068.3", 
              "name": [
                "Laborat\u00f3rio Interdisciplinar de Pesquisas M\u00e9dicas, Instituto Oswaldo Cruz, Funda\u00e7\u00e3o Oswaldo Cruz, Rio de Janeiro, RJ, Brazil"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Salom\u00e3o", 
            "givenName": "Nat\u00e1lia G.", 
            "id": "sg:person.014052405745.96", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014052405745.96"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Federal University of the State of Rio de Janeiro", 
              "id": "https://www.grid.ac/institutes/grid.467095.9", 
              "name": [
                "Anatomia Patol\u00f3gica, Hospital Gaffr\u00e9e Guinle, Universidade Federal do Estado do Rio de Janeiro, Rio de Janeiro, Brazil"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Bas\u00edlio-de-Oliveira", 
            "givenName": "Carlos A.", 
            "id": "sg:person.01104325164.47", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01104325164.47"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Federal University of Rio de Janeiro", 
              "id": "https://www.grid.ac/institutes/grid.8536.8", 
              "name": [
                "Laborat\u00f3rio de Biologia das C\u00e9lulas Gliais, Instituto de Ci\u00eancias Biom\u00e9dicas, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Geraldo", 
            "givenName": "Luiz H. M.", 
            "id": "sg:person.0651471026.70", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0651471026.70"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Federal University of Rio de Janeiro", 
              "id": "https://www.grid.ac/institutes/grid.8536.8", 
              "name": [
                "Laborat\u00f3rio de Biologia das C\u00e9lulas Gliais, Instituto de Ci\u00eancias Biom\u00e9dicas, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Fonseca", 
            "givenName": "Celina G.", 
            "id": "sg:person.015225506156.21", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015225506156.21"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Federal University of Rio de Janeiro", 
              "id": "https://www.grid.ac/institutes/grid.8536.8", 
              "name": [
                "Laborat\u00f3rio de Biologia das C\u00e9lulas Gliais, Instituto de Ci\u00eancias Biom\u00e9dicas, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lima", 
            "givenName": "Fl\u00e1via R. S.", 
            "id": "sg:person.013711766362.93", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013711766362.93"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Federal University of Rio de Janeiro", 
              "id": "https://www.grid.ac/institutes/grid.8536.8", 
              "name": [
                "Laborat\u00f3rio de Gen\u00f4mica Estrutural, Instituto de Biof\u00edsica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Mohana-Borges", 
            "givenName": "Ronaldo", 
            "id": "sg:person.01252754145.69", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01252754145.69"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Oswaldo Cruz Foundation", 
              "id": "https://www.grid.ac/institutes/grid.418068.3", 
              "name": [
                "Laborat\u00f3rio Interdisciplinar de Pesquisas M\u00e9dicas, Instituto Oswaldo Cruz, Funda\u00e7\u00e3o Oswaldo Cruz, Rio de Janeiro, RJ, Brazil"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Paes", 
            "givenName": "Marciano V.", 
            "id": "sg:person.01032527271.11", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01032527271.11"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1371/journal.pntd.0004804", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000733982"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ijcard.2008.05.023", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001876994"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.virusres.2014.08.017", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002925096"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1586/1744666x.2014.909730", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003023106"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.ppat.1005738", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004763358"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature12060", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004869272", 
              "https://doi.org/10.1038/nature12060"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.icb.7100008", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004939989", 
              "https://doi.org/10.1038/sj.icb.7100008"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pntd.0002194", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005245486"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0140-6736(07)61687-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007191151"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4269/ajtmh.2012.12-0619", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008239135"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0096313", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009735248"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0096313", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009735248"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.20120189", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010939839"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.146.1.218", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011069247"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jvs.2012.11.071", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011740938"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-1-62703-230-8_15", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011844123", 
              "https://doi.org/10.1007/978-1-62703-230-8_15"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.mehy.2004.01.037", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013130928"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3389/fmicb.2014.00733", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013139117"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/labinvest.2009.83", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013339833", 
              "https://doi.org/10.1038/labinvest.2009.83"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/labinvest.2009.83", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013339833", 
              "https://doi.org/10.1038/labinvest.2009.83"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.mam.2014.05.001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013376376"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0083386", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014654272"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/liv.12197", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014824030"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1099/vir.0.82093-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015669166"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1749-6632.2010.05728.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015817496"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1749-6632.2010.05728.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015817496"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-3-642-02215-9_7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016844099", 
              "https://doi.org/10.1007/978-3-642-02215-9_7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0041932", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017456561"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/sj.embor.7400205", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017658408"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3109/10520297409116929", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019526096"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm887", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022286438", 
              "https://doi.org/10.1038/nm887"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm887", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022286438", 
              "https://doi.org/10.1038/nm887"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s12879-016-1596-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022373414", 
              "https://doi.org/10.1186/s12879-016-1596-x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s12879-016-1596-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022373414", 
              "https://doi.org/10.1186/s12879-016-1596-x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.virol.2015.12.006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022422333"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nri3014", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022630717", 
              "https://doi.org/10.1038/nri3014"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.cr.7290049", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023347275", 
              "https://doi.org/10.1038/sj.cr.7290049"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.cr.7290049", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023347275", 
              "https://doi.org/10.1038/sj.cr.7290049"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/emboj.2010.94", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023616202"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1083/jcb.17.1.208", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024183842"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.bbagrm.2009.11.019", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026462834"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1590/s0074-02762001000200015", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031150325"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1146/annurev-immunol-030409-101323", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033807071"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/1873-3468.12545", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035172904"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1155/2015/917143", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037587229"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1006/viro.1999.9656", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039051150"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm1204-1268a", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039859738", 
              "https://doi.org/10.1038/nm1204-1268a"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm1204-1268a", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039859738", 
              "https://doi.org/10.1038/nm1204-1268a"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10753-011-9325-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040060723", 
              "https://doi.org/10.1007/s10753-011-9325-5"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10753-011-9325-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040060723", 
              "https://doi.org/10.1007/s10753-011-9325-5"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3181/00379727-151-39160", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040320448"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3181/00379727-151-39160", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040320448"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/jvi.02795-15", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040588678"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1152/ajpcell.00616.2005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041984337"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0115809", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042246290"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.bbagrm.2009.09.008", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042990771"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1042/bst20120014", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043832191"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1042/bst20120014", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043832191"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jcv.2012.07.010", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044431767"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1522288113", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046619511"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/jvi.00062-06", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047397615"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/bcr-2015-209443", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047970626"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m306793200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048478419"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0168973", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050215562"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/01.qco.0000244047.31135.fa", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050828913"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/01.qco.0000244047.31135.fa", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050828913"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/01.qco.0000244047.31135.fa", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050828913"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrrheum.2011.222", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050879640", 
              "https://doi.org/10.1038/nrrheum.2011.222"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-3-642-02215-9_6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052144412", 
              "https://doi.org/10.1007/978-3-642-02215-9_6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1146/annurev.immunol.021908.132603", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052420244"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1091/mbc.e16-02-0126", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1059352091"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/infdis/128.1.15", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1059695002"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/infdis/140.4.527", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1059697274"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/infdis/jiw494", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1059710440"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1099/vir.0.009027-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1060398224"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1099/vir.0.009027-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1060398224"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.12998/wjcc.v3.i2.125", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064867807"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.2119/molmed.2011.00001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1068965350", 
              "https://doi.org/10.2119/molmed.2011.00001"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.2119/molmed.2011.00001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1068965350", 
              "https://doi.org/10.2119/molmed.2011.00001"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.2119/molmed.2012.00330", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1068965582", 
              "https://doi.org/10.2119/molmed.2012.00330"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.2119/molmed.2012.00330", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1068965582", 
              "https://doi.org/10.2119/molmed.2012.00330"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4269/ajtmh.16-0374", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1072431131"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1077376331", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1078242806", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1078427544", 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.2119/molmed.2012.00306", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1078705145", 
              "https://doi.org/10.2119/molmed.2012.00306"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.2119/molmed.2012.00306", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1078705145", 
              "https://doi.org/10.2119/molmed.2012.00306"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1083249105", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4049/jimmunol.1601342", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1083687614"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1473-3099(16)30471-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1083691458"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/md.0000000000006764", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1085118890"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/md.0000000000006764", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1085118890"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1080/17474124.2017.1345625", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1090383141"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41598-017-12285-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1091790213", 
              "https://doi.org/10.1038/s41598-017-12285-8"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2017-12", 
        "datePublishedReg": "2017-12-01", 
        "description": "Dengue is an important infectious disease that presents high incidence and yields a relevant number of fatal cases (about 20,000) every year worldwide. Despite its epidemiological relevance, there are many knowledge gaps concerning dengue pathogenesis, especially with regards to the circumstances that drive a mild clinical course to a severe disease. In this work, we investigated the participation of high mobility group box 1 (HMGB1), an important modulator of inflammation, in dengue fatal cases. Histopathological and ultrastructural analyses revealed that liver, lung and heart post-mortem samples were marked by tissue abnormalities, such as necrosis and apoptotic cell death. These observations go in line with an HMGB1-mediated response and raised concerns regarding the participation of this cytokine in promoting/perpetuating inflammation in severe dengue. Further experiments of immunohistochemistry (IHC) showed increased expression of cytoplasmic HMGB1 in dengue-extracted tissues when compared to non-dengue controls. Co-staining of DENV RNA and HMGB1 in the host cell cytoplasm, as found by in situ hybridization and IHC, confirmed the virus specific induction of the HMGB1-mediated response in these peripheral tissues. This report brings the first in-situ evidence of the participation of HMGB1 in severe dengue and highlights novel considerations in the development of dengue immunopathogenesis.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/s41598-017-16197-5", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isPartOf": [
          {
            "id": "sg:journal.1045337", 
            "issn": [
              "2045-2322"
            ], 
            "name": "Scientific Reports", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "1", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "7"
          }
        ], 
        "name": "Dengue fatal cases present virus-specific HMGB1 response in peripheral organs", 
        "pagination": "16011", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "2eea1b3a4291eb2520050a17fc816d289fbe8366f1adc232f8a39d2692729c5b"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "29167501"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "101563288"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/s41598-017-16197-5"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1092730399"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/s41598-017-16197-5", 
          "https://app.dimensions.ai/details/publication/pub.1092730399"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-10T17:27", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8672_00000493.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://www.nature.com/articles/s41598-017-16197-5"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41598-017-16197-5'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41598-017-16197-5'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41598-017-16197-5'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41598-017-16197-5'


     

    This table displays all metadata directly associated to this object as RDF triples.

    396 TRIPLES      21 PREDICATES      106 URIs      21 LITERALS      9 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/s41598-017-16197-5 schema:about anzsrc-for:11
    2 anzsrc-for:1108
    3 schema:author Nc234b5e2610b4a7a85f06058f5861513
    4 schema:citation sg:pub.10.1007/978-1-62703-230-8_15
    5 sg:pub.10.1007/978-3-642-02215-9_6
    6 sg:pub.10.1007/978-3-642-02215-9_7
    7 sg:pub.10.1007/s10753-011-9325-5
    8 sg:pub.10.1038/labinvest.2009.83
    9 sg:pub.10.1038/nature12060
    10 sg:pub.10.1038/nm1204-1268a
    11 sg:pub.10.1038/nm887
    12 sg:pub.10.1038/nri3014
    13 sg:pub.10.1038/nrrheum.2011.222
    14 sg:pub.10.1038/s41598-017-12285-8
    15 sg:pub.10.1038/sj.cr.7290049
    16 sg:pub.10.1038/sj.icb.7100008
    17 sg:pub.10.1186/s12879-016-1596-x
    18 sg:pub.10.2119/molmed.2011.00001
    19 sg:pub.10.2119/molmed.2012.00306
    20 sg:pub.10.2119/molmed.2012.00330
    21 https://app.dimensions.ai/details/publication/pub.1077376331
    22 https://app.dimensions.ai/details/publication/pub.1078242806
    23 https://app.dimensions.ai/details/publication/pub.1078427544
    24 https://app.dimensions.ai/details/publication/pub.1083249105
    25 https://doi.org/10.1002/1873-3468.12545
    26 https://doi.org/10.1006/viro.1999.9656
    27 https://doi.org/10.1016/j.bbagrm.2009.09.008
    28 https://doi.org/10.1016/j.bbagrm.2009.11.019
    29 https://doi.org/10.1016/j.ijcard.2008.05.023
    30 https://doi.org/10.1016/j.jcv.2012.07.010
    31 https://doi.org/10.1016/j.jvs.2012.11.071
    32 https://doi.org/10.1016/j.mam.2014.05.001
    33 https://doi.org/10.1016/j.mehy.2004.01.037
    34 https://doi.org/10.1016/j.virol.2015.12.006
    35 https://doi.org/10.1016/j.virusres.2014.08.017
    36 https://doi.org/10.1016/s0140-6736(07)61687-0
    37 https://doi.org/10.1016/s1473-3099(16)30471-6
    38 https://doi.org/10.1038/emboj.2010.94
    39 https://doi.org/10.1038/sj.embor.7400205
    40 https://doi.org/10.1042/bst20120014
    41 https://doi.org/10.1073/pnas.1522288113
    42 https://doi.org/10.1074/jbc.m306793200
    43 https://doi.org/10.1080/17474124.2017.1345625
    44 https://doi.org/10.1083/jcb.17.1.208
    45 https://doi.org/10.1084/jem.146.1.218
    46 https://doi.org/10.1084/jem.20120189
    47 https://doi.org/10.1091/mbc.e16-02-0126
    48 https://doi.org/10.1093/infdis/128.1.15
    49 https://doi.org/10.1093/infdis/140.4.527
    50 https://doi.org/10.1093/infdis/jiw494
    51 https://doi.org/10.1097/01.qco.0000244047.31135.fa
    52 https://doi.org/10.1097/md.0000000000006764
    53 https://doi.org/10.1099/vir.0.009027-0
    54 https://doi.org/10.1099/vir.0.82093-0
    55 https://doi.org/10.1111/j.1749-6632.2010.05728.x
    56 https://doi.org/10.1111/liv.12197
    57 https://doi.org/10.1128/jvi.00062-06
    58 https://doi.org/10.1128/jvi.02795-15
    59 https://doi.org/10.1136/bcr-2015-209443
    60 https://doi.org/10.1146/annurev-immunol-030409-101323
    61 https://doi.org/10.1146/annurev.immunol.021908.132603
    62 https://doi.org/10.1152/ajpcell.00616.2005
    63 https://doi.org/10.1155/2015/917143
    64 https://doi.org/10.12998/wjcc.v3.i2.125
    65 https://doi.org/10.1371/journal.pntd.0002194
    66 https://doi.org/10.1371/journal.pntd.0004804
    67 https://doi.org/10.1371/journal.pone.0041932
    68 https://doi.org/10.1371/journal.pone.0083386
    69 https://doi.org/10.1371/journal.pone.0096313
    70 https://doi.org/10.1371/journal.pone.0115809
    71 https://doi.org/10.1371/journal.pone.0168973
    72 https://doi.org/10.1371/journal.ppat.1005738
    73 https://doi.org/10.1586/1744666x.2014.909730
    74 https://doi.org/10.1590/s0074-02762001000200015
    75 https://doi.org/10.3109/10520297409116929
    76 https://doi.org/10.3181/00379727-151-39160
    77 https://doi.org/10.3389/fmicb.2014.00733
    78 https://doi.org/10.4049/jimmunol.1601342
    79 https://doi.org/10.4269/ajtmh.16-0374
    80 https://doi.org/10.4269/ajtmh.2012.12-0619
    81 schema:datePublished 2017-12
    82 schema:datePublishedReg 2017-12-01
    83 schema:description Dengue is an important infectious disease that presents high incidence and yields a relevant number of fatal cases (about 20,000) every year worldwide. Despite its epidemiological relevance, there are many knowledge gaps concerning dengue pathogenesis, especially with regards to the circumstances that drive a mild clinical course to a severe disease. In this work, we investigated the participation of high mobility group box 1 (HMGB1), an important modulator of inflammation, in dengue fatal cases. Histopathological and ultrastructural analyses revealed that liver, lung and heart post-mortem samples were marked by tissue abnormalities, such as necrosis and apoptotic cell death. These observations go in line with an HMGB1-mediated response and raised concerns regarding the participation of this cytokine in promoting/perpetuating inflammation in severe dengue. Further experiments of immunohistochemistry (IHC) showed increased expression of cytoplasmic HMGB1 in dengue-extracted tissues when compared to non-dengue controls. Co-staining of DENV RNA and HMGB1 in the host cell cytoplasm, as found by in situ hybridization and IHC, confirmed the virus specific induction of the HMGB1-mediated response in these peripheral tissues. This report brings the first in-situ evidence of the participation of HMGB1 in severe dengue and highlights novel considerations in the development of dengue immunopathogenesis.
    84 schema:genre research_article
    85 schema:inLanguage en
    86 schema:isAccessibleForFree true
    87 schema:isPartOf N0d730cdee96e466db70ece674b7445d9
    88 N8cb3143d9fc049f39d34e1af1493d841
    89 sg:journal.1045337
    90 schema:name Dengue fatal cases present virus-specific HMGB1 response in peripheral organs
    91 schema:pagination 16011
    92 schema:productId N5a84dc54b2f448db8046d3c77320b2be
    93 N5be3e0b01b054fb0b24991124f494b9b
    94 N658aea4d442b411cae429f327f1c0104
    95 Nb5dffa9642f54585b1f541173d0d3405
    96 Neeb4e9711cbe4e1fb7b2f15c983ca97c
    97 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092730399
    98 https://doi.org/10.1038/s41598-017-16197-5
    99 schema:sdDatePublished 2019-04-10T17:27
    100 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    101 schema:sdPublisher N1e0262793ce44853a21655bb6f58af41
    102 schema:url https://www.nature.com/articles/s41598-017-16197-5
    103 sgo:license sg:explorer/license/
    104 sgo:sdDataset articles
    105 rdf:type schema:ScholarlyArticle
    106 N0d730cdee96e466db70ece674b7445d9 schema:issueNumber 1
    107 rdf:type schema:PublicationIssue
    108 N16ec0d3662ea4450ab99f5666845fa12 rdf:first sg:person.01207205631.89
    109 rdf:rest Na7cbb9faee4844cfbb7bb7f0ff289417
    110 N1e0262793ce44853a21655bb6f58af41 schema:name Springer Nature - SN SciGraph project
    111 rdf:type schema:Organization
    112 N2502e98932774b27a63bd204ef99bccc rdf:first sg:person.014052405745.96
    113 rdf:rest Nce8acb6cd1774d1aaa9ac51a2317e897
    114 N3ecb283c4c07450b8cccb725bc53818d schema:name Instituto de Criminalística, Tocantins, Brazil
    115 rdf:type schema:Organization
    116 N5a84dc54b2f448db8046d3c77320b2be schema:name dimensions_id
    117 schema:value pub.1092730399
    118 rdf:type schema:PropertyValue
    119 N5be3e0b01b054fb0b24991124f494b9b schema:name pubmed_id
    120 schema:value 29167501
    121 rdf:type schema:PropertyValue
    122 N658aea4d442b411cae429f327f1c0104 schema:name doi
    123 schema:value 10.1038/s41598-017-16197-5
    124 rdf:type schema:PropertyValue
    125 N743f0189385c4a3b8921c2245dc21a21 rdf:first sg:person.013711766362.93
    126 rdf:rest N91ccc4dc2cb646f09a79ced89a7a1ad6
    127 N8816ee3a8d734be68ff1b20161d7c376 rdf:first sg:person.015225506156.21
    128 rdf:rest N743f0189385c4a3b8921c2245dc21a21
    129 N8cb3143d9fc049f39d34e1af1493d841 schema:volumeNumber 7
    130 rdf:type schema:PublicationVolume
    131 N91ccc4dc2cb646f09a79ced89a7a1ad6 rdf:first sg:person.01252754145.69
    132 rdf:rest Na72e50eb52de44cf82653ed8716bc6a5
    133 Na4800e65574047969e05e8ee5f8c01f3 rdf:first sg:person.0651471026.70
    134 rdf:rest N8816ee3a8d734be68ff1b20161d7c376
    135 Na72e50eb52de44cf82653ed8716bc6a5 rdf:first sg:person.01032527271.11
    136 rdf:rest rdf:nil
    137 Na7cbb9faee4844cfbb7bb7f0ff289417 rdf:first sg:person.0655621461.30
    138 rdf:rest N2502e98932774b27a63bd204ef99bccc
    139 Nb5dffa9642f54585b1f541173d0d3405 schema:name nlm_unique_id
    140 schema:value 101563288
    141 rdf:type schema:PropertyValue
    142 Nbbeea6acbec94cdabc472fd28a16fcd4 rdf:first sg:person.01242156230.54
    143 rdf:rest N16ec0d3662ea4450ab99f5666845fa12
    144 Nc234b5e2610b4a7a85f06058f5861513 rdf:first sg:person.01234076673.32
    145 rdf:rest Nbbeea6acbec94cdabc472fd28a16fcd4
    146 Nce8acb6cd1774d1aaa9ac51a2317e897 rdf:first sg:person.01104325164.47
    147 rdf:rest Na4800e65574047969e05e8ee5f8c01f3
    148 Neeb4e9711cbe4e1fb7b2f15c983ca97c schema:name readcube_id
    149 schema:value 2eea1b3a4291eb2520050a17fc816d289fbe8366f1adc232f8a39d2692729c5b
    150 rdf:type schema:PropertyValue
    151 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    152 schema:name Medical and Health Sciences
    153 rdf:type schema:DefinedTerm
    154 anzsrc-for:1108 schema:inDefinedTermSet anzsrc-for:
    155 schema:name Medical Microbiology
    156 rdf:type schema:DefinedTerm
    157 sg:journal.1045337 schema:issn 2045-2322
    158 schema:name Scientific Reports
    159 rdf:type schema:Periodical
    160 sg:person.01032527271.11 schema:affiliation https://www.grid.ac/institutes/grid.418068.3
    161 schema:familyName Paes
    162 schema:givenName Marciano V.
    163 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01032527271.11
    164 rdf:type schema:Person
    165 sg:person.01104325164.47 schema:affiliation https://www.grid.ac/institutes/grid.467095.9
    166 schema:familyName Basílio-de-Oliveira
    167 schema:givenName Carlos A.
    168 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01104325164.47
    169 rdf:type schema:Person
    170 sg:person.01207205631.89 schema:affiliation https://www.grid.ac/institutes/grid.430298.4
    171 schema:familyName Nuovo
    172 schema:givenName Gerard J.
    173 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01207205631.89
    174 rdf:type schema:Person
    175 sg:person.01234076673.32 schema:affiliation https://www.grid.ac/institutes/grid.8536.8
    176 schema:familyName Oliveira
    177 schema:givenName Edson R. A.
    178 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01234076673.32
    179 rdf:type schema:Person
    180 sg:person.01242156230.54 schema:affiliation N3ecb283c4c07450b8cccb725bc53818d
    181 schema:familyName Póvoa
    182 schema:givenName Tiago F.
    183 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01242156230.54
    184 rdf:type schema:Person
    185 sg:person.01252754145.69 schema:affiliation https://www.grid.ac/institutes/grid.8536.8
    186 schema:familyName Mohana-Borges
    187 schema:givenName Ronaldo
    188 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01252754145.69
    189 rdf:type schema:Person
    190 sg:person.013711766362.93 schema:affiliation https://www.grid.ac/institutes/grid.8536.8
    191 schema:familyName Lima
    192 schema:givenName Flávia R. S.
    193 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013711766362.93
    194 rdf:type schema:Person
    195 sg:person.014052405745.96 schema:affiliation https://www.grid.ac/institutes/grid.418068.3
    196 schema:familyName Salomão
    197 schema:givenName Natália G.
    198 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014052405745.96
    199 rdf:type schema:Person
    200 sg:person.015225506156.21 schema:affiliation https://www.grid.ac/institutes/grid.8536.8
    201 schema:familyName Fonseca
    202 schema:givenName Celina G.
    203 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015225506156.21
    204 rdf:type schema:Person
    205 sg:person.0651471026.70 schema:affiliation https://www.grid.ac/institutes/grid.8536.8
    206 schema:familyName Geraldo
    207 schema:givenName Luiz H. M.
    208 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0651471026.70
    209 rdf:type schema:Person
    210 sg:person.0655621461.30 schema:affiliation https://www.grid.ac/institutes/grid.8536.8
    211 schema:familyName Allonso
    212 schema:givenName Diego
    213 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0655621461.30
    214 rdf:type schema:Person
    215 sg:pub.10.1007/978-1-62703-230-8_15 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011844123
    216 https://doi.org/10.1007/978-1-62703-230-8_15
    217 rdf:type schema:CreativeWork
    218 sg:pub.10.1007/978-3-642-02215-9_6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052144412
    219 https://doi.org/10.1007/978-3-642-02215-9_6
    220 rdf:type schema:CreativeWork
    221 sg:pub.10.1007/978-3-642-02215-9_7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016844099
    222 https://doi.org/10.1007/978-3-642-02215-9_7
    223 rdf:type schema:CreativeWork
    224 sg:pub.10.1007/s10753-011-9325-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040060723
    225 https://doi.org/10.1007/s10753-011-9325-5
    226 rdf:type schema:CreativeWork
    227 sg:pub.10.1038/labinvest.2009.83 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013339833
    228 https://doi.org/10.1038/labinvest.2009.83
    229 rdf:type schema:CreativeWork
    230 sg:pub.10.1038/nature12060 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004869272
    231 https://doi.org/10.1038/nature12060
    232 rdf:type schema:CreativeWork
    233 sg:pub.10.1038/nm1204-1268a schema:sameAs https://app.dimensions.ai/details/publication/pub.1039859738
    234 https://doi.org/10.1038/nm1204-1268a
    235 rdf:type schema:CreativeWork
    236 sg:pub.10.1038/nm887 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022286438
    237 https://doi.org/10.1038/nm887
    238 rdf:type schema:CreativeWork
    239 sg:pub.10.1038/nri3014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022630717
    240 https://doi.org/10.1038/nri3014
    241 rdf:type schema:CreativeWork
    242 sg:pub.10.1038/nrrheum.2011.222 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050879640
    243 https://doi.org/10.1038/nrrheum.2011.222
    244 rdf:type schema:CreativeWork
    245 sg:pub.10.1038/s41598-017-12285-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091790213
    246 https://doi.org/10.1038/s41598-017-12285-8
    247 rdf:type schema:CreativeWork
    248 sg:pub.10.1038/sj.cr.7290049 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023347275
    249 https://doi.org/10.1038/sj.cr.7290049
    250 rdf:type schema:CreativeWork
    251 sg:pub.10.1038/sj.icb.7100008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004939989
    252 https://doi.org/10.1038/sj.icb.7100008
    253 rdf:type schema:CreativeWork
    254 sg:pub.10.1186/s12879-016-1596-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1022373414
    255 https://doi.org/10.1186/s12879-016-1596-x
    256 rdf:type schema:CreativeWork
    257 sg:pub.10.2119/molmed.2011.00001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1068965350
    258 https://doi.org/10.2119/molmed.2011.00001
    259 rdf:type schema:CreativeWork
    260 sg:pub.10.2119/molmed.2012.00306 schema:sameAs https://app.dimensions.ai/details/publication/pub.1078705145
    261 https://doi.org/10.2119/molmed.2012.00306
    262 rdf:type schema:CreativeWork
    263 sg:pub.10.2119/molmed.2012.00330 schema:sameAs https://app.dimensions.ai/details/publication/pub.1068965582
    264 https://doi.org/10.2119/molmed.2012.00330
    265 rdf:type schema:CreativeWork
    266 https://app.dimensions.ai/details/publication/pub.1077376331 schema:CreativeWork
    267 https://app.dimensions.ai/details/publication/pub.1078242806 schema:CreativeWork
    268 https://app.dimensions.ai/details/publication/pub.1078427544 schema:CreativeWork
    269 https://app.dimensions.ai/details/publication/pub.1083249105 schema:CreativeWork
    270 https://doi.org/10.1002/1873-3468.12545 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035172904
    271 rdf:type schema:CreativeWork
    272 https://doi.org/10.1006/viro.1999.9656 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039051150
    273 rdf:type schema:CreativeWork
    274 https://doi.org/10.1016/j.bbagrm.2009.09.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042990771
    275 rdf:type schema:CreativeWork
    276 https://doi.org/10.1016/j.bbagrm.2009.11.019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026462834
    277 rdf:type schema:CreativeWork
    278 https://doi.org/10.1016/j.ijcard.2008.05.023 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001876994
    279 rdf:type schema:CreativeWork
    280 https://doi.org/10.1016/j.jcv.2012.07.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044431767
    281 rdf:type schema:CreativeWork
    282 https://doi.org/10.1016/j.jvs.2012.11.071 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011740938
    283 rdf:type schema:CreativeWork
    284 https://doi.org/10.1016/j.mam.2014.05.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013376376
    285 rdf:type schema:CreativeWork
    286 https://doi.org/10.1016/j.mehy.2004.01.037 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013130928
    287 rdf:type schema:CreativeWork
    288 https://doi.org/10.1016/j.virol.2015.12.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022422333
    289 rdf:type schema:CreativeWork
    290 https://doi.org/10.1016/j.virusres.2014.08.017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002925096
    291 rdf:type schema:CreativeWork
    292 https://doi.org/10.1016/s0140-6736(07)61687-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007191151
    293 rdf:type schema:CreativeWork
    294 https://doi.org/10.1016/s1473-3099(16)30471-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083691458
    295 rdf:type schema:CreativeWork
    296 https://doi.org/10.1038/emboj.2010.94 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023616202
    297 rdf:type schema:CreativeWork
    298 https://doi.org/10.1038/sj.embor.7400205 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017658408
    299 rdf:type schema:CreativeWork
    300 https://doi.org/10.1042/bst20120014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043832191
    301 rdf:type schema:CreativeWork
    302 https://doi.org/10.1073/pnas.1522288113 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046619511
    303 rdf:type schema:CreativeWork
    304 https://doi.org/10.1074/jbc.m306793200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048478419
    305 rdf:type schema:CreativeWork
    306 https://doi.org/10.1080/17474124.2017.1345625 schema:sameAs https://app.dimensions.ai/details/publication/pub.1090383141
    307 rdf:type schema:CreativeWork
    308 https://doi.org/10.1083/jcb.17.1.208 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024183842
    309 rdf:type schema:CreativeWork
    310 https://doi.org/10.1084/jem.146.1.218 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011069247
    311 rdf:type schema:CreativeWork
    312 https://doi.org/10.1084/jem.20120189 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010939839
    313 rdf:type schema:CreativeWork
    314 https://doi.org/10.1091/mbc.e16-02-0126 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059352091
    315 rdf:type schema:CreativeWork
    316 https://doi.org/10.1093/infdis/128.1.15 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059695002
    317 rdf:type schema:CreativeWork
    318 https://doi.org/10.1093/infdis/140.4.527 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059697274
    319 rdf:type schema:CreativeWork
    320 https://doi.org/10.1093/infdis/jiw494 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059710440
    321 rdf:type schema:CreativeWork
    322 https://doi.org/10.1097/01.qco.0000244047.31135.fa schema:sameAs https://app.dimensions.ai/details/publication/pub.1050828913
    323 rdf:type schema:CreativeWork
    324 https://doi.org/10.1097/md.0000000000006764 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085118890
    325 rdf:type schema:CreativeWork
    326 https://doi.org/10.1099/vir.0.009027-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060398224
    327 rdf:type schema:CreativeWork
    328 https://doi.org/10.1099/vir.0.82093-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015669166
    329 rdf:type schema:CreativeWork
    330 https://doi.org/10.1111/j.1749-6632.2010.05728.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1015817496
    331 rdf:type schema:CreativeWork
    332 https://doi.org/10.1111/liv.12197 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014824030
    333 rdf:type schema:CreativeWork
    334 https://doi.org/10.1128/jvi.00062-06 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047397615
    335 rdf:type schema:CreativeWork
    336 https://doi.org/10.1128/jvi.02795-15 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040588678
    337 rdf:type schema:CreativeWork
    338 https://doi.org/10.1136/bcr-2015-209443 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047970626
    339 rdf:type schema:CreativeWork
    340 https://doi.org/10.1146/annurev-immunol-030409-101323 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033807071
    341 rdf:type schema:CreativeWork
    342 https://doi.org/10.1146/annurev.immunol.021908.132603 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052420244
    343 rdf:type schema:CreativeWork
    344 https://doi.org/10.1152/ajpcell.00616.2005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041984337
    345 rdf:type schema:CreativeWork
    346 https://doi.org/10.1155/2015/917143 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037587229
    347 rdf:type schema:CreativeWork
    348 https://doi.org/10.12998/wjcc.v3.i2.125 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064867807
    349 rdf:type schema:CreativeWork
    350 https://doi.org/10.1371/journal.pntd.0002194 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005245486
    351 rdf:type schema:CreativeWork
    352 https://doi.org/10.1371/journal.pntd.0004804 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000733982
    353 rdf:type schema:CreativeWork
    354 https://doi.org/10.1371/journal.pone.0041932 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017456561
    355 rdf:type schema:CreativeWork
    356 https://doi.org/10.1371/journal.pone.0083386 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014654272
    357 rdf:type schema:CreativeWork
    358 https://doi.org/10.1371/journal.pone.0096313 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009735248
    359 rdf:type schema:CreativeWork
    360 https://doi.org/10.1371/journal.pone.0115809 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042246290
    361 rdf:type schema:CreativeWork
    362 https://doi.org/10.1371/journal.pone.0168973 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050215562
    363 rdf:type schema:CreativeWork
    364 https://doi.org/10.1371/journal.ppat.1005738 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004763358
    365 rdf:type schema:CreativeWork
    366 https://doi.org/10.1586/1744666x.2014.909730 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003023106
    367 rdf:type schema:CreativeWork
    368 https://doi.org/10.1590/s0074-02762001000200015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031150325
    369 rdf:type schema:CreativeWork
    370 https://doi.org/10.3109/10520297409116929 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019526096
    371 rdf:type schema:CreativeWork
    372 https://doi.org/10.3181/00379727-151-39160 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040320448
    373 rdf:type schema:CreativeWork
    374 https://doi.org/10.3389/fmicb.2014.00733 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013139117
    375 rdf:type schema:CreativeWork
    376 https://doi.org/10.4049/jimmunol.1601342 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083687614
    377 rdf:type schema:CreativeWork
    378 https://doi.org/10.4269/ajtmh.16-0374 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072431131
    379 rdf:type schema:CreativeWork
    380 https://doi.org/10.4269/ajtmh.2012.12-0619 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008239135
    381 rdf:type schema:CreativeWork
    382 https://www.grid.ac/institutes/grid.418068.3 schema:alternateName Oswaldo Cruz Foundation
    383 schema:name Laboratório Interdisciplinar de Pesquisas Médicas, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, RJ, Brazil
    384 rdf:type schema:Organization
    385 https://www.grid.ac/institutes/grid.430298.4 schema:alternateName Phylogeny (United States)
    386 schema:name Ohio State University Comprehensive Cancer Center, Columbus, Ohio, United States of America
    387 Phylogeny Inc, Powell, Ohio, United States of America
    388 rdf:type schema:Organization
    389 https://www.grid.ac/institutes/grid.467095.9 schema:alternateName Federal University of the State of Rio de Janeiro
    390 schema:name Anatomia Patológica, Hospital Gaffrée Guinle, Universidade Federal do Estado do Rio de Janeiro, Rio de Janeiro, Brazil
    391 rdf:type schema:Organization
    392 https://www.grid.ac/institutes/grid.8536.8 schema:alternateName Federal University of Rio de Janeiro
    393 schema:name Laboratóio de Modelagem Molecular, Instituto de Química Orgânica, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil
    394 Laboratório de Biologia das Células Gliais, Instituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil
    395 Laboratório de Genômica Estrutural, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil
    396 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...