Transcription factor NF-κB is modulated by symbiotic status in a sea anemone model of cnidarian bleaching View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-12

AUTHORS

Katelyn M. Mansfield, Nicole M. Carter, Linda Nguyen, Phillip A. Cleves, Anar Alshanbayeva, Leah M. Williams, Camerron Crowder, Ashley R. Penvose, John R. Finnerty, Virginia M. Weis, Trevor W. Siggers, Thomas D. Gilmore

ABSTRACT

Transcription factor NF-κB plays a central role in immunity from fruit flies to humans, and NF-κB activity is altered in many human diseases. To investigate a role for NF-κB in immunity and disease on a broader evolutionary scale we have characterized NF-κB in a sea anemone (Exaiptasia pallida; called Aiptasia herein) model for cnidarian symbiosis and dysbiosis (i.e., "bleaching"). We show that the DNA-binding site specificity of Aiptasia NF-κB is similar to NF-κB proteins from a broad expanse of organisms. Analyses of NF-κB and IκB kinase proteins from Aiptasia suggest that non-canonical NF-κB processing is an evolutionarily ancient pathway, which can be reconstituted in human cells. In Aiptasia, NF-κB protein levels, DNA-binding activity, and tissue expression increase when loss of the algal symbiont Symbiodinium is induced by heat or chemical treatment. Kinetic analysis of NF-κB levels following loss of symbiosis show that NF-κB levels increase only after Symbiodinium is cleared. Moreover, introduction of Symbiodinium into naïve Aiptasia larvae results in a decrease in NF-κB expression. Our results suggest that Symbiodinium suppresses NF-κB in order to enable establishment of symbiosis in Aiptasia. These results are the first to demonstrate a link between changes in the conserved immune regulatory protein NF-κB and cnidarian symbiotic status. More... »

PAGES

16025

References to SciGraph publications

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  • Journal

    TITLE

    Scientific Reports

    ISSUE

    1

    VOLUME

    7

    From Grant

  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41598-017-16168-w

    DOI

    http://dx.doi.org/10.1038/s41598-017-16168-w

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1092730394

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/29167511


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