Insights into gene expression profiles induced by Socs3 depletion in keratinocytes View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-12

AUTHORS

Archana Bajpai, Takashi Ishii, Kosuke Miyauchi, Vipul Gupta, Yuka Nishio-Masaike, Yuki Shimizu-Yoshida, Masato Kubo, Hiroaki Kitano

ABSTRACT

Specific deletion of suppressor of cytokine signaling 3 (Socs3) in keratinocytes can cause severe skin inflammation with infiltration of immune cells. The molecular mechanisms and key regulatory pathways involved in these processes remain elusive. To investigate the role of Socs3 in keratinocytes, we generated and analyzed global RNA-Seq profiles from Socs3 conditional knockout (cKO) mice of two different ages (2 and 10 weeks). Over 400 genes were significantly regulated at both time points. Samples from 2-week-old mice exhibited down-regulation of genes involved in keratin-related functions and up-regulation of genes involved in lipid metabolism. At week 10, multiple chemokine and cytokine genes were up-regulated. Functional annotation revealed that the genes differentially expressed in the 2-week-old mice play roles in keratinization, keratinocyte differentiation, and epidermal cell differentiation. By contrast, differentially expressed genes in the 10-week-old animals are involved in acute immune-related functions. A group of activator protein-1-related genes were highly up-regulated in Socs3 cKO mice of both ages. This observation was validated using qRT-PCR by SOCS3-depleted human keratinocyte-derived HaCaT cells. Our results suggest that, in addition to participating in immune-mediated pathways, SOCS3 also plays important roles in skin barrier homeostasis. More... »

PAGES

15830

References to SciGraph publications

  • 2000-05. Gene Ontology: tool for the unification of biology in NATURE GENETICS
  • 2012-06. Anti-apoptotic effects of suppressor of cytokine signaling 3 and 1 in psoriasis in CELL DEATH & DISEASE
  • 2008-07. Mapping and quantifying mammalian transcriptomes by RNA-Seq in NATURE METHODS
  • 2005-01. Fos and Jun Proteins Are Specifically Expressed During Differentiation of Human Keratinocytes in JOURNAL OF INVESTIGATIVE DERMATOLOGY
  • 2014-05. Mechanisms regulating skin immunity and inflammation in NATURE REVIEWS IMMUNOLOGY
  • 2001-04. AP-1 in cell proliferation and survival in ONCOGENE
  • 2009-10. Skin immune sentinels in health and disease in NATURE REVIEWS IMMUNOLOGY
  • 2001-04. Function and regulation of AP-1 subunits in skin physiology and pathology in ONCOGENE
  • 2007-10. Biphasic Regulation of AP-1 Subunits during Human Epidermal Wound Healing in JOURNAL OF INVESTIGATIVE DERMATOLOGY
  • 2010-10. The Antimicrobial Heterodimer S100A8/S100A9 (Calprotectin) Is Upregulated by Bacterial Flagellin in Human Epidermal Keratinocytes in JOURNAL OF INVESTIGATIVE DERMATOLOGY
  • 2001-04. AP-1 in mouse development and tumorigenesis in ONCOGENE
  • 1997-09. Opposing activities of c-Fos and Fra-2 on AP-1 regulated transcriptional activity in mouse keratinocytes induced to differentiate by calcium and phorbol esters in ONCOGENE
  • 2012-01. IL-6 promotes acute and chronic inflammatory disease in the absence of SOCS3 in IMMUNOLOGY AND CELL BIOLOGY
  • 2006-02. Keratinocyte Apoptosis in Epidermal Development and Disease in JOURNAL OF INVESTIGATIVE DERMATOLOGY
  • 2005-02. Constitutive SOCS-3 expression protects T-cell lymphoma against growth inhibition by IFNα in LEUKEMIA
  • 2010-11. AP1 factor inactivation in the suprabasal epidermis causes increased epidermal hyperproliferation and hyperkeratosis but reduced carcinogen-dependent tumor formation in ONCOGENE
  • 2003-12. Suppressors of cytokine signaling and immunity in NATURE IMMUNOLOGY
  • 2013-07. TREM-1 as a Potential Therapeutic Target in Psoriasis in JOURNAL OF INVESTIGATIVE DERMATOLOGY
  • 2013-02. Involvement of p38 MAPK-dependent activator protein (AP-1) activation in modulation of gastric mucosal inflammatory responses to Helicobacter pylori by ghrelin in INFLAMMOPHARMACOLOGY
  • 2008-07. SOCS3 Negatively Regulates the gp130–STAT3 Pathway in Mouse Skin Wound Healing in JOURNAL OF INVESTIGATIVE DERMATOLOGY
  • 2012-03. Skin Barrier Disruption: A Requirement for Allergen Sensitization? in JOURNAL OF INVESTIGATIVE DERMATOLOGY
  • 2011-01. Matrix metalloproteinase-13 expression in IL-1β-treated chondrocytes by activation of the p38 MAPK/c-Fos/AP-1 and JAK/STAT pathways in ARCHIVES OF PHARMACAL RESEARCH
  • 2005-01. Stat3 links activated keratinocytes and immunocytes required for development of psoriasis in a novel transgenic mouse model in NATURE MEDICINE
  • 2007-06. SOCS proteins, cytokine signalling and immune regulation in NATURE REVIEWS IMMUNOLOGY
  • 2001-03. Mammalian MAP kinase signalling cascades in NATURE
  • 2010-07. Assessment of the Psoriatic Transcriptome in a Large Sample: Additional Regulated Genes and Comparisons with In Vitro Models in JOURNAL OF INVESTIGATIVE DERMATOLOGY
  • 2002-05. AP-1 as a regulator of cell life and death in NATURE CELL BIOLOGY
  • 2008-02. Peroxisome Proliferator-Activated Receptors (PPARs) and the Human Skin in AMERICAN JOURNAL OF CLINICAL DERMATOLOGY
  • 2000-12. Dysregulated Activation of Activator Protein 1 in Keratinocytes of Atopic Dermatitis Patients with Enhanced Expression of Granulocyte/Macrophage-Colony Stimulating Factor in JOURNAL OF INVESTIGATIVE DERMATOLOGY
  • 2011-05. c-Jun Promotes whereas JunB Inhibits Epidermal Neoplasia in JOURNAL OF INVESTIGATIVE DERMATOLOGY
  • 1994-12. A protein kinase involved in the regulation of inflammatory cytokine biosynthesis in NATURE
  • 2010-06. Deficient SOCS3 and SHP-1 Expression in Psoriatic T Cells in JOURNAL OF INVESTIGATIVE DERMATOLOGY
  • 2006-09. Serine Protease Signaling of Epidermal Permeability Barrier Homeostasis in JOURNAL OF INVESTIGATIVE DERMATOLOGY
  • 2006-07. Serine Protease Activity and Residual LEKTI Expression Determine Phenotype in Netherton Syndrome in JOURNAL OF INVESTIGATIVE DERMATOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41598-017-16155-1

    DOI

    http://dx.doi.org/10.1038/s41598-017-16155-1

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1092697033

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/29158586


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biochemistry and Cell Biology", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biological Sciences", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "name": [
                "RIKEN-IMS, Laboratory for Disease Systems Modeling, Yokohama, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Bajpai", 
            "givenName": "Archana", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "RIKEN-IMS, Laboratory for Disease Systems Modeling, Yokohama, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ishii", 
            "givenName": "Takashi", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "RIKEN-IMS, Laboratory for Cytokine Regulation, Yokohama, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Miyauchi", 
            "givenName": "Kosuke", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Systems Biology Institute", 
              "id": "https://www.grid.ac/institutes/grid.452864.9", 
              "name": [
                "RIKEN-IMS, Laboratory for Disease Systems Modeling, Yokohama, Japan", 
                "The Systems Biology Institute, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Gupta", 
            "givenName": "Vipul", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "RIKEN-IMS, Laboratory for Disease Systems Modeling, Yokohama, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Nishio-Masaike", 
            "givenName": "Yuka", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Sony Computer Science Laboratories", 
              "id": "https://www.grid.ac/institutes/grid.452725.3", 
              "name": [
                "RIKEN-IMS, Laboratory for Disease Systems Modeling, Yokohama, Japan", 
                "Sony Computer Science Laboratories, Inc, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Shimizu-Yoshida", 
            "givenName": "Yuki", 
            "id": "sg:person.01057035523.63", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01057035523.63"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Tokyo University of Science", 
              "id": "https://www.grid.ac/institutes/grid.143643.7", 
              "name": [
                "RIKEN-IMS, Laboratory for Cytokine Regulation, Yokohama, Japan", 
                "Division of Molecular Pathology, Research Institute for Biomedical Science, Tokyo University of Science, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kubo", 
            "givenName": "Masato", 
            "id": "sg:person.01015126626.29", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01015126626.29"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Okinawa Institute of Science and Technology", 
              "id": "https://www.grid.ac/institutes/grid.250464.1", 
              "name": [
                "RIKEN-IMS, Laboratory for Disease Systems Modeling, Yokohama, Japan", 
                "The Systems Biology Institute, Tokyo, Japan", 
                "Sony Computer Science Laboratories, Inc, Tokyo, Japan", 
                "Okinawa Institute of Science and Technology, Okinawa, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kitano", 
            "givenName": "Hiroaki", 
            "id": "sg:person.01355755204.11", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01355755204.11"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1002/eji.1830261009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000887836"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.271.39.24105", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001985379"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1600-0625.2012.01571.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002417566"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.mcn.2007.10.010", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002618507"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.jid.5700008", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003322438", 
              "https://doi.org/10.1038/sj.jid.5700008"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m110.165704", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003667618"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1098/rsfs.2012.0090", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004569383"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/jid.2011.435", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004903245", 
              "https://doi.org/10.1038/jid.2011.435"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s12272-011-0113-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004926408", 
              "https://doi.org/10.1007/s12272-011-0113-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.0906-6705.2005.00317.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005505918"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.0906-6705.2005.00317.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005505918"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/jid.2013.68", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005771915", 
              "https://doi.org/10.1038/jid.2013.68"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2002-01-0073", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005962923"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.2165/00128071-200809010-00002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007344856", 
              "https://doi.org/10.2165/00128071-200809010-00002"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3389/fimmu.2014.00058", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007667435"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/gkl842", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008035809"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1155/2014/630797", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008158503"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1204389", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008288156", 
              "https://doi.org/10.1038/sj.onc.1204389"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1204389", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008288156", 
              "https://doi.org/10.1038/sj.onc.1204389"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nri2622", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008342059", 
              "https://doi.org/10.1038/nri2622"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nri2622", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008342059", 
              "https://doi.org/10.1038/nri2622"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0072783", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009384914"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm1162", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009892213", 
              "https://doi.org/10.1038/nm1162"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm1162", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009892213", 
              "https://doi.org/10.1038/nm1162"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/jid.2010.158", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010718450", 
              "https://doi.org/10.1038/jid.2010.158"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nri2093", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010853272", 
              "https://doi.org/10.1038/nri2093"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/cddis.2012.69", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011669818", 
              "https://doi.org/10.1038/cddis.2012.69"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/bioinformatics/btp120", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012425816"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0923-1811(02)00064-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012655275"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.273.21.12901", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013460825"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni1012", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013582066", 
              "https://doi.org/10.1038/ni1012"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni1012", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013582066", 
              "https://doi.org/10.1038/ni1012"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0190-9622(94)70059-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013752398"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1159/000078582", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013862530"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1365-2133.2007.07986.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014375133"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1204380", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014799250", 
              "https://doi.org/10.1038/sj.onc.1204380"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1204380", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014799250", 
              "https://doi.org/10.1038/sj.onc.1204380"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/jid.2010.36", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014958529", 
              "https://doi.org/10.1038/jid.2010.36"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci82887", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016706599"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/onc.2010.315", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018136074", 
              "https://doi.org/10.1038/onc.2010.315"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10787-012-0141-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018697043", 
              "https://doi.org/10.1007/s10787-012-0141-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ajhg.2013.09.015", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019059577"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1111/j.0022-202x.2004.23558.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019480461", 
              "https://doi.org/10.1111/j.0022-202x.2004.23558.x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nri3646", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021112613", 
              "https://doi.org/10.1038/nri3646"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1600-065x.2011.01027.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021464207"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/bioinformatics/btp616", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023247882"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jaci.2016.10.026", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023365788"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jaci.2016.10.026", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023365788"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1204383", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023622224", 
              "https://doi.org/10.1038/sj.onc.1204383"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1204383", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023622224", 
              "https://doi.org/10.1038/sj.onc.1204383"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.humimm.2015.09.037", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023906190"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.jid.5700351", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025912020", 
              "https://doi.org/10.1038/sj.jid.5700351"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncb0502-e131", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026096121", 
              "https://doi.org/10.1038/ncb0502-e131"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncb0502-e131", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026096121", 
              "https://doi.org/10.1038/ncb0502-e131"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1155/2010/535612", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027884044"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35065000", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029421135", 
              "https://doi.org/10.1038/35065000"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35065000", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029421135", 
              "https://doi.org/10.1038/35065000"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/sqb.2008.73.032", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029612929"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1096/fj.02-0664fje", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030577273"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.bbalip.2013.11.012", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030610095"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0040343", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031431218"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.jid.5700288", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031551392", 
              "https://doi.org/10.1038/sj.jid.5700288"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1201293", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032154161", 
              "https://doi.org/10.1038/sj.onc.1201293"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1201293", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032154161", 
              "https://doi.org/10.1038/sj.onc.1201293"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0307-4412(95)90183-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032893449"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mcb.24.18.8167-8183.2004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035248096"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/002215540305100513", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036040183"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/002215540305100513", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036040183"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/jid.2011.1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036465574", 
              "https://doi.org/10.1038/jid.2011.1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1046/j.1523-1747.2000.00149.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037084362", 
              "https://doi.org/10.1046/j.1523-1747.2000.00149.x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/jid.2010.6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037275317", 
              "https://doi.org/10.1038/jid.2010.6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.gpb.2015.04.002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038856008"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1146/annurev.immunol.20.091301.131133", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039092091"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0602574103", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039439948"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1155/2013/537028", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040482056"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1096/fj.00-0908fje", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040853959"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1080/02699050500284218", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041309884"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/icb.2011.29", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041689941", 
              "https://doi.org/10.1038/icb.2011.29"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jaci.2008.03.027", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041790193"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.jid.5700864", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042780267", 
              "https://doi.org/10.1038/sj.jid.5700864"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ajpath.2015.09.005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043936187"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/75556", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044135237", 
              "https://doi.org/10.1038/75556"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/75556", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044135237", 
              "https://doi.org/10.1038/75556"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nmeth.1226", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045381177", 
              "https://doi.org/10.1038/nmeth.1226"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.leu.2403610", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045490303", 
              "https://doi.org/10.1038/sj.leu.2403610"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.leu.2403610", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045490303", 
              "https://doi.org/10.1038/sj.leu.2403610"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.immuni.2013.11.011", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046034451"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1155/2014/696415", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046602943"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/372739a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047199166", 
              "https://doi.org/10.1038/372739a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.jid.5701224", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050314792", 
              "https://doi.org/10.1038/sj.jid.5701224"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1146/annurev.cellbio.23.090506.123357", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050750066"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1086/504272", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1058784213"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2174/156800907780809714", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1069190810"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4049/jimmunol.174.8.4870", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1077034555"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4049/jimmunol.174.8.4870", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1077034555"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082392190", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082396179", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082853109", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1083224239", 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2017-12", 
        "datePublishedReg": "2017-12-01", 
        "description": "Specific deletion of suppressor of cytokine signaling 3 (Socs3) in keratinocytes can cause severe skin inflammation with infiltration of immune cells. The molecular mechanisms and key regulatory pathways involved in these processes remain elusive. To investigate the role of Socs3 in keratinocytes, we generated and analyzed global RNA-Seq profiles from Socs3 conditional knockout (cKO) mice of two different ages (2 and 10 weeks). Over 400 genes were significantly regulated at both time points. Samples from 2-week-old mice exhibited down-regulation of genes involved in keratin-related functions and up-regulation of genes involved in lipid metabolism. At week 10, multiple chemokine and cytokine genes were up-regulated. Functional annotation revealed that the genes differentially expressed in the 2-week-old mice play roles in keratinization, keratinocyte differentiation, and epidermal cell differentiation. By contrast, differentially expressed genes in the 10-week-old animals are involved in acute immune-related functions. A group of activator protein-1-related genes were highly up-regulated in Socs3 cKO mice of both ages. This observation was validated using qRT-PCR by SOCS3-depleted human keratinocyte-derived HaCaT cells. Our results suggest that, in addition to participating in immune-mediated pathways, SOCS3 also plays important roles in skin barrier homeostasis.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/s41598-017-16155-1", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isPartOf": [
          {
            "id": "sg:journal.1045337", 
            "issn": [
              "2045-2322"
            ], 
            "name": "Scientific Reports", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "1", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "7"
          }
        ], 
        "name": "Insights into gene expression profiles induced by Socs3 depletion in keratinocytes", 
        "pagination": "15830", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "efc1ce5609468f7559f7096f988fc206e84c095d40850c22193836fc9464fa56"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "29158586"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "101563288"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/s41598-017-16155-1"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1092697033"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/s41598-017-16155-1", 
          "https://app.dimensions.ai/details/publication/pub.1092697033"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-10T16:55", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8669_00000601.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://www.nature.com/articles/s41598-017-16155-1"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41598-017-16155-1'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41598-017-16155-1'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41598-017-16155-1'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41598-017-16155-1'


     

    This table displays all metadata directly associated to this object as RDF triples.

    417 TRIPLES      21 PREDICATES      113 URIs      21 LITERALS      9 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/s41598-017-16155-1 schema:about anzsrc-for:06
    2 anzsrc-for:0601
    3 schema:author N5cd5985942ff45e68dcc0995ea23fc60
    4 schema:citation sg:pub.10.1007/s10787-012-0141-9
    5 sg:pub.10.1007/s12272-011-0113-4
    6 sg:pub.10.1038/35065000
    7 sg:pub.10.1038/372739a0
    8 sg:pub.10.1038/75556
    9 sg:pub.10.1038/cddis.2012.69
    10 sg:pub.10.1038/icb.2011.29
    11 sg:pub.10.1038/jid.2010.158
    12 sg:pub.10.1038/jid.2010.36
    13 sg:pub.10.1038/jid.2010.6
    14 sg:pub.10.1038/jid.2011.1
    15 sg:pub.10.1038/jid.2011.435
    16 sg:pub.10.1038/jid.2013.68
    17 sg:pub.10.1038/ncb0502-e131
    18 sg:pub.10.1038/ni1012
    19 sg:pub.10.1038/nm1162
    20 sg:pub.10.1038/nmeth.1226
    21 sg:pub.10.1038/nri2093
    22 sg:pub.10.1038/nri2622
    23 sg:pub.10.1038/nri3646
    24 sg:pub.10.1038/onc.2010.315
    25 sg:pub.10.1038/sj.jid.5700008
    26 sg:pub.10.1038/sj.jid.5700288
    27 sg:pub.10.1038/sj.jid.5700351
    28 sg:pub.10.1038/sj.jid.5700864
    29 sg:pub.10.1038/sj.jid.5701224
    30 sg:pub.10.1038/sj.leu.2403610
    31 sg:pub.10.1038/sj.onc.1201293
    32 sg:pub.10.1038/sj.onc.1204380
    33 sg:pub.10.1038/sj.onc.1204383
    34 sg:pub.10.1038/sj.onc.1204389
    35 sg:pub.10.1046/j.1523-1747.2000.00149.x
    36 sg:pub.10.1111/j.0022-202x.2004.23558.x
    37 sg:pub.10.2165/00128071-200809010-00002
    38 https://app.dimensions.ai/details/publication/pub.1082392190
    39 https://app.dimensions.ai/details/publication/pub.1082396179
    40 https://app.dimensions.ai/details/publication/pub.1082853109
    41 https://app.dimensions.ai/details/publication/pub.1083224239
    42 https://doi.org/10.1002/eji.1830261009
    43 https://doi.org/10.1016/0307-4412(95)90183-3
    44 https://doi.org/10.1016/j.ajhg.2013.09.015
    45 https://doi.org/10.1016/j.ajpath.2015.09.005
    46 https://doi.org/10.1016/j.bbalip.2013.11.012
    47 https://doi.org/10.1016/j.gpb.2015.04.002
    48 https://doi.org/10.1016/j.humimm.2015.09.037
    49 https://doi.org/10.1016/j.immuni.2013.11.011
    50 https://doi.org/10.1016/j.jaci.2008.03.027
    51 https://doi.org/10.1016/j.jaci.2016.10.026
    52 https://doi.org/10.1016/j.mcn.2007.10.010
    53 https://doi.org/10.1016/s0190-9622(94)70059-1
    54 https://doi.org/10.1016/s0923-1811(02)00064-6
    55 https://doi.org/10.1073/pnas.0602574103
    56 https://doi.org/10.1074/jbc.271.39.24105
    57 https://doi.org/10.1074/jbc.273.21.12901
    58 https://doi.org/10.1074/jbc.m110.165704
    59 https://doi.org/10.1080/02699050500284218
    60 https://doi.org/10.1086/504272
    61 https://doi.org/10.1093/bioinformatics/btp120
    62 https://doi.org/10.1093/bioinformatics/btp616
    63 https://doi.org/10.1093/nar/gkl842
    64 https://doi.org/10.1096/fj.00-0908fje
    65 https://doi.org/10.1096/fj.02-0664fje
    66 https://doi.org/10.1098/rsfs.2012.0090
    67 https://doi.org/10.1101/sqb.2008.73.032
    68 https://doi.org/10.1111/j.0906-6705.2005.00317.x
    69 https://doi.org/10.1111/j.1365-2133.2007.07986.x
    70 https://doi.org/10.1111/j.1600-0625.2012.01571.x
    71 https://doi.org/10.1111/j.1600-065x.2011.01027.x
    72 https://doi.org/10.1128/mcb.24.18.8167-8183.2004
    73 https://doi.org/10.1146/annurev.cellbio.23.090506.123357
    74 https://doi.org/10.1146/annurev.immunol.20.091301.131133
    75 https://doi.org/10.1155/2010/535612
    76 https://doi.org/10.1155/2013/537028
    77 https://doi.org/10.1155/2014/630797
    78 https://doi.org/10.1155/2014/696415
    79 https://doi.org/10.1159/000078582
    80 https://doi.org/10.1172/jci82887
    81 https://doi.org/10.1177/002215540305100513
    82 https://doi.org/10.1182/blood-2002-01-0073
    83 https://doi.org/10.1371/journal.pone.0040343
    84 https://doi.org/10.1371/journal.pone.0072783
    85 https://doi.org/10.2174/156800907780809714
    86 https://doi.org/10.3389/fimmu.2014.00058
    87 https://doi.org/10.4049/jimmunol.174.8.4870
    88 schema:datePublished 2017-12
    89 schema:datePublishedReg 2017-12-01
    90 schema:description Specific deletion of suppressor of cytokine signaling 3 (Socs3) in keratinocytes can cause severe skin inflammation with infiltration of immune cells. The molecular mechanisms and key regulatory pathways involved in these processes remain elusive. To investigate the role of Socs3 in keratinocytes, we generated and analyzed global RNA-Seq profiles from Socs3 conditional knockout (cKO) mice of two different ages (2 and 10 weeks). Over 400 genes were significantly regulated at both time points. Samples from 2-week-old mice exhibited down-regulation of genes involved in keratin-related functions and up-regulation of genes involved in lipid metabolism. At week 10, multiple chemokine and cytokine genes were up-regulated. Functional annotation revealed that the genes differentially expressed in the 2-week-old mice play roles in keratinization, keratinocyte differentiation, and epidermal cell differentiation. By contrast, differentially expressed genes in the 10-week-old animals are involved in acute immune-related functions. A group of activator protein-1-related genes were highly up-regulated in Socs3 cKO mice of both ages. This observation was validated using qRT-PCR by SOCS3-depleted human keratinocyte-derived HaCaT cells. Our results suggest that, in addition to participating in immune-mediated pathways, SOCS3 also plays important roles in skin barrier homeostasis.
    91 schema:genre research_article
    92 schema:inLanguage en
    93 schema:isAccessibleForFree true
    94 schema:isPartOf N9d1039197a3e487d88adcbb9a3568ea0
    95 Ne9b2766abda34473b492af65bc425ebe
    96 sg:journal.1045337
    97 schema:name Insights into gene expression profiles induced by Socs3 depletion in keratinocytes
    98 schema:pagination 15830
    99 schema:productId N32e6d610ab274aa9849dab0f04468ccb
    100 N73b1c07ee1a049f189f1b5be92c0649d
    101 N9c79167399bc4516861f557fd017d3d0
    102 Naaddd6ceb74e4888a1158c38723a45d1
    103 Ne03417e97bd24f73a344e08a1106b020
    104 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092697033
    105 https://doi.org/10.1038/s41598-017-16155-1
    106 schema:sdDatePublished 2019-04-10T16:55
    107 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    108 schema:sdPublisher Nb8469910486849c690139fa257efae38
    109 schema:url https://www.nature.com/articles/s41598-017-16155-1
    110 sgo:license sg:explorer/license/
    111 sgo:sdDataset articles
    112 rdf:type schema:ScholarlyArticle
    113 N002f463eece64a6aa4fb245a717c2944 rdf:first N3bf0d19e8374415d8770cfa8fdfd920f
    114 rdf:rest Nd085c42120f84e758bcd0b21871820af
    115 N0bbf078b9a394933ac31b59f965ec683 rdf:first N8a59006090094926a6c3fd7c94923d01
    116 rdf:rest N2ff75364640a4f98bc0245a020db9ea7
    117 N1f267d3ea07a434fa1493ce4dd727fdb schema:name RIKEN-IMS, Laboratory for Disease Systems Modeling, Yokohama, Japan
    118 rdf:type schema:Organization
    119 N2ff75364640a4f98bc0245a020db9ea7 rdf:first sg:person.01057035523.63
    120 rdf:rest N69d1b3f6913a41be840e8507b68d0efe
    121 N3158aeb93dbe426bb3cf9a2fd57a2531 schema:affiliation https://www.grid.ac/institutes/grid.452864.9
    122 schema:familyName Gupta
    123 schema:givenName Vipul
    124 rdf:type schema:Person
    125 N32e6d610ab274aa9849dab0f04468ccb schema:name dimensions_id
    126 schema:value pub.1092697033
    127 rdf:type schema:PropertyValue
    128 N3bf0d19e8374415d8770cfa8fdfd920f schema:affiliation Ndf5836c573144ce4aeab3ea17d79a33b
    129 schema:familyName Miyauchi
    130 schema:givenName Kosuke
    131 rdf:type schema:Person
    132 N4d109b88186b456fab7a91e8c54c50bf schema:name RIKEN-IMS, Laboratory for Disease Systems Modeling, Yokohama, Japan
    133 rdf:type schema:Organization
    134 N5cd5985942ff45e68dcc0995ea23fc60 rdf:first N7815dabbf4094c189904ce0d242882a3
    135 rdf:rest Nf1f6b35992334232a5e2da73f8b70eb7
    136 N69d1b3f6913a41be840e8507b68d0efe rdf:first sg:person.01015126626.29
    137 rdf:rest Nb73b3efcc42145a488c9fb494b57a0bf
    138 N73b1c07ee1a049f189f1b5be92c0649d schema:name pubmed_id
    139 schema:value 29158586
    140 rdf:type schema:PropertyValue
    141 N7815dabbf4094c189904ce0d242882a3 schema:affiliation N4d109b88186b456fab7a91e8c54c50bf
    142 schema:familyName Bajpai
    143 schema:givenName Archana
    144 rdf:type schema:Person
    145 N8a59006090094926a6c3fd7c94923d01 schema:affiliation Nb52c68a606c144f4a2b93dcd0bbdb04f
    146 schema:familyName Nishio-Masaike
    147 schema:givenName Yuka
    148 rdf:type schema:Person
    149 N9bb3288cb66c476c8acd812e10b83971 schema:affiliation N1f267d3ea07a434fa1493ce4dd727fdb
    150 schema:familyName Ishii
    151 schema:givenName Takashi
    152 rdf:type schema:Person
    153 N9c79167399bc4516861f557fd017d3d0 schema:name readcube_id
    154 schema:value efc1ce5609468f7559f7096f988fc206e84c095d40850c22193836fc9464fa56
    155 rdf:type schema:PropertyValue
    156 N9d1039197a3e487d88adcbb9a3568ea0 schema:issueNumber 1
    157 rdf:type schema:PublicationIssue
    158 Naaddd6ceb74e4888a1158c38723a45d1 schema:name doi
    159 schema:value 10.1038/s41598-017-16155-1
    160 rdf:type schema:PropertyValue
    161 Nb52c68a606c144f4a2b93dcd0bbdb04f schema:name RIKEN-IMS, Laboratory for Disease Systems Modeling, Yokohama, Japan
    162 rdf:type schema:Organization
    163 Nb73b3efcc42145a488c9fb494b57a0bf rdf:first sg:person.01355755204.11
    164 rdf:rest rdf:nil
    165 Nb8469910486849c690139fa257efae38 schema:name Springer Nature - SN SciGraph project
    166 rdf:type schema:Organization
    167 Nd085c42120f84e758bcd0b21871820af rdf:first N3158aeb93dbe426bb3cf9a2fd57a2531
    168 rdf:rest N0bbf078b9a394933ac31b59f965ec683
    169 Ndf5836c573144ce4aeab3ea17d79a33b schema:name RIKEN-IMS, Laboratory for Cytokine Regulation, Yokohama, Japan
    170 rdf:type schema:Organization
    171 Ne03417e97bd24f73a344e08a1106b020 schema:name nlm_unique_id
    172 schema:value 101563288
    173 rdf:type schema:PropertyValue
    174 Ne9b2766abda34473b492af65bc425ebe schema:volumeNumber 7
    175 rdf:type schema:PublicationVolume
    176 Nf1f6b35992334232a5e2da73f8b70eb7 rdf:first N9bb3288cb66c476c8acd812e10b83971
    177 rdf:rest N002f463eece64a6aa4fb245a717c2944
    178 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    179 schema:name Biological Sciences
    180 rdf:type schema:DefinedTerm
    181 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
    182 schema:name Biochemistry and Cell Biology
    183 rdf:type schema:DefinedTerm
    184 sg:journal.1045337 schema:issn 2045-2322
    185 schema:name Scientific Reports
    186 rdf:type schema:Periodical
    187 sg:person.01015126626.29 schema:affiliation https://www.grid.ac/institutes/grid.143643.7
    188 schema:familyName Kubo
    189 schema:givenName Masato
    190 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01015126626.29
    191 rdf:type schema:Person
    192 sg:person.01057035523.63 schema:affiliation https://www.grid.ac/institutes/grid.452725.3
    193 schema:familyName Shimizu-Yoshida
    194 schema:givenName Yuki
    195 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01057035523.63
    196 rdf:type schema:Person
    197 sg:person.01355755204.11 schema:affiliation https://www.grid.ac/institutes/grid.250464.1
    198 schema:familyName Kitano
    199 schema:givenName Hiroaki
    200 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01355755204.11
    201 rdf:type schema:Person
    202 sg:pub.10.1007/s10787-012-0141-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018697043
    203 https://doi.org/10.1007/s10787-012-0141-9
    204 rdf:type schema:CreativeWork
    205 sg:pub.10.1007/s12272-011-0113-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004926408
    206 https://doi.org/10.1007/s12272-011-0113-4
    207 rdf:type schema:CreativeWork
    208 sg:pub.10.1038/35065000 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029421135
    209 https://doi.org/10.1038/35065000
    210 rdf:type schema:CreativeWork
    211 sg:pub.10.1038/372739a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047199166
    212 https://doi.org/10.1038/372739a0
    213 rdf:type schema:CreativeWork
    214 sg:pub.10.1038/75556 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044135237
    215 https://doi.org/10.1038/75556
    216 rdf:type schema:CreativeWork
    217 sg:pub.10.1038/cddis.2012.69 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011669818
    218 https://doi.org/10.1038/cddis.2012.69
    219 rdf:type schema:CreativeWork
    220 sg:pub.10.1038/icb.2011.29 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041689941
    221 https://doi.org/10.1038/icb.2011.29
    222 rdf:type schema:CreativeWork
    223 sg:pub.10.1038/jid.2010.158 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010718450
    224 https://doi.org/10.1038/jid.2010.158
    225 rdf:type schema:CreativeWork
    226 sg:pub.10.1038/jid.2010.36 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014958529
    227 https://doi.org/10.1038/jid.2010.36
    228 rdf:type schema:CreativeWork
    229 sg:pub.10.1038/jid.2010.6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037275317
    230 https://doi.org/10.1038/jid.2010.6
    231 rdf:type schema:CreativeWork
    232 sg:pub.10.1038/jid.2011.1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036465574
    233 https://doi.org/10.1038/jid.2011.1
    234 rdf:type schema:CreativeWork
    235 sg:pub.10.1038/jid.2011.435 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004903245
    236 https://doi.org/10.1038/jid.2011.435
    237 rdf:type schema:CreativeWork
    238 sg:pub.10.1038/jid.2013.68 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005771915
    239 https://doi.org/10.1038/jid.2013.68
    240 rdf:type schema:CreativeWork
    241 sg:pub.10.1038/ncb0502-e131 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026096121
    242 https://doi.org/10.1038/ncb0502-e131
    243 rdf:type schema:CreativeWork
    244 sg:pub.10.1038/ni1012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013582066
    245 https://doi.org/10.1038/ni1012
    246 rdf:type schema:CreativeWork
    247 sg:pub.10.1038/nm1162 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009892213
    248 https://doi.org/10.1038/nm1162
    249 rdf:type schema:CreativeWork
    250 sg:pub.10.1038/nmeth.1226 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045381177
    251 https://doi.org/10.1038/nmeth.1226
    252 rdf:type schema:CreativeWork
    253 sg:pub.10.1038/nri2093 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010853272
    254 https://doi.org/10.1038/nri2093
    255 rdf:type schema:CreativeWork
    256 sg:pub.10.1038/nri2622 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008342059
    257 https://doi.org/10.1038/nri2622
    258 rdf:type schema:CreativeWork
    259 sg:pub.10.1038/nri3646 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021112613
    260 https://doi.org/10.1038/nri3646
    261 rdf:type schema:CreativeWork
    262 sg:pub.10.1038/onc.2010.315 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018136074
    263 https://doi.org/10.1038/onc.2010.315
    264 rdf:type schema:CreativeWork
    265 sg:pub.10.1038/sj.jid.5700008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003322438
    266 https://doi.org/10.1038/sj.jid.5700008
    267 rdf:type schema:CreativeWork
    268 sg:pub.10.1038/sj.jid.5700288 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031551392
    269 https://doi.org/10.1038/sj.jid.5700288
    270 rdf:type schema:CreativeWork
    271 sg:pub.10.1038/sj.jid.5700351 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025912020
    272 https://doi.org/10.1038/sj.jid.5700351
    273 rdf:type schema:CreativeWork
    274 sg:pub.10.1038/sj.jid.5700864 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042780267
    275 https://doi.org/10.1038/sj.jid.5700864
    276 rdf:type schema:CreativeWork
    277 sg:pub.10.1038/sj.jid.5701224 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050314792
    278 https://doi.org/10.1038/sj.jid.5701224
    279 rdf:type schema:CreativeWork
    280 sg:pub.10.1038/sj.leu.2403610 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045490303
    281 https://doi.org/10.1038/sj.leu.2403610
    282 rdf:type schema:CreativeWork
    283 sg:pub.10.1038/sj.onc.1201293 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032154161
    284 https://doi.org/10.1038/sj.onc.1201293
    285 rdf:type schema:CreativeWork
    286 sg:pub.10.1038/sj.onc.1204380 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014799250
    287 https://doi.org/10.1038/sj.onc.1204380
    288 rdf:type schema:CreativeWork
    289 sg:pub.10.1038/sj.onc.1204383 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023622224
    290 https://doi.org/10.1038/sj.onc.1204383
    291 rdf:type schema:CreativeWork
    292 sg:pub.10.1038/sj.onc.1204389 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008288156
    293 https://doi.org/10.1038/sj.onc.1204389
    294 rdf:type schema:CreativeWork
    295 sg:pub.10.1046/j.1523-1747.2000.00149.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1037084362
    296 https://doi.org/10.1046/j.1523-1747.2000.00149.x
    297 rdf:type schema:CreativeWork
    298 sg:pub.10.1111/j.0022-202x.2004.23558.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1019480461
    299 https://doi.org/10.1111/j.0022-202x.2004.23558.x
    300 rdf:type schema:CreativeWork
    301 sg:pub.10.2165/00128071-200809010-00002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007344856
    302 https://doi.org/10.2165/00128071-200809010-00002
    303 rdf:type schema:CreativeWork
    304 https://app.dimensions.ai/details/publication/pub.1082392190 schema:CreativeWork
    305 https://app.dimensions.ai/details/publication/pub.1082396179 schema:CreativeWork
    306 https://app.dimensions.ai/details/publication/pub.1082853109 schema:CreativeWork
    307 https://app.dimensions.ai/details/publication/pub.1083224239 schema:CreativeWork
    308 https://doi.org/10.1002/eji.1830261009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000887836
    309 rdf:type schema:CreativeWork
    310 https://doi.org/10.1016/0307-4412(95)90183-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032893449
    311 rdf:type schema:CreativeWork
    312 https://doi.org/10.1016/j.ajhg.2013.09.015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019059577
    313 rdf:type schema:CreativeWork
    314 https://doi.org/10.1016/j.ajpath.2015.09.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043936187
    315 rdf:type schema:CreativeWork
    316 https://doi.org/10.1016/j.bbalip.2013.11.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030610095
    317 rdf:type schema:CreativeWork
    318 https://doi.org/10.1016/j.gpb.2015.04.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038856008
    319 rdf:type schema:CreativeWork
    320 https://doi.org/10.1016/j.humimm.2015.09.037 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023906190
    321 rdf:type schema:CreativeWork
    322 https://doi.org/10.1016/j.immuni.2013.11.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046034451
    323 rdf:type schema:CreativeWork
    324 https://doi.org/10.1016/j.jaci.2008.03.027 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041790193
    325 rdf:type schema:CreativeWork
    326 https://doi.org/10.1016/j.jaci.2016.10.026 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023365788
    327 rdf:type schema:CreativeWork
    328 https://doi.org/10.1016/j.mcn.2007.10.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002618507
    329 rdf:type schema:CreativeWork
    330 https://doi.org/10.1016/s0190-9622(94)70059-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013752398
    331 rdf:type schema:CreativeWork
    332 https://doi.org/10.1016/s0923-1811(02)00064-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012655275
    333 rdf:type schema:CreativeWork
    334 https://doi.org/10.1073/pnas.0602574103 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039439948
    335 rdf:type schema:CreativeWork
    336 https://doi.org/10.1074/jbc.271.39.24105 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001985379
    337 rdf:type schema:CreativeWork
    338 https://doi.org/10.1074/jbc.273.21.12901 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013460825
    339 rdf:type schema:CreativeWork
    340 https://doi.org/10.1074/jbc.m110.165704 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003667618
    341 rdf:type schema:CreativeWork
    342 https://doi.org/10.1080/02699050500284218 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041309884
    343 rdf:type schema:CreativeWork
    344 https://doi.org/10.1086/504272 schema:sameAs https://app.dimensions.ai/details/publication/pub.1058784213
    345 rdf:type schema:CreativeWork
    346 https://doi.org/10.1093/bioinformatics/btp120 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012425816
    347 rdf:type schema:CreativeWork
    348 https://doi.org/10.1093/bioinformatics/btp616 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023247882
    349 rdf:type schema:CreativeWork
    350 https://doi.org/10.1093/nar/gkl842 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008035809
    351 rdf:type schema:CreativeWork
    352 https://doi.org/10.1096/fj.00-0908fje schema:sameAs https://app.dimensions.ai/details/publication/pub.1040853959
    353 rdf:type schema:CreativeWork
    354 https://doi.org/10.1096/fj.02-0664fje schema:sameAs https://app.dimensions.ai/details/publication/pub.1030577273
    355 rdf:type schema:CreativeWork
    356 https://doi.org/10.1098/rsfs.2012.0090 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004569383
    357 rdf:type schema:CreativeWork
    358 https://doi.org/10.1101/sqb.2008.73.032 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029612929
    359 rdf:type schema:CreativeWork
    360 https://doi.org/10.1111/j.0906-6705.2005.00317.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1005505918
    361 rdf:type schema:CreativeWork
    362 https://doi.org/10.1111/j.1365-2133.2007.07986.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1014375133
    363 rdf:type schema:CreativeWork
    364 https://doi.org/10.1111/j.1600-0625.2012.01571.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1002417566
    365 rdf:type schema:CreativeWork
    366 https://doi.org/10.1111/j.1600-065x.2011.01027.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1021464207
    367 rdf:type schema:CreativeWork
    368 https://doi.org/10.1128/mcb.24.18.8167-8183.2004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035248096
    369 rdf:type schema:CreativeWork
    370 https://doi.org/10.1146/annurev.cellbio.23.090506.123357 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050750066
    371 rdf:type schema:CreativeWork
    372 https://doi.org/10.1146/annurev.immunol.20.091301.131133 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039092091
    373 rdf:type schema:CreativeWork
    374 https://doi.org/10.1155/2010/535612 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027884044
    375 rdf:type schema:CreativeWork
    376 https://doi.org/10.1155/2013/537028 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040482056
    377 rdf:type schema:CreativeWork
    378 https://doi.org/10.1155/2014/630797 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008158503
    379 rdf:type schema:CreativeWork
    380 https://doi.org/10.1155/2014/696415 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046602943
    381 rdf:type schema:CreativeWork
    382 https://doi.org/10.1159/000078582 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013862530
    383 rdf:type schema:CreativeWork
    384 https://doi.org/10.1172/jci82887 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016706599
    385 rdf:type schema:CreativeWork
    386 https://doi.org/10.1177/002215540305100513 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036040183
    387 rdf:type schema:CreativeWork
    388 https://doi.org/10.1182/blood-2002-01-0073 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005962923
    389 rdf:type schema:CreativeWork
    390 https://doi.org/10.1371/journal.pone.0040343 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031431218
    391 rdf:type schema:CreativeWork
    392 https://doi.org/10.1371/journal.pone.0072783 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009384914
    393 rdf:type schema:CreativeWork
    394 https://doi.org/10.2174/156800907780809714 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069190810
    395 rdf:type schema:CreativeWork
    396 https://doi.org/10.3389/fimmu.2014.00058 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007667435
    397 rdf:type schema:CreativeWork
    398 https://doi.org/10.4049/jimmunol.174.8.4870 schema:sameAs https://app.dimensions.ai/details/publication/pub.1077034555
    399 rdf:type schema:CreativeWork
    400 https://www.grid.ac/institutes/grid.143643.7 schema:alternateName Tokyo University of Science
    401 schema:name Division of Molecular Pathology, Research Institute for Biomedical Science, Tokyo University of Science, Tokyo, Japan
    402 RIKEN-IMS, Laboratory for Cytokine Regulation, Yokohama, Japan
    403 rdf:type schema:Organization
    404 https://www.grid.ac/institutes/grid.250464.1 schema:alternateName Okinawa Institute of Science and Technology
    405 schema:name Okinawa Institute of Science and Technology, Okinawa, Japan
    406 RIKEN-IMS, Laboratory for Disease Systems Modeling, Yokohama, Japan
    407 Sony Computer Science Laboratories, Inc, Tokyo, Japan
    408 The Systems Biology Institute, Tokyo, Japan
    409 rdf:type schema:Organization
    410 https://www.grid.ac/institutes/grid.452725.3 schema:alternateName Sony Computer Science Laboratories
    411 schema:name RIKEN-IMS, Laboratory for Disease Systems Modeling, Yokohama, Japan
    412 Sony Computer Science Laboratories, Inc, Tokyo, Japan
    413 rdf:type schema:Organization
    414 https://www.grid.ac/institutes/grid.452864.9 schema:alternateName Systems Biology Institute
    415 schema:name RIKEN-IMS, Laboratory for Disease Systems Modeling, Yokohama, Japan
    416 The Systems Biology Institute, Tokyo, Japan
    417 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...