Immunohistochemical Detection of Propionibacterium acnes in the Retinal Granulomas in Patients with Ocular Sarcoidosis View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-11-09

AUTHORS

Kenji Nagata, Yoshinobu Eishi, Keisuke Uchida, Kazuhito Yoneda, Hiroki Hatanaka, Toru Yasuhara, Maho Nagata, Chie Sotozono, Shigeru Kinoshita

ABSTRACT

The etiology of sarcoidosis is still obscure; however, Mycobacteria and Propionibacterium acnes are considered the most implicated etiological agent for sarcoidosis. To investigate whether P. acnes is an etiological agent for sarcoid uveitis, we analyzed the frequency of P. acnes detected within the biopsied retinas from patients with ocular sarcoidosis by immunohistochemistry with a P. acnes-specific monoclonal antibody (PAB antibody). Eleven patients (12 eyes) with sarcoid uveitis were enrolled in this study. Eight patients with rhegmatogenous retinal detachment, two patients with non-sarcoid uveitis, and two patients with vitreoretinal lymphoma were enrolled as controls. In the sarcoidosis group, granulomas were mainly observed in the inner retinal layer filled with CD4+ cells and CD68+ cells, indicating the Th1 immune response. P. acnes, identified as round bodies that reacted with the PAB antibody, were present in 10/12 samples (83%) from 9/11 patients (82%) with sarcoidosis. These round bodies were scattered within the retinal granulomas mainly in the inner retinal layer. In the control group, no round bodies were detected. Our results suggested that P. acnes could be associated with sarcoid uveitis. We hypothesize that sarcoid granulomas may be formed by a Th1 immune response to P. acnes hematogenously transmitted to the retina. More... »

PAGES

15226

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41598-017-15710-0

DOI

http://dx.doi.org/10.1038/s41598-017-15710-0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1092523075

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29123243


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Immunology", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Biopsy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Case-Control Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gram-Positive Bacterial Infections", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Granuloma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Immunohistochemistry", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Propionibacterium acnes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prospective Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Retina", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Sarcoidosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Uveitis", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Ophthalmology, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Hirokoji-agaru, Kawaramachi-dori, 602-0841, Kamigyo-ku, Kyoto, Japan", 
          "id": "http://www.grid.ac/institutes/grid.272458.e", 
          "name": [
            "Department of Ophthalmology, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Hirokoji-agaru, Kawaramachi-dori, 602-0841, Kamigyo-ku, Kyoto, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nagata", 
        "givenName": "Kenji", 
        "id": "sg:person.01012673202.27", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01012673202.27"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Human Pathology, Tokyo Medical and Dental University, 1-5-45 Yushima, 113-8510, Bunkyo-ku, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.265073.5", 
          "name": [
            "Department of Human Pathology, Tokyo Medical and Dental University, 1-5-45 Yushima, 113-8510, Bunkyo-ku, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Eishi", 
        "givenName": "Yoshinobu", 
        "id": "sg:person.01242554143.18", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01242554143.18"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Human Pathology, Tokyo Medical and Dental University, 1-5-45 Yushima, 113-8510, Bunkyo-ku, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.265073.5", 
          "name": [
            "Department of Human Pathology, Tokyo Medical and Dental University, 1-5-45 Yushima, 113-8510, Bunkyo-ku, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Uchida", 
        "givenName": "Keisuke", 
        "id": "sg:person.01147510603.78", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01147510603.78"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Ophthalmology, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Hirokoji-agaru, Kawaramachi-dori, 602-0841, Kamigyo-ku, Kyoto, Japan", 
          "id": "http://www.grid.ac/institutes/grid.272458.e", 
          "name": [
            "Department of Ophthalmology, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Hirokoji-agaru, Kawaramachi-dori, 602-0841, Kamigyo-ku, Kyoto, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yoneda", 
        "givenName": "Kazuhito", 
        "id": "sg:person.01213723655.53", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01213723655.53"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Ophthalmology, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Hirokoji-agaru, Kawaramachi-dori, 602-0841, Kamigyo-ku, Kyoto, Japan", 
          "id": "http://www.grid.ac/institutes/grid.272458.e", 
          "name": [
            "Department of Ophthalmology, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Hirokoji-agaru, Kawaramachi-dori, 602-0841, Kamigyo-ku, Kyoto, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hatanaka", 
        "givenName": "Hiroki", 
        "id": "sg:person.0722041150.58", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0722041150.58"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Ophthalmology, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Hirokoji-agaru, Kawaramachi-dori, 602-0841, Kamigyo-ku, Kyoto, Japan", 
          "id": "http://www.grid.ac/institutes/grid.272458.e", 
          "name": [
            "Department of Ophthalmology, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Hirokoji-agaru, Kawaramachi-dori, 602-0841, Kamigyo-ku, Kyoto, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yasuhara", 
        "givenName": "Toru", 
        "id": "sg:person.0642762510.53", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0642762510.53"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Ophthalmology, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Hirokoji-agaru, Kawaramachi-dori, 602-0841, Kamigyo-ku, Kyoto, Japan", 
          "id": "http://www.grid.ac/institutes/grid.272458.e", 
          "name": [
            "Department of Ophthalmology, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Hirokoji-agaru, Kawaramachi-dori, 602-0841, Kamigyo-ku, Kyoto, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nagata", 
        "givenName": "Maho", 
        "id": "sg:person.01014647645.64", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01014647645.64"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Ophthalmology, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Hirokoji-agaru, Kawaramachi-dori, 602-0841, Kamigyo-ku, Kyoto, Japan", 
          "id": "http://www.grid.ac/institutes/grid.272458.e", 
          "name": [
            "Department of Ophthalmology, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Hirokoji-agaru, Kawaramachi-dori, 602-0841, Kamigyo-ku, Kyoto, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sotozono", 
        "givenName": "Chie", 
        "id": "sg:person.0624777723.12", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0624777723.12"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of frontier medical science and technology for ophthalmology, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Hirokoji-agaru, Kawaramachi-dori, 602-0841, Kamigyo-ku, Kyoto, Japan", 
          "id": "http://www.grid.ac/institutes/grid.272458.e", 
          "name": [
            "Department of frontier medical science and technology for ophthalmology, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Hirokoji-agaru, Kawaramachi-dori, 602-0841, Kamigyo-ku, Kyoto, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kinoshita", 
        "givenName": "Shigeru", 
        "id": "sg:person.01016754101.20", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01016754101.20"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1023/b:anto.0000024911.67625.27", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048268388", 
          "https://doi.org/10.1023/b:anto.0000024911.67625.27"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/modpathol.2012.80", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021263719", 
          "https://doi.org/10.1038/modpathol.2012.80"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10875-012-9700-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033776945", 
          "https://doi.org/10.1007/s10875-012-9700-5"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2017-11-09", 
    "datePublishedReg": "2017-11-09", 
    "description": "The etiology of sarcoidosis is still obscure; however, Mycobacteria and Propionibacterium acnes are considered the most implicated etiological agent for sarcoidosis. To investigate whether P. acnes is an etiological agent for sarcoid uveitis, we analyzed the frequency of P. acnes detected within the biopsied retinas from patients with ocular sarcoidosis by immunohistochemistry with a P. acnes-specific monoclonal antibody (PAB antibody). Eleven patients (12 eyes) with sarcoid uveitis were enrolled in this study. Eight patients with rhegmatogenous retinal detachment, two patients with non-sarcoid uveitis, and two patients with vitreoretinal lymphoma were enrolled as controls. In the sarcoidosis group, granulomas were mainly observed in the inner retinal layer filled with CD4+ cells and CD68+ cells, indicating the Th1 immune response. P. acnes, identified as round bodies that reacted with the PAB antibody, were present in 10/12 samples (83%) from 9/11 patients (82%) with sarcoidosis. These round bodies were scattered within the retinal granulomas mainly in the inner retinal layer. In the control group, no round bodies were detected. Our results suggested that P. acnes could be associated with sarcoid uveitis. We hypothesize that sarcoid granulomas may be formed by a Th1 immune response to P. acnes hematogenously transmitted to the retina.", 
    "genre": "article", 
    "id": "sg:pub.10.1038/s41598-017-15710-0", 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.6842400", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1045337", 
        "issn": [
          "2045-2322"
        ], 
        "name": "Scientific Reports", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "7"
      }
    ], 
    "keywords": [
      "Th1 immune response", 
      "inner retinal layers", 
      "sarcoid uveitis", 
      "P. acnes", 
      "retinal granuloma", 
      "ocular sarcoidosis", 
      "immune response", 
      "retinal layers", 
      "P. acnes-specific monoclonal antibody", 
      "Propionibacterium acnes", 
      "etiological agent", 
      "rhegmatogenous retinal detachment", 
      "etiology of sarcoidosis", 
      "PAB antibody", 
      "vitreoretinal lymphoma", 
      "retinal detachment", 
      "sarcoidosis group", 
      "sarcoidosis", 
      "uveitis", 
      "patients", 
      "immunohistochemical detection", 
      "control group", 
      "granulomas", 
      "acne", 
      "monoclonal antibodies", 
      "round bodies", 
      "retina", 
      "antibodies", 
      "CD4", 
      "cells", 
      "CD68", 
      "lymphoma", 
      "group", 
      "etiology", 
      "immunohistochemistry", 
      "agents", 
      "response", 
      "mycobacteria", 
      "body", 
      "detachment", 
      "control", 
      "study", 
      "frequency", 
      "samples", 
      "detection", 
      "results", 
      "layer"
    ], 
    "name": "Immunohistochemical Detection of Propionibacterium acnes in the Retinal Granulomas in Patients with Ocular Sarcoidosis", 
    "pagination": "15226", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1092523075"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/s41598-017-15710-0"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "29123243"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/s41598-017-15710-0", 
      "https://app.dimensions.ai/details/publication/pub.1092523075"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-08-04T17:06", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220804/entities/gbq_results/article/article_751.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1038/s41598-017-15710-0"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41598-017-15710-0'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41598-017-15710-0'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41598-017-15710-0'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41598-017-15710-0'


 

This table displays all metadata directly associated to this object as RDF triples.

234 TRIPLES      21 PREDICATES      88 URIs      77 LITERALS      20 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/s41598-017-15710-0 schema:about N10ac2777f60e4905ac56a39fa060965e
2 N3d0b37364edb42d38381e832dea262ae
3 N5be1f9364be5438bb1624b2549c7708d
4 N6adfa8b786924f2fb5fd04f93632e4e1
5 N72290e2c9b4c44b2936fc97623134af0
6 N97d7ee1fb065443a80203165f8e40c3c
7 N99f2566e10284ac0bd24a67b7d90e548
8 N9be2a641aa7c437191a1e1df3674f875
9 N9c153b911e394fa48f2bb5a3db6608ef
10 Nb548f9ea594a4408af0c1f191f3ce424
11 Nc8686a297aba490f87c41e99b8fd31ca
12 Ne49c47d4d34a4c39818c0ff7df3b9ccf
13 Neac163dca8e14cb6bb6c79cdb260ecc6
14 anzsrc-for:11
15 anzsrc-for:1107
16 schema:author N48a59a135a384f7ca9612ffd915096ad
17 schema:citation sg:pub.10.1007/s10875-012-9700-5
18 sg:pub.10.1023/b:anto.0000024911.67625.27
19 sg:pub.10.1038/modpathol.2012.80
20 schema:datePublished 2017-11-09
21 schema:datePublishedReg 2017-11-09
22 schema:description The etiology of sarcoidosis is still obscure; however, Mycobacteria and Propionibacterium acnes are considered the most implicated etiological agent for sarcoidosis. To investigate whether P. acnes is an etiological agent for sarcoid uveitis, we analyzed the frequency of P. acnes detected within the biopsied retinas from patients with ocular sarcoidosis by immunohistochemistry with a P. acnes-specific monoclonal antibody (PAB antibody). Eleven patients (12 eyes) with sarcoid uveitis were enrolled in this study. Eight patients with rhegmatogenous retinal detachment, two patients with non-sarcoid uveitis, and two patients with vitreoretinal lymphoma were enrolled as controls. In the sarcoidosis group, granulomas were mainly observed in the inner retinal layer filled with CD4+ cells and CD68+ cells, indicating the Th1 immune response. P. acnes, identified as round bodies that reacted with the PAB antibody, were present in 10/12 samples (83%) from 9/11 patients (82%) with sarcoidosis. These round bodies were scattered within the retinal granulomas mainly in the inner retinal layer. In the control group, no round bodies were detected. Our results suggested that P. acnes could be associated with sarcoid uveitis. We hypothesize that sarcoid granulomas may be formed by a Th1 immune response to P. acnes hematogenously transmitted to the retina.
23 schema:genre article
24 schema:isAccessibleForFree true
25 schema:isPartOf N1d0bb670796a4f128209253d3d367b40
26 Nb24ba6e58f7244568a9871833a5b1bfd
27 sg:journal.1045337
28 schema:keywords CD4
29 CD68
30 P. acnes
31 P. acnes-specific monoclonal antibody
32 PAB antibody
33 Propionibacterium acnes
34 Th1 immune response
35 acne
36 agents
37 antibodies
38 body
39 cells
40 control
41 control group
42 detachment
43 detection
44 etiological agent
45 etiology
46 etiology of sarcoidosis
47 frequency
48 granulomas
49 group
50 immune response
51 immunohistochemical detection
52 immunohistochemistry
53 inner retinal layers
54 layer
55 lymphoma
56 monoclonal antibodies
57 mycobacteria
58 ocular sarcoidosis
59 patients
60 response
61 results
62 retina
63 retinal detachment
64 retinal granuloma
65 retinal layers
66 rhegmatogenous retinal detachment
67 round bodies
68 samples
69 sarcoid uveitis
70 sarcoidosis
71 sarcoidosis group
72 study
73 uveitis
74 vitreoretinal lymphoma
75 schema:name Immunohistochemical Detection of Propionibacterium acnes in the Retinal Granulomas in Patients with Ocular Sarcoidosis
76 schema:pagination 15226
77 schema:productId N880ebd4e70644adb903144566703f427
78 N8890a87736c74419867811cb6ec09595
79 Nf4bd20a360fd43b6b2caeb2abf91ef02
80 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092523075
81 https://doi.org/10.1038/s41598-017-15710-0
82 schema:sdDatePublished 2022-08-04T17:06
83 schema:sdLicense https://scigraph.springernature.com/explorer/license/
84 schema:sdPublisher N85061aa0e0cf4f9a8a8c7d9be743892f
85 schema:url https://doi.org/10.1038/s41598-017-15710-0
86 sgo:license sg:explorer/license/
87 sgo:sdDataset articles
88 rdf:type schema:ScholarlyArticle
89 N0ac0905c6a7448a38614a1cb7c31641c rdf:first sg:person.01147510603.78
90 rdf:rest N0b8c332178df4963b25c7bf8cb90ecc7
91 N0b8c332178df4963b25c7bf8cb90ecc7 rdf:first sg:person.01213723655.53
92 rdf:rest Nd6f98aebbf784221bdd2f90d94da6ff9
93 N10ac2777f60e4905ac56a39fa060965e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
94 schema:name Case-Control Studies
95 rdf:type schema:DefinedTerm
96 N1d0bb670796a4f128209253d3d367b40 schema:volumeNumber 7
97 rdf:type schema:PublicationVolume
98 N27013342c3724f4b8d07b49a5eef5953 rdf:first sg:person.01014647645.64
99 rdf:rest N56f723820fbc4c7992648298f678fec3
100 N3d0b37364edb42d38381e832dea262ae schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
101 schema:name Aged
102 rdf:type schema:DefinedTerm
103 N48a59a135a384f7ca9612ffd915096ad rdf:first sg:person.01012673202.27
104 rdf:rest Nefb270f32fd94c208ffc2c54c8ea90dd
105 N56f723820fbc4c7992648298f678fec3 rdf:first sg:person.0624777723.12
106 rdf:rest Nbaa9532da98b4caaab66bc381173f2a8
107 N5be1f9364be5438bb1624b2549c7708d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
108 schema:name Granuloma
109 rdf:type schema:DefinedTerm
110 N6adfa8b786924f2fb5fd04f93632e4e1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
111 schema:name Prospective Studies
112 rdf:type schema:DefinedTerm
113 N72290e2c9b4c44b2936fc97623134af0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
114 schema:name Middle Aged
115 rdf:type schema:DefinedTerm
116 N85061aa0e0cf4f9a8a8c7d9be743892f schema:name Springer Nature - SN SciGraph project
117 rdf:type schema:Organization
118 N880ebd4e70644adb903144566703f427 schema:name dimensions_id
119 schema:value pub.1092523075
120 rdf:type schema:PropertyValue
121 N8890a87736c74419867811cb6ec09595 schema:name doi
122 schema:value 10.1038/s41598-017-15710-0
123 rdf:type schema:PropertyValue
124 N97d7ee1fb065443a80203165f8e40c3c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name Retina
126 rdf:type schema:DefinedTerm
127 N99f2566e10284ac0bd24a67b7d90e548 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
128 schema:name Humans
129 rdf:type schema:DefinedTerm
130 N9be2a641aa7c437191a1e1df3674f875 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
131 schema:name Sarcoidosis
132 rdf:type schema:DefinedTerm
133 N9c153b911e394fa48f2bb5a3db6608ef schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Propionibacterium acnes
135 rdf:type schema:DefinedTerm
136 Nb24ba6e58f7244568a9871833a5b1bfd schema:issueNumber 1
137 rdf:type schema:PublicationIssue
138 Nb548f9ea594a4408af0c1f191f3ce424 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
139 schema:name Immunohistochemistry
140 rdf:type schema:DefinedTerm
141 Nbaa9532da98b4caaab66bc381173f2a8 rdf:first sg:person.01016754101.20
142 rdf:rest rdf:nil
143 Nc8686a297aba490f87c41e99b8fd31ca schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
144 schema:name Biopsy
145 rdf:type schema:DefinedTerm
146 Nd6f98aebbf784221bdd2f90d94da6ff9 rdf:first sg:person.0722041150.58
147 rdf:rest Nf1e98a9b724d4817be10890a1ec47625
148 Ne49c47d4d34a4c39818c0ff7df3b9ccf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
149 schema:name Uveitis
150 rdf:type schema:DefinedTerm
151 Neac163dca8e14cb6bb6c79cdb260ecc6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
152 schema:name Gram-Positive Bacterial Infections
153 rdf:type schema:DefinedTerm
154 Nefb270f32fd94c208ffc2c54c8ea90dd rdf:first sg:person.01242554143.18
155 rdf:rest N0ac0905c6a7448a38614a1cb7c31641c
156 Nf1e98a9b724d4817be10890a1ec47625 rdf:first sg:person.0642762510.53
157 rdf:rest N27013342c3724f4b8d07b49a5eef5953
158 Nf4bd20a360fd43b6b2caeb2abf91ef02 schema:name pubmed_id
159 schema:value 29123243
160 rdf:type schema:PropertyValue
161 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
162 schema:name Medical and Health Sciences
163 rdf:type schema:DefinedTerm
164 anzsrc-for:1107 schema:inDefinedTermSet anzsrc-for:
165 schema:name Immunology
166 rdf:type schema:DefinedTerm
167 sg:grant.6842400 http://pending.schema.org/fundedItem sg:pub.10.1038/s41598-017-15710-0
168 rdf:type schema:MonetaryGrant
169 sg:journal.1045337 schema:issn 2045-2322
170 schema:name Scientific Reports
171 schema:publisher Springer Nature
172 rdf:type schema:Periodical
173 sg:person.01012673202.27 schema:affiliation grid-institutes:grid.272458.e
174 schema:familyName Nagata
175 schema:givenName Kenji
176 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01012673202.27
177 rdf:type schema:Person
178 sg:person.01014647645.64 schema:affiliation grid-institutes:grid.272458.e
179 schema:familyName Nagata
180 schema:givenName Maho
181 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01014647645.64
182 rdf:type schema:Person
183 sg:person.01016754101.20 schema:affiliation grid-institutes:grid.272458.e
184 schema:familyName Kinoshita
185 schema:givenName Shigeru
186 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01016754101.20
187 rdf:type schema:Person
188 sg:person.01147510603.78 schema:affiliation grid-institutes:grid.265073.5
189 schema:familyName Uchida
190 schema:givenName Keisuke
191 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01147510603.78
192 rdf:type schema:Person
193 sg:person.01213723655.53 schema:affiliation grid-institutes:grid.272458.e
194 schema:familyName Yoneda
195 schema:givenName Kazuhito
196 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01213723655.53
197 rdf:type schema:Person
198 sg:person.01242554143.18 schema:affiliation grid-institutes:grid.265073.5
199 schema:familyName Eishi
200 schema:givenName Yoshinobu
201 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01242554143.18
202 rdf:type schema:Person
203 sg:person.0624777723.12 schema:affiliation grid-institutes:grid.272458.e
204 schema:familyName Sotozono
205 schema:givenName Chie
206 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0624777723.12
207 rdf:type schema:Person
208 sg:person.0642762510.53 schema:affiliation grid-institutes:grid.272458.e
209 schema:familyName Yasuhara
210 schema:givenName Toru
211 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0642762510.53
212 rdf:type schema:Person
213 sg:person.0722041150.58 schema:affiliation grid-institutes:grid.272458.e
214 schema:familyName Hatanaka
215 schema:givenName Hiroki
216 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0722041150.58
217 rdf:type schema:Person
218 sg:pub.10.1007/s10875-012-9700-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033776945
219 https://doi.org/10.1007/s10875-012-9700-5
220 rdf:type schema:CreativeWork
221 sg:pub.10.1023/b:anto.0000024911.67625.27 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048268388
222 https://doi.org/10.1023/b:anto.0000024911.67625.27
223 rdf:type schema:CreativeWork
224 sg:pub.10.1038/modpathol.2012.80 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021263719
225 https://doi.org/10.1038/modpathol.2012.80
226 rdf:type schema:CreativeWork
227 grid-institutes:grid.265073.5 schema:alternateName Department of Human Pathology, Tokyo Medical and Dental University, 1-5-45 Yushima, 113-8510, Bunkyo-ku, Tokyo, Japan
228 schema:name Department of Human Pathology, Tokyo Medical and Dental University, 1-5-45 Yushima, 113-8510, Bunkyo-ku, Tokyo, Japan
229 rdf:type schema:Organization
230 grid-institutes:grid.272458.e schema:alternateName Department of Ophthalmology, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Hirokoji-agaru, Kawaramachi-dori, 602-0841, Kamigyo-ku, Kyoto, Japan
231 Department of frontier medical science and technology for ophthalmology, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Hirokoji-agaru, Kawaramachi-dori, 602-0841, Kamigyo-ku, Kyoto, Japan
232 schema:name Department of Ophthalmology, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Hirokoji-agaru, Kawaramachi-dori, 602-0841, Kamigyo-ku, Kyoto, Japan
233 Department of frontier medical science and technology for ophthalmology, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Hirokoji-agaru, Kawaramachi-dori, 602-0841, Kamigyo-ku, Kyoto, Japan
234 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...