Clinical and immunopathological findings during long term follow-up in Leishmania infantum experimentally infected dogs View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-12

AUTHORS

Melissa Moura Costa Abbehusen, Valter dos Anjos Almeida, Manuela da S. Solcà, Laís da Silva Pereira, Dirceu Joaquim Costa, Leonardo Gil-Santana, Patricia Torres Bozza, Deborah Bittencourt Moté Fraga, Patrícia Sampaio Tavares Veras, Washington Luis Conrado dos-Santos, Bruno Bezerril Andrade, Claudia Ida Brodskyn

ABSTRACT

Canine Visceral Leishmaniasis (CVL) is caused by Leishmania infantum, which in the New World is transmitted by Lutzomyia longipalpis. While prospective clinical and immunological assessments of dogs experimentally challenged with L. infantum have been previously reported over a relatively short follow-up period, the long-term characterization of infected animals has not been performed to date. We evaluated dogs in a subclinical state for six years following experimental infection with L. infantum and Lu. longipalpis saliva, via an intradermal route, to characterize clinical, parasitological and immunological parameters arising from L. infantum experimental infection. We also assess these parameters in a group of naturally infected animals. The immune profiles of the experimentally and naturally infected animals exhibited increases of IFN-γ, IL-6 and IL-18, and decreases in TNF, IL-2, IL-8 and CXCL1, compared to controls. Our results indicate that over a six-year follow-up post-challenge, subclinically infected dogs presented low CVL clinical scores despite the persistence of Leishmania parasites in the lymph nodes, spleen and skin. Similarities observed among immune profiles in the context of experimental and natural infection seem to suggest that an enduring activation of the host immune response may lead to the control of parasite growth, thereby limiting disease severity. More... »

PAGES

15914

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41598-017-15651-8

DOI

http://dx.doi.org/10.1038/s41598-017-15651-8

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1092714972

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29162847


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