Ontology type: schema:ScholarlyArticle Open Access: True
2017-12
AUTHORSTetsuya Shiuchi, Chitoku Toda, Shiki Okamoto, Eulalia A. Coutinho, Kumiko Saito, Shinji Miura, Osamu Ezaki, Yasuhiko Minokoshi
ABSTRACTLeptin increases glucose uptake and fatty acid oxidation (FAO) in red-type skeletal muscle. However, the mechanism remains unknown. We have investigated the role of β2-adrenergic receptor (AR), the major β-AR isoform in skeletal muscle, and AMPK in leptin-induced muscle glucose uptake of mice. Leptin injection into the ventromedial hypothalamus (VMH) increased 2-deoxy-D-glucose (2DG) uptake in red-type skeletal muscle in wild-type (WT) mice accompanied with increased phosphorylation of the insulin receptor (IR) and Akt as well as of norepinephrine (NE) turnover in the muscle. Leptin-induced 2DG uptake was not observed in β-AR-deficient (β-less) mice despite that AMPK phosphorylation was increased in the muscle. Forced expression of β2-AR in the unilateral hind limb of β-less mice restored leptin-induced glucose uptake and enhancement of insulin signalling in red-type skeletal muscle. Leptin increased 2DG uptake and enhanced insulin signalling in red-type skeletal muscle of mice expressing a dominant negative form of AMPK (DN-AMPK) in skeletal muscle. Thus, leptin increases glucose uptake and enhances insulin signalling in red-type skeletal muscle via activation of sympathetic nerves and β2-AR in muscle and in a manner independent of muscle AMPK. More... »
PAGES15141
http://scigraph.springernature.com/pub.10.1038/s41598-017-15548-6
DOIhttp://dx.doi.org/10.1038/s41598-017-15548-6
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1092523053
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/29123236
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Clinical Sciences",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "University of Tokushima",
"id": "https://www.grid.ac/institutes/grid.267335.6",
"name": [
"Division of Endocrinology and Metabolism, Department of Homeostatic Regulation, National Institute for Physiological Sciences, National Institutes of Natural Sciences, 444-8585, Okazaki, Aichi, Japan",
"Department of Physiological Sciences, School of Life Sciences, SOKENDAI (The Graduate University for Advanced Studies), 444-8585, Okazaki, Aichi, Japan",
"Department of Integrative Physiology, Institute of Biomedical Sciences, Tokushima University Graduate School, 770-8503, Tokushima, Japan"
],
"type": "Organization"
},
"familyName": "Shiuchi",
"givenName": "Tetsuya",
"id": "sg:person.01177055372.32",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01177055372.32"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Hokkaido University",
"id": "https://www.grid.ac/institutes/grid.39158.36",
"name": [
"Division of Endocrinology and Metabolism, Department of Homeostatic Regulation, National Institute for Physiological Sciences, National Institutes of Natural Sciences, 444-8585, Okazaki, Aichi, Japan",
"Laboratory of Biochemistry, Graduate School of Veterinary Medicine, Hokkaido University, 060-0818, Sapporo, Japan"
],
"type": "Organization"
},
"familyName": "Toda",
"givenName": "Chitoku",
"id": "sg:person.01344306306.40",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01344306306.40"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of the Ryukyus",
"id": "https://www.grid.ac/institutes/grid.267625.2",
"name": [
"Division of Endocrinology and Metabolism, Department of Homeostatic Regulation, National Institute for Physiological Sciences, National Institutes of Natural Sciences, 444-8585, Okazaki, Aichi, Japan",
"Department of Physiological Sciences, School of Life Sciences, SOKENDAI (The Graduate University for Advanced Studies), 444-8585, Okazaki, Aichi, Japan",
"Second Department of Internal Medicine (Endocrinology, Diabetes and Metabolism, Hematology, Rheumatology), Graduate School of Medicine, University of the Ryukyus, 903-0215, Okinawa, Japan"
],
"type": "Organization"
},
"familyName": "Okamoto",
"givenName": "Shiki",
"id": "sg:person.01316442265.38",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01316442265.38"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Otago",
"id": "https://www.grid.ac/institutes/grid.29980.3a",
"name": [
"Division of Endocrinology and Metabolism, Department of Homeostatic Regulation, National Institute for Physiological Sciences, National Institutes of Natural Sciences, 444-8585, Okazaki, Aichi, Japan",
"Department of Physiological Sciences, School of Life Sciences, SOKENDAI (The Graduate University for Advanced Studies), 444-8585, Okazaki, Aichi, Japan",
"Centre for Neuroendocrinology and Department of Physiology, School of Biomedical Sciences, University of Otago, 9054, Dunedin, New Zealand"
],
"type": "Organization"
},
"familyName": "Coutinho",
"givenName": "Eulalia A.",
"id": "sg:person.0756754674.19",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0756754674.19"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "National Institute for Physiological Sciences",
"id": "https://www.grid.ac/institutes/grid.467811.d",
"name": [
"Division of Endocrinology and Metabolism, Department of Homeostatic Regulation, National Institute for Physiological Sciences, National Institutes of Natural Sciences, 444-8585, Okazaki, Aichi, Japan"
],
"type": "Organization"
},
"familyName": "Saito",
"givenName": "Kumiko",
"id": "sg:person.01151213263.43",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01151213263.43"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "National Institute of Biomedical Innovation, Health and Nutrition",
"id": "https://www.grid.ac/institutes/grid.482562.f",
"name": [
"Nutritional Science Program, National Institute of Health and Nutrition, 162-8636, Tokyo, Japan",
"Laboratory of Nutritional Biochemistry, Graduate School of Nutritional and Environmental Sciences, University of Shizuoka, 422-8526, Shizuoka, Japan"
],
"type": "Organization"
},
"familyName": "Miura",
"givenName": "Shinji",
"id": "sg:person.0655505665.72",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0655505665.72"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Showa Women's University",
"id": "https://www.grid.ac/institutes/grid.412583.9",
"name": [
"Nutritional Science Program, National Institute of Health and Nutrition, 162-8636, Tokyo, Japan",
"Department of Human Health and Design, Showa Women\u2019s University, 154-8533, Tokyo, Japan"
],
"type": "Organization"
},
"familyName": "Ezaki",
"givenName": "Osamu",
"id": "sg:person.01336637665.95",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01336637665.95"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Graduate University For Advanced Studies",
"id": "https://www.grid.ac/institutes/grid.275033.0",
"name": [
"Division of Endocrinology and Metabolism, Department of Homeostatic Regulation, National Institute for Physiological Sciences, National Institutes of Natural Sciences, 444-8585, Okazaki, Aichi, Japan",
"Department of Physiological Sciences, School of Life Sciences, SOKENDAI (The Graduate University for Advanced Studies), 444-8585, Okazaki, Aichi, Japan"
],
"type": "Organization"
},
"familyName": "Minokoshi",
"givenName": "Yasuhiko",
"id": "sg:person.0600451377.68",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0600451377.68"
],
"type": "Person"
}
],
"citation": [
{
"id": "https://doi.org/10.1113/jphysiol.2006.108944",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1001462354"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1152/ajpendo.90259.2008",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1004094015"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1152/ajpendo.00455.2001",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1004661991"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/415339a",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1009350695",
"https://doi.org/10.1038/415339a"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/415339a",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1009350695",
"https://doi.org/10.1038/415339a"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1146/annurev.physiol.70.113006.100707",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1013104070"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.cmet.2009.09.013",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1014422910"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.2337/db07-1444",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1015004446"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1111/j.1471-4159.1977.tb10649.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1016554520"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.7554/elife.18206",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1016972058"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1096/fj.02-0991fje",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1018139838"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/0006-8993(89)90806-8",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1018371193"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/0006-8993(89)90806-8",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1018371193"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/43448",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1019690626",
"https://doi.org/10.1038/43448"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/43448",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1019690626",
"https://doi.org/10.1038/43448"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1152/ajpendo.90690.2008",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1020636499"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/0378-1119(91)90434-d",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1021517814"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/0378-1119(91)90434-d",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1021517814"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.2337/diabetes.54.12.3490",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1022310759"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1056/nejm200408053510623",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1023243003"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.2337/db12-1629",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1023489111"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1152/ajpendo.00400.2010",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1024661362"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1038/sj.bjp.0706626",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1026139874"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1038/sj.bjp.0706626",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1026139874"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1126/science.1073160",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1026205873"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1172/jci10842",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1027896398"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.cmet.2004.12.003",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1033736922"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1042/bj3630167",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1037901073"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1042/bj3630167",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1037901073"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1038/sj.bjp.0702605",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1040895604"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.2337/db13-1860",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1042145240"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.neuron.2005.12.021",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1042811765"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.2337/db09-0638",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1047395058"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/38717",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1047557472",
"https://doi.org/10.1038/38717"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/38717",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1047557472",
"https://doi.org/10.1038/38717"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s1097-2765(01)00251-9",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1048560997"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1073/pnas.1008025107",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1049147877"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1172/jci16567",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1051399457"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1152/physrev.00007.2010",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1052040370"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1042/0264-6021:3630167",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1056716088"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1152/japplphysiol.00017.2002",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1063197911"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1210/en.2008-0466",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1064249417"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1210/endo.142.2.7964",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1064284186"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.2337/diab.33.2.141",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1070734502"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.2337/diab.46.12.2040",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1070738060"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.2337/diabetes.46.12.2040",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1070743469"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.2337/diabetes.48.2.287",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1070744065"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.2337/diabetes.48.9.1706",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1070744267"
],
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1074815354",
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1152/ajpendo.1991.261.3.e298",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1077757825"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1152/ajpcell.1997.273.3.c1082",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1083154509"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1152/ajpendo.1998.275.6.e909",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1083357749"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1152/ajpendo.1998.275.6.e909",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1083357749"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.2337/db16-1344",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1090340832"
],
"type": "CreativeWork"
}
],
"datePublished": "2017-12",
"datePublishedReg": "2017-12-01",
"description": "Leptin increases glucose uptake and fatty acid oxidation (FAO) in red-type skeletal muscle. However, the mechanism remains unknown. We have investigated the role of \u03b22-adrenergic receptor (AR), the major \u03b2-AR isoform in skeletal muscle, and AMPK in leptin-induced muscle glucose uptake of mice. Leptin injection into the ventromedial hypothalamus (VMH) increased 2-deoxy-D-glucose (2DG) uptake in red-type skeletal muscle in wild-type (WT) mice accompanied with increased phosphorylation of the insulin receptor (IR) and Akt as well as of norepinephrine (NE) turnover in the muscle. Leptin-induced 2DG uptake was not observed in \u03b2-AR-deficient (\u03b2-less) mice despite that AMPK phosphorylation was increased in the muscle. Forced expression of \u03b22-AR in the unilateral hind limb of \u03b2-less mice restored leptin-induced glucose uptake and enhancement of insulin signalling in red-type skeletal muscle. Leptin increased 2DG uptake and enhanced insulin signalling in red-type skeletal muscle of mice expressing a dominant negative form of AMPK (DN-AMPK) in skeletal muscle. Thus, leptin increases glucose uptake and enhances insulin signalling in red-type skeletal muscle via activation of sympathetic nerves and \u03b22-AR in muscle and in a manner independent of muscle AMPK.",
"genre": "research_article",
"id": "sg:pub.10.1038/s41598-017-15548-6",
"inLanguage": [
"en"
],
"isAccessibleForFree": true,
"isFundedItemOf": [
{
"id": "sg:grant.5988323",
"type": "MonetaryGrant"
},
{
"id": "sg:grant.5892345",
"type": "MonetaryGrant"
},
{
"id": "sg:grant.5966414",
"type": "MonetaryGrant"
},
{
"id": "sg:grant.6084042",
"type": "MonetaryGrant"
},
{
"id": "sg:grant.5941078",
"type": "MonetaryGrant"
},
{
"id": "sg:grant.5868215",
"type": "MonetaryGrant"
},
{
"id": "sg:grant.6013579",
"type": "MonetaryGrant"
},
{
"id": "sg:grant.6035021",
"type": "MonetaryGrant"
}
],
"isPartOf": [
{
"id": "sg:journal.1045337",
"issn": [
"2045-2322"
],
"name": "Scientific Reports",
"type": "Periodical"
},
{
"issueNumber": "1",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "7"
}
],
"name": "Induction of glucose uptake in skeletal muscle by central leptin is mediated by muscle \u03b22-adrenergic receptor but not by AMPK",
"pagination": "15141",
"productId": [
{
"name": "readcube_id",
"type": "PropertyValue",
"value": [
"2b988640f7e3215db74a4b8234eda235db4b62c9251b36b754636bca6673a72d"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"29123236"
]
},
{
"name": "nlm_unique_id",
"type": "PropertyValue",
"value": [
"101563288"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1038/s41598-017-15548-6"
]
},
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1092523053"
]
}
],
"sameAs": [
"https://doi.org/10.1038/s41598-017-15548-6",
"https://app.dimensions.ai/details/publication/pub.1092523053"
],
"sdDataset": "articles",
"sdDatePublished": "2019-04-10T17:45",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8672_00000608.jsonl",
"type": "ScholarlyArticle",
"url": "https://www.nature.com/articles/s41598-017-15548-6"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41598-017-15548-6'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41598-017-15548-6'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41598-017-15548-6'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41598-017-15548-6'
This table displays all metadata directly associated to this object as RDF triples.
304 TRIPLES
21 PREDICATES
75 URIs
21 LITERALS
9 BLANK NODES