Ontology type: schema:ScholarlyArticle Open Access: True
2017-12
AUTHORSAparna Jakkampudi, Ramaiah Jangala, Ratnakar Reddy, Sasikala Mitnala, G. Venkat Rao, Rebala Pradeep, D. Nageshwar Reddy, Rupjyoti Talukdar
ABSTRACTClinical acute pancreatitis (AP) is marked by an early phase of systemic inflammatory response syndrome (SIRS) with multiorgan dysfunction (MODS), and a late phase characterized by sepsis with MODS. However, the mechanisms of acinar injury in human AP and the associated systemic inflammation are not clearly understood. This study, for the first time, evaluated the early interactions of bile acid induced human pancreatic acinar injury and the resulting cytokine response. We exposed freshly procured resected human pancreata to taurolithocolic acid (TLCS) and evaluated for acinar injury, cytokine release and interaction with peripheral blood mononuclear cells (PBMCs). We observed autophagy in acinar cells in response to TLCS exposure. There was also time-dependent release of IL-6, IL-8 and TNF-α from the injured acini that resulted in activation of PBMCs. We also observed that cytokines secreted by activated PBMCs resulted in acinar cell apoptosis and further cytokine release from them. Our data suggests that the earliest immune response in human AP originates within the acinar cell itself, which subsequently activates circulating PBMCs leading to SIRS. These findings need further detailed evaluation so that specific therapeutic targets to curb SIRS and resulting early adverse outcomes could be identified and tested. More... »
PAGES15276
http://scigraph.springernature.com/pub.10.1038/s41598-017-15479-2
DOIhttp://dx.doi.org/10.1038/s41598-017-15479-2
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1092558570
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/29127325
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Immunology",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "Department of Biotechnology",
"id": "https://www.grid.ac/institutes/grid.454774.1",
"name": [
"Wellcome DBT Labs., Division of Basic Sciences, Asian Healthcare Foundation, New Delhi, India"
],
"type": "Organization"
},
"familyName": "Jakkampudi",
"givenName": "Aparna",
"id": "sg:person.01064313532.50",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01064313532.50"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Biotechnology",
"id": "https://www.grid.ac/institutes/grid.454774.1",
"name": [
"Wellcome DBT Labs., Division of Basic Sciences, Asian Healthcare Foundation, New Delhi, India"
],
"type": "Organization"
},
"familyName": "Jangala",
"givenName": "Ramaiah",
"id": "sg:person.016243354771.41",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016243354771.41"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Biotechnology",
"id": "https://www.grid.ac/institutes/grid.454774.1",
"name": [
"Wellcome DBT Labs., Division of Basic Sciences, Asian Healthcare Foundation, New Delhi, India"
],
"type": "Organization"
},
"familyName": "Reddy",
"givenName": "Ratnakar",
"id": "sg:person.013664001627.97",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013664001627.97"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Biotechnology",
"id": "https://www.grid.ac/institutes/grid.454774.1",
"name": [
"Wellcome DBT Labs., Division of Basic Sciences, Asian Healthcare Foundation, New Delhi, India"
],
"type": "Organization"
},
"familyName": "Mitnala",
"givenName": "Sasikala",
"id": "sg:person.0652226620.04",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0652226620.04"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Asian Institute of Gastroenterology",
"id": "https://www.grid.ac/institutes/grid.410866.d",
"name": [
"Department of Surgical Gastroenterology, Asian Institute of Gastroenterology, Hyderabad, India"
],
"type": "Organization"
},
"familyName": "Rao",
"givenName": "G. Venkat",
"id": "sg:person.013242021052.43",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013242021052.43"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Asian Institute of Gastroenterology",
"id": "https://www.grid.ac/institutes/grid.410866.d",
"name": [
"Department of Surgical Gastroenterology, Asian Institute of Gastroenterology, Hyderabad, India"
],
"type": "Organization"
},
"familyName": "Pradeep",
"givenName": "Rebala",
"id": "sg:person.0700434364.60",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0700434364.60"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Asian Institute of Gastroenterology",
"id": "https://www.grid.ac/institutes/grid.410866.d",
"name": [
"Department of Medical Gastroenterology, Asian Institute of Gastroenterology, Hyderabad, India"
],
"type": "Organization"
},
"familyName": "Reddy",
"givenName": "D. Nageshwar",
"id": "sg:person.01026170275.76",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01026170275.76"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Asian Institute of Gastroenterology",
"id": "https://www.grid.ac/institutes/grid.410866.d",
"name": [
"Wellcome DBT Labs., Division of Basic Sciences, Asian Healthcare Foundation, New Delhi, India",
"Department of Medical Gastroenterology, Asian Institute of Gastroenterology, Hyderabad, India"
],
"type": "Organization"
},
"familyName": "Talukdar",
"givenName": "Rupjyoti",
"id": "sg:person.0762364577.65",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0762364577.65"
],
"type": "Person"
}
],
"citation": [
{
"id": "https://doi.org/10.1016/j.pan.2014.06.003",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1003574430"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.pan.2016.05.001",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1004712632"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1053/j.gastro.2009.04.003",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1004833307"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1053/j.gastro.2013.01.068",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1007896416"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1074/jbc.m113.471425",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1007957506"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1111/j.1572-0241.2007.01446.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1010303309",
"https://doi.org/10.1111/j.1572-0241.2007.01446.x"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1136/gutjnl-2011-300771",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1011559135"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1136/gutjnl-2012-304058",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1012113458"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1083/jcb.200712156",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1015056808"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1111/j.1432-1033.1988.tb13849.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1015083046"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1053/j.gastro.2011.08.033",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1015380426"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/cddis.2013.354",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1015784028",
"https://doi.org/10.1038/cddis.2013.354"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1053/j.gastro.2009.10.052",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1023281046"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1172/jci119714",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1023956344"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1136/gutjnl-2012-302779",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1025127467"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1074/jbc.m112.428896",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1025583731"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1053/j.gastro.2010.06.010",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1026099373"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.pan.2014.08.009",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1029206154"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1053/j.gastro.2008.05.026",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1029579842"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/00006676-200104000-00008",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1032795131"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/00006676-200104000-00008",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1032795131"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/mpa.0000000000000329",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1033862488"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/mpa.0000000000000329",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1033862488"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1152/ajpgi.00143.2014",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1034630216"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1053/j.gastro.2016.06.042",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1035056566"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1053/j.gastro.2016.06.042",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1035056566"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1172/jci38674",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1035107445"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1172/jci38674",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1035107445"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1053/j.gastro.2015.04.015",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1037805017"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1152/ajpgi.00546.2011",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1037925173"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1053/j.gastro.2005.05.005",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1038021480"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1111/j.1572-0241.2006.00856.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1038203297",
"https://doi.org/10.1111/j.1572-0241.2006.00856.x"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1159/000214191",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1040510133"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/00006676-199911000-00009",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1043107026"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/00006676-199911000-00009",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1043107026"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1186/1476-9255-9-1",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1047045898",
"https://doi.org/10.1186/1476-9255-9-1"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/0024-3205(75)90137-x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1050093992"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/0024-3205(75)90137-x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1050093992"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.gastro.2005.05.005",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1054735464"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.3748/wjg.v11.i34.5309",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1071363602"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1152/ajpgi.1998.275.2.g352",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1083299888"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1152/ajpgi.1998.275.2.g352",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1083299888"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1074/jbc.m117.777433",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1084153217"
],
"type": "CreativeWork"
}
],
"datePublished": "2017-12",
"datePublishedReg": "2017-12-01",
"description": "Clinical acute pancreatitis (AP) is marked by an early phase of systemic inflammatory response syndrome (SIRS) with multiorgan dysfunction (MODS), and a late phase characterized by sepsis with MODS. However, the mechanisms of acinar injury in human AP and the associated systemic inflammation are not clearly understood. This study, for the first time, evaluated the early interactions of bile acid induced human pancreatic acinar injury and the resulting cytokine response. We exposed freshly procured resected human pancreata to taurolithocolic acid (TLCS) and evaluated for acinar injury, cytokine release and interaction with peripheral blood mononuclear cells (PBMCs). We observed autophagy in acinar cells in response to TLCS exposure. There was also time-dependent release of IL-6, IL-8 and TNF-\u03b1 from the injured acini that resulted in activation of PBMCs. We also observed that cytokines secreted by activated PBMCs resulted in acinar cell apoptosis and further cytokine release from them. Our data suggests that the earliest immune response in human AP originates within the acinar cell itself, which subsequently activates circulating PBMCs leading to SIRS. These findings need further detailed evaluation so that specific therapeutic targets to curb SIRS and resulting early adverse outcomes could be identified and tested.",
"genre": "research_article",
"id": "sg:pub.10.1038/s41598-017-15479-2",
"inLanguage": [
"en"
],
"isAccessibleForFree": true,
"isPartOf": [
{
"id": "sg:journal.1045337",
"issn": [
"2045-2322"
],
"name": "Scientific Reports",
"type": "Periodical"
},
{
"issueNumber": "1",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "7"
}
],
"name": "Acinar injury and early cytokine response in human acute biliary pancreatitis",
"pagination": "15276",
"productId": [
{
"name": "readcube_id",
"type": "PropertyValue",
"value": [
"9d8c7920f8286e34f0c68a4223a23261e5d99c6ee13fa9739eb8f4ea9cfc8cf1"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"29127325"
]
},
{
"name": "nlm_unique_id",
"type": "PropertyValue",
"value": [
"101563288"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1038/s41598-017-15479-2"
]
},
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1092558570"
]
}
],
"sameAs": [
"https://doi.org/10.1038/s41598-017-15479-2",
"https://app.dimensions.ai/details/publication/pub.1092558570"
],
"sdDataset": "articles",
"sdDatePublished": "2019-04-10T20:11",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8681_00000609.jsonl",
"type": "ScholarlyArticle",
"url": "https://www.nature.com/articles/s41598-017-15479-2"
}
]
Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41598-017-15479-2'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41598-017-15479-2'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41598-017-15479-2'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41598-017-15479-2'
This table displays all metadata directly associated to this object as RDF triples.
234 TRIPLES
21 PREDICATES
65 URIs
21 LITERALS
9 BLANK NODES