The NOD2 receptor is crucial for immune responses towards New World Leishmania species View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-12

AUTHORS

Jéssica Cristina dos Santos, Michelle S. M. A. Damen, Marije Oosting, Dirk J. de Jong, Bas Heinhuis, Rodrigo Saar Gomes, Carla Santos Araújo, Mihai G. Netea, Fátima Ribeiro-Dias, Leo A. B. Joosten

ABSTRACT

American Tegumentary Leishmaniasis is a chronic infection caused by Leishmania protozoan. It is not known whether genetic variances in NOD-like receptor (NLR) family members influence the immune response towards Leishmania parasites and modulate intracellular killing. Using functional genomics, we investigated whether genetic variants in NOD1 or NOD2 influence the production of cytokines by human PBMCs exposed to Leishmania. In addition, we examined whether recognition of Leishmania by NOD2 contributes to intracellular killing. Polymorphisms in the NOD2 gene decreased monocyte- and lymphocyte-derived cytokine production after stimulation with L. amazonensis or L. braziliensis compared to individuals with a functional NOD2 receptor. The phagolysosome formation is important for Leishmania-induced cytokine production and upregulation of NOD2 mRNA expression. NOD2 is crucial to control intracellular infection caused by Leishmania spp. NOD2 receptor is important for Leishmania recognition, the control of intracellular killing, and the induction of innate and adaptive immune responses. More... »

PAGES

15219

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41598-017-15412-7

DOI

http://dx.doi.org/10.1038/s41598-017-15412-7

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1092523016

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29123157


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Immunology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Universidade Federal de Goi\u00e1s", 
          "id": "https://www.grid.ac/institutes/grid.411195.9", 
          "name": [
            "Department of Internal Medicine and Radboud Center of Infectious Diseases (RCI), Radboud University Medical Center, Nijmegen, The Netherlands", 
            "Instituto de Patologia Tropical e Sa\u00fade P\u00fablica, Universidade Federal de Goi\u00e1s, Goi\u00e2nia, Goi\u00e1s, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "dos Santos", 
        "givenName": "J\u00e9ssica Cristina", 
        "id": "sg:person.01340156472.83", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01340156472.83"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Radboud University Nijmegen Medical Centre", 
          "id": "https://www.grid.ac/institutes/grid.10417.33", 
          "name": [
            "Department of Internal Medicine and Radboud Center of Infectious Diseases (RCI), Radboud University Medical Center, Nijmegen, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Damen", 
        "givenName": "Michelle S. M. A.", 
        "id": "sg:person.01016131115.91", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01016131115.91"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Radboud University Nijmegen Medical Centre", 
          "id": "https://www.grid.ac/institutes/grid.10417.33", 
          "name": [
            "Department of Internal Medicine and Radboud Center of Infectious Diseases (RCI), Radboud University Medical Center, Nijmegen, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Oosting", 
        "givenName": "Marije", 
        "id": "sg:person.01274350215.14", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01274350215.14"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Radboud University Nijmegen Medical Centre", 
          "id": "https://www.grid.ac/institutes/grid.10417.33", 
          "name": [
            "Department of Gastroenterology and Hepatology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "de Jong", 
        "givenName": "Dirk J.", 
        "id": "sg:person.01077446114.87", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01077446114.87"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Radboud University Nijmegen Medical Centre", 
          "id": "https://www.grid.ac/institutes/grid.10417.33", 
          "name": [
            "Department of Internal Medicine and Radboud Center of Infectious Diseases (RCI), Radboud University Medical Center, Nijmegen, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Heinhuis", 
        "givenName": "Bas", 
        "id": "sg:person.01122067045.83", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01122067045.83"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Universidade Federal de Goi\u00e1s", 
          "id": "https://www.grid.ac/institutes/grid.411195.9", 
          "name": [
            "Instituto de Patologia Tropical e Sa\u00fade P\u00fablica, Universidade Federal de Goi\u00e1s, Goi\u00e2nia, Goi\u00e1s, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gomes", 
        "givenName": "Rodrigo Saar", 
        "id": "sg:person.016201601302.95", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016201601302.95"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Universidade Federal do Vale do S\u00e3o Francisco", 
          "id": "https://www.grid.ac/institutes/grid.412386.a", 
          "name": [
            "Universidade Federal do Vale do S\u00e3o Francisco, Petrolina, Pernambuco, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ara\u00fajo", 
        "givenName": "Carla Santos", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Craiova", 
          "id": "https://www.grid.ac/institutes/grid.413091.e", 
          "name": [
            "Department of Internal Medicine and Radboud Center of Infectious Diseases (RCI), Radboud University Medical Center, Nijmegen, The Netherlands", 
            "Human Genomics Laboratory, Craiova University of Medicine and Pharmacy, Craiova, Romania"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Netea", 
        "givenName": "Mihai G.", 
        "id": "sg:person.01263677437.18", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01263677437.18"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Universidade Federal de Goi\u00e1s", 
          "id": "https://www.grid.ac/institutes/grid.411195.9", 
          "name": [
            "Instituto de Patologia Tropical e Sa\u00fade P\u00fablica, Universidade Federal de Goi\u00e1s, Goi\u00e2nia, Goi\u00e1s, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ribeiro-Dias", 
        "givenName": "F\u00e1tima", 
        "id": "sg:person.01210152740.27", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01210152740.27"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Universidade Federal de Goi\u00e1s", 
          "id": "https://www.grid.ac/institutes/grid.411195.9", 
          "name": [
            "Department of Internal Medicine and Radboud Center of Infectious Diseases (RCI), Radboud University Medical Center, Nijmegen, The Netherlands", 
            "Instituto de Patologia Tropical e Sa\u00fade P\u00fablica, Universidade Federal de Goi\u00e1s, Goi\u00e2nia, Goi\u00e1s, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Joosten", 
        "givenName": "Leo A. B.", 
        "id": "sg:person.014645240657.77", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014645240657.77"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1111/j.1365-2230.2005.01991.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000364548"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2230.2005.01991.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000364548"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.ppat.0030051", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001314379"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m307198200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002913430"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0148084", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003469503"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/bioinformatics/bts180", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004083738"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.chembiol.2015.07.017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004213523"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1096/fj.13-245126", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006368353"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cyto.2016.09.009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006405246"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3389/fimmu.2012.00301", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007556208"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.0802860", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008791421"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj2940305", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010829690"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj2940305", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010829690"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1590/s0037-86822003000100011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011302425"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0003-2697(87)90021-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013321498"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0076-6879(03)01066-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013356117"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.exppara.2012.06.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014214146"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2016.10.017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015765877"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/gast.2003.50019", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017438331"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/gast.2003.50019", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017438331"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/eji.200737182", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018057246"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.c200673200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020011276"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m509537200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021473336"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pntd.0001543", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022298935"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.c200651200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025051617"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.micinf.2014.08.015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025080624"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.178.4.2380", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025153744"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.chom.2016.10.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025349315"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1317723111", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025553287"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4269/ajtmh.2011.10-0680", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025604231"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1086/652871", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027732880"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1756-3305-6-54", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029634789", 
          "https://doi.org/10.1186/1756-3305-6-54"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35079114", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030806509", 
          "https://doi.org/10.1038/35079114"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35079114", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030806509", 
          "https://doi.org/10.1038/35079114"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35079107", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031360950", 
          "https://doi.org/10.1038/35079107"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35079107", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031360950", 
          "https://doi.org/10.1038/35079107"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pntd.0004848", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032037406"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/eji.201546015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032386311"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(05)66582-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035309939"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1473-3099(07)70209-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036327160"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1247/csf.23.33", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037831603"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.imlet.2005.06.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039118192"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.imlet.2005.06.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039118192"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev-immunol-031210-101405", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040658091"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm.2069", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042587063", 
          "https://doi.org/10.1038/nm.2069"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm.2069", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042587063", 
          "https://doi.org/10.1038/nm.2069"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0166-6851(03)00160-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045045491"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0166-6851(03)00160-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045045491"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2016.10.018", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047190195"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/pim.12100", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049097260"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3389/fimmu.2012.00328", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049455886"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm.3221", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050740882", 
          "https://doi.org/10.1038/nm.3221"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/j.gastro.2010.07.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051436587"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj20090272", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051905406"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj20090272", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051905406"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj20090272", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051905406"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s13071-016-1934-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052530220", 
          "https://doi.org/10.1186/s13071-016-1934-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s13071-016-1934-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052530220", 
          "https://doi.org/10.1186/s13071-016-1934-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/9780471729259.mc03c01s10", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053277755"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/abio.1987.9999", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1054484911"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/infdis/jiw446", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059710396"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1104911", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062451179"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.ppat.1006196", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083814341"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pntd.0005413", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084273863"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2017-12", 
    "datePublishedReg": "2017-12-01", 
    "description": "American Tegumentary Leishmaniasis is a chronic infection caused by Leishmania protozoan. It is not known whether genetic variances in NOD-like receptor (NLR) family members influence the immune response towards Leishmania parasites and modulate intracellular killing. Using functional genomics, we investigated whether genetic variants in NOD1 or NOD2 influence the production of cytokines by human PBMCs exposed to Leishmania. In addition, we examined whether recognition of Leishmania by NOD2 contributes to intracellular killing. Polymorphisms in the NOD2 gene decreased monocyte- and lymphocyte-derived cytokine production after stimulation with L. amazonensis or L. braziliensis compared to individuals with a functional NOD2 receptor. The phagolysosome formation is important for Leishmania-induced cytokine production and upregulation of NOD2 mRNA expression. NOD2 is crucial to control intracellular infection caused by Leishmania spp. NOD2 receptor is important for Leishmania recognition, the control of intracellular killing, and the induction of innate and adaptive immune responses.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/s41598-017-15412-7", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.3797303", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1045337", 
        "issn": [
          "2045-2322"
        ], 
        "name": "Scientific Reports", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "7"
      }
    ], 
    "name": "The NOD2 receptor is crucial for immune responses towards New World Leishmania species", 
    "pagination": "15219", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "0c07e763044ea0c5c671f2d319181c0bf84ff9387d60fa0aa7435056855f64f6"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "29123157"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101563288"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/s41598-017-15412-7"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1092523016"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/s41598-017-15412-7", 
      "https://app.dimensions.ai/details/publication/pub.1092523016"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T13:32", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8659_00000609.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/s41598-017-15412-7"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41598-017-15412-7'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41598-017-15412-7'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41598-017-15412-7'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41598-017-15412-7'


 

This table displays all metadata directly associated to this object as RDF triples.

309 TRIPLES      21 PREDICATES      82 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/s41598-017-15412-7 schema:about anzsrc-for:11
2 anzsrc-for:1107
3 schema:author Nf34f7af73c3e4787b72b5559b7a6d61b
4 schema:citation sg:pub.10.1038/35079107
5 sg:pub.10.1038/35079114
6 sg:pub.10.1038/nm.2069
7 sg:pub.10.1038/nm.3221
8 sg:pub.10.1186/1756-3305-6-54
9 sg:pub.10.1186/s13071-016-1934-2
10 https://doi.org/10.1002/9780471729259.mc03c01s10
11 https://doi.org/10.1002/eji.200737182
12 https://doi.org/10.1002/eji.201546015
13 https://doi.org/10.1006/abio.1987.9999
14 https://doi.org/10.1016/0003-2697(87)90021-2
15 https://doi.org/10.1016/j.cell.2016.10.017
16 https://doi.org/10.1016/j.cell.2016.10.018
17 https://doi.org/10.1016/j.chembiol.2015.07.017
18 https://doi.org/10.1016/j.chom.2016.10.006
19 https://doi.org/10.1016/j.cyto.2016.09.009
20 https://doi.org/10.1016/j.exppara.2012.06.006
21 https://doi.org/10.1016/j.imlet.2005.06.004
22 https://doi.org/10.1016/j.micinf.2014.08.015
23 https://doi.org/10.1016/s0076-6879(03)01066-8
24 https://doi.org/10.1016/s0140-6736(05)66582-8
25 https://doi.org/10.1016/s0166-6851(03)00160-9
26 https://doi.org/10.1016/s1473-3099(07)70209-8
27 https://doi.org/10.1042/bj20090272
28 https://doi.org/10.1042/bj2940305
29 https://doi.org/10.1053/gast.2003.50019
30 https://doi.org/10.1053/j.gastro.2010.07.006
31 https://doi.org/10.1073/pnas.1317723111
32 https://doi.org/10.1074/jbc.c200651200
33 https://doi.org/10.1074/jbc.c200673200
34 https://doi.org/10.1074/jbc.m307198200
35 https://doi.org/10.1074/jbc.m509537200
36 https://doi.org/10.1086/652871
37 https://doi.org/10.1093/bioinformatics/bts180
38 https://doi.org/10.1093/infdis/jiw446
39 https://doi.org/10.1096/fj.13-245126
40 https://doi.org/10.1111/j.1365-2230.2005.01991.x
41 https://doi.org/10.1111/pim.12100
42 https://doi.org/10.1126/science.1104911
43 https://doi.org/10.1146/annurev-immunol-031210-101405
44 https://doi.org/10.1247/csf.23.33
45 https://doi.org/10.1371/journal.pntd.0001543
46 https://doi.org/10.1371/journal.pntd.0004848
47 https://doi.org/10.1371/journal.pntd.0005413
48 https://doi.org/10.1371/journal.pone.0148084
49 https://doi.org/10.1371/journal.ppat.0030051
50 https://doi.org/10.1371/journal.ppat.1006196
51 https://doi.org/10.1590/s0037-86822003000100011
52 https://doi.org/10.3389/fimmu.2012.00301
53 https://doi.org/10.3389/fimmu.2012.00328
54 https://doi.org/10.4049/jimmunol.0802860
55 https://doi.org/10.4049/jimmunol.178.4.2380
56 https://doi.org/10.4269/ajtmh.2011.10-0680
57 schema:datePublished 2017-12
58 schema:datePublishedReg 2017-12-01
59 schema:description American Tegumentary Leishmaniasis is a chronic infection caused by Leishmania protozoan. It is not known whether genetic variances in NOD-like receptor (NLR) family members influence the immune response towards Leishmania parasites and modulate intracellular killing. Using functional genomics, we investigated whether genetic variants in NOD1 or NOD2 influence the production of cytokines by human PBMCs exposed to Leishmania. In addition, we examined whether recognition of Leishmania by NOD2 contributes to intracellular killing. Polymorphisms in the NOD2 gene decreased monocyte- and lymphocyte-derived cytokine production after stimulation with L. amazonensis or L. braziliensis compared to individuals with a functional NOD2 receptor. The phagolysosome formation is important for Leishmania-induced cytokine production and upregulation of NOD2 mRNA expression. NOD2 is crucial to control intracellular infection caused by Leishmania spp. NOD2 receptor is important for Leishmania recognition, the control of intracellular killing, and the induction of innate and adaptive immune responses.
60 schema:genre research_article
61 schema:inLanguage en
62 schema:isAccessibleForFree true
63 schema:isPartOf N1a728732cf484661bac4b8b974f7e61f
64 N66cc1bab367e47ea9d47bab4e760e647
65 sg:journal.1045337
66 schema:name The NOD2 receptor is crucial for immune responses towards New World Leishmania species
67 schema:pagination 15219
68 schema:productId N12b8fba6198a407f9c1abd1e3546dfc2
69 N1ab81f32a5344f948eac88e30cf44b77
70 N21c9758903d14009931c0059a26e4c15
71 N25589eac008f4361aa8e89a8de2d3426
72 N441164a866784c30a1ae4d00f15cedd1
73 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092523016
74 https://doi.org/10.1038/s41598-017-15412-7
75 schema:sdDatePublished 2019-04-10T13:32
76 schema:sdLicense https://scigraph.springernature.com/explorer/license/
77 schema:sdPublisher Na75f511e0bc44cfd9bc4549ff6935f97
78 schema:url https://www.nature.com/articles/s41598-017-15412-7
79 sgo:license sg:explorer/license/
80 sgo:sdDataset articles
81 rdf:type schema:ScholarlyArticle
82 N12b8fba6198a407f9c1abd1e3546dfc2 schema:name dimensions_id
83 schema:value pub.1092523016
84 rdf:type schema:PropertyValue
85 N1a728732cf484661bac4b8b974f7e61f schema:volumeNumber 7
86 rdf:type schema:PublicationVolume
87 N1ab81f32a5344f948eac88e30cf44b77 schema:name doi
88 schema:value 10.1038/s41598-017-15412-7
89 rdf:type schema:PropertyValue
90 N21c9758903d14009931c0059a26e4c15 schema:name nlm_unique_id
91 schema:value 101563288
92 rdf:type schema:PropertyValue
93 N25589eac008f4361aa8e89a8de2d3426 schema:name readcube_id
94 schema:value 0c07e763044ea0c5c671f2d319181c0bf84ff9387d60fa0aa7435056855f64f6
95 rdf:type schema:PropertyValue
96 N25d482203531471c952884cf9873ecc0 rdf:first sg:person.01077446114.87
97 rdf:rest Naf5530212fe6413ab1faab3b574dbaae
98 N2c59d060a2dc4018ab0469ff495adb77 rdf:first sg:person.01274350215.14
99 rdf:rest N25d482203531471c952884cf9873ecc0
100 N33670bdba4b743d3832192abf9592915 rdf:first sg:person.016201601302.95
101 rdf:rest N37e2f83913dd4e43a71213fe248df6d5
102 N36aed17d6bf74fb79360b13c18114a99 rdf:first sg:person.01210152740.27
103 rdf:rest N53211ba448544da4985629f6b054ec5b
104 N37e2f83913dd4e43a71213fe248df6d5 rdf:first N554f99581f804ccd987784d0f040a4cb
105 rdf:rest Nacebc0c93748458d98faa82fe4b9c34f
106 N441164a866784c30a1ae4d00f15cedd1 schema:name pubmed_id
107 schema:value 29123157
108 rdf:type schema:PropertyValue
109 N53211ba448544da4985629f6b054ec5b rdf:first sg:person.014645240657.77
110 rdf:rest rdf:nil
111 N554f99581f804ccd987784d0f040a4cb schema:affiliation https://www.grid.ac/institutes/grid.412386.a
112 schema:familyName Araújo
113 schema:givenName Carla Santos
114 rdf:type schema:Person
115 N66cc1bab367e47ea9d47bab4e760e647 schema:issueNumber 1
116 rdf:type schema:PublicationIssue
117 Na75f511e0bc44cfd9bc4549ff6935f97 schema:name Springer Nature - SN SciGraph project
118 rdf:type schema:Organization
119 Nacebc0c93748458d98faa82fe4b9c34f rdf:first sg:person.01263677437.18
120 rdf:rest N36aed17d6bf74fb79360b13c18114a99
121 Naf5530212fe6413ab1faab3b574dbaae rdf:first sg:person.01122067045.83
122 rdf:rest N33670bdba4b743d3832192abf9592915
123 Nd8441b504c234dd1ba4293a0330fc66c rdf:first sg:person.01016131115.91
124 rdf:rest N2c59d060a2dc4018ab0469ff495adb77
125 Nf34f7af73c3e4787b72b5559b7a6d61b rdf:first sg:person.01340156472.83
126 rdf:rest Nd8441b504c234dd1ba4293a0330fc66c
127 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
128 schema:name Medical and Health Sciences
129 rdf:type schema:DefinedTerm
130 anzsrc-for:1107 schema:inDefinedTermSet anzsrc-for:
131 schema:name Immunology
132 rdf:type schema:DefinedTerm
133 sg:grant.3797303 http://pending.schema.org/fundedItem sg:pub.10.1038/s41598-017-15412-7
134 rdf:type schema:MonetaryGrant
135 sg:journal.1045337 schema:issn 2045-2322
136 schema:name Scientific Reports
137 rdf:type schema:Periodical
138 sg:person.01016131115.91 schema:affiliation https://www.grid.ac/institutes/grid.10417.33
139 schema:familyName Damen
140 schema:givenName Michelle S. M. A.
141 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01016131115.91
142 rdf:type schema:Person
143 sg:person.01077446114.87 schema:affiliation https://www.grid.ac/institutes/grid.10417.33
144 schema:familyName de Jong
145 schema:givenName Dirk J.
146 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01077446114.87
147 rdf:type schema:Person
148 sg:person.01122067045.83 schema:affiliation https://www.grid.ac/institutes/grid.10417.33
149 schema:familyName Heinhuis
150 schema:givenName Bas
151 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01122067045.83
152 rdf:type schema:Person
153 sg:person.01210152740.27 schema:affiliation https://www.grid.ac/institutes/grid.411195.9
154 schema:familyName Ribeiro-Dias
155 schema:givenName Fátima
156 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01210152740.27
157 rdf:type schema:Person
158 sg:person.01263677437.18 schema:affiliation https://www.grid.ac/institutes/grid.413091.e
159 schema:familyName Netea
160 schema:givenName Mihai G.
161 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01263677437.18
162 rdf:type schema:Person
163 sg:person.01274350215.14 schema:affiliation https://www.grid.ac/institutes/grid.10417.33
164 schema:familyName Oosting
165 schema:givenName Marije
166 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01274350215.14
167 rdf:type schema:Person
168 sg:person.01340156472.83 schema:affiliation https://www.grid.ac/institutes/grid.411195.9
169 schema:familyName dos Santos
170 schema:givenName Jéssica Cristina
171 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01340156472.83
172 rdf:type schema:Person
173 sg:person.014645240657.77 schema:affiliation https://www.grid.ac/institutes/grid.411195.9
174 schema:familyName Joosten
175 schema:givenName Leo A. B.
176 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014645240657.77
177 rdf:type schema:Person
178 sg:person.016201601302.95 schema:affiliation https://www.grid.ac/institutes/grid.411195.9
179 schema:familyName Gomes
180 schema:givenName Rodrigo Saar
181 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016201601302.95
182 rdf:type schema:Person
183 sg:pub.10.1038/35079107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031360950
184 https://doi.org/10.1038/35079107
185 rdf:type schema:CreativeWork
186 sg:pub.10.1038/35079114 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030806509
187 https://doi.org/10.1038/35079114
188 rdf:type schema:CreativeWork
189 sg:pub.10.1038/nm.2069 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042587063
190 https://doi.org/10.1038/nm.2069
191 rdf:type schema:CreativeWork
192 sg:pub.10.1038/nm.3221 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050740882
193 https://doi.org/10.1038/nm.3221
194 rdf:type schema:CreativeWork
195 sg:pub.10.1186/1756-3305-6-54 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029634789
196 https://doi.org/10.1186/1756-3305-6-54
197 rdf:type schema:CreativeWork
198 sg:pub.10.1186/s13071-016-1934-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052530220
199 https://doi.org/10.1186/s13071-016-1934-2
200 rdf:type schema:CreativeWork
201 https://doi.org/10.1002/9780471729259.mc03c01s10 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053277755
202 rdf:type schema:CreativeWork
203 https://doi.org/10.1002/eji.200737182 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018057246
204 rdf:type schema:CreativeWork
205 https://doi.org/10.1002/eji.201546015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032386311
206 rdf:type schema:CreativeWork
207 https://doi.org/10.1006/abio.1987.9999 schema:sameAs https://app.dimensions.ai/details/publication/pub.1054484911
208 rdf:type schema:CreativeWork
209 https://doi.org/10.1016/0003-2697(87)90021-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013321498
210 rdf:type schema:CreativeWork
211 https://doi.org/10.1016/j.cell.2016.10.017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015765877
212 rdf:type schema:CreativeWork
213 https://doi.org/10.1016/j.cell.2016.10.018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047190195
214 rdf:type schema:CreativeWork
215 https://doi.org/10.1016/j.chembiol.2015.07.017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004213523
216 rdf:type schema:CreativeWork
217 https://doi.org/10.1016/j.chom.2016.10.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025349315
218 rdf:type schema:CreativeWork
219 https://doi.org/10.1016/j.cyto.2016.09.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006405246
220 rdf:type schema:CreativeWork
221 https://doi.org/10.1016/j.exppara.2012.06.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014214146
222 rdf:type schema:CreativeWork
223 https://doi.org/10.1016/j.imlet.2005.06.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039118192
224 rdf:type schema:CreativeWork
225 https://doi.org/10.1016/j.micinf.2014.08.015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025080624
226 rdf:type schema:CreativeWork
227 https://doi.org/10.1016/s0076-6879(03)01066-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013356117
228 rdf:type schema:CreativeWork
229 https://doi.org/10.1016/s0140-6736(05)66582-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035309939
230 rdf:type schema:CreativeWork
231 https://doi.org/10.1016/s0166-6851(03)00160-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045045491
232 rdf:type schema:CreativeWork
233 https://doi.org/10.1016/s1473-3099(07)70209-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036327160
234 rdf:type schema:CreativeWork
235 https://doi.org/10.1042/bj20090272 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051905406
236 rdf:type schema:CreativeWork
237 https://doi.org/10.1042/bj2940305 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010829690
238 rdf:type schema:CreativeWork
239 https://doi.org/10.1053/gast.2003.50019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017438331
240 rdf:type schema:CreativeWork
241 https://doi.org/10.1053/j.gastro.2010.07.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051436587
242 rdf:type schema:CreativeWork
243 https://doi.org/10.1073/pnas.1317723111 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025553287
244 rdf:type schema:CreativeWork
245 https://doi.org/10.1074/jbc.c200651200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025051617
246 rdf:type schema:CreativeWork
247 https://doi.org/10.1074/jbc.c200673200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020011276
248 rdf:type schema:CreativeWork
249 https://doi.org/10.1074/jbc.m307198200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002913430
250 rdf:type schema:CreativeWork
251 https://doi.org/10.1074/jbc.m509537200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021473336
252 rdf:type schema:CreativeWork
253 https://doi.org/10.1086/652871 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027732880
254 rdf:type schema:CreativeWork
255 https://doi.org/10.1093/bioinformatics/bts180 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004083738
256 rdf:type schema:CreativeWork
257 https://doi.org/10.1093/infdis/jiw446 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059710396
258 rdf:type schema:CreativeWork
259 https://doi.org/10.1096/fj.13-245126 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006368353
260 rdf:type schema:CreativeWork
261 https://doi.org/10.1111/j.1365-2230.2005.01991.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1000364548
262 rdf:type schema:CreativeWork
263 https://doi.org/10.1111/pim.12100 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049097260
264 rdf:type schema:CreativeWork
265 https://doi.org/10.1126/science.1104911 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062451179
266 rdf:type schema:CreativeWork
267 https://doi.org/10.1146/annurev-immunol-031210-101405 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040658091
268 rdf:type schema:CreativeWork
269 https://doi.org/10.1247/csf.23.33 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037831603
270 rdf:type schema:CreativeWork
271 https://doi.org/10.1371/journal.pntd.0001543 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022298935
272 rdf:type schema:CreativeWork
273 https://doi.org/10.1371/journal.pntd.0004848 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032037406
274 rdf:type schema:CreativeWork
275 https://doi.org/10.1371/journal.pntd.0005413 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084273863
276 rdf:type schema:CreativeWork
277 https://doi.org/10.1371/journal.pone.0148084 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003469503
278 rdf:type schema:CreativeWork
279 https://doi.org/10.1371/journal.ppat.0030051 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001314379
280 rdf:type schema:CreativeWork
281 https://doi.org/10.1371/journal.ppat.1006196 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083814341
282 rdf:type schema:CreativeWork
283 https://doi.org/10.1590/s0037-86822003000100011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011302425
284 rdf:type schema:CreativeWork
285 https://doi.org/10.3389/fimmu.2012.00301 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007556208
286 rdf:type schema:CreativeWork
287 https://doi.org/10.3389/fimmu.2012.00328 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049455886
288 rdf:type schema:CreativeWork
289 https://doi.org/10.4049/jimmunol.0802860 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008791421
290 rdf:type schema:CreativeWork
291 https://doi.org/10.4049/jimmunol.178.4.2380 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025153744
292 rdf:type schema:CreativeWork
293 https://doi.org/10.4269/ajtmh.2011.10-0680 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025604231
294 rdf:type schema:CreativeWork
295 https://www.grid.ac/institutes/grid.10417.33 schema:alternateName Radboud University Nijmegen Medical Centre
296 schema:name Department of Gastroenterology and Hepatology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
297 Department of Internal Medicine and Radboud Center of Infectious Diseases (RCI), Radboud University Medical Center, Nijmegen, The Netherlands
298 rdf:type schema:Organization
299 https://www.grid.ac/institutes/grid.411195.9 schema:alternateName Universidade Federal de Goiás
300 schema:name Department of Internal Medicine and Radboud Center of Infectious Diseases (RCI), Radboud University Medical Center, Nijmegen, The Netherlands
301 Instituto de Patologia Tropical e Saúde Pública, Universidade Federal de Goiás, Goiânia, Goiás, Brazil
302 rdf:type schema:Organization
303 https://www.grid.ac/institutes/grid.412386.a schema:alternateName Universidade Federal do Vale do São Francisco
304 schema:name Universidade Federal do Vale do São Francisco, Petrolina, Pernambuco, Brazil
305 rdf:type schema:Organization
306 https://www.grid.ac/institutes/grid.413091.e schema:alternateName University of Craiova
307 schema:name Department of Internal Medicine and Radboud Center of Infectious Diseases (RCI), Radboud University Medical Center, Nijmegen, The Netherlands
308 Human Genomics Laboratory, Craiova University of Medicine and Pharmacy, Craiova, Romania
309 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...