Protein nutrition governs within-host race of honey bee pathogens View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-11-08

AUTHORS

Manuel Tritschler, Jutta J. Vollmann, Orlando Yañez, Nor Chejanovsky, Karl Crailsheim, Peter Neumann

ABSTRACT

Multiple infections are common in honey bees, Apis mellifera, but the possible role of nutrition in this regard is poorly understood. Microsporidian infections, which are promoted by protein-fed, can negatively correlate with virus infections, but the role of protein nutrition for the microsporidian-virus interface is unknown. Here, we challenged naturally deformed wing virus - B (DWV-B) infected adult honey bee workers fed with or without pollen ( = protein) in hoarding cages, with the microsporidian Nosema ceranae. Bee mortality was recorded for 14 days and N. ceranae spore loads and DWV-B titers were quantified. Amongst the groups inoculated with N. ceranae, more spores were counted in protein-fed bees. However, N. ceranae infected bees without protein-diet had reduced longevity compared to all other groups. N. ceranae infection had no effect on protein-fed bee’s longevity, whereas bees supplied only with sugar-water showed reduced survival. Our data also support that protein-feeding can have a significant negative impact on virus infections in insects. The negative correlation between N. ceranae spore loads and DWV-B titers was stronger expressed in protein-fed hosts. Proteins not only enhance survival of infected hosts, but also significantly shape the microsporidian-virus interface, probably due to increased spore production and enhanced host immunity. More... »

PAGES

14988

References to SciGraph publications

  • 2011-03-01. Comparison of the energetic stress associated with experimental Nosema ceranae and Nosema apis infection of honeybees (Apis mellifera) in PARASITOLOGY RESEARCH
  • 2015-08-07. Co-evolution in a landrace meta-population: two closely related pathogens interacting with the same host can lead to different adaptive outcomes in SCIENTIFIC REPORTS
  • 2013-11-18. Chronic parasitization by Nosema microsporidia causes global expression changes in core nutritional, metabolic and behavioral pathways in honey bee workers (Apis mellifera) in BMC GENOMICS
  • 2014-08-09. Pathogen-associated self-medication behavior in the honeybee Apis mellifera in BEHAVIORAL ECOLOGY AND SOCIOBIOLOGY
  • 2009-06-17. Behavioral changes mediated by hunger in honeybees infected with Nosema ceranae in APIDOLOGIE
  • 2012-03-22. Parasite-insecticide interactions: a case study of Nosema ceranae and fipronil synergy on honeybee in SCIENTIFIC REPORTS
  • 2013-01-16. The complex transcriptional landscape of the anucleate human platelet in BMC GENOMICS
  • 2002-12. Biological and biomedical implications of the co-evolution of pathogens and their hosts in NATURE GENETICS
  • 2010-04-21. Nutrition and health in honey bees in APIDOLOGIE
  • 2016-03-07. Metabolic crosstalk between host and pathogen: sensing, adapting and competing in NATURE REVIEWS MICROBIOLOGY
  • 2007-11. Nosema ceranae has infected Apis mellifera in Europe since at least 1998 and may be more virulent than Nosema apis in APIDOLOGIE
  • 2004-08. Cooperation and competition in pathogenic bacteria in NATURE
  • 2011-10-10. Nutrigenomics in honey bees: digital gene expression analysis of pollen's nutritive effects on healthy and varroa-parasitized bees in BMC GENOMICS
  • Identifiers

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    http://scigraph.springernature.com/pub.10.1038/s41598-017-15358-w

    DOI

    http://dx.doi.org/10.1038/s41598-017-15358-w

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1092504189

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/29118416


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