Causes of Death in Patients with Severe Aortic Stenosis: An Observational study View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-11-07

AUTHORS

Eri Minamino-Muta, Takao Kato, Takeshi Morimoto, Tomohiko Taniguchi, Hiroki Shiomi, Kenji Nakatsuma, Shinichi Shirai, Kenji Ando, Norio Kanamori, Koichiro Murata, Takeshi Kitai, Yuichi Kawase, Makoto Miyake, Chisato Izumi, Hirokazu Mitsuoka, Masashi Kato, Yutaka Hirano, Shintaro Matsuda, Kazuya Nagao, Tsukasa Inada, Tomoyuki Murakami, Yasuyo Takeuchi, Keiichiro Yamane, Mamoru Toyofuku, Mitsuru Ishii, Moriaki Inoko, Tomoyuki Ikeda, Akihiro Komasa, Eiji Tada, Katsuhisa Ishii, Kozo Hotta, Nobuya Higashitani, Toshikazu Jinnai, Yoshihiro Kato, Yasutaka Inuzuka, Chiyo Maeda, Yuko Morikami, Naritatsu Saito, Ryuzo Sakata, Kenji Minatoya, Takeshi Kimura

ABSTRACT

Whether patients with severe aortic stenosis (AS) die because of AS-related causes is an important issue for the management of these patients. We used data from CURRENT AS registry, a Japanese multicenter registry, to assess the causes of death in severe AS patients and to identify the factors associated with non-cardiac mortality. We enrolled 3815 consecutive patients with a median follow-up of 1176 days; the 1449 overall deaths comprised 802 (55.3%) from cardiac and 647 (44.7%) from non-cardiac causes. Heart failure (HF) (25.7%) and sudden death (13.0%) caused the most cardiac deaths, whereas infection (13.0%) and malignancy (11.1%) were the main non-cardiac causes. According to treatment strategies, infection was the most common cause of non-cardiac death, followed by malignancy, in both the initial aortic valve replacement (AVR) cohort (N = 1197), and the conservative management cohort (N = 2618). Both non-cardiac factors (age, male, body mass index <22, diabetes, prior history of stroke, dialysis, anemia, and malignancy) and cardiac factors (atrial fibrillation, ejection fraction <68%, and the initial AVR strategy) were associated with non-cardiac death. These findings highlight the importance of close monitoring of non-cardiac comorbidities, as well as HF and sudden death, to improve the mortality rate of severe AS patients. More... »

PAGES

14723

References to SciGraph publications

Journal

TITLE

Scientific Reports

ISSUE

1

VOLUME

7

Author Affiliations

  • Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan
  • Department of Clinical Epidemiology, Hyogo College of Medicine, Nishinomiya, Japan
  • Department of Cardiology, Kokura Memorial Hospital, Kokura, Japan
  • Division of Cardiology, Shimada Municipal Hospital, Shimada, Japan
  • Department of Cardiology, Shizuoka City Shizuoka Hospital, Shizuoka, Japan
  • Department of Cardiovascular Medicine, Kobe City Medical Center General Hospital, Kobe, Japan
  • Department of Cardiovascular Medicine, Kurashiki Central Hospital, Kurashiki, Japan
  • Department of Cardiology, Tenri Hospital, Tenri, Japan
  • Division of Cardiology, Nara Hospital, Kinki University Faculty of Medicine, Ikoma, Japan
  • Department of Cardiology, Mitsubishi Kyoto Hospital, Kyoto, Japan
  • Department of Cardiology, Kinki University Hospital, Osakasayama, Japan
  • Department of Cardiovascular Center, Osaka Red Cross Hospital, Osaka, Japan
  • Department of Cardiology, Koto Memorial Hospital, Higashiomi, Japan
  • Department of Cardiology, Shizuoka General Hospital, Shizuoka, Japan
  • Department of Cardiology, Nishikobe Medical Center, Kobe, Japan
  • Department of Cardiology, Japanese Red Cross Wakayama Medical Center, Wakayama, Japan
  • Department of Cardiology, National Hospital Organization Kyoto Medical Center, Kyoto, Japan
  • Cardiovascular Center, The Tazuke Kofukai Medical Research Institute, Kitano Hospital, Osaka, Japan
  • Department of Cardiology, Hikone Municipal Hospital, Hikone, Japan
  • Department of Cardiology, Kansai Electric Power Hospital, Osaka, Japan
  • Department of Cardiology, Hyogo Prefectural Amagasaki General Medical Center, Amagasaki, Japan
  • Department of Cardiology, Japanese Red Cross Otsu Hospital, Otsu, Japan
  • Department of Cardiology, Saiseikai Noe Hospital, Osaka, Japan
  • Department of Cardiology, Shiga Medical Center for Adults, Moriyama, Japan
  • Department of Cardiology, Hamamatsu Rosai Hospital, Hamamatsu, Japan
  • Department of Cardiology, Hirakata Kohsai Hospital, Hirakata, Japan
  • Department of Cardiovascular Surgery, Kobe City Medical Center General Hospital, Kobe, Japan
  • Department of Cardiovascular Surgery, Kyoto University Graduate School of Medicine, Kyoto, Japan
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41598-017-15316-6

    DOI

    http://dx.doi.org/10.1038/s41598-017-15316-6

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1092483374

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/29116212


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