Ontology type: schema:ScholarlyArticle Open Access: True
2017-12
AUTHORSArshad Khan, Lovepreet Mann, Ramesha Papanna, Mi-Ae Lyu, Christopher R. Singh, Scott Olson, N. Tony Eissa, Jeffrey Cirillo, Gobardhan Das, Robert L. Hunter, Chinnaswamy Jagannath
ABSTRACTHuman mesenchymal stem cells (MSCs) express scavenger receptors that internalize lipids, including oxidized low-density lipoprotein (oxLDL). We report that MSCs phagocytose Mycobacterium tuberculosis (Mtb) through two types of scavenger receptors (SRs; MARCO and SR-B1), as blockade of the receptors with antibodies or siRNA knockdown decreased the uptake of Mtb. MSCs also expressed mannose receptor (MR) that was found to endocytose rhodamine-labeled mannosylated BSA (rMBSA), though the receptor was not involved in the uptake of Mtb. Dil-oxLDL and rMBSA taken up into MSC endosomes colocalized with Mtb phagosomes, thus suggesting that the latter were fusion competent. Phagocytosed Mtb did not replicate within MSCs, thus suggesting an intrinsic control of bacterial growth. Indeed, MSCs exhibited intrinsic autophagy, which was up-regulated after activation with rapamycin. SiRNA knockdown of autophagy initiator beclin-1 enhanced Mtb survival, whereas rapamycin-induced autophagy increased intracellular killing of Mtb. In addition, MSCs secreted nitric oxide after Mtb infection, and inhibition of NO by N(G)-monomethyl-L-arginine enhanced intracellular survival of Mtb. MSCs can be grown in large numbers in vitro, and autologous MSCs transfused into tuberculosis patients have been found to be safe and improve lung immunity. Thus, MSCs are novel phagocytic cells with a potential for immunotherapy in treating multidrug-resistant tuberculosis. More... »
PAGES15010
http://scigraph.springernature.com/pub.10.1038/s41598-017-15290-z
DOIhttp://dx.doi.org/10.1038/s41598-017-15290-z
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PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/29118429
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JSON-LD is a popular format for linked data which is fully compatible with JSON.
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This table displays all metadata directly associated to this object as RDF triples.
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