Modulating medial septal cholinergic activity reduces medial entorhinal theta frequency without affecting speed or grid coding View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-12

AUTHORS

Francis Carpenter, Neil Burgess, Caswell Barry

ABSTRACT

Medial septal inputs to the hippocampal system are crucial for aspects of temporal and spatial processing, such as theta oscillations and grid cell firing. However, the precise contributions of the medial septum's cholinergic neurones to these functions remain unknown. Here, we recorded neuronal firing and local field potentials from the medial entorhinal cortex of freely foraging mice, while modulating the excitability of medial septal cholinergic neurones. Alteration of cholinergic activity produced a reduction in the frequency of theta oscillations, without affecting the slope of the non-linear theta frequency vs running speed relationship observed. Modifying septal cholinergic tone in this way also led mice to exhibit behaviours associated with novelty or anxiety. However, grid cell firing patterns were unaffected, concordant with an absence of change in the slopes of the theta frequency and firing rate speed signals thought to be used by grid cells. More... »

PAGES

14573

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41598-017-15100-6

DOI

http://dx.doi.org/10.1038/s41598-017-15100-6

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1092462862

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29109512


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1109", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Neurosciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University College London", 
          "id": "https://www.grid.ac/institutes/grid.83440.3b", 
          "name": [
            "Institute of Neurology, UCL, Queen Square, WC1N 3BG, London, UK", 
            "Research Department of Cell & Developmental Biology, UCL, Gower Street, WC1E 6BT, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Carpenter", 
        "givenName": "Francis", 
        "id": "sg:person.01300624516.79", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01300624516.79"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University College London", 
          "id": "https://www.grid.ac/institutes/grid.83440.3b", 
          "name": [
            "Institute of Neurology, UCL, Queen Square, WC1N 3BG, London, UK", 
            "Institute of Cognitive Neuroscience, UCL, Queen Square, WC1N 3AR, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Burgess", 
        "givenName": "Neil", 
        "id": "sg:person.0723124371.28", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0723124371.28"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University College London", 
          "id": "https://www.grid.ac/institutes/grid.83440.3b", 
          "name": [
            "Research Department of Cell & Developmental Biology, UCL, Gower Street, WC1E 6BT, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Barry", 
        "givenName": "Caswell", 
        "id": "sg:person.0725101317.86", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0725101317.86"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1097/00001756-199511000-00017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000703281"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00001756-199511000-00017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000703281"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00001756-199511000-00017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000703281"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.7554/elife.01481", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001031407"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neuron.2015.05.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002079483"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1113/jphysiol.2012.250431", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002208890"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0006-8993(98)00390-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004725942"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/syn.20184", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005179203"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/syn.20184", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005179203"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0006-8993(96)01304-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008169978"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0013-4694(60)90101-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008313860"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0013-4694(60)90101-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008313860"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nn.4447", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010321431", 
          "https://doi.org/10.1038/nn.4447"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pcbi.1000291", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011718575"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.4353-05.2006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012374642"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cub.2016.06.043", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014269557"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbr.2010.11.036", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015233256"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cne.901860408", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015352482"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cne.902250303", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015731137"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/hipo.20062", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016245473"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/jn.00492.2009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016723538"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neuron.2016.06.027", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019153944"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1209918109", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021779181"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/336170a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021927311", 
          "https://doi.org/10.1038/336170a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1411233111", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023140477"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0013-4694(62)90030-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024648951"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0013-4694(62)90030-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024648951"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1469-7793.2003.00927.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024824861"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0306-4522(94)90341-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025036797"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0306-4522(94)90341-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025036797"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1162/neco_a_00701", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025298691"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3389/fncir.2012.00005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025381862"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/hipo.20327", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026193472"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1201685", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027748352"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/hipo.20510", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028010093"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neuron.2009.06.014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028697987"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1098/rstb.2012.0532", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029479442"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0014-4886(75)90195-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030539570"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.5040-12.2013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033054369"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0166-4328(88)90105-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033659560"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0166-4328(88)90105-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033659560"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.2586-13.2013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033952127"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.2141-15.2016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036353775"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0014-4886(73)90290-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040089448"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0014-2999(03)01272-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040843120"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0014-2999(03)01272-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040843120"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0306-4522(01)00302-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046325373"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.conb.2006.09.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046909314"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature14622", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047627049", 
          "https://doi.org/10.1038/nature14622"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.5665-08.2009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048136773"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nn.3904", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048291118", 
          "https://doi.org/10.1038/nn.3904"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1037/h0033536", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048394491"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neuron.2015.05.027", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049680455"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1460-9568.1998.00026.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051866318"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1460-9568.1998.00026.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051866318"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1113/jphysiol.2005.089664", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052359950"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1113/jphysiol.2005.089664", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052359950"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/hipo.22253", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052605627"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.1401-06.2006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053524374"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1201652", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062464426"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.168.3936.1246", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062500022"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.663646", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062639303"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.20-21-08103.2000", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074718184"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/jn.1954.17.6.533", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1075549347"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/jn.1997.77.4.1829", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083075778"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00429-017-1368-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083537073", 
          "https://doi.org/10.1007/s00429-017-1368-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00429-017-1368-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083537073", 
          "https://doi.org/10.1007/s00429-017-1368-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.aan2475", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1090991623"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.aan2475", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1090991623"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2017-12", 
    "datePublishedReg": "2017-12-01", 
    "description": "Medial septal inputs to the hippocampal system are crucial for aspects of temporal and spatial processing, such as theta oscillations and grid cell firing. However, the precise contributions of the medial septum's cholinergic neurones to these functions remain unknown. Here, we recorded neuronal firing and local field potentials from the medial entorhinal cortex of freely foraging mice, while modulating the excitability of medial septal cholinergic neurones. Alteration of cholinergic activity produced a reduction in the frequency of theta oscillations, without affecting the slope of the non-linear theta frequency vs running speed relationship observed. Modifying septal cholinergic tone in this way also led mice to exhibit behaviours associated with novelty or anxiety. However, grid cell firing patterns were unaffected, concordant with an absence of change in the slopes of the theta frequency and firing rate speed signals thought to be used by grid cells.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/s41598-017-15100-6", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.6384338", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1045337", 
        "issn": [
          "2045-2322"
        ], 
        "name": "Scientific Reports", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "7"
      }
    ], 
    "name": "Modulating medial septal cholinergic activity reduces medial entorhinal theta frequency without affecting speed or grid coding", 
    "pagination": "14573", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "58839f02ba52f1f2a86fe611226032c2f257277f75ecdf6d0c103422c165d9d9"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "29109512"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101563288"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/s41598-017-15100-6"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1092462862"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/s41598-017-15100-6", 
      "https://app.dimensions.ai/details/publication/pub.1092462862"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T18:29", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8675_00000577.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/s41598-017-15100-6"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41598-017-15100-6'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41598-017-15100-6'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41598-017-15100-6'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41598-017-15100-6'


 

This table displays all metadata directly associated to this object as RDF triples.

262 TRIPLES      21 PREDICATES      86 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/s41598-017-15100-6 schema:about anzsrc-for:11
2 anzsrc-for:1109
3 schema:author N29b93e4da6024ef5bd97648c1895ddfa
4 schema:citation sg:pub.10.1007/s00429-017-1368-4
5 sg:pub.10.1038/336170a0
6 sg:pub.10.1038/nature14622
7 sg:pub.10.1038/nn.3904
8 sg:pub.10.1038/nn.4447
9 https://doi.org/10.1002/cne.901860408
10 https://doi.org/10.1002/cne.902250303
11 https://doi.org/10.1002/hipo.20062
12 https://doi.org/10.1002/hipo.20327
13 https://doi.org/10.1002/hipo.20510
14 https://doi.org/10.1002/hipo.22253
15 https://doi.org/10.1002/syn.20184
16 https://doi.org/10.1016/0013-4694(60)90101-2
17 https://doi.org/10.1016/0013-4694(62)90030-5
18 https://doi.org/10.1016/0014-4886(73)90290-2
19 https://doi.org/10.1016/0014-4886(75)90195-8
20 https://doi.org/10.1016/0166-4328(88)90105-2
21 https://doi.org/10.1016/0306-4522(94)90341-7
22 https://doi.org/10.1016/j.bbr.2010.11.036
23 https://doi.org/10.1016/j.conb.2006.09.002
24 https://doi.org/10.1016/j.cub.2016.06.043
25 https://doi.org/10.1016/j.neuron.2009.06.014
26 https://doi.org/10.1016/j.neuron.2015.05.001
27 https://doi.org/10.1016/j.neuron.2015.05.027
28 https://doi.org/10.1016/j.neuron.2016.06.027
29 https://doi.org/10.1016/s0006-8993(96)01304-2
30 https://doi.org/10.1016/s0006-8993(98)00390-4
31 https://doi.org/10.1016/s0014-2999(03)01272-x
32 https://doi.org/10.1016/s0306-4522(01)00302-5
33 https://doi.org/10.1037/h0033536
34 https://doi.org/10.1046/j.1460-9568.1998.00026.x
35 https://doi.org/10.1073/pnas.1209918109
36 https://doi.org/10.1073/pnas.1411233111
37 https://doi.org/10.1097/00001756-199511000-00017
38 https://doi.org/10.1098/rstb.2012.0532
39 https://doi.org/10.1111/j.1469-7793.2003.00927.x
40 https://doi.org/10.1113/jphysiol.2005.089664
41 https://doi.org/10.1113/jphysiol.2012.250431
42 https://doi.org/10.1126/science.1201652
43 https://doi.org/10.1126/science.1201685
44 https://doi.org/10.1126/science.168.3936.1246
45 https://doi.org/10.1126/science.663646
46 https://doi.org/10.1126/science.aan2475
47 https://doi.org/10.1152/jn.00492.2009
48 https://doi.org/10.1152/jn.1954.17.6.533
49 https://doi.org/10.1152/jn.1997.77.4.1829
50 https://doi.org/10.1162/neco_a_00701
51 https://doi.org/10.1371/journal.pcbi.1000291
52 https://doi.org/10.1523/jneurosci.1401-06.2006
53 https://doi.org/10.1523/jneurosci.20-21-08103.2000
54 https://doi.org/10.1523/jneurosci.2141-15.2016
55 https://doi.org/10.1523/jneurosci.2586-13.2013
56 https://doi.org/10.1523/jneurosci.4353-05.2006
57 https://doi.org/10.1523/jneurosci.5040-12.2013
58 https://doi.org/10.1523/jneurosci.5665-08.2009
59 https://doi.org/10.3389/fncir.2012.00005
60 https://doi.org/10.7554/elife.01481
61 schema:datePublished 2017-12
62 schema:datePublishedReg 2017-12-01
63 schema:description Medial septal inputs to the hippocampal system are crucial for aspects of temporal and spatial processing, such as theta oscillations and grid cell firing. However, the precise contributions of the medial septum's cholinergic neurones to these functions remain unknown. Here, we recorded neuronal firing and local field potentials from the medial entorhinal cortex of freely foraging mice, while modulating the excitability of medial septal cholinergic neurones. Alteration of cholinergic activity produced a reduction in the frequency of theta oscillations, without affecting the slope of the non-linear theta frequency vs running speed relationship observed. Modifying septal cholinergic tone in this way also led mice to exhibit behaviours associated with novelty or anxiety. However, grid cell firing patterns were unaffected, concordant with an absence of change in the slopes of the theta frequency and firing rate speed signals thought to be used by grid cells.
64 schema:genre research_article
65 schema:inLanguage en
66 schema:isAccessibleForFree true
67 schema:isPartOf N3f2c72f32521418ab5cbd60abb4e01d1
68 N6e9614189ffe483dadd23fde3e9758b3
69 sg:journal.1045337
70 schema:name Modulating medial septal cholinergic activity reduces medial entorhinal theta frequency without affecting speed or grid coding
71 schema:pagination 14573
72 schema:productId Nb19753e125ab4c84a82a8b13ba76bb2e
73 Nba6a98abd2ce42df89cd31a6f5e5f04e
74 Nc12ad46e9c4b4f1da8b9df5073ec31d5
75 Nd6423c8c500046e7bbb1f2a1b8aef01b
76 Nfcb630511fe542c7bc3365d0f79968c5
77 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092462862
78 https://doi.org/10.1038/s41598-017-15100-6
79 schema:sdDatePublished 2019-04-10T18:29
80 schema:sdLicense https://scigraph.springernature.com/explorer/license/
81 schema:sdPublisher Nc6ebec7b25a94b10a96694d866eb651a
82 schema:url https://www.nature.com/articles/s41598-017-15100-6
83 sgo:license sg:explorer/license/
84 sgo:sdDataset articles
85 rdf:type schema:ScholarlyArticle
86 N0115c66dc1dc4794abd5e5042e5c324b rdf:first sg:person.0725101317.86
87 rdf:rest rdf:nil
88 N29b93e4da6024ef5bd97648c1895ddfa rdf:first sg:person.01300624516.79
89 rdf:rest N5b680fc9a8ca43718f619ec822c3f449
90 N3f2c72f32521418ab5cbd60abb4e01d1 schema:issueNumber 1
91 rdf:type schema:PublicationIssue
92 N5b680fc9a8ca43718f619ec822c3f449 rdf:first sg:person.0723124371.28
93 rdf:rest N0115c66dc1dc4794abd5e5042e5c324b
94 N6e9614189ffe483dadd23fde3e9758b3 schema:volumeNumber 7
95 rdf:type schema:PublicationVolume
96 Nb19753e125ab4c84a82a8b13ba76bb2e schema:name dimensions_id
97 schema:value pub.1092462862
98 rdf:type schema:PropertyValue
99 Nba6a98abd2ce42df89cd31a6f5e5f04e schema:name doi
100 schema:value 10.1038/s41598-017-15100-6
101 rdf:type schema:PropertyValue
102 Nc12ad46e9c4b4f1da8b9df5073ec31d5 schema:name readcube_id
103 schema:value 58839f02ba52f1f2a86fe611226032c2f257277f75ecdf6d0c103422c165d9d9
104 rdf:type schema:PropertyValue
105 Nc6ebec7b25a94b10a96694d866eb651a schema:name Springer Nature - SN SciGraph project
106 rdf:type schema:Organization
107 Nd6423c8c500046e7bbb1f2a1b8aef01b schema:name nlm_unique_id
108 schema:value 101563288
109 rdf:type schema:PropertyValue
110 Nfcb630511fe542c7bc3365d0f79968c5 schema:name pubmed_id
111 schema:value 29109512
112 rdf:type schema:PropertyValue
113 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
114 schema:name Medical and Health Sciences
115 rdf:type schema:DefinedTerm
116 anzsrc-for:1109 schema:inDefinedTermSet anzsrc-for:
117 schema:name Neurosciences
118 rdf:type schema:DefinedTerm
119 sg:grant.6384338 http://pending.schema.org/fundedItem sg:pub.10.1038/s41598-017-15100-6
120 rdf:type schema:MonetaryGrant
121 sg:journal.1045337 schema:issn 2045-2322
122 schema:name Scientific Reports
123 rdf:type schema:Periodical
124 sg:person.01300624516.79 schema:affiliation https://www.grid.ac/institutes/grid.83440.3b
125 schema:familyName Carpenter
126 schema:givenName Francis
127 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01300624516.79
128 rdf:type schema:Person
129 sg:person.0723124371.28 schema:affiliation https://www.grid.ac/institutes/grid.83440.3b
130 schema:familyName Burgess
131 schema:givenName Neil
132 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0723124371.28
133 rdf:type schema:Person
134 sg:person.0725101317.86 schema:affiliation https://www.grid.ac/institutes/grid.83440.3b
135 schema:familyName Barry
136 schema:givenName Caswell
137 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0725101317.86
138 rdf:type schema:Person
139 sg:pub.10.1007/s00429-017-1368-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083537073
140 https://doi.org/10.1007/s00429-017-1368-4
141 rdf:type schema:CreativeWork
142 sg:pub.10.1038/336170a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021927311
143 https://doi.org/10.1038/336170a0
144 rdf:type schema:CreativeWork
145 sg:pub.10.1038/nature14622 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047627049
146 https://doi.org/10.1038/nature14622
147 rdf:type schema:CreativeWork
148 sg:pub.10.1038/nn.3904 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048291118
149 https://doi.org/10.1038/nn.3904
150 rdf:type schema:CreativeWork
151 sg:pub.10.1038/nn.4447 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010321431
152 https://doi.org/10.1038/nn.4447
153 rdf:type schema:CreativeWork
154 https://doi.org/10.1002/cne.901860408 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015352482
155 rdf:type schema:CreativeWork
156 https://doi.org/10.1002/cne.902250303 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015731137
157 rdf:type schema:CreativeWork
158 https://doi.org/10.1002/hipo.20062 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016245473
159 rdf:type schema:CreativeWork
160 https://doi.org/10.1002/hipo.20327 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026193472
161 rdf:type schema:CreativeWork
162 https://doi.org/10.1002/hipo.20510 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028010093
163 rdf:type schema:CreativeWork
164 https://doi.org/10.1002/hipo.22253 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052605627
165 rdf:type schema:CreativeWork
166 https://doi.org/10.1002/syn.20184 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005179203
167 rdf:type schema:CreativeWork
168 https://doi.org/10.1016/0013-4694(60)90101-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008313860
169 rdf:type schema:CreativeWork
170 https://doi.org/10.1016/0013-4694(62)90030-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024648951
171 rdf:type schema:CreativeWork
172 https://doi.org/10.1016/0014-4886(73)90290-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040089448
173 rdf:type schema:CreativeWork
174 https://doi.org/10.1016/0014-4886(75)90195-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030539570
175 rdf:type schema:CreativeWork
176 https://doi.org/10.1016/0166-4328(88)90105-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033659560
177 rdf:type schema:CreativeWork
178 https://doi.org/10.1016/0306-4522(94)90341-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025036797
179 rdf:type schema:CreativeWork
180 https://doi.org/10.1016/j.bbr.2010.11.036 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015233256
181 rdf:type schema:CreativeWork
182 https://doi.org/10.1016/j.conb.2006.09.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046909314
183 rdf:type schema:CreativeWork
184 https://doi.org/10.1016/j.cub.2016.06.043 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014269557
185 rdf:type schema:CreativeWork
186 https://doi.org/10.1016/j.neuron.2009.06.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028697987
187 rdf:type schema:CreativeWork
188 https://doi.org/10.1016/j.neuron.2015.05.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002079483
189 rdf:type schema:CreativeWork
190 https://doi.org/10.1016/j.neuron.2015.05.027 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049680455
191 rdf:type schema:CreativeWork
192 https://doi.org/10.1016/j.neuron.2016.06.027 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019153944
193 rdf:type schema:CreativeWork
194 https://doi.org/10.1016/s0006-8993(96)01304-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008169978
195 rdf:type schema:CreativeWork
196 https://doi.org/10.1016/s0006-8993(98)00390-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004725942
197 rdf:type schema:CreativeWork
198 https://doi.org/10.1016/s0014-2999(03)01272-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1040843120
199 rdf:type schema:CreativeWork
200 https://doi.org/10.1016/s0306-4522(01)00302-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046325373
201 rdf:type schema:CreativeWork
202 https://doi.org/10.1037/h0033536 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048394491
203 rdf:type schema:CreativeWork
204 https://doi.org/10.1046/j.1460-9568.1998.00026.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1051866318
205 rdf:type schema:CreativeWork
206 https://doi.org/10.1073/pnas.1209918109 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021779181
207 rdf:type schema:CreativeWork
208 https://doi.org/10.1073/pnas.1411233111 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023140477
209 rdf:type schema:CreativeWork
210 https://doi.org/10.1097/00001756-199511000-00017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000703281
211 rdf:type schema:CreativeWork
212 https://doi.org/10.1098/rstb.2012.0532 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029479442
213 rdf:type schema:CreativeWork
214 https://doi.org/10.1111/j.1469-7793.2003.00927.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1024824861
215 rdf:type schema:CreativeWork
216 https://doi.org/10.1113/jphysiol.2005.089664 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052359950
217 rdf:type schema:CreativeWork
218 https://doi.org/10.1113/jphysiol.2012.250431 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002208890
219 rdf:type schema:CreativeWork
220 https://doi.org/10.1126/science.1201652 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062464426
221 rdf:type schema:CreativeWork
222 https://doi.org/10.1126/science.1201685 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027748352
223 rdf:type schema:CreativeWork
224 https://doi.org/10.1126/science.168.3936.1246 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062500022
225 rdf:type schema:CreativeWork
226 https://doi.org/10.1126/science.663646 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062639303
227 rdf:type schema:CreativeWork
228 https://doi.org/10.1126/science.aan2475 schema:sameAs https://app.dimensions.ai/details/publication/pub.1090991623
229 rdf:type schema:CreativeWork
230 https://doi.org/10.1152/jn.00492.2009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016723538
231 rdf:type schema:CreativeWork
232 https://doi.org/10.1152/jn.1954.17.6.533 schema:sameAs https://app.dimensions.ai/details/publication/pub.1075549347
233 rdf:type schema:CreativeWork
234 https://doi.org/10.1152/jn.1997.77.4.1829 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083075778
235 rdf:type schema:CreativeWork
236 https://doi.org/10.1162/neco_a_00701 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025298691
237 rdf:type schema:CreativeWork
238 https://doi.org/10.1371/journal.pcbi.1000291 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011718575
239 rdf:type schema:CreativeWork
240 https://doi.org/10.1523/jneurosci.1401-06.2006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053524374
241 rdf:type schema:CreativeWork
242 https://doi.org/10.1523/jneurosci.20-21-08103.2000 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074718184
243 rdf:type schema:CreativeWork
244 https://doi.org/10.1523/jneurosci.2141-15.2016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036353775
245 rdf:type schema:CreativeWork
246 https://doi.org/10.1523/jneurosci.2586-13.2013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033952127
247 rdf:type schema:CreativeWork
248 https://doi.org/10.1523/jneurosci.4353-05.2006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012374642
249 rdf:type schema:CreativeWork
250 https://doi.org/10.1523/jneurosci.5040-12.2013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033054369
251 rdf:type schema:CreativeWork
252 https://doi.org/10.1523/jneurosci.5665-08.2009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048136773
253 rdf:type schema:CreativeWork
254 https://doi.org/10.3389/fncir.2012.00005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025381862
255 rdf:type schema:CreativeWork
256 https://doi.org/10.7554/elife.01481 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001031407
257 rdf:type schema:CreativeWork
258 https://www.grid.ac/institutes/grid.83440.3b schema:alternateName University College London
259 schema:name Institute of Cognitive Neuroscience, UCL, Queen Square, WC1N 3AR, London, UK
260 Institute of Neurology, UCL, Queen Square, WC1N 3BG, London, UK
261 Research Department of Cell & Developmental Biology, UCL, Gower Street, WC1E 6BT, London, UK
262 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...