A guanidine-appended scyllo-inositol derivative AAD-66 enhances brain delivery and ameliorates Alzheimer’s phenotypes View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-12

AUTHORS

Dohyun Lee, Woo-Sirl Lee, Sungsu Lim, Yun Kyung Kim, Hoe-Yune Jung, Sanket Das, Juhyun Lee, Wenjie Luo, Kyong-Tai Kim, Sung-Kee Chung

ABSTRACT

Alzheimer's disease (AD) is a degenerative brain disease that destroys memory and other important mental functions but lacks efficient therapeutic agents. Blocking toxic amyloid β (Aβ) could be beneficial for AD and represents a promising therapeutic strategy for AD treatment. scyllo-Inositol (SI) is a potential therapeutic for AD by directly interacting with the Aβ peptide to inhibit Aβ42 fiber formation. Clinical studies of SI showed promising benefits on mild to moderate AD, however, with limitations on dosage regime. A new strategy to enhance the brain delivery of SI is needed to achieve the efficacy with minimum adverse effects. Herein, we report that a novel guanidine-appended SI derivative AAD-66 resulted in more effective reductions of brain Aβ and plaque deposits, gliosis, and behavioral memory deficits in the disease-established 5xFAD mice. Overall, our present study reveals the potential of AAD-66 as a promising therapeutic agent for AD. More... »

PAGES

14125

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41598-017-14559-7

DOI

http://dx.doi.org/10.1038/s41598-017-14559-7

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1092352942

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29074878


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1109", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Neurosciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Pohang University of Science and Technology", 
          "id": "https://www.grid.ac/institutes/grid.49100.3c", 
          "name": [
            "Department of Life Sciences, Pohang University of Science and Technology (POSTECH), 37673, Pohang, Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lee", 
        "givenName": "Dohyun", 
        "id": "sg:person.01365450061.54", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01365450061.54"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Pohang University of Science and Technology", 
          "id": "https://www.grid.ac/institutes/grid.49100.3c", 
          "name": [
            "Department of Chemistry, Pohang University of Science and Technology (POSTECH), 37673, Pohang, Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lee", 
        "givenName": "Woo-Sirl", 
        "id": "sg:person.01116114707.37", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01116114707.37"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Korea Institute of Science and Technology", 
          "id": "https://www.grid.ac/institutes/grid.35541.36", 
          "name": [
            "Center for Neuro-Medicine, Korea Institute of Science and Technology (KIST), 02790, Seoul, Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lim", 
        "givenName": "Sungsu", 
        "id": "sg:person.0634700720.10", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0634700720.10"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Korea Institute of Science and Technology", 
          "id": "https://www.grid.ac/institutes/grid.35541.36", 
          "name": [
            "Center for Neuro-Medicine, Korea Institute of Science and Technology (KIST), 02790, Seoul, Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kim", 
        "givenName": "Yun Kyung", 
        "id": "sg:person.01065355720.29", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01065355720.29"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Pohang University of Science and Technology", 
          "id": "https://www.grid.ac/institutes/grid.49100.3c", 
          "name": [
            "Division of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology (POSTECH), 37673, Pohang, Republic of Korea", 
            "R&D Center, NovMetaPharma Co., Ltd., Jigok-dong, 37666, Pohang, Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jung", 
        "givenName": "Hoe-Yune", 
        "id": "sg:person.01023345125.55", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01023345125.55"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Pohang University of Science and Technology", 
          "id": "https://www.grid.ac/institutes/grid.49100.3c", 
          "name": [
            "Department of Chemistry, Pohang University of Science and Technology (POSTECH), 37673, Pohang, Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Das", 
        "givenName": "Sanket", 
        "id": "sg:person.012000153533.59", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012000153533.59"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Pohang University of Science and Technology", 
          "id": "https://www.grid.ac/institutes/grid.49100.3c", 
          "name": [
            "Division of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology (POSTECH), 37673, Pohang, Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lee", 
        "givenName": "Juhyun", 
        "id": "sg:person.01075214021.49", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01075214021.49"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Cornell University", 
          "id": "https://www.grid.ac/institutes/grid.5386.8", 
          "name": [
            "Helen and Robert Appel Alzheimer\u2019s Disease Research Institute, Brain and Mind Research Institute, Weill Cornell Medical College, 10065, New York, NY, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Luo", 
        "givenName": "Wenjie", 
        "id": "sg:person.07746213717.52", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07746213717.52"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Pohang University of Science and Technology", 
          "id": "https://www.grid.ac/institutes/grid.49100.3c", 
          "name": [
            "Department of Life Sciences, Pohang University of Science and Technology (POSTECH), 37673, Pohang, Republic of Korea", 
            "Division of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology (POSTECH), 37673, Pohang, Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kim", 
        "givenName": "Kyong-Tai", 
        "id": "sg:person.01106706670.04", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01106706670.04"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Pohang University of Science and Technology", 
          "id": "https://www.grid.ac/institutes/grid.49100.3c", 
          "name": [
            "Department of Chemistry, Pohang University of Science and Technology (POSTECH), 37673, Pohang, Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chung", 
        "givenName": "Sung-Kee", 
        "id": "sg:person.01321376620.52", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01321376620.52"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/b978-0-12-394816-8.00006-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003220156"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00234656", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003460750", 
          "https://doi.org/10.1007/bf00234656"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00234656", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003460750", 
          "https://doi.org/10.1007/bf00234656"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/anie.200600312", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005558091"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/anie.200600312", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005558091"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000318750", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006027060"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.5012/bkcs.2011.32.3.873", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009333343"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0361-9230(99)00072-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013726043"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0361-9230(99)00072-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013726043"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1039/b901846h", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013835358"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1039/b901846h", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013835358"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0166-2236(00)02031-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014149899"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neuropharm.2010.03.011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014589323"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/anie.200701346", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017088228"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1039/c0md00235f", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019640698"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/pr100798r", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023279974"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/nbm.1940060116", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023743377"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm1423", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025172209", 
          "https://doi.org/10.1038/nm1423"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm1423", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025172209", 
          "https://doi.org/10.1038/nm1423"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000441-197707000-00007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026895862"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000441-197707000-00007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026895862"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(10)61349-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028084828"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0165-6147(91)90609-v", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028134537"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0165-6147(91)90609-v", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028134537"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1155/2008/453120", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029520340"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0896-6273(00)80187-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030886620"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/chem.200600898", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032074711"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev.nu.06.070186.003023", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033470666"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1039/c2md20112g", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035171267"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00109-007-0156-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035316186", 
          "https://doi.org/10.1007/s00109-007-0156-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00109-007-0156-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035316186", 
          "https://doi.org/10.1007/s00109-007-0156-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3389/fncel.2015.00278", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035497145"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m906994199", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035703800"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/brain/awh531", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036198726"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncomms9997", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042562419", 
          "https://doi.org/10.1038/ncomms9997"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/glia.20967", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045687456"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/glia.20967", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045687456"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cnr.2006.09.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047087918"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.1202-06.2006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047102131"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0024032", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052051787"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/wnl.0b013e3182309fa5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064356489"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/wnl.0b013e3182309fa5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064356489"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/wnl.0b013e3182309fa5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064356489"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.23-07-02665.2003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1075266248"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2017-12", 
    "datePublishedReg": "2017-12-01", 
    "description": "Alzheimer's disease (AD) is a degenerative brain disease that destroys memory and other important mental functions but lacks efficient therapeutic agents. Blocking toxic amyloid \u03b2 (A\u03b2) could be beneficial for AD and represents a promising therapeutic strategy for AD treatment. scyllo-Inositol (SI) is a potential therapeutic for AD by directly interacting with the A\u03b2 peptide to inhibit A\u03b242 fiber formation. Clinical studies of SI showed promising benefits on mild to moderate AD, however, with limitations on dosage regime. A new strategy to enhance the brain delivery of SI is needed to achieve the efficacy with minimum adverse effects. Herein, we report that a novel guanidine-appended SI derivative AAD-66 resulted in more effective reductions of brain A\u03b2 and plaque deposits, gliosis, and behavioral memory deficits in the disease-established 5xFAD mice. Overall, our present study reveals the potential of AAD-66 as a promising therapeutic agent for AD.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/s41598-017-14559-7", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1045337", 
        "issn": [
          "2045-2322"
        ], 
        "name": "Scientific Reports", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "7"
      }
    ], 
    "name": "A guanidine-appended scyllo-inositol derivative AAD-66 enhances brain delivery and ameliorates Alzheimer\u2019s phenotypes", 
    "pagination": "14125", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "d9dc0fe75c45993701e140370e493d2fdca79bdafda8e7595baf402f8a509546"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "29074878"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101563288"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/s41598-017-14559-7"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1092352942"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/s41598-017-14559-7", 
      "https://app.dimensions.ai/details/publication/pub.1092352942"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T00:26", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8695_00000570.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/s41598-017-14559-7"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41598-017-14559-7'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41598-017-14559-7'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41598-017-14559-7'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41598-017-14559-7'


 

This table displays all metadata directly associated to this object as RDF triples.

243 TRIPLES      21 PREDICATES      62 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/s41598-017-14559-7 schema:about anzsrc-for:11
2 anzsrc-for:1109
3 schema:author N3d81f290fbc54645af84ca9d01b56702
4 schema:citation sg:pub.10.1007/bf00234656
5 sg:pub.10.1007/s00109-007-0156-7
6 sg:pub.10.1038/ncomms9997
7 sg:pub.10.1038/nm1423
8 https://doi.org/10.1002/anie.200600312
9 https://doi.org/10.1002/anie.200701346
10 https://doi.org/10.1002/chem.200600898
11 https://doi.org/10.1002/glia.20967
12 https://doi.org/10.1002/nbm.1940060116
13 https://doi.org/10.1016/0165-6147(91)90609-v
14 https://doi.org/10.1016/b978-0-12-394816-8.00006-4
15 https://doi.org/10.1016/j.cnr.2006.09.005
16 https://doi.org/10.1016/j.neuropharm.2010.03.011
17 https://doi.org/10.1016/s0140-6736(10)61349-9
18 https://doi.org/10.1016/s0166-2236(00)02031-2
19 https://doi.org/10.1016/s0361-9230(99)00072-6
20 https://doi.org/10.1016/s0896-6273(00)80187-7
21 https://doi.org/10.1021/pr100798r
22 https://doi.org/10.1039/b901846h
23 https://doi.org/10.1039/c0md00235f
24 https://doi.org/10.1039/c2md20112g
25 https://doi.org/10.1074/jbc.m906994199
26 https://doi.org/10.1093/brain/awh531
27 https://doi.org/10.1097/00000441-197707000-00007
28 https://doi.org/10.1146/annurev.nu.06.070186.003023
29 https://doi.org/10.1155/2008/453120
30 https://doi.org/10.1159/000318750
31 https://doi.org/10.1212/wnl.0b013e3182309fa5
32 https://doi.org/10.1371/journal.pone.0024032
33 https://doi.org/10.1523/jneurosci.1202-06.2006
34 https://doi.org/10.1523/jneurosci.23-07-02665.2003
35 https://doi.org/10.3389/fncel.2015.00278
36 https://doi.org/10.5012/bkcs.2011.32.3.873
37 schema:datePublished 2017-12
38 schema:datePublishedReg 2017-12-01
39 schema:description Alzheimer's disease (AD) is a degenerative brain disease that destroys memory and other important mental functions but lacks efficient therapeutic agents. Blocking toxic amyloid β (Aβ) could be beneficial for AD and represents a promising therapeutic strategy for AD treatment. scyllo-Inositol (SI) is a potential therapeutic for AD by directly interacting with the Aβ peptide to inhibit Aβ42 fiber formation. Clinical studies of SI showed promising benefits on mild to moderate AD, however, with limitations on dosage regime. A new strategy to enhance the brain delivery of SI is needed to achieve the efficacy with minimum adverse effects. Herein, we report that a novel guanidine-appended SI derivative AAD-66 resulted in more effective reductions of brain Aβ and plaque deposits, gliosis, and behavioral memory deficits in the disease-established 5xFAD mice. Overall, our present study reveals the potential of AAD-66 as a promising therapeutic agent for AD.
40 schema:genre research_article
41 schema:inLanguage en
42 schema:isAccessibleForFree true
43 schema:isPartOf Nb7e9e17f0777473dabb64c79abd582d3
44 Nce30eabeb44e4858af5fb50f769ddc42
45 sg:journal.1045337
46 schema:name A guanidine-appended scyllo-inositol derivative AAD-66 enhances brain delivery and ameliorates Alzheimer’s phenotypes
47 schema:pagination 14125
48 schema:productId N17b36d097d01419db2dbccce8ae261c2
49 N1d70812a7e7d4f50b7d294074263315e
50 N26802a34c05646bbbc4fc673c03f2cb5
51 N9fe1940ab2e843fcbdd365f5cbbac398
52 Na749a76f2c374f6a837fda8b1e09af73
53 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092352942
54 https://doi.org/10.1038/s41598-017-14559-7
55 schema:sdDatePublished 2019-04-11T00:26
56 schema:sdLicense https://scigraph.springernature.com/explorer/license/
57 schema:sdPublisher N58d496daf8ab4febb824c42d93216427
58 schema:url https://www.nature.com/articles/s41598-017-14559-7
59 sgo:license sg:explorer/license/
60 sgo:sdDataset articles
61 rdf:type schema:ScholarlyArticle
62 N0b847d4055c04b2ba68407f411729d3d rdf:first sg:person.0634700720.10
63 rdf:rest Nd5c31dc94b664b53b38fa773f7fca695
64 N17b36d097d01419db2dbccce8ae261c2 schema:name pubmed_id
65 schema:value 29074878
66 rdf:type schema:PropertyValue
67 N1d70812a7e7d4f50b7d294074263315e schema:name doi
68 schema:value 10.1038/s41598-017-14559-7
69 rdf:type schema:PropertyValue
70 N23fa798ea85f48d5b9bbc4dfb487b8a4 rdf:first sg:person.01116114707.37
71 rdf:rest N0b847d4055c04b2ba68407f411729d3d
72 N26802a34c05646bbbc4fc673c03f2cb5 schema:name dimensions_id
73 schema:value pub.1092352942
74 rdf:type schema:PropertyValue
75 N3d81f290fbc54645af84ca9d01b56702 rdf:first sg:person.01365450061.54
76 rdf:rest N23fa798ea85f48d5b9bbc4dfb487b8a4
77 N58d496daf8ab4febb824c42d93216427 schema:name Springer Nature - SN SciGraph project
78 rdf:type schema:Organization
79 N77ab290e44f040968767a428280ad65d rdf:first sg:person.01321376620.52
80 rdf:rest rdf:nil
81 N780ed9a401064b4e96c1484407f1ed2a rdf:first sg:person.01106706670.04
82 rdf:rest N77ab290e44f040968767a428280ad65d
83 N8f83c86a55bc4702a65b5405d911c8b1 rdf:first sg:person.012000153533.59
84 rdf:rest Nd44375baf6da493e8cc9b8429a2ff363
85 N9fe1940ab2e843fcbdd365f5cbbac398 schema:name nlm_unique_id
86 schema:value 101563288
87 rdf:type schema:PropertyValue
88 Na749a76f2c374f6a837fda8b1e09af73 schema:name readcube_id
89 schema:value d9dc0fe75c45993701e140370e493d2fdca79bdafda8e7595baf402f8a509546
90 rdf:type schema:PropertyValue
91 Nb7e9e17f0777473dabb64c79abd582d3 schema:volumeNumber 7
92 rdf:type schema:PublicationVolume
93 Nce30eabeb44e4858af5fb50f769ddc42 schema:issueNumber 1
94 rdf:type schema:PublicationIssue
95 Nd44375baf6da493e8cc9b8429a2ff363 rdf:first sg:person.01075214021.49
96 rdf:rest Nf27b59acad2948ad9ca528beb3d7429d
97 Nd5c31dc94b664b53b38fa773f7fca695 rdf:first sg:person.01065355720.29
98 rdf:rest Nfdbea3850d7d4b49815191a78e5aebcc
99 Nf27b59acad2948ad9ca528beb3d7429d rdf:first sg:person.07746213717.52
100 rdf:rest N780ed9a401064b4e96c1484407f1ed2a
101 Nfdbea3850d7d4b49815191a78e5aebcc rdf:first sg:person.01023345125.55
102 rdf:rest N8f83c86a55bc4702a65b5405d911c8b1
103 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
104 schema:name Medical and Health Sciences
105 rdf:type schema:DefinedTerm
106 anzsrc-for:1109 schema:inDefinedTermSet anzsrc-for:
107 schema:name Neurosciences
108 rdf:type schema:DefinedTerm
109 sg:journal.1045337 schema:issn 2045-2322
110 schema:name Scientific Reports
111 rdf:type schema:Periodical
112 sg:person.01023345125.55 schema:affiliation https://www.grid.ac/institutes/grid.49100.3c
113 schema:familyName Jung
114 schema:givenName Hoe-Yune
115 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01023345125.55
116 rdf:type schema:Person
117 sg:person.01065355720.29 schema:affiliation https://www.grid.ac/institutes/grid.35541.36
118 schema:familyName Kim
119 schema:givenName Yun Kyung
120 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01065355720.29
121 rdf:type schema:Person
122 sg:person.01075214021.49 schema:affiliation https://www.grid.ac/institutes/grid.49100.3c
123 schema:familyName Lee
124 schema:givenName Juhyun
125 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01075214021.49
126 rdf:type schema:Person
127 sg:person.01106706670.04 schema:affiliation https://www.grid.ac/institutes/grid.49100.3c
128 schema:familyName Kim
129 schema:givenName Kyong-Tai
130 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01106706670.04
131 rdf:type schema:Person
132 sg:person.01116114707.37 schema:affiliation https://www.grid.ac/institutes/grid.49100.3c
133 schema:familyName Lee
134 schema:givenName Woo-Sirl
135 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01116114707.37
136 rdf:type schema:Person
137 sg:person.012000153533.59 schema:affiliation https://www.grid.ac/institutes/grid.49100.3c
138 schema:familyName Das
139 schema:givenName Sanket
140 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012000153533.59
141 rdf:type schema:Person
142 sg:person.01321376620.52 schema:affiliation https://www.grid.ac/institutes/grid.49100.3c
143 schema:familyName Chung
144 schema:givenName Sung-Kee
145 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01321376620.52
146 rdf:type schema:Person
147 sg:person.01365450061.54 schema:affiliation https://www.grid.ac/institutes/grid.49100.3c
148 schema:familyName Lee
149 schema:givenName Dohyun
150 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01365450061.54
151 rdf:type schema:Person
152 sg:person.0634700720.10 schema:affiliation https://www.grid.ac/institutes/grid.35541.36
153 schema:familyName Lim
154 schema:givenName Sungsu
155 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0634700720.10
156 rdf:type schema:Person
157 sg:person.07746213717.52 schema:affiliation https://www.grid.ac/institutes/grid.5386.8
158 schema:familyName Luo
159 schema:givenName Wenjie
160 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07746213717.52
161 rdf:type schema:Person
162 sg:pub.10.1007/bf00234656 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003460750
163 https://doi.org/10.1007/bf00234656
164 rdf:type schema:CreativeWork
165 sg:pub.10.1007/s00109-007-0156-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035316186
166 https://doi.org/10.1007/s00109-007-0156-7
167 rdf:type schema:CreativeWork
168 sg:pub.10.1038/ncomms9997 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042562419
169 https://doi.org/10.1038/ncomms9997
170 rdf:type schema:CreativeWork
171 sg:pub.10.1038/nm1423 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025172209
172 https://doi.org/10.1038/nm1423
173 rdf:type schema:CreativeWork
174 https://doi.org/10.1002/anie.200600312 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005558091
175 rdf:type schema:CreativeWork
176 https://doi.org/10.1002/anie.200701346 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017088228
177 rdf:type schema:CreativeWork
178 https://doi.org/10.1002/chem.200600898 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032074711
179 rdf:type schema:CreativeWork
180 https://doi.org/10.1002/glia.20967 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045687456
181 rdf:type schema:CreativeWork
182 https://doi.org/10.1002/nbm.1940060116 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023743377
183 rdf:type schema:CreativeWork
184 https://doi.org/10.1016/0165-6147(91)90609-v schema:sameAs https://app.dimensions.ai/details/publication/pub.1028134537
185 rdf:type schema:CreativeWork
186 https://doi.org/10.1016/b978-0-12-394816-8.00006-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003220156
187 rdf:type schema:CreativeWork
188 https://doi.org/10.1016/j.cnr.2006.09.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047087918
189 rdf:type schema:CreativeWork
190 https://doi.org/10.1016/j.neuropharm.2010.03.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014589323
191 rdf:type schema:CreativeWork
192 https://doi.org/10.1016/s0140-6736(10)61349-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028084828
193 rdf:type schema:CreativeWork
194 https://doi.org/10.1016/s0166-2236(00)02031-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014149899
195 rdf:type schema:CreativeWork
196 https://doi.org/10.1016/s0361-9230(99)00072-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013726043
197 rdf:type schema:CreativeWork
198 https://doi.org/10.1016/s0896-6273(00)80187-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030886620
199 rdf:type schema:CreativeWork
200 https://doi.org/10.1021/pr100798r schema:sameAs https://app.dimensions.ai/details/publication/pub.1023279974
201 rdf:type schema:CreativeWork
202 https://doi.org/10.1039/b901846h schema:sameAs https://app.dimensions.ai/details/publication/pub.1013835358
203 rdf:type schema:CreativeWork
204 https://doi.org/10.1039/c0md00235f schema:sameAs https://app.dimensions.ai/details/publication/pub.1019640698
205 rdf:type schema:CreativeWork
206 https://doi.org/10.1039/c2md20112g schema:sameAs https://app.dimensions.ai/details/publication/pub.1035171267
207 rdf:type schema:CreativeWork
208 https://doi.org/10.1074/jbc.m906994199 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035703800
209 rdf:type schema:CreativeWork
210 https://doi.org/10.1093/brain/awh531 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036198726
211 rdf:type schema:CreativeWork
212 https://doi.org/10.1097/00000441-197707000-00007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026895862
213 rdf:type schema:CreativeWork
214 https://doi.org/10.1146/annurev.nu.06.070186.003023 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033470666
215 rdf:type schema:CreativeWork
216 https://doi.org/10.1155/2008/453120 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029520340
217 rdf:type schema:CreativeWork
218 https://doi.org/10.1159/000318750 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006027060
219 rdf:type schema:CreativeWork
220 https://doi.org/10.1212/wnl.0b013e3182309fa5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064356489
221 rdf:type schema:CreativeWork
222 https://doi.org/10.1371/journal.pone.0024032 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052051787
223 rdf:type schema:CreativeWork
224 https://doi.org/10.1523/jneurosci.1202-06.2006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047102131
225 rdf:type schema:CreativeWork
226 https://doi.org/10.1523/jneurosci.23-07-02665.2003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1075266248
227 rdf:type schema:CreativeWork
228 https://doi.org/10.3389/fncel.2015.00278 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035497145
229 rdf:type schema:CreativeWork
230 https://doi.org/10.5012/bkcs.2011.32.3.873 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009333343
231 rdf:type schema:CreativeWork
232 https://www.grid.ac/institutes/grid.35541.36 schema:alternateName Korea Institute of Science and Technology
233 schema:name Center for Neuro-Medicine, Korea Institute of Science and Technology (KIST), 02790, Seoul, Republic of Korea
234 rdf:type schema:Organization
235 https://www.grid.ac/institutes/grid.49100.3c schema:alternateName Pohang University of Science and Technology
236 schema:name Department of Chemistry, Pohang University of Science and Technology (POSTECH), 37673, Pohang, Republic of Korea
237 Department of Life Sciences, Pohang University of Science and Technology (POSTECH), 37673, Pohang, Republic of Korea
238 Division of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology (POSTECH), 37673, Pohang, Republic of Korea
239 R&D Center, NovMetaPharma Co., Ltd., Jigok-dong, 37666, Pohang, Republic of Korea
240 rdf:type schema:Organization
241 https://www.grid.ac/institutes/grid.5386.8 schema:alternateName Cornell University
242 schema:name Helen and Robert Appel Alzheimer’s Disease Research Institute, Brain and Mind Research Institute, Weill Cornell Medical College, 10065, New York, NY, USA
243 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...