A guanidine-appended scyllo-inositol derivative AAD-66 enhances brain delivery and ameliorates Alzheimer’s phenotypes View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-12

AUTHORS

Dohyun Lee, Woo-Sirl Lee, Sungsu Lim, Yun Kyung Kim, Hoe-Yune Jung, Sanket Das, Juhyun Lee, Wenjie Luo, Kyong-Tai Kim, Sung-Kee Chung

ABSTRACT

Alzheimer's disease (AD) is a degenerative brain disease that destroys memory and other important mental functions but lacks efficient therapeutic agents. Blocking toxic amyloid β (Aβ) could be beneficial for AD and represents a promising therapeutic strategy for AD treatment. scyllo-Inositol (SI) is a potential therapeutic for AD by directly interacting with the Aβ peptide to inhibit Aβ42 fiber formation. Clinical studies of SI showed promising benefits on mild to moderate AD, however, with limitations on dosage regime. A new strategy to enhance the brain delivery of SI is needed to achieve the efficacy with minimum adverse effects. Herein, we report that a novel guanidine-appended SI derivative AAD-66 resulted in more effective reductions of brain Aβ and plaque deposits, gliosis, and behavioral memory deficits in the disease-established 5xFAD mice. Overall, our present study reveals the potential of AAD-66 as a promising therapeutic agent for AD. More... »

PAGES

14125

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41598-017-14559-7

DOI

http://dx.doi.org/10.1038/s41598-017-14559-7

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1092352942

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29074878


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