Hydration number: crucial role in nuclear magnetic relaxivity of Gd(III) chelate-based nanoparticles View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-12

AUTHORS

Rustem Zairov, Gulshat Khakimullina, Sergey Podyachev, Irek Nizameev, Georgy Safiullin, Rustem Amirov, Alberto Vomiero, Asiya Mustafina

ABSTRACT

Today, nanostructure-based contrast agents (CA) are emerging in the field of magnetic resonance imaging (MRI). Their sensitivity is reported as greatly improved in comparison to commercially used chelate-based ones. The present work is aimed at revealing the factors governing the efficiency of longitudinal magnetic relaxivity (r1) in aqueous colloids of core-shell Gd(III)-based nanoparticles. We report for the first time on hydration number (q) of gadolinium(III) as a substantial factor in controlling r1 values of polyelectrolyte-stabilized nanoparticles built from water insoluble complexes of Gd(III). The use of specific complex structure enables to reveal the impact of the inner-sphere hydration number on both r1 values for the Gd(III)-based nanoparticles and the photophysical properties of their luminescent Tb(III) and Eu(III) counterparts. The low hydration of TTA-based Gd(III) complexes (q ≈ 1) agrees well with the poor relaxivity values (r1 = 2.82 mM-1s-1 and r2 = 3.95 mM-1s-1), while these values tend to increase substantially (r1 = 12.41 mM-1s-1, r2 = 14.36 mM-1s-1) for aqueous Gd(III)-based colloids, when macrocyclic 1,3-diketonate is applied as the ligand (q ≈ 3). The regularities obtained in this work are fundamental in understanding the efficiency of MRI probes in the fast growing field of nanoparticulate contrast agents. More... »

PAGES

14010

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41598-017-14409-6

DOI

http://dx.doi.org/10.1038/s41598-017-14409-6

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1092297839

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29070882


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