A simple surface plasmon resonance biosensor for detection of PML/RARα based on heterogeneous fusion gene-triggered nonlinear hybridization chain reaction View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-10-25

AUTHORS

Bin Guo, Wei Cheng, Yongjie Xu, Xiaoyan Zhou, Xinmin Li, Xiaojuan Ding, Shijia Ding

ABSTRACT

In this work, a simple and enzyme-free surface plasmon resonance (SPR) biosensing strategy has been developed for highly sensitive detection of two major PML/RARα (promyelocytic leukemia, retinoic acid receptor alpha) subtypes based on the heterogeneous fusion gene-triggered nonlinear hybridization chain reaction (HCR). On the gold chip surface, the cascade self-assembly process is triggered after the introduction of PML/RARα. The different fragments of PML/RARα can specifically hybridize with capture probes (Cp) immobilized on the chip and the hybridization DNA1 (H1). Then, the nonlinear HCR is initiated by the complex of Cp-PML/RARα-H1 with the introduction of two hybridization DNA chains (H2 and H3). As a result, a dendritic nanostructure is achieved on the surface of chip, leading to a significant SPR amplification signal owing to its high molecular weight. The developed method shows good specificity and high sensitivity with detection limit of 0.72 pM for "L" subtype and 0.65 pM for "S" subtype. Moreover, this method has been successfully applied for efficient identification of clinical positive and negative PCR samples of the PML/RARα subtype. Thus, this developed biosensing strategy presents a potential platform for analysis of fusion gene and early diagnosis of clinical disease. More... »

PAGES

14037

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41598-017-14361-5

DOI

http://dx.doi.org/10.1038/s41598-017-14361-5

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1092297826

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29070911


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/03", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Chemical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0306", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Physical Chemistry (incl. Structural)", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Clinical Laboratory, The Affiliated Hospital of North Sichuan Medical College, Nanchong, 637000 China", 
          "id": "http://www.grid.ac/institutes/grid.413387.a", 
          "name": [
            "Key Laboratory of Clinical Laboratory Diagnostics (Ministry of Education), College of Laboratory Medicine, Chongqing Medical University, Chongqing, 400016 China", 
            "Department of Clinical Laboratory, The Affiliated Hospital of North Sichuan Medical College, Nanchong, 637000 China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Guo", 
        "givenName": "Bin", 
        "id": "sg:person.01070742336.73", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01070742336.73"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The Center for Clinical Molecular Medical Detection, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016 China", 
          "id": "http://www.grid.ac/institutes/grid.452206.7", 
          "name": [
            "The Center for Clinical Molecular Medical Detection, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016 China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cheng", 
        "givenName": "Wei", 
        "id": "sg:person.015647357356.82", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015647357356.82"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Key Laboratory of Clinical Laboratory Diagnostics (Ministry of Education), College of Laboratory Medicine, Chongqing Medical University, Chongqing, 400016 China", 
          "id": "http://www.grid.ac/institutes/grid.203458.8", 
          "name": [
            "Key Laboratory of Clinical Laboratory Diagnostics (Ministry of Education), College of Laboratory Medicine, Chongqing Medical University, Chongqing, 400016 China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Xu", 
        "givenName": "Yongjie", 
        "id": "sg:person.07677335745.64", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07677335745.64"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Key Laboratory of Clinical Laboratory Diagnostics (Ministry of Education), College of Laboratory Medicine, Chongqing Medical University, Chongqing, 400016 China", 
          "id": "http://www.grid.ac/institutes/grid.203458.8", 
          "name": [
            "Key Laboratory of Clinical Laboratory Diagnostics (Ministry of Education), College of Laboratory Medicine, Chongqing Medical University, Chongqing, 400016 China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhou", 
        "givenName": "Xiaoyan", 
        "id": "sg:person.01010610662.09", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01010610662.09"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Key Laboratory of Clinical Laboratory Diagnostics (Ministry of Education), College of Laboratory Medicine, Chongqing Medical University, Chongqing, 400016 China", 
          "id": "http://www.grid.ac/institutes/grid.203458.8", 
          "name": [
            "Key Laboratory of Clinical Laboratory Diagnostics (Ministry of Education), College of Laboratory Medicine, Chongqing Medical University, Chongqing, 400016 China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Li", 
        "givenName": "Xinmin", 
        "id": "sg:person.0650046103.40", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0650046103.40"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Key Laboratory of Clinical Laboratory Diagnostics (Ministry of Education), College of Laboratory Medicine, Chongqing Medical University, Chongqing, 400016 China", 
          "id": "http://www.grid.ac/institutes/grid.203458.8", 
          "name": [
            "Key Laboratory of Clinical Laboratory Diagnostics (Ministry of Education), College of Laboratory Medicine, Chongqing Medical University, Chongqing, 400016 China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ding", 
        "givenName": "Xiaojuan", 
        "id": "sg:person.0651322736.97", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0651322736.97"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Key Laboratory of Clinical Laboratory Diagnostics (Ministry of Education), College of Laboratory Medicine, Chongqing Medical University, Chongqing, 400016 China", 
          "id": "http://www.grid.ac/institutes/grid.203458.8", 
          "name": [
            "Key Laboratory of Clinical Laboratory Diagnostics (Ministry of Education), College of Laboratory Medicine, Chongqing Medical University, Chongqing, 400016 China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ding", 
        "givenName": "Shijia", 
        "id": "sg:person.01364257713.08", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01364257713.08"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/347558a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041963568", 
          "https://doi.org/10.1038/347558a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.leu.2401592", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034947020", 
          "https://doi.org/10.1038/sj.leu.2401592"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nnano.2010.211", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038619626", 
          "https://doi.org/10.1038/nnano.2010.211"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature06451", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041585382", 
          "https://doi.org/10.1038/nature06451"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2017-10-25", 
    "datePublishedReg": "2017-10-25", 
    "description": "In this work, a simple and enzyme-free surface plasmon resonance (SPR) biosensing strategy has been developed for highly sensitive detection of two major PML/RAR\u03b1 (promyelocytic leukemia, retinoic acid receptor alpha) subtypes based on the heterogeneous fusion gene-triggered nonlinear hybridization chain reaction (HCR). On the gold chip surface, the cascade self-assembly process is triggered after the introduction of PML/RAR\u03b1. The different fragments of PML/RAR\u03b1 can specifically hybridize with capture probes (Cp) immobilized on the chip and the hybridization DNA1 (H1). Then, the nonlinear HCR is initiated by the complex of Cp-PML/RAR\u03b1-H1 with the introduction of two hybridization DNA chains (H2 and H3). As a result, a dendritic nanostructure is achieved on the surface of chip, leading to a significant SPR amplification signal owing to its high molecular weight. The developed method shows good specificity and high sensitivity with detection limit of 0.72 pM for \"L\" subtype and 0.65 pM for \"S\" subtype. Moreover, this method has been successfully applied for efficient identification of clinical positive and negative PCR samples of the PML/RAR\u03b1 subtype. Thus, this developed biosensing strategy presents a potential platform for analysis of fusion gene and early diagnosis of clinical disease.", 
    "genre": "article", 
    "id": "sg:pub.10.1038/s41598-017-14361-5", 
    "inLanguage": "en", 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.8333326", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.8376228", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.8350916", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1045337", 
        "issn": [
          "2045-2322"
        ], 
        "name": "Scientific Reports", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "7"
      }
    ], 
    "keywords": [
      "nonlinear hybridization chain reaction", 
      "hybridization chain reaction", 
      "surface plasmon resonance", 
      "surface plasmon resonance biosensor", 
      "plasmon resonance biosensor", 
      "gold chip surface", 
      "surface of chip", 
      "hybridization DNA", 
      "resonance biosensor", 
      "capture probe", 
      "dendritic nanostructures", 
      "plasmon resonance", 
      "chip surface", 
      "sensitive detection", 
      "self-assembly process", 
      "potential platform", 
      "detection limit", 
      "PCR samples", 
      "amplification signal", 
      "high sensitivity", 
      "good specificity", 
      "chip", 
      "chain reaction", 
      "nanostructures", 
      "biosensor", 
      "DNA chains", 
      "high molecular weight", 
      "detection", 
      "developed method", 
      "surface", 
      "molecular weight", 
      "platform", 
      "efficient identification", 
      "reaction", 
      "fusion gene", 
      "probe", 
      "signals", 
      "PM", 
      "sensitivity", 
      "method", 
      "limit", 
      "resonance", 
      "DNA", 
      "strategies", 
      "specificity", 
      "complexes", 
      "introduction", 
      "work", 
      "chain", 
      "different fragments", 
      "early diagnosis", 
      "PML/RAR\u03b1", 
      "samples", 
      "process", 
      "genes", 
      "fragments", 
      "results", 
      "analysis", 
      "identification", 
      "weight", 
      "diagnosis", 
      "clinical disease", 
      "disease", 
      "RAR\u03b1", 
      "subtypes", 
      "enzyme-free surface plasmon resonance", 
      "major PML/RAR\u03b1 (promyelocytic leukemia, retinoic acid receptor alpha) subtypes", 
      "PML/RAR\u03b1 (promyelocytic leukemia, retinoic acid receptor alpha) subtypes", 
      "RAR\u03b1 (promyelocytic leukemia, retinoic acid receptor alpha) subtypes", 
      "heterogeneous fusion gene-triggered nonlinear hybridization chain reaction", 
      "fusion gene-triggered nonlinear hybridization chain reaction", 
      "gene-triggered nonlinear hybridization chain reaction", 
      "cascade self-assembly process", 
      "nonlinear HCR", 
      "Cp-PML/RAR\u03b1", 
      "hybridization DNA chains", 
      "significant SPR amplification signal", 
      "SPR amplification signal", 
      "negative PCR samples", 
      "simple surface plasmon resonance biosensor"
    ], 
    "name": "A simple surface plasmon resonance biosensor for detection of PML/RAR\u03b1 based on heterogeneous fusion gene-triggered nonlinear hybridization chain reaction", 
    "pagination": "14037", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1092297826"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/s41598-017-14361-5"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "29070911"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/s41598-017-14361-5", 
      "https://app.dimensions.ai/details/publication/pub.1092297826"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-01-01T18:42", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220101/entities/gbq_results/article/article_724.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1038/s41598-017-14361-5"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41598-017-14361-5'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41598-017-14361-5'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41598-017-14361-5'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41598-017-14361-5'


 

This table displays all metadata directly associated to this object as RDF triples.

212 TRIPLES      22 PREDICATES      110 URIs      98 LITERALS      7 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/s41598-017-14361-5 schema:about anzsrc-for:03
2 anzsrc-for:0306
3 schema:author N06438503a59545ba8f6177a11d5baa22
4 schema:citation sg:pub.10.1038/347558a0
5 sg:pub.10.1038/nature06451
6 sg:pub.10.1038/nnano.2010.211
7 sg:pub.10.1038/sj.leu.2401592
8 schema:datePublished 2017-10-25
9 schema:datePublishedReg 2017-10-25
10 schema:description In this work, a simple and enzyme-free surface plasmon resonance (SPR) biosensing strategy has been developed for highly sensitive detection of two major PML/RARα (promyelocytic leukemia, retinoic acid receptor alpha) subtypes based on the heterogeneous fusion gene-triggered nonlinear hybridization chain reaction (HCR). On the gold chip surface, the cascade self-assembly process is triggered after the introduction of PML/RARα. The different fragments of PML/RARα can specifically hybridize with capture probes (Cp) immobilized on the chip and the hybridization DNA<sub>1</sub> (H<sub>1</sub>). Then, the nonlinear HCR is initiated by the complex of Cp-PML/RARα-H<sub>1</sub> with the introduction of two hybridization DNA chains (H<sub>2</sub> and H<sub>3</sub>). As a result, a dendritic nanostructure is achieved on the surface of chip, leading to a significant SPR amplification signal owing to its high molecular weight. The developed method shows good specificity and high sensitivity with detection limit of 0.72 pM for "L" subtype and 0.65 pM for "S" subtype. Moreover, this method has been successfully applied for efficient identification of clinical positive and negative PCR samples of the PML/RARα subtype. Thus, this developed biosensing strategy presents a potential platform for analysis of fusion gene and early diagnosis of clinical disease.
11 schema:genre article
12 schema:inLanguage en
13 schema:isAccessibleForFree true
14 schema:isPartOf N1bd6e417bf624fb599f273e8495f8f20
15 Nd46c1fbb83ac4780a3b316b9ca6bae95
16 sg:journal.1045337
17 schema:keywords Cp-PML/RARα
18 DNA
19 DNA chains
20 PCR samples
21 PM
22 PML/RARα
23 PML/RARα (promyelocytic leukemia, retinoic acid receptor alpha) subtypes
24 RARα
25 RARα (promyelocytic leukemia, retinoic acid receptor alpha) subtypes
26 SPR amplification signal
27 amplification signal
28 analysis
29 biosensor
30 capture probe
31 cascade self-assembly process
32 chain
33 chain reaction
34 chip
35 chip surface
36 clinical disease
37 complexes
38 dendritic nanostructures
39 detection
40 detection limit
41 developed method
42 diagnosis
43 different fragments
44 disease
45 early diagnosis
46 efficient identification
47 enzyme-free surface plasmon resonance
48 fragments
49 fusion gene
50 fusion gene-triggered nonlinear hybridization chain reaction
51 gene-triggered nonlinear hybridization chain reaction
52 genes
53 gold chip surface
54 good specificity
55 heterogeneous fusion gene-triggered nonlinear hybridization chain reaction
56 high molecular weight
57 high sensitivity
58 hybridization DNA
59 hybridization DNA chains
60 hybridization chain reaction
61 identification
62 introduction
63 limit
64 major PML/RARα (promyelocytic leukemia, retinoic acid receptor alpha) subtypes
65 method
66 molecular weight
67 nanostructures
68 negative PCR samples
69 nonlinear HCR
70 nonlinear hybridization chain reaction
71 plasmon resonance
72 plasmon resonance biosensor
73 platform
74 potential platform
75 probe
76 process
77 reaction
78 resonance
79 resonance biosensor
80 results
81 samples
82 self-assembly process
83 sensitive detection
84 sensitivity
85 signals
86 significant SPR amplification signal
87 simple surface plasmon resonance biosensor
88 specificity
89 strategies
90 subtypes
91 surface
92 surface of chip
93 surface plasmon resonance
94 surface plasmon resonance biosensor
95 weight
96 work
97 schema:name A simple surface plasmon resonance biosensor for detection of PML/RARα based on heterogeneous fusion gene-triggered nonlinear hybridization chain reaction
98 schema:pagination 14037
99 schema:productId N4b805e2fbdfd42a0a9704eba1de4d0e7
100 N4e4d9423f53b4f608ee3f3938d27d247
101 Nc38f1de363454df8bef7db51a7fba471
102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092297826
103 https://doi.org/10.1038/s41598-017-14361-5
104 schema:sdDatePublished 2022-01-01T18:42
105 schema:sdLicense https://scigraph.springernature.com/explorer/license/
106 schema:sdPublisher Nfba3b5371afc46f2851b4ded42437497
107 schema:url https://doi.org/10.1038/s41598-017-14361-5
108 sgo:license sg:explorer/license/
109 sgo:sdDataset articles
110 rdf:type schema:ScholarlyArticle
111 N06438503a59545ba8f6177a11d5baa22 rdf:first sg:person.01070742336.73
112 rdf:rest Ned9f23c3434a41d6826d838cc8482023
113 N1bd6e417bf624fb599f273e8495f8f20 schema:volumeNumber 7
114 rdf:type schema:PublicationVolume
115 N2d0af1df1be94155ad6408cdef795777 rdf:first sg:person.01010610662.09
116 rdf:rest Ne4edef3ea81c49959a2256bd4940d8d4
117 N4b805e2fbdfd42a0a9704eba1de4d0e7 schema:name doi
118 schema:value 10.1038/s41598-017-14361-5
119 rdf:type schema:PropertyValue
120 N4e4d9423f53b4f608ee3f3938d27d247 schema:name pubmed_id
121 schema:value 29070911
122 rdf:type schema:PropertyValue
123 N838da11848894b03899627763543ec0f rdf:first sg:person.01364257713.08
124 rdf:rest rdf:nil
125 N981d4f28d267468083f9b5b33f13fae9 rdf:first sg:person.07677335745.64
126 rdf:rest N2d0af1df1be94155ad6408cdef795777
127 Nc38f1de363454df8bef7db51a7fba471 schema:name dimensions_id
128 schema:value pub.1092297826
129 rdf:type schema:PropertyValue
130 Nc42eb7a534ce4d89b47b0befc70b6e62 rdf:first sg:person.0651322736.97
131 rdf:rest N838da11848894b03899627763543ec0f
132 Nd46c1fbb83ac4780a3b316b9ca6bae95 schema:issueNumber 1
133 rdf:type schema:PublicationIssue
134 Ne4edef3ea81c49959a2256bd4940d8d4 rdf:first sg:person.0650046103.40
135 rdf:rest Nc42eb7a534ce4d89b47b0befc70b6e62
136 Ned9f23c3434a41d6826d838cc8482023 rdf:first sg:person.015647357356.82
137 rdf:rest N981d4f28d267468083f9b5b33f13fae9
138 Nfba3b5371afc46f2851b4ded42437497 schema:name Springer Nature - SN SciGraph project
139 rdf:type schema:Organization
140 anzsrc-for:03 schema:inDefinedTermSet anzsrc-for:
141 schema:name Chemical Sciences
142 rdf:type schema:DefinedTerm
143 anzsrc-for:0306 schema:inDefinedTermSet anzsrc-for:
144 schema:name Physical Chemistry (incl. Structural)
145 rdf:type schema:DefinedTerm
146 sg:grant.8333326 http://pending.schema.org/fundedItem sg:pub.10.1038/s41598-017-14361-5
147 rdf:type schema:MonetaryGrant
148 sg:grant.8350916 http://pending.schema.org/fundedItem sg:pub.10.1038/s41598-017-14361-5
149 rdf:type schema:MonetaryGrant
150 sg:grant.8376228 http://pending.schema.org/fundedItem sg:pub.10.1038/s41598-017-14361-5
151 rdf:type schema:MonetaryGrant
152 sg:journal.1045337 schema:issn 2045-2322
153 schema:name Scientific Reports
154 schema:publisher Springer Nature
155 rdf:type schema:Periodical
156 sg:person.01010610662.09 schema:affiliation grid-institutes:grid.203458.8
157 schema:familyName Zhou
158 schema:givenName Xiaoyan
159 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01010610662.09
160 rdf:type schema:Person
161 sg:person.01070742336.73 schema:affiliation grid-institutes:grid.413387.a
162 schema:familyName Guo
163 schema:givenName Bin
164 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01070742336.73
165 rdf:type schema:Person
166 sg:person.01364257713.08 schema:affiliation grid-institutes:grid.203458.8
167 schema:familyName Ding
168 schema:givenName Shijia
169 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01364257713.08
170 rdf:type schema:Person
171 sg:person.015647357356.82 schema:affiliation grid-institutes:grid.452206.7
172 schema:familyName Cheng
173 schema:givenName Wei
174 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015647357356.82
175 rdf:type schema:Person
176 sg:person.0650046103.40 schema:affiliation grid-institutes:grid.203458.8
177 schema:familyName Li
178 schema:givenName Xinmin
179 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0650046103.40
180 rdf:type schema:Person
181 sg:person.0651322736.97 schema:affiliation grid-institutes:grid.203458.8
182 schema:familyName Ding
183 schema:givenName Xiaojuan
184 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0651322736.97
185 rdf:type schema:Person
186 sg:person.07677335745.64 schema:affiliation grid-institutes:grid.203458.8
187 schema:familyName Xu
188 schema:givenName Yongjie
189 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07677335745.64
190 rdf:type schema:Person
191 sg:pub.10.1038/347558a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041963568
192 https://doi.org/10.1038/347558a0
193 rdf:type schema:CreativeWork
194 sg:pub.10.1038/nature06451 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041585382
195 https://doi.org/10.1038/nature06451
196 rdf:type schema:CreativeWork
197 sg:pub.10.1038/nnano.2010.211 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038619626
198 https://doi.org/10.1038/nnano.2010.211
199 rdf:type schema:CreativeWork
200 sg:pub.10.1038/sj.leu.2401592 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034947020
201 https://doi.org/10.1038/sj.leu.2401592
202 rdf:type schema:CreativeWork
203 grid-institutes:grid.203458.8 schema:alternateName Key Laboratory of Clinical Laboratory Diagnostics (Ministry of Education), College of Laboratory Medicine, Chongqing Medical University, Chongqing, 400016 China
204 schema:name Key Laboratory of Clinical Laboratory Diagnostics (Ministry of Education), College of Laboratory Medicine, Chongqing Medical University, Chongqing, 400016 China
205 rdf:type schema:Organization
206 grid-institutes:grid.413387.a schema:alternateName Department of Clinical Laboratory, The Affiliated Hospital of North Sichuan Medical College, Nanchong, 637000 China
207 schema:name Department of Clinical Laboratory, The Affiliated Hospital of North Sichuan Medical College, Nanchong, 637000 China
208 Key Laboratory of Clinical Laboratory Diagnostics (Ministry of Education), College of Laboratory Medicine, Chongqing Medical University, Chongqing, 400016 China
209 rdf:type schema:Organization
210 grid-institutes:grid.452206.7 schema:alternateName The Center for Clinical Molecular Medical Detection, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016 China
211 schema:name The Center for Clinical Molecular Medical Detection, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016 China
212 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...