Ontology type: schema:ScholarlyArticle Open Access: True
2017-12
AUTHORSTakuya Okada, Kazuko Keino-Masu, Satoshi Nagamine, Fuyuki Kametani, Tatsuyuki Ohto, Masato Hasegawa, Toin H. van Kuppevelt, Satoshi Kunita, Satoru Takahashi, Masayuki Masu
ABSTRACTHeparan sulfate (HS) has been implicated in a wide range of cell signaling. Here we report a novel mechanism in which extracellular removal of 6-O-sulfate groups from HS by the endosulfatases, Sulf1 and Sulf2, is essential for axon guidance during development. In Sulf1/2 double knockout (DKO) mice, the corticospinal tract (CST) was dorsally displaced on the midbrain surface. In utero electroporation of Sulf1/2 into radial glial cells along the third ventricle, where Sulf1/2 mRNAs are normally expressed, rescued the CST defects in the DKO mice. Proteomic analysis and functional testing identified Slit2 as the key molecule associated with the DKO phenotype. In the DKO brain, 6-O-sulfated HS was increased, leading to abnormal accumulation of Slit2 protein on the pial surface of the cerebral peduncle and hypothalamus, which caused dorsal repulsion of CST axons. Our findings indicate that postbiosynthetic desulfation of HS by Sulfs controls CST axon guidance through fine-tuning of Slit2 presentation. More... »
PAGES13847
http://scigraph.springernature.com/pub.10.1038/s41598-017-14185-3
DOIhttp://dx.doi.org/10.1038/s41598-017-14185-3
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PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/29062064
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{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1092262058"
]
}
],
"sameAs": [
"https://doi.org/10.1038/s41598-017-14185-3",
"https://app.dimensions.ai/details/publication/pub.1092262058"
],
"sdDataset": "articles",
"sdDatePublished": "2019-04-10T23:34",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8693_00000568.jsonl",
"type": "ScholarlyArticle",
"url": "https://www.nature.com/articles/s41598-017-14185-3"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41598-017-14185-3'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41598-017-14185-3'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41598-017-14185-3'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41598-017-14185-3'
This table displays all metadata directly associated to this object as RDF triples.
305 TRIPLES
21 PREDICATES
75 URIs
21 LITERALS
9 BLANK NODES