Deoxyribonuclease 1 reduces pathogenic effects of cigarette smoke exposure in the lung View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-12

AUTHORS

Paul T. King, Roleen Sharma, Kim M. O’Sullivan, Judy Callaghan, Lovisa Dousha, Belinda Thomas, Saleela Ruwanpura, Steven Lim, Michael W. Farmer, Barton R. Jennings, Michaela Finsterbusch, Gavin Brooks, Stavros Selemidis, Gary P. Anderson, Stephen R. Holdsworth, Philip G. Bardin

ABSTRACT

Our aim was to investigate if deoxyribonuclease (DNase) 1 is a potential therapeutic agent to reduce pathogenic effects of cigarette smoke exposure in the lung. Cigarette smoke causes protease imbalance with excess production of proteases, which is a key process in the pathogenesis of emphysema. The mechanisms responsible for this effect are not well-defined. Our studies demonstrate both in vitro and in vivo that cigarette smoke significantly increases the expression of neutrophil and macrophage extracellular traps with coexpression of the pathogenic proteases, neutrophil elastase and matrix metalloproteinases 9 and 12. This response to cigarette smoke was significantly reduced by the addition of DNase 1, which also significantly decreased macrophage numbers and lung proteolysis. DNase 1, a treatment currently in clinical use, can diminish the pathogenic effects of cigarette smoke. More... »

PAGES

12128

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41598-017-12474-5

DOI

http://dx.doi.org/10.1038/s41598-017-12474-5

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1091807538

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28935869


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Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41598-017-12474-5'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41598-017-12474-5'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41598-017-12474-5'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41598-017-12474-5'


 

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