Exercise training enhances in vivo clearance of endotoxin and attenuates inflammatory responses by potentiating Kupffer cell phagocytosis View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-12

AUTHORS

Shoichi Komine, Kentaro Akiyama, Eiji Warabi, Sechang Oh, Keisuke Kuga, Kazunori Ishige, Shinji Togashi, Toru Yanagawa, Junichi Shoda

ABSTRACT

The failure of Kupffer cells (KCs) to remove endotoxin is an important factor in the pathogenesis of non-alcoholic fatty liver disease (NAFLD). In this study, the effects of exercise training on KC function were studied in terms of in vivo endotoxin clearance and inflammatory responses. Mice were allocated into rest and exercise groups. KC bead phagocytic capacity and plasma steroid hormone levels were determined following exercise training. Endotoxin and inflammatory cytokine levels in plasma were determined over time following endotoxin injection. KC bead phagocytic capacity was potentiated and clearance of exogenously-injected endotoxin was increased in the exercise group. Inflammatory cytokine (TNF-α and IL-6) levels were lower in the exercise group. We found that only DHEA was increased in the plasma of the exercise group. In an in vitro experiment, the addition of DHEA to RAW264.7 cells increased bead phagocytic capacity and attenuated endotoxin-induced inflammatory responses. These results suggest that exercise training modulates in vivo endotoxin clearance and inflammatory responses in association with increased DHEA production. These exercise-induced changes in KC capacity may contribute to a slowing of disease progression in NAFLD patients. More... »

PAGES

11977

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41598-017-12358-8

DOI

http://dx.doi.org/10.1038/s41598-017-12358-8

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1091790235

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28931917


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1102", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Cardiorespiratory Medicine and Haematology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of Tsukuba Hospital", 
          "id": "https://www.grid.ac/institutes/grid.412814.a", 
          "name": [
            "Graduate School of Comprehensive Human Sciences, University of Tsukuba, 305-8575, Ibaraki, Japan", 
            "The Center of Sports Medicine and Health Sciences, Tsukuba University Hospital, 305-8576, Ibaraki, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Komine", 
        "givenName": "Shoichi", 
        "id": "sg:person.01014635152.26", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01014635152.26"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Japan Society for the Promotion of Science", 
          "id": "https://www.grid.ac/institutes/grid.54432.34", 
          "name": [
            "Graduate School of Comprehensive Human Sciences, University of Tsukuba, 305-8575, Ibaraki, Japan", 
            "Japan Society for the Promotion of Science, 102-0083, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Akiyama", 
        "givenName": "Kentaro", 
        "id": "sg:person.01203570670.46", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01203570670.46"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Tsukuba", 
          "id": "https://www.grid.ac/institutes/grid.20515.33", 
          "name": [
            "Division of Molecular and Cellular Physiology, Faculty of Medicine, University of Tsukuba, Tsukuba, 305-8575, Ibaraki, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Warabi", 
        "givenName": "Eiji", 
        "id": "sg:person.01202657066.87", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01202657066.87"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Tsukuba", 
          "id": "https://www.grid.ac/institutes/grid.20515.33", 
          "name": [
            "The Center of Sports Medicine and Health Sciences, Tsukuba University Hospital, 305-8576, Ibaraki, Japan", 
            "Medical Sciences, Faculty of Medicine, University of Tsukuba, Tsukuba, 305-8575, Ibaraki, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Oh", 
        "givenName": "Sechang", 
        "id": "sg:person.01325617536.19", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01325617536.19"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Tsukuba", 
          "id": "https://www.grid.ac/institutes/grid.20515.33", 
          "name": [
            "Division of Cardiology, Faculty of Medicine, University of Tsukuba, Tsukuba, 305-8575, Ibaraki, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kuga", 
        "givenName": "Keisuke", 
        "id": "sg:person.0726133460.79", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0726133460.79"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Tsukuba", 
          "id": "https://www.grid.ac/institutes/grid.20515.33", 
          "name": [
            "Division of Gastroenterology, Faculty of Medicine, University of Tsukuba, Tsukuba, 305-8575, Ibaraki, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ishige", 
        "givenName": "Kazunori", 
        "id": "sg:person.01037607655.40", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01037607655.40"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Tsukuba", 
          "id": "https://www.grid.ac/institutes/grid.20515.33", 
          "name": [
            "Division of Plastic Surgery, Faculty of Medicine, University of Tsukuba, Tsukuba, 305-8575, Ibaraki, Japan", 
            "Plastic Surgery, Shonai Amarume Hospital, 999-7782, Yamagata, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Togashi", 
        "givenName": "Shinji", 
        "id": "sg:person.01260132716.35", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01260132716.35"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Tsukuba", 
          "id": "https://www.grid.ac/institutes/grid.20515.33", 
          "name": [
            "Division of Oral and Maxillofacial Surgery, Faculty of Medicine, University of Tsukuba, Tsukuba, 305-8575, Ibaraki, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yanagawa", 
        "givenName": "Toru", 
        "id": "sg:person.0641614566.45", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0641614566.45"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Tsukuba", 
          "id": "https://www.grid.ac/institutes/grid.20515.33", 
          "name": [
            "The Center of Sports Medicine and Health Sciences, Tsukuba University Hospital, 305-8576, Ibaraki, Japan", 
            "Medical Sciences, Faculty of Medicine, University of Tsukuba, Tsukuba, 305-8575, Ibaraki, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shoda", 
        "givenName": "Junichi", 
        "id": "sg:person.01167712513.14", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01167712513.14"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/j.jhep.2010.04.037", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000333917"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/j.gastro.2014.01.020", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002443786"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1034/j.1600-0676.2001.210110.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002845977"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/aac.46.10.3180-3184.2002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005254280"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jhep.2012.02.023", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006057689"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cmet.2012.05.012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008451022"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/hep.1840060430", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008541609"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/aac.36.10.2275", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009150594"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-201x.2004.01343.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010217690"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1600-0838.2010.01132.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010415769"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/gut.35.11.1509", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017885101"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2265.1987.tb00832.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025767590"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1872-034x.2007.00130.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028800610"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/hep.27544", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028907703"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.tube.2015.05.011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035066666"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/hep.24001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036889282"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/hep.24001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036889282"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/hep.22063", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037209527"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jmri.24674", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037288163"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature10758", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039125257", 
          "https://doi.org/10.1038/nature10758"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpgi.00304.2014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039583146"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/352342a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045508154", 
          "https://doi.org/10.1038/352342a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/gut.48.2.206", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045842906"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1462-5822.2009.01326.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046550333"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1462-5822.2009.01326.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046550333"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00535-013-0902-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050248272", 
          "https://doi.org/10.1007/s00535-013-0902-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1600-0897.1996.tb00015.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052256068"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpendo.90424.2008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052737176"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1099/00222615-48-5-425", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060379460"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3748/wjg.14.6036", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071360937"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074270069", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074690879", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/jappl.2001.90.3.789", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074754749"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.168.8.4018", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1075027727"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1080669846", 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/srep43029", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083854879", 
          "https://doi.org/10.1038/srep43029"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2017-12", 
    "datePublishedReg": "2017-12-01", 
    "description": "The failure of Kupffer cells (KCs) to remove endotoxin is an important factor in the pathogenesis of non-alcoholic fatty liver disease (NAFLD). In this study, the effects of exercise training on KC function were studied in terms of in vivo endotoxin clearance and inflammatory responses. Mice were allocated into rest and exercise groups. KC bead phagocytic capacity and plasma steroid hormone levels were determined following exercise training. Endotoxin and inflammatory cytokine levels in plasma were determined over time following endotoxin injection. KC bead phagocytic capacity was potentiated and clearance of exogenously-injected endotoxin was increased in the exercise group. Inflammatory cytokine (TNF-\u03b1 and IL-6) levels were lower in the exercise group. We found that only DHEA was increased in the plasma of the exercise group. In an in vitro experiment, the addition of DHEA to RAW264.7 cells increased bead phagocytic capacity and attenuated endotoxin-induced inflammatory responses. These results suggest that exercise training modulates in vivo endotoxin clearance and inflammatory responses in association with increased DHEA production. These exercise-induced changes in KC capacity may contribute to a slowing of disease progression in NAFLD patients.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/s41598-017-12358-8", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.6096237", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.6097190", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.5902490", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.6820320", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1045337", 
        "issn": [
          "2045-2322"
        ], 
        "name": "Scientific Reports", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "7"
      }
    ], 
    "name": "Exercise training enhances in vivo clearance of endotoxin and attenuates inflammatory responses by potentiating Kupffer cell phagocytosis", 
    "pagination": "11977", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "faca5dfb49ba755ee0fb0b3fae328f6cde4831ef46350de7bca642fea1625f5f"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "28931917"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101563288"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/s41598-017-12358-8"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1091790235"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/s41598-017-12358-8", 
      "https://app.dimensions.ai/details/publication/pub.1091790235"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T15:56", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8664_00000535.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/s41598-017-12358-8"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41598-017-12358-8'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41598-017-12358-8'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41598-017-12358-8'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41598-017-12358-8'


 

This table displays all metadata directly associated to this object as RDF triples.

250 TRIPLES      21 PREDICATES      63 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/s41598-017-12358-8 schema:about anzsrc-for:11
2 anzsrc-for:1102
3 schema:author N04b5054d323a4eed9a48b3ca3742e2bb
4 schema:citation sg:pub.10.1007/s00535-013-0902-2
5 sg:pub.10.1038/352342a0
6 sg:pub.10.1038/nature10758
7 sg:pub.10.1038/srep43029
8 https://app.dimensions.ai/details/publication/pub.1074270069
9 https://app.dimensions.ai/details/publication/pub.1074690879
10 https://app.dimensions.ai/details/publication/pub.1080669846
11 https://doi.org/10.1002/hep.1840060430
12 https://doi.org/10.1002/hep.22063
13 https://doi.org/10.1002/hep.24001
14 https://doi.org/10.1002/hep.27544
15 https://doi.org/10.1002/jmri.24674
16 https://doi.org/10.1016/j.cmet.2012.05.012
17 https://doi.org/10.1016/j.jhep.2010.04.037
18 https://doi.org/10.1016/j.jhep.2012.02.023
19 https://doi.org/10.1016/j.tube.2015.05.011
20 https://doi.org/10.1034/j.1600-0676.2001.210110.x
21 https://doi.org/10.1053/j.gastro.2014.01.020
22 https://doi.org/10.1099/00222615-48-5-425
23 https://doi.org/10.1111/j.1365-201x.2004.01343.x
24 https://doi.org/10.1111/j.1365-2265.1987.tb00832.x
25 https://doi.org/10.1111/j.1462-5822.2009.01326.x
26 https://doi.org/10.1111/j.1600-0838.2010.01132.x
27 https://doi.org/10.1111/j.1600-0897.1996.tb00015.x
28 https://doi.org/10.1111/j.1872-034x.2007.00130.x
29 https://doi.org/10.1128/aac.36.10.2275
30 https://doi.org/10.1128/aac.46.10.3180-3184.2002
31 https://doi.org/10.1136/gut.35.11.1509
32 https://doi.org/10.1136/gut.48.2.206
33 https://doi.org/10.1152/ajpendo.90424.2008
34 https://doi.org/10.1152/ajpgi.00304.2014
35 https://doi.org/10.1152/jappl.2001.90.3.789
36 https://doi.org/10.3748/wjg.14.6036
37 https://doi.org/10.4049/jimmunol.168.8.4018
38 schema:datePublished 2017-12
39 schema:datePublishedReg 2017-12-01
40 schema:description The failure of Kupffer cells (KCs) to remove endotoxin is an important factor in the pathogenesis of non-alcoholic fatty liver disease (NAFLD). In this study, the effects of exercise training on KC function were studied in terms of in vivo endotoxin clearance and inflammatory responses. Mice were allocated into rest and exercise groups. KC bead phagocytic capacity and plasma steroid hormone levels were determined following exercise training. Endotoxin and inflammatory cytokine levels in plasma were determined over time following endotoxin injection. KC bead phagocytic capacity was potentiated and clearance of exogenously-injected endotoxin was increased in the exercise group. Inflammatory cytokine (TNF-α and IL-6) levels were lower in the exercise group. We found that only DHEA was increased in the plasma of the exercise group. In an in vitro experiment, the addition of DHEA to RAW264.7 cells increased bead phagocytic capacity and attenuated endotoxin-induced inflammatory responses. These results suggest that exercise training modulates in vivo endotoxin clearance and inflammatory responses in association with increased DHEA production. These exercise-induced changes in KC capacity may contribute to a slowing of disease progression in NAFLD patients.
41 schema:genre research_article
42 schema:inLanguage en
43 schema:isAccessibleForFree true
44 schema:isPartOf N508cb1f6be6a4457bc1decb60bd1f3b2
45 Na59753e3e08f42b4bb78057ec4b22442
46 sg:journal.1045337
47 schema:name Exercise training enhances in vivo clearance of endotoxin and attenuates inflammatory responses by potentiating Kupffer cell phagocytosis
48 schema:pagination 11977
49 schema:productId N4276f210602544139012d38537f24262
50 Na49e6bc4a5254ea6af4769be00c674c7
51 Nc3c5939be3a84a9099daa15d2998bfdc
52 Ne4a22abd99ee48eca8762c1675af6ca8
53 Ne52682f1073543dcabeb2b24fd059032
54 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091790235
55 https://doi.org/10.1038/s41598-017-12358-8
56 schema:sdDatePublished 2019-04-10T15:56
57 schema:sdLicense https://scigraph.springernature.com/explorer/license/
58 schema:sdPublisher N9d5c4f11ecac4584a0ee79d19c4474e8
59 schema:url https://www.nature.com/articles/s41598-017-12358-8
60 sgo:license sg:explorer/license/
61 sgo:sdDataset articles
62 rdf:type schema:ScholarlyArticle
63 N012f4db4ab0447e7a7b8e61c7859eaa3 rdf:first sg:person.01037607655.40
64 rdf:rest N97c02394fda84864a5c9684a076c95ee
65 N04b5054d323a4eed9a48b3ca3742e2bb rdf:first sg:person.01014635152.26
66 rdf:rest N9ce280cb1a994e8dac159f8edbd5a39e
67 N1bff9cc9816d46e3803c31ce36d35bc0 rdf:first sg:person.01167712513.14
68 rdf:rest rdf:nil
69 N4276f210602544139012d38537f24262 schema:name dimensions_id
70 schema:value pub.1091790235
71 rdf:type schema:PropertyValue
72 N508cb1f6be6a4457bc1decb60bd1f3b2 schema:volumeNumber 7
73 rdf:type schema:PublicationVolume
74 N97c02394fda84864a5c9684a076c95ee rdf:first sg:person.01260132716.35
75 rdf:rest Ne67d83d16550474a94701d24ae1e6340
76 N9ce280cb1a994e8dac159f8edbd5a39e rdf:first sg:person.01203570670.46
77 rdf:rest Nccc24b76af2442ff808dcfb683b3b757
78 N9d5c4f11ecac4584a0ee79d19c4474e8 schema:name Springer Nature - SN SciGraph project
79 rdf:type schema:Organization
80 N9df5f5ab26b04fdfa657cc166134a263 rdf:first sg:person.01325617536.19
81 rdf:rest Nbb00ce6ec0cf40cd922c23b0ebe81d9a
82 Na49e6bc4a5254ea6af4769be00c674c7 schema:name readcube_id
83 schema:value faca5dfb49ba755ee0fb0b3fae328f6cde4831ef46350de7bca642fea1625f5f
84 rdf:type schema:PropertyValue
85 Na59753e3e08f42b4bb78057ec4b22442 schema:issueNumber 1
86 rdf:type schema:PublicationIssue
87 Nbb00ce6ec0cf40cd922c23b0ebe81d9a rdf:first sg:person.0726133460.79
88 rdf:rest N012f4db4ab0447e7a7b8e61c7859eaa3
89 Nc3c5939be3a84a9099daa15d2998bfdc schema:name pubmed_id
90 schema:value 28931917
91 rdf:type schema:PropertyValue
92 Nccc24b76af2442ff808dcfb683b3b757 rdf:first sg:person.01202657066.87
93 rdf:rest N9df5f5ab26b04fdfa657cc166134a263
94 Ne4a22abd99ee48eca8762c1675af6ca8 schema:name doi
95 schema:value 10.1038/s41598-017-12358-8
96 rdf:type schema:PropertyValue
97 Ne52682f1073543dcabeb2b24fd059032 schema:name nlm_unique_id
98 schema:value 101563288
99 rdf:type schema:PropertyValue
100 Ne67d83d16550474a94701d24ae1e6340 rdf:first sg:person.0641614566.45
101 rdf:rest N1bff9cc9816d46e3803c31ce36d35bc0
102 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
103 schema:name Medical and Health Sciences
104 rdf:type schema:DefinedTerm
105 anzsrc-for:1102 schema:inDefinedTermSet anzsrc-for:
106 schema:name Cardiorespiratory Medicine and Haematology
107 rdf:type schema:DefinedTerm
108 sg:grant.5902490 http://pending.schema.org/fundedItem sg:pub.10.1038/s41598-017-12358-8
109 rdf:type schema:MonetaryGrant
110 sg:grant.6096237 http://pending.schema.org/fundedItem sg:pub.10.1038/s41598-017-12358-8
111 rdf:type schema:MonetaryGrant
112 sg:grant.6097190 http://pending.schema.org/fundedItem sg:pub.10.1038/s41598-017-12358-8
113 rdf:type schema:MonetaryGrant
114 sg:grant.6820320 http://pending.schema.org/fundedItem sg:pub.10.1038/s41598-017-12358-8
115 rdf:type schema:MonetaryGrant
116 sg:journal.1045337 schema:issn 2045-2322
117 schema:name Scientific Reports
118 rdf:type schema:Periodical
119 sg:person.01014635152.26 schema:affiliation https://www.grid.ac/institutes/grid.412814.a
120 schema:familyName Komine
121 schema:givenName Shoichi
122 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01014635152.26
123 rdf:type schema:Person
124 sg:person.01037607655.40 schema:affiliation https://www.grid.ac/institutes/grid.20515.33
125 schema:familyName Ishige
126 schema:givenName Kazunori
127 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01037607655.40
128 rdf:type schema:Person
129 sg:person.01167712513.14 schema:affiliation https://www.grid.ac/institutes/grid.20515.33
130 schema:familyName Shoda
131 schema:givenName Junichi
132 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01167712513.14
133 rdf:type schema:Person
134 sg:person.01202657066.87 schema:affiliation https://www.grid.ac/institutes/grid.20515.33
135 schema:familyName Warabi
136 schema:givenName Eiji
137 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01202657066.87
138 rdf:type schema:Person
139 sg:person.01203570670.46 schema:affiliation https://www.grid.ac/institutes/grid.54432.34
140 schema:familyName Akiyama
141 schema:givenName Kentaro
142 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01203570670.46
143 rdf:type schema:Person
144 sg:person.01260132716.35 schema:affiliation https://www.grid.ac/institutes/grid.20515.33
145 schema:familyName Togashi
146 schema:givenName Shinji
147 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01260132716.35
148 rdf:type schema:Person
149 sg:person.01325617536.19 schema:affiliation https://www.grid.ac/institutes/grid.20515.33
150 schema:familyName Oh
151 schema:givenName Sechang
152 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01325617536.19
153 rdf:type schema:Person
154 sg:person.0641614566.45 schema:affiliation https://www.grid.ac/institutes/grid.20515.33
155 schema:familyName Yanagawa
156 schema:givenName Toru
157 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0641614566.45
158 rdf:type schema:Person
159 sg:person.0726133460.79 schema:affiliation https://www.grid.ac/institutes/grid.20515.33
160 schema:familyName Kuga
161 schema:givenName Keisuke
162 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0726133460.79
163 rdf:type schema:Person
164 sg:pub.10.1007/s00535-013-0902-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050248272
165 https://doi.org/10.1007/s00535-013-0902-2
166 rdf:type schema:CreativeWork
167 sg:pub.10.1038/352342a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045508154
168 https://doi.org/10.1038/352342a0
169 rdf:type schema:CreativeWork
170 sg:pub.10.1038/nature10758 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039125257
171 https://doi.org/10.1038/nature10758
172 rdf:type schema:CreativeWork
173 sg:pub.10.1038/srep43029 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083854879
174 https://doi.org/10.1038/srep43029
175 rdf:type schema:CreativeWork
176 https://app.dimensions.ai/details/publication/pub.1074270069 schema:CreativeWork
177 https://app.dimensions.ai/details/publication/pub.1074690879 schema:CreativeWork
178 https://app.dimensions.ai/details/publication/pub.1080669846 schema:CreativeWork
179 https://doi.org/10.1002/hep.1840060430 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008541609
180 rdf:type schema:CreativeWork
181 https://doi.org/10.1002/hep.22063 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037209527
182 rdf:type schema:CreativeWork
183 https://doi.org/10.1002/hep.24001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036889282
184 rdf:type schema:CreativeWork
185 https://doi.org/10.1002/hep.27544 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028907703
186 rdf:type schema:CreativeWork
187 https://doi.org/10.1002/jmri.24674 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037288163
188 rdf:type schema:CreativeWork
189 https://doi.org/10.1016/j.cmet.2012.05.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008451022
190 rdf:type schema:CreativeWork
191 https://doi.org/10.1016/j.jhep.2010.04.037 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000333917
192 rdf:type schema:CreativeWork
193 https://doi.org/10.1016/j.jhep.2012.02.023 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006057689
194 rdf:type schema:CreativeWork
195 https://doi.org/10.1016/j.tube.2015.05.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035066666
196 rdf:type schema:CreativeWork
197 https://doi.org/10.1034/j.1600-0676.2001.210110.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1002845977
198 rdf:type schema:CreativeWork
199 https://doi.org/10.1053/j.gastro.2014.01.020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002443786
200 rdf:type schema:CreativeWork
201 https://doi.org/10.1099/00222615-48-5-425 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060379460
202 rdf:type schema:CreativeWork
203 https://doi.org/10.1111/j.1365-201x.2004.01343.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1010217690
204 rdf:type schema:CreativeWork
205 https://doi.org/10.1111/j.1365-2265.1987.tb00832.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1025767590
206 rdf:type schema:CreativeWork
207 https://doi.org/10.1111/j.1462-5822.2009.01326.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1046550333
208 rdf:type schema:CreativeWork
209 https://doi.org/10.1111/j.1600-0838.2010.01132.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1010415769
210 rdf:type schema:CreativeWork
211 https://doi.org/10.1111/j.1600-0897.1996.tb00015.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1052256068
212 rdf:type schema:CreativeWork
213 https://doi.org/10.1111/j.1872-034x.2007.00130.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1028800610
214 rdf:type schema:CreativeWork
215 https://doi.org/10.1128/aac.36.10.2275 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009150594
216 rdf:type schema:CreativeWork
217 https://doi.org/10.1128/aac.46.10.3180-3184.2002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005254280
218 rdf:type schema:CreativeWork
219 https://doi.org/10.1136/gut.35.11.1509 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017885101
220 rdf:type schema:CreativeWork
221 https://doi.org/10.1136/gut.48.2.206 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045842906
222 rdf:type schema:CreativeWork
223 https://doi.org/10.1152/ajpendo.90424.2008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052737176
224 rdf:type schema:CreativeWork
225 https://doi.org/10.1152/ajpgi.00304.2014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039583146
226 rdf:type schema:CreativeWork
227 https://doi.org/10.1152/jappl.2001.90.3.789 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074754749
228 rdf:type schema:CreativeWork
229 https://doi.org/10.3748/wjg.14.6036 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071360937
230 rdf:type schema:CreativeWork
231 https://doi.org/10.4049/jimmunol.168.8.4018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1075027727
232 rdf:type schema:CreativeWork
233 https://www.grid.ac/institutes/grid.20515.33 schema:alternateName University of Tsukuba
234 schema:name Division of Cardiology, Faculty of Medicine, University of Tsukuba, Tsukuba, 305-8575, Ibaraki, Japan
235 Division of Gastroenterology, Faculty of Medicine, University of Tsukuba, Tsukuba, 305-8575, Ibaraki, Japan
236 Division of Molecular and Cellular Physiology, Faculty of Medicine, University of Tsukuba, Tsukuba, 305-8575, Ibaraki, Japan
237 Division of Oral and Maxillofacial Surgery, Faculty of Medicine, University of Tsukuba, Tsukuba, 305-8575, Ibaraki, Japan
238 Division of Plastic Surgery, Faculty of Medicine, University of Tsukuba, Tsukuba, 305-8575, Ibaraki, Japan
239 Medical Sciences, Faculty of Medicine, University of Tsukuba, Tsukuba, 305-8575, Ibaraki, Japan
240 Plastic Surgery, Shonai Amarume Hospital, 999-7782, Yamagata, Japan
241 The Center of Sports Medicine and Health Sciences, Tsukuba University Hospital, 305-8576, Ibaraki, Japan
242 rdf:type schema:Organization
243 https://www.grid.ac/institutes/grid.412814.a schema:alternateName University of Tsukuba Hospital
244 schema:name Graduate School of Comprehensive Human Sciences, University of Tsukuba, 305-8575, Ibaraki, Japan
245 The Center of Sports Medicine and Health Sciences, Tsukuba University Hospital, 305-8576, Ibaraki, Japan
246 rdf:type schema:Organization
247 https://www.grid.ac/institutes/grid.54432.34 schema:alternateName Japan Society for the Promotion of Science
248 schema:name Graduate School of Comprehensive Human Sciences, University of Tsukuba, 305-8575, Ibaraki, Japan
249 Japan Society for the Promotion of Science, 102-0083, Tokyo, Japan
250 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...