Lipidomes of lung cancer and tumour-free lung tissues reveal distinct molecular signatures for cancer differentiation, age, inflammation, and pulmonary emphysema View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-12

AUTHORS

Lars F. Eggers, Julia Müller, Chakravarthy Marella, Verena Scholz, Henrik Watz, Christian Kugler, Klaus F. Rabe, Torsten Goldmann, Dominik Schwudke

ABSTRACT

Little is known about the human lung lipidome, its variability in different physiological states, its alterations during carcinogenesis and the development of pulmonary emphysema. We investigated how health status might be mirrored in the lung lipidome. Tissues were sampled for both lipidomic and histological analysis. Using a screening approach, we characterised lipidomes of lung cancer tissues and corresponding tumour-free alveolar tissues. We quantified 311 lipids from 11 classes in 43 tissue samples from 26 patients. Tumour tissues exhibited elevated levels of triacylglycerols and cholesteryl esters, as well as a significantly lower abundance of phosphatidylglycerols, which are typical lung surfactant components. Adenocarcinomas and squamous cell carcinomas were distinguished with high specificity based on lipid panels. Lipidomes of tumour biopsy samples showed clear changes depending on their histology and, in particular, their proportion of active tumour cells and stroma. Partial least squares regression showed correlations between lipid profiles of tumour-free alveolar tissues and the degree of emphysema, inflammation status, and the age of patients. Unsaturated long-chain phosphatidylserines and phosphatidylinositols showed a positive correlation with a worsened emphysema status and ageing. This work provides a resource for the human lung lipidome and a systematic data analysis strategy to link clinical characteristics and histology. More... »

PAGES

11087

References to SciGraph publications

  • 2015-03. Lipid Analysis of Airway Epithelial Cells for Studying Respiratory Diseases in CHROMATOGRAPHIA
  • 2015-05. Lactosylceramide-accumulation in lipid-rafts mediate aberrant-autophagy, inflammation and apoptosis in cigarette smoke induced emphysema in APOPTOSIS
  • 2015-12. A machine learning heuristic to identify biologically relevant and minimal biomarker panels from omics data in BMC GENOMICS
  • 2016-12. Functional networks inference from rule-based machine learning models in BIODATA MINING
  • 2010-03. Visualization of omics data for systems biology in NATURE METHODS
  • 2013-06. Mass spectrometry imaging with high resolution in mass and space in HISTOCHEMISTRY AND CELL BIOLOGY
  • 2011-01. A novel informatics concept for high-throughput shotgun lipidomics based on the molecular fragmentation query language in GENOME BIOLOGY
  • 2001-09. Studies on phosphatidylglycerol with triple quadrupole tandem mass spectrometry with electrospray ionization: Fragmentation processes and structural characterization in JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
  • 2005-05. Ceramide upregulation causes pulmonary cell apoptosis and emphysema-like disease in mice in NATURE MEDICINE
  • 2015-02. PCK2 activation mediates an adaptive response to glucose depletion in lung cancer in ONCOGENE
  • 2004-10. Using chemometrics for navigating in the large data sets of genomics, proteomics, and metabonomics (gpm) in ANALYTICAL AND BIOANALYTICAL CHEMISTRY
  • 2015-01. Spatial Segmentation of MALDI FT-ICR MSI Data: A Powerful Tool to Explore the Head and Neck Tumor In Situ Lipidome in JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41598-017-11339-1

    DOI

    http://dx.doi.org/10.1038/s41598-017-11339-1

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1091520362

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/28894173


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