3D imaging of the brain morphology and connectivity defects in a model of psychiatric disorders: MAP6-KO mice View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-12

AUTHORS

Ulysse Gimenez, Benoit Boulan, Franck Mauconduit, Fanny Taurel, Maxime Leclercq, Eric Denarier, Jacques Brocard, Sylvie Gory-Fauré, Annie Andrieux, Hana Lahrech, Jean Christophe Deloulme

ABSTRACT

In the central nervous system, microtubule-associated protein 6 (MAP6) is expressed at high levels and is crucial for cognitive abilities. The large spectrum of social and cognitive impairments observed in MAP6-KO mice are reminiscent of the symptoms observed in psychiatric diseases, such as schizophrenia, and respond positively to long-term treatment with antipsychotics. MAP6-KO mice have therefore been proposed to be a useful animal model for these diseases. Here, we explored the brain anatomy in MAP6-KO mice using high spatial resolution 3D MRI, including a volumetric T1w method to image brain structures, and Diffusion Tensor Imaging (DTI) for white matter fiber tractography. 3D DTI imaging of neuronal tracts was validated by comparing results to optical images of cleared brains. Changes to brain architecture included reduced volume of the cerebellum and the thalamus and altered size, integrity and spatial orientation of some neuronal tracks such as the anterior commissure, the mammillary tract, the corpus callosum, the corticospinal tract, the fasciculus retroflexus and the fornix. Our results provide information on the neuroanatomical defects behind the neurological phenotype displayed in the MAP6-KO mice model and especially highlight a severe damage of the corticospinal tract with defasciculation at the location of the pontine nuclei. More... »

PAGES

10308

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41598-017-10544-2

DOI

http://dx.doi.org/10.1038/s41598-017-10544-2

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1091427571

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28871106


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