Omega-3 fatty acids correlate with gut microbiome diversity and production of N-carbamylglutamate in middle aged and elderly women View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-12

AUTHORS

Cristina Menni, Jonas Zierer, Tess Pallister, Matthew A. Jackson, Tao Long, Robert P. Mohney, Claire J. Steves, Tim D. Spector, Ana M. Valdes

ABSTRACT

Omega-3 fatty acids may influence human physiological parameters in part by affecting the gut microbiome. The aim of this study was to investigate the links between omega-3 fatty acids, gut microbiome diversity and composition and faecal metabolomic profiles in middle aged and elderly women. We analysed data from 876 twins with 16S microbiome data and DHA, total omega-3, and other circulating fatty acids. Estimated food intake of omega-3 fatty acids were obtained from food frequency questionnaires. Both total omega-3and DHA serum levels were significantly correlated with microbiome alpha diversity (Shannon index) after adjusting for confounders (DHA Beta(SE) = 0.13(0.04), P = 0.0006 total omega-3: 0.13(0.04), P = 0.001). These associations remained significant after adjusting for dietary fibre intake. We found even stronger associations between DHA and 38 operational taxonomic units (OTUs), the strongest ones being with OTUs from the Lachnospiraceae family (Beta(SE) = 0.13(0.03), P = 8 × 10-7). Some of the associations with gut bacterial OTUs appear to be mediated by the abundance of the faecal metabolite N-carbamylglutamate. Our data indicate a link between omega-3 circulating levels/intake and microbiome composition independent of dietary fibre intake, particularly with bacteria of the Lachnospiraceae family. These data suggest the potential use of omega-3 supplementation to improve the microbiome composition. More... »

PAGES

11079

References to SciGraph publications

  • 2010-05. QIIME allows analysis of high-throughput community sequencing data in NATURE METHODS
  • 2014-11. Defining the role of common variation in the genomic and biological architecture of adult human height in NATURE GENETICS
  • 2016-11-23. Altered intestinal microbiota–host mitochondria crosstalk in new onset Crohn’s disease in NATURE COMMUNICATIONS
  • 2017-07. Gut microbiome diversity and high-fibre intake are related to lower long-term weight gain in INTERNATIONAL JOURNAL OF OBESITY
  • 2012-08. Antibiotics in early life alter the murine colonic microbiome and adiposity in NATURE
  • 2016-12. The effect of marine n-3 polyunsaturated fatty acids on cardiac autonomic and hemodynamic function in patients with psoriatic arthritis: a randomised, double-blind, placebo-controlled trial in LIPIDS IN HEALTH AND DISEASE
  • 2012-08. Gut microbiota composition correlates with diet and health in the elderly in NATURE
  • 2010-08. Dietary supplementation with l-arginine or N-carbamylglutamate enhances intestinal growth and heat shock protein-70 expression in weanling pigs fed a corn- and soybean meal-based diet in AMINO ACIDS
  • 2014-06. An atlas of genetic influences on human blood metabolites in NATURE GENETICS
  • 2016-12. Effects of sardine-enriched diet on metabolic control, inflammation and gut microbiota in drug-naïve patients with type 2 diabetes: a pilot randomized trial in LIPIDS IN HEALTH AND DISEASE
  • 2015-09. A host-microbiome interaction mediates the opposing effects of omega-6 and omega-3 fatty acids on metabolic endotoxemia in SCIENTIFIC REPORTS
  • 2013-12. Potential role of N-carbamoyl glutamate in biosynthesis of arginine and its significance in production of ruminant animals in JOURNAL OF ANIMAL SCIENCE AND BIOTECHNOLOGY
  • 2015-12. Comparison of the gut microbiota composition between obese and non-obese individuals in a Japanese population, as analyzed by terminal restriction fragment length polymorphism and next-generation sequencing in BMC GASTROENTEROLOGY
  • 2017-12. ω-3 free fatty acids and all-trans retinoic acid synergistically induce growth inhibition of three subtypes of breast cancer cell lines in SCIENTIFIC REPORTS
  • 2013-12. Stool substitute transplant therapy for the eradication of Clostridium difficile infection: ‘RePOOPulating’ the gut in MICROBIOME
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41598-017-10382-2

    DOI

    http://dx.doi.org/10.1038/s41598-017-10382-2

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1091514092

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/28894110


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