Substrate properties modulate cell membrane roughness by way of actin filaments View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-12

AUTHORS

Chao-Hung Chang, Hsiao-Hui Lee, Chau-Hwang Lee

ABSTRACT

Cell membrane roughness has been proposed as a sensitive feature to reflect cellular physiological conditions. In order to know whether membrane roughness is associated with the substrate properties, we employed the non-interferometric wide-field optical profilometry (NIWOP) technique to measure the membrane roughness of living mouse embryonic fibroblasts with different conditions of the culture substrate. By controlling the surface density of fibronectin (FN) coated on the substrate, we found that cells exhibited higher membrane roughness as the FN density increased in company with larger focal adhesion (FA) sizes. The examination of membrane roughness was also confirmed with atomic force microscopy. Using reagents altering actin or microtubule cytoskeletons, we provided evidence that the dynamics of actin filaments rather than that of microtubules plays a crucial role for the regulation of membrane roughness. By changing the substrate rigidity, we further demonstrated that the cells seeded on compliant gels exhibited significantly lower membrane roughness and smaller FAs than the cells on rigid substrate. Taken together, our data suggest that the magnitude of membrane roughness is modulated by way of actin dynamics in cells responding to substrate properties. More... »

PAGES

9068

References to SciGraph publications

  • 2010-04. Organizing the cell cortex: the role of ERM proteins in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 2000-04. Dynamics and segregation of cell–matrix adhesions in cultured fibroblasts in NATURE CELL BIOLOGY
  • 2016-12. Conversion of nanoscale topographical information of cluster-assembled zirconia surfaces into mechanotransductive events promotes neuronal differentiation in JOURNAL OF NANOBIOTECHNOLOGY
  • 2014-06. Rigidity sensing and adaptation through regulation of integrin types in NATURE MATERIALS
  • 2009-01. Environmental sensing through focal adhesions in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 2012-07. Extracellular-matrix tethering regulates stem-cell fate in NATURE MATERIALS
  • 2002-12. How do microtubules guide migrating cells? in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 2009-01. Mechanotransduction gone awry in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 2009-01. Mechanotransduction at a distance: mechanically coupling the extracellular matrix with the nucleus in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 2005-06. Microtubule-induced focal adhesion disassembly is mediated by dynamin and focal adhesion kinase in NATURE CELL BIOLOGY
  • 2013-12. Changes in red blood cell membrane structure in type 2 diabetes: a scanning electron and atomic force microscopy study in CARDIOVASCULAR DIABETOLOGY
  • 2005-12. Membrane curvature and mechanisms of dynamic cell membrane remodelling in NATURE
  • 2015-05. Investigating dynamic structural and mechanical changes of neuroblastoma cells associated with glutamate-mediated neurodegeneration in SCIENTIFIC REPORTS
  • 2016-12. Membrane roughness as a sensitive parameter reflecting the status of neuronal cells in response to chemical and nanoparticle treatments in JOURNAL OF NANOBIOTECHNOLOGY
  • 2006-04. Local force and geometry sensing regulate cell functions in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41598-017-09618-y

    DOI

    http://dx.doi.org/10.1038/s41598-017-09618-y

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1091260157

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/28831175


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