Histological Evaluation of Diabetic Neurodegeneration in the Retina of Zucker Diabetic Fatty (ZDF) Rats View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-08-21

AUTHORS

Klaudia Szabó, Anna Énzsöly, Bulcsú Dékány, Arnold Szabó, Rozina I. Hajdú, Tamás Radovits, Csaba Mátyás, Attila Oláh, Lenke K. Laurik, Gábor M. Somfai, Béla Merkely, Ágoston Szél, Ákos Lukáts

ABSTRACT

In diabetes, retinal dysfunctions exist prior to clinically detectable vasculopathy, however the pathology behind these functional deficits is still not fully established. Previously, our group published a detailed study on the retinal histopathology of type 1 diabetic (T1D) rat model, where specific alterations were detected. Although the majority of human diabetic patients have type 2 diabetes (T2D), similar studies on T2D models are practically absent. To fill this gap, we examined Zucker Diabetic Fatty (ZDF) rats - a model for T2D - by immunohistochemistry at the age of 32 weeks. Glial reactivity was observed in all diabetic specimens, accompanied by an increase in the number of microglia cells. Prominent outer segment degeneration was detectable with changes in cone opsin expression pattern, without a decrease in the number of labelled elements. The immunoreactivity of AII amacrine cells was markedly decreased and changes were detectable in the number and staining of some other amacrine cell subtypes, while most other cells examined did not show any major alterations. Overall, the retinal histology of ZDF rats shows a surprising similarity to T1D rats indicating that despite the different evolution of the disease, the neuroretinal cells affected are the same in both subtypes of diabetes. More... »

PAGES

8891

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41598-017-09068-6

DOI

http://dx.doi.org/10.1038/s41598-017-09068-6

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1091255902

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28827737


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33 schema:description In diabetes, retinal dysfunctions exist prior to clinically detectable vasculopathy, however the pathology behind these functional deficits is still not fully established. Previously, our group published a detailed study on the retinal histopathology of type 1 diabetic (T1D) rat model, where specific alterations were detected. Although the majority of human diabetic patients have type 2 diabetes (T2D), similar studies on T2D models are practically absent. To fill this gap, we examined Zucker Diabetic Fatty (ZDF) rats - a model for T2D - by immunohistochemistry at the age of 32 weeks. Glial reactivity was observed in all diabetic specimens, accompanied by an increase in the number of microglia cells. Prominent outer segment degeneration was detectable with changes in cone opsin expression pattern, without a decrease in the number of labelled elements. The immunoreactivity of AII amacrine cells was markedly decreased and changes were detectable in the number and staining of some other amacrine cell subtypes, while most other cells examined did not show any major alterations. Overall, the retinal histology of ZDF rats shows a surprising similarity to T1D rats indicating that despite the different evolution of the disease, the neuroretinal cells affected are the same in both subtypes of diabetes.
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44 ZDF rats
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46 age
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48 amacrine cell subtypes
49 amacrine cells
50 cell subtypes
51 cells
52 changes
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54 deficits
55 degeneration
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57 diabetes
58 diabetic neurodegeneration
59 diabetic patients
60 diabetic rat model
61 diabetic specimens
62 different evolution
63 disease
64 dysfunction
65 elements
66 evaluation
67 evolution
68 expression patterns
69 fatty
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71 gap
72 glial reactivity
73 group
74 histological evaluation
75 histology
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77 human diabetic patients
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80 increase
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83 microglia cells
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96 retina
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101 similar studies
102 similarity
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