In vivo and in vitro sex differences in the dendritic morphology of developing murine hippocampal and cortical neurons View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-12

AUTHORS

Kimberly P. Keil, Sunjay Sethi, Machelle D. Wilson, Hao Chen, Pamela J. Lein

ABSTRACT

Altered dendritic morphology is common in neurodevelopmental disorders (NDDs), many of which show sex biases in prevalence, onset and/or severity. However, whether dendritic morphology varies as a function of sex in juvenile mice or primary neuronal cell cultures is largely unknown even though both are widely used models for studying NDDs. To address this gap, we quantified dendritic morphology in CA1 pyramidal hippocampal and adjacent somatosensory pyramidal cortical neurons from male and female postnatal day (P)28 C57BL/6J mice. As determined by Sholl analysis of Golgi-stained brain sections, dendritic arbors of male hippocampal neurons are more complex than females. Conversely, dendritic morphology of female cortical neurons is more complex than males. In primary neuron-glia co-cultures from P0 mouse hippocampi, male neurons have more complex dendritic arbors than female neurons. Sex differences are less pronounced in cortical cultures. In vitro sex differences in dendritic morphology are driven in part by estrogen-dependent mechanisms, as evidenced by decreased dendritic complexity in male hippocampal neurons cultured in phenol red-free media or in the presence of an estrogen receptor antagonist. Evidence that sex influences dendritic morphogenesis in two models of neurodevelopment in a region-specific manner has significant mechanistic implications regarding sex biases in NDDs. More... »

PAGES

8486

References to SciGraph publications

  • 2013-01-16. Activity-dependent neuronal signalling and autism spectrum disorder in NATURE
  • 2015. Translational Mouse Models of Autism: Advancing Toward Pharmacological Therapeutics in TRANSLATIONAL NEUROPSYCHOPHARMACOLOGY
  • 2013-12. ADHD in girls and boys – gender differences in co-existing symptoms and executive function measures in BMC PSYCHIATRY
  • 2004-03. In vivo imaging of synapse formation on a growing dendritic arbor in NATURE NEUROSCIENCE
  • 1988-11. Trophic regulation of nerve cell morphology and innervation in the autonomic nervous system in NATURE
  • 2010-12. A developmental sex difference in hippocampal neurogenesis is mediated by endogenous oestradiol in BIOLOGY OF SEX DIFFERENCES
  • 2012-07. NIH Image to ImageJ: 25 years of image analysis in NATURE METHODS
  • 1999-10. Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2 in NATURE GENETICS
  • 2016-10. The cellular mechanisms that maintain neuronal polarity in NATURE REVIEWS NEUROSCIENCE
  • 2002-10. Dendrite growth increased by visual activity requires NMDA receptor and Rho GTPases in NATURE
  • 2011-03. Dendritic spine pathology in neuropsychiatric disorders in NATURE NEUROSCIENCE
  • 2001-11. Visualizing synapse formation in arborizing optic axons in vivo: dynamics and modulation by BDNF in NATURE NEUROSCIENCE
  • 2014-10. Neuronal morphometry directly from bitmap images in NATURE METHODS
  • 2001-04. How do dendrites take their shape? in NATURE NEUROSCIENCE
  • 2013-05. Gender differences in neurodevelopment and epigenetics in PFLÜGERS ARCHIV - EUROPEAN JOURNAL OF PHYSIOLOGY
  • 2015-12. Ontogeny of biochemical, morphological and functional parameters of synaptogenesis in primary cultures of rat hippocampal and cortical neurons in MOLECULAR BRAIN
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41598-017-08459-z

    DOI

    http://dx.doi.org/10.1038/s41598-017-08459-z

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1091148311

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/28814778


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1109", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Neurosciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "University of California, Davis", 
              "id": "https://www.grid.ac/institutes/grid.27860.3b", 
              "name": [
                "Department of Molecular Biosciences, School of Veterinary Medicine, University of California Davis, Davis, CA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Keil", 
            "givenName": "Kimberly P.", 
            "id": "sg:person.01254270460.84", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01254270460.84"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of California, Davis", 
              "id": "https://www.grid.ac/institutes/grid.27860.3b", 
              "name": [
                "Department of Molecular Biosciences, School of Veterinary Medicine, University of California Davis, Davis, CA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Sethi", 
            "givenName": "Sunjay", 
            "id": "sg:person.010775705675.77", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010775705675.77"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of California, Davis", 
              "id": "https://www.grid.ac/institutes/grid.27860.3b", 
              "name": [
                "Clinical and Translational Science Center, Department of Public Health Sciences, Division of Biostatistics, University of California, Davis, CA, United States"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Wilson", 
            "givenName": "Machelle D.", 
            "id": "sg:person.01223360165.04", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01223360165.04"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of California, Davis", 
              "id": "https://www.grid.ac/institutes/grid.27860.3b", 
              "name": [
                "Department of Molecular Biosciences, School of Veterinary Medicine, University of California Davis, Davis, CA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Chen", 
            "givenName": "Hao", 
            "id": "sg:person.0646677556.81", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0646677556.81"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of California, Davis", 
              "id": "https://www.grid.ac/institutes/grid.27860.3b", 
              "name": [
                "Department of Molecular Biosciences, School of Veterinary Medicine, University of California Davis, Davis, CA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lein", 
            "givenName": "Pamela J.", 
            "id": "sg:person.01255734227.00", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01255734227.00"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1016/0006-8993(93)91228-k", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001234297"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0006-8993(93)91228-k", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001234297"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0006-8993(00)02289-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001697907"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/13810", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002301472", 
              "https://doi.org/10.1038/13810"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/13810", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002301472", 
              "https://doi.org/10.1038/13810"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0012-1606(02)00031-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002532397"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0012-1606(02)00031-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002532397"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/cyto.a.20022", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002906095"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.bbrc.2009.05.005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003442949"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/dneu.20638", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004994411"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/scan/nsw027", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005606446"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/2042-6410-1-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005939741", 
              "https://doi.org/10.1186/2042-6410-1-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.mce.2006.04.016", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007007349"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1289/ehp.1104833", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007014196"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1507/endocrj1954.30.277", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008933486"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.fct.2016.11.028", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011240763"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/cne.22419", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011393654"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/cne.22419", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011393654"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/108705470200500302", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011790483"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/108705470200500302", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011790483"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.conb.2010.06.002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011804510"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/brain/awt216", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014442860"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/syn.21716", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014577843"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/86006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014979222", 
              "https://doi.org/10.1038/86006"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/86006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014979222", 
              "https://doi.org/10.1038/86006"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0006-8993(78)90723-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015053249"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0006-8993(78)90723-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015053249"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-244x-13-298", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015259122", 
              "https://doi.org/10.1186/1471-244x-13-298"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-244x-13-298", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015259122", 
              "https://doi.org/10.1186/1471-244x-13-298"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nn735", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015379780", 
              "https://doi.org/10.1038/nn735"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nn735", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015379780", 
              "https://doi.org/10.1038/nn735"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nn1191", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021111716", 
              "https://doi.org/10.1038/nn1191"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nn1191", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021111716", 
              "https://doi.org/10.1038/nn1191"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature00987", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021244681", 
              "https://doi.org/10.1038/nature00987"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature00987", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021244681", 
              "https://doi.org/10.1038/nature00987"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.physbeh.2016.09.014", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021416767"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1523/jneurosci.5372-11.2012", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022510461"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0006-8993(85)90007-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022533111"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0006-8993(85)90007-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022533111"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nmeth.3125", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023026506", 
              "https://doi.org/10.1038/nmeth.3125"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.yhbeh.2015.06.008", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023125006"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1146/annurev.neuro.22.1.511", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023851092"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.neuron.2006.05.008", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024097994"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1006/hbeh.1998.1477", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024397882"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/jnr.23864", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025001735"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.diff.2012.07.005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025725765"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.diff.2012.07.005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025725765"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0165-3806(83)90085-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026747862"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0165-3806(83)90085-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026747862"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1364-6613(02)01904-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027124370"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1006/meth.2001.1262", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027621591"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1006/meth.2001.1262", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027621591"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1750-3639.2007.00102.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028055642"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00424-013-1258-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028230202", 
              "https://doi.org/10.1007/s00424-013-1258-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.yhbeh.2010.08.009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028254591"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0006-8993(89)91341-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030453703"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0006-8993(89)91341-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030453703"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.neuroscience.2008.11.038", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032136423"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.expneurol.2015.06.005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032836012"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/hmg/ddi102", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033215670"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/cne.23262", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034565754"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1365-2826.1993.tb00523.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035153914"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.yhbeh.2015.04.013", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035178200"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.yhbeh.2015.11.007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035668404"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nmeth.2089", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035817137", 
              "https://doi.org/10.1038/nmeth.2089"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nn.2741", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037440395", 
              "https://doi.org/10.1038/nn.2741"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1289/ehp.1104832", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038468343"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/336123a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038883584", 
              "https://doi.org/10.1038/336123a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/jnr.21083", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039743166"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0959-4388(97)80078-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040575478"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0959-4388(00)00182-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040619843"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0166-4328(05)80261-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041770007"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ntt.2012.12.001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042001650"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1289/ehp.9773", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042039590"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/7854_2015_5003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042698477", 
              "https://doi.org/10.1007/7854_2015_5003"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1155/2016/6810215", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042789494"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1460-9568.2008.06073.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043450877"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0197-4580(02)00004-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044737352"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s13041-015-0099-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045001591", 
              "https://doi.org/10.1186/s13041-015-0099-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s13041-015-0099-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045001591", 
              "https://doi.org/10.1186/s13041-015-0099-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrn.2016.100", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045733950", 
              "https://doi.org/10.1038/nrn.2016.100"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1146/annurev.ne.07.030184.002213", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046061067"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1242/dev.117903", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046721431"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature11860", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048290884", 
              "https://doi.org/10.1038/nature11860"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/cercor/6.4.551", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049487642"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jneumeth.2017.01.003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049689782"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0060189", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050120751"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.neuroimage.2013.09.073", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051010068"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3389/neuro.04.018.2009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051116178"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0038355", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051171563"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.brainres.2009.09.120", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052081622"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.neubiorev.2016.04.008", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052131235"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.neubiorev.2016.04.008", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052131235"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1159/000437413", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052205467"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/cercor/bhq137", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053090466"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/acschemneuro.5b00096", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053782694"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1192/bjp.161.4.556", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064171462"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1210/en.2009-0305", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064249965"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1210/endo-103-6-1985", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064253922"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1210/endo-106-1-306", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064254608"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1210/endo-116-5-1845", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064258802"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3791/52919", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1071425198"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1077396561", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1078886835", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1081982941", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1083735572", 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2017-12", 
        "datePublishedReg": "2017-12-01", 
        "description": "Altered dendritic morphology is common in neurodevelopmental disorders (NDDs), many of which show sex biases in prevalence, onset and/or severity. However, whether dendritic morphology varies as a function of sex in juvenile mice or primary neuronal cell cultures is largely unknown even though both are widely used models for studying NDDs. To address this gap, we quantified dendritic morphology in CA1 pyramidal hippocampal and adjacent somatosensory pyramidal cortical neurons from male and female postnatal day (P)28 C57BL/6J mice. As determined by Sholl analysis of Golgi-stained brain sections, dendritic arbors of male hippocampal neurons are more complex than females. Conversely, dendritic morphology of female cortical neurons is more complex than males. In primary neuron-glia co-cultures from P0 mouse hippocampi, male neurons have more complex dendritic arbors than female neurons. Sex differences are less pronounced in cortical cultures. In vitro sex differences in dendritic morphology are driven in part by estrogen-dependent mechanisms, as evidenced by decreased dendritic complexity in male hippocampal neurons cultured in phenol red-free media or in the presence of an estrogen receptor antagonist. Evidence that sex influences dendritic morphogenesis in two models of neurodevelopment in a region-specific manner has significant mechanistic implications regarding sex biases in NDDs.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/s41598-017-08459-z", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.2683494", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2436271", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2699307", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2503823", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.4596239", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.5475852", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.6460610", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1045337", 
            "issn": [
              "2045-2322"
            ], 
            "name": "Scientific Reports", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "1", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "7"
          }
        ], 
        "name": "In vivo and in vitro sex differences in the dendritic morphology of developing murine hippocampal and cortical neurons", 
        "pagination": "8486", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "24695488a7e301ae112ef5a044e674afdd2d09d04cbac67cfcc847103bcc8559"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "28814778"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "101563288"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/s41598-017-08459-z"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1091148311"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/s41598-017-08459-z", 
          "https://app.dimensions.ai/details/publication/pub.1091148311"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-11T09:41", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000346_0000000346/records_99841_00000004.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://www.nature.com/articles/s41598-017-08459-z"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41598-017-08459-z'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41598-017-08459-z'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41598-017-08459-z'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41598-017-08459-z'


     

    This table displays all metadata directly associated to this object as RDF triples.

    387 TRIPLES      21 PREDICATES      117 URIs      21 LITERALS      9 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/s41598-017-08459-z schema:about anzsrc-for:11
    2 anzsrc-for:1109
    3 schema:author N9ebf3c0c5fc1440790a538668cc31de1
    4 schema:citation sg:pub.10.1007/7854_2015_5003
    5 sg:pub.10.1007/s00424-013-1258-4
    6 sg:pub.10.1038/13810
    7 sg:pub.10.1038/336123a0
    8 sg:pub.10.1038/86006
    9 sg:pub.10.1038/nature00987
    10 sg:pub.10.1038/nature11860
    11 sg:pub.10.1038/nmeth.2089
    12 sg:pub.10.1038/nmeth.3125
    13 sg:pub.10.1038/nn.2741
    14 sg:pub.10.1038/nn1191
    15 sg:pub.10.1038/nn735
    16 sg:pub.10.1038/nrn.2016.100
    17 sg:pub.10.1186/1471-244x-13-298
    18 sg:pub.10.1186/2042-6410-1-8
    19 sg:pub.10.1186/s13041-015-0099-9
    20 https://app.dimensions.ai/details/publication/pub.1077396561
    21 https://app.dimensions.ai/details/publication/pub.1078886835
    22 https://app.dimensions.ai/details/publication/pub.1081982941
    23 https://app.dimensions.ai/details/publication/pub.1083735572
    24 https://doi.org/10.1002/cne.22419
    25 https://doi.org/10.1002/cne.23262
    26 https://doi.org/10.1002/cyto.a.20022
    27 https://doi.org/10.1002/dneu.20638
    28 https://doi.org/10.1002/jnr.21083
    29 https://doi.org/10.1002/jnr.23864
    30 https://doi.org/10.1002/syn.21716
    31 https://doi.org/10.1006/hbeh.1998.1477
    32 https://doi.org/10.1006/meth.2001.1262
    33 https://doi.org/10.1016/0006-8993(78)90723-0
    34 https://doi.org/10.1016/0006-8993(85)90007-1
    35 https://doi.org/10.1016/0006-8993(89)91341-3
    36 https://doi.org/10.1016/0006-8993(93)91228-k
    37 https://doi.org/10.1016/0165-3806(83)90085-8
    38 https://doi.org/10.1016/j.bbrc.2009.05.005
    39 https://doi.org/10.1016/j.brainres.2009.09.120
    40 https://doi.org/10.1016/j.conb.2010.06.002
    41 https://doi.org/10.1016/j.diff.2012.07.005
    42 https://doi.org/10.1016/j.expneurol.2015.06.005
    43 https://doi.org/10.1016/j.fct.2016.11.028
    44 https://doi.org/10.1016/j.jneumeth.2017.01.003
    45 https://doi.org/10.1016/j.mce.2006.04.016
    46 https://doi.org/10.1016/j.neubiorev.2016.04.008
    47 https://doi.org/10.1016/j.neuroimage.2013.09.073
    48 https://doi.org/10.1016/j.neuron.2006.05.008
    49 https://doi.org/10.1016/j.neuroscience.2008.11.038
    50 https://doi.org/10.1016/j.ntt.2012.12.001
    51 https://doi.org/10.1016/j.physbeh.2016.09.014
    52 https://doi.org/10.1016/j.yhbeh.2010.08.009
    53 https://doi.org/10.1016/j.yhbeh.2015.04.013
    54 https://doi.org/10.1016/j.yhbeh.2015.06.008
    55 https://doi.org/10.1016/j.yhbeh.2015.11.007
    56 https://doi.org/10.1016/s0006-8993(00)02289-7
    57 https://doi.org/10.1016/s0012-1606(02)00031-3
    58 https://doi.org/10.1016/s0166-4328(05)80261-x
    59 https://doi.org/10.1016/s0197-4580(02)00004-0
    60 https://doi.org/10.1016/s0959-4388(00)00182-3
    61 https://doi.org/10.1016/s0959-4388(97)80078-5
    62 https://doi.org/10.1016/s1364-6613(02)01904-6
    63 https://doi.org/10.1021/acschemneuro.5b00096
    64 https://doi.org/10.1093/brain/awt216
    65 https://doi.org/10.1093/cercor/6.4.551
    66 https://doi.org/10.1093/cercor/bhq137
    67 https://doi.org/10.1093/hmg/ddi102
    68 https://doi.org/10.1093/scan/nsw027
    69 https://doi.org/10.1111/j.1365-2826.1993.tb00523.x
    70 https://doi.org/10.1111/j.1460-9568.2008.06073.x
    71 https://doi.org/10.1111/j.1750-3639.2007.00102.x
    72 https://doi.org/10.1146/annurev.ne.07.030184.002213
    73 https://doi.org/10.1146/annurev.neuro.22.1.511
    74 https://doi.org/10.1155/2016/6810215
    75 https://doi.org/10.1159/000437413
    76 https://doi.org/10.1177/108705470200500302
    77 https://doi.org/10.1192/bjp.161.4.556
    78 https://doi.org/10.1210/en.2009-0305
    79 https://doi.org/10.1210/endo-103-6-1985
    80 https://doi.org/10.1210/endo-106-1-306
    81 https://doi.org/10.1210/endo-116-5-1845
    82 https://doi.org/10.1242/dev.117903
    83 https://doi.org/10.1289/ehp.1104832
    84 https://doi.org/10.1289/ehp.1104833
    85 https://doi.org/10.1289/ehp.9773
    86 https://doi.org/10.1371/journal.pone.0038355
    87 https://doi.org/10.1371/journal.pone.0060189
    88 https://doi.org/10.1507/endocrj1954.30.277
    89 https://doi.org/10.1523/jneurosci.5372-11.2012
    90 https://doi.org/10.3389/neuro.04.018.2009
    91 https://doi.org/10.3791/52919
    92 schema:datePublished 2017-12
    93 schema:datePublishedReg 2017-12-01
    94 schema:description Altered dendritic morphology is common in neurodevelopmental disorders (NDDs), many of which show sex biases in prevalence, onset and/or severity. However, whether dendritic morphology varies as a function of sex in juvenile mice or primary neuronal cell cultures is largely unknown even though both are widely used models for studying NDDs. To address this gap, we quantified dendritic morphology in CA1 pyramidal hippocampal and adjacent somatosensory pyramidal cortical neurons from male and female postnatal day (P)28 C57BL/6J mice. As determined by Sholl analysis of Golgi-stained brain sections, dendritic arbors of male hippocampal neurons are more complex than females. Conversely, dendritic morphology of female cortical neurons is more complex than males. In primary neuron-glia co-cultures from P0 mouse hippocampi, male neurons have more complex dendritic arbors than female neurons. Sex differences are less pronounced in cortical cultures. In vitro sex differences in dendritic morphology are driven in part by estrogen-dependent mechanisms, as evidenced by decreased dendritic complexity in male hippocampal neurons cultured in phenol red-free media or in the presence of an estrogen receptor antagonist. Evidence that sex influences dendritic morphogenesis in two models of neurodevelopment in a region-specific manner has significant mechanistic implications regarding sex biases in NDDs.
    95 schema:genre research_article
    96 schema:inLanguage en
    97 schema:isAccessibleForFree true
    98 schema:isPartOf N4811a23011814d79b384b135bbcc90e6
    99 Nae677d1cb8434242b49992278d2a5e44
    100 sg:journal.1045337
    101 schema:name In vivo and in vitro sex differences in the dendritic morphology of developing murine hippocampal and cortical neurons
    102 schema:pagination 8486
    103 schema:productId N08e2f0788b364f8a884b36290f5c6334
    104 N1e07be0d672246bf80680e13bcfcf240
    105 N5d8391f7405c4eca89519147c4745ec2
    106 N937e2e12956c4ed198faf1ea94eab8bb
    107 Nfccf9212306f4bb9878d0d62949dd917
    108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091148311
    109 https://doi.org/10.1038/s41598-017-08459-z
    110 schema:sdDatePublished 2019-04-11T09:41
    111 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    112 schema:sdPublisher N212ee25a407041b28b141ddd19492638
    113 schema:url https://www.nature.com/articles/s41598-017-08459-z
    114 sgo:license sg:explorer/license/
    115 sgo:sdDataset articles
    116 rdf:type schema:ScholarlyArticle
    117 N08e2f0788b364f8a884b36290f5c6334 schema:name nlm_unique_id
    118 schema:value 101563288
    119 rdf:type schema:PropertyValue
    120 N1938f14e148c40c4b12af4fb99f9e065 rdf:first sg:person.010775705675.77
    121 rdf:rest Nab9ba8f3a33f4b21adf48f471f95c8b1
    122 N1e07be0d672246bf80680e13bcfcf240 schema:name pubmed_id
    123 schema:value 28814778
    124 rdf:type schema:PropertyValue
    125 N212ee25a407041b28b141ddd19492638 schema:name Springer Nature - SN SciGraph project
    126 rdf:type schema:Organization
    127 N4811a23011814d79b384b135bbcc90e6 schema:volumeNumber 7
    128 rdf:type schema:PublicationVolume
    129 N5d8391f7405c4eca89519147c4745ec2 schema:name dimensions_id
    130 schema:value pub.1091148311
    131 rdf:type schema:PropertyValue
    132 N937e2e12956c4ed198faf1ea94eab8bb schema:name doi
    133 schema:value 10.1038/s41598-017-08459-z
    134 rdf:type schema:PropertyValue
    135 N9a51bf441bc643c383b86b45feff3e3d rdf:first sg:person.01255734227.00
    136 rdf:rest rdf:nil
    137 N9ebf3c0c5fc1440790a538668cc31de1 rdf:first sg:person.01254270460.84
    138 rdf:rest N1938f14e148c40c4b12af4fb99f9e065
    139 Nab9ba8f3a33f4b21adf48f471f95c8b1 rdf:first sg:person.01223360165.04
    140 rdf:rest Nac098e164a664847a707153986cfd5c3
    141 Nac098e164a664847a707153986cfd5c3 rdf:first sg:person.0646677556.81
    142 rdf:rest N9a51bf441bc643c383b86b45feff3e3d
    143 Nae677d1cb8434242b49992278d2a5e44 schema:issueNumber 1
    144 rdf:type schema:PublicationIssue
    145 Nfccf9212306f4bb9878d0d62949dd917 schema:name readcube_id
    146 schema:value 24695488a7e301ae112ef5a044e674afdd2d09d04cbac67cfcc847103bcc8559
    147 rdf:type schema:PropertyValue
    148 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    149 schema:name Medical and Health Sciences
    150 rdf:type schema:DefinedTerm
    151 anzsrc-for:1109 schema:inDefinedTermSet anzsrc-for:
    152 schema:name Neurosciences
    153 rdf:type schema:DefinedTerm
    154 sg:grant.2436271 http://pending.schema.org/fundedItem sg:pub.10.1038/s41598-017-08459-z
    155 rdf:type schema:MonetaryGrant
    156 sg:grant.2503823 http://pending.schema.org/fundedItem sg:pub.10.1038/s41598-017-08459-z
    157 rdf:type schema:MonetaryGrant
    158 sg:grant.2683494 http://pending.schema.org/fundedItem sg:pub.10.1038/s41598-017-08459-z
    159 rdf:type schema:MonetaryGrant
    160 sg:grant.2699307 http://pending.schema.org/fundedItem sg:pub.10.1038/s41598-017-08459-z
    161 rdf:type schema:MonetaryGrant
    162 sg:grant.4596239 http://pending.schema.org/fundedItem sg:pub.10.1038/s41598-017-08459-z
    163 rdf:type schema:MonetaryGrant
    164 sg:grant.5475852 http://pending.schema.org/fundedItem sg:pub.10.1038/s41598-017-08459-z
    165 rdf:type schema:MonetaryGrant
    166 sg:grant.6460610 http://pending.schema.org/fundedItem sg:pub.10.1038/s41598-017-08459-z
    167 rdf:type schema:MonetaryGrant
    168 sg:journal.1045337 schema:issn 2045-2322
    169 schema:name Scientific Reports
    170 rdf:type schema:Periodical
    171 sg:person.010775705675.77 schema:affiliation https://www.grid.ac/institutes/grid.27860.3b
    172 schema:familyName Sethi
    173 schema:givenName Sunjay
    174 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010775705675.77
    175 rdf:type schema:Person
    176 sg:person.01223360165.04 schema:affiliation https://www.grid.ac/institutes/grid.27860.3b
    177 schema:familyName Wilson
    178 schema:givenName Machelle D.
    179 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01223360165.04
    180 rdf:type schema:Person
    181 sg:person.01254270460.84 schema:affiliation https://www.grid.ac/institutes/grid.27860.3b
    182 schema:familyName Keil
    183 schema:givenName Kimberly P.
    184 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01254270460.84
    185 rdf:type schema:Person
    186 sg:person.01255734227.00 schema:affiliation https://www.grid.ac/institutes/grid.27860.3b
    187 schema:familyName Lein
    188 schema:givenName Pamela J.
    189 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01255734227.00
    190 rdf:type schema:Person
    191 sg:person.0646677556.81 schema:affiliation https://www.grid.ac/institutes/grid.27860.3b
    192 schema:familyName Chen
    193 schema:givenName Hao
    194 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0646677556.81
    195 rdf:type schema:Person
    196 sg:pub.10.1007/7854_2015_5003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042698477
    197 https://doi.org/10.1007/7854_2015_5003
    198 rdf:type schema:CreativeWork
    199 sg:pub.10.1007/s00424-013-1258-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028230202
    200 https://doi.org/10.1007/s00424-013-1258-4
    201 rdf:type schema:CreativeWork
    202 sg:pub.10.1038/13810 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002301472
    203 https://doi.org/10.1038/13810
    204 rdf:type schema:CreativeWork
    205 sg:pub.10.1038/336123a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038883584
    206 https://doi.org/10.1038/336123a0
    207 rdf:type schema:CreativeWork
    208 sg:pub.10.1038/86006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014979222
    209 https://doi.org/10.1038/86006
    210 rdf:type schema:CreativeWork
    211 sg:pub.10.1038/nature00987 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021244681
    212 https://doi.org/10.1038/nature00987
    213 rdf:type schema:CreativeWork
    214 sg:pub.10.1038/nature11860 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048290884
    215 https://doi.org/10.1038/nature11860
    216 rdf:type schema:CreativeWork
    217 sg:pub.10.1038/nmeth.2089 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035817137
    218 https://doi.org/10.1038/nmeth.2089
    219 rdf:type schema:CreativeWork
    220 sg:pub.10.1038/nmeth.3125 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023026506
    221 https://doi.org/10.1038/nmeth.3125
    222 rdf:type schema:CreativeWork
    223 sg:pub.10.1038/nn.2741 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037440395
    224 https://doi.org/10.1038/nn.2741
    225 rdf:type schema:CreativeWork
    226 sg:pub.10.1038/nn1191 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021111716
    227 https://doi.org/10.1038/nn1191
    228 rdf:type schema:CreativeWork
    229 sg:pub.10.1038/nn735 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015379780
    230 https://doi.org/10.1038/nn735
    231 rdf:type schema:CreativeWork
    232 sg:pub.10.1038/nrn.2016.100 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045733950
    233 https://doi.org/10.1038/nrn.2016.100
    234 rdf:type schema:CreativeWork
    235 sg:pub.10.1186/1471-244x-13-298 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015259122
    236 https://doi.org/10.1186/1471-244x-13-298
    237 rdf:type schema:CreativeWork
    238 sg:pub.10.1186/2042-6410-1-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005939741
    239 https://doi.org/10.1186/2042-6410-1-8
    240 rdf:type schema:CreativeWork
    241 sg:pub.10.1186/s13041-015-0099-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045001591
    242 https://doi.org/10.1186/s13041-015-0099-9
    243 rdf:type schema:CreativeWork
    244 https://app.dimensions.ai/details/publication/pub.1077396561 schema:CreativeWork
    245 https://app.dimensions.ai/details/publication/pub.1078886835 schema:CreativeWork
    246 https://app.dimensions.ai/details/publication/pub.1081982941 schema:CreativeWork
    247 https://app.dimensions.ai/details/publication/pub.1083735572 schema:CreativeWork
    248 https://doi.org/10.1002/cne.22419 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011393654
    249 rdf:type schema:CreativeWork
    250 https://doi.org/10.1002/cne.23262 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034565754
    251 rdf:type schema:CreativeWork
    252 https://doi.org/10.1002/cyto.a.20022 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002906095
    253 rdf:type schema:CreativeWork
    254 https://doi.org/10.1002/dneu.20638 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004994411
    255 rdf:type schema:CreativeWork
    256 https://doi.org/10.1002/jnr.21083 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039743166
    257 rdf:type schema:CreativeWork
    258 https://doi.org/10.1002/jnr.23864 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025001735
    259 rdf:type schema:CreativeWork
    260 https://doi.org/10.1002/syn.21716 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014577843
    261 rdf:type schema:CreativeWork
    262 https://doi.org/10.1006/hbeh.1998.1477 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024397882
    263 rdf:type schema:CreativeWork
    264 https://doi.org/10.1006/meth.2001.1262 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027621591
    265 rdf:type schema:CreativeWork
    266 https://doi.org/10.1016/0006-8993(78)90723-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015053249
    267 rdf:type schema:CreativeWork
    268 https://doi.org/10.1016/0006-8993(85)90007-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022533111
    269 rdf:type schema:CreativeWork
    270 https://doi.org/10.1016/0006-8993(89)91341-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030453703
    271 rdf:type schema:CreativeWork
    272 https://doi.org/10.1016/0006-8993(93)91228-k schema:sameAs https://app.dimensions.ai/details/publication/pub.1001234297
    273 rdf:type schema:CreativeWork
    274 https://doi.org/10.1016/0165-3806(83)90085-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026747862
    275 rdf:type schema:CreativeWork
    276 https://doi.org/10.1016/j.bbrc.2009.05.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003442949
    277 rdf:type schema:CreativeWork
    278 https://doi.org/10.1016/j.brainres.2009.09.120 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052081622
    279 rdf:type schema:CreativeWork
    280 https://doi.org/10.1016/j.conb.2010.06.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011804510
    281 rdf:type schema:CreativeWork
    282 https://doi.org/10.1016/j.diff.2012.07.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025725765
    283 rdf:type schema:CreativeWork
    284 https://doi.org/10.1016/j.expneurol.2015.06.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032836012
    285 rdf:type schema:CreativeWork
    286 https://doi.org/10.1016/j.fct.2016.11.028 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011240763
    287 rdf:type schema:CreativeWork
    288 https://doi.org/10.1016/j.jneumeth.2017.01.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049689782
    289 rdf:type schema:CreativeWork
    290 https://doi.org/10.1016/j.mce.2006.04.016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007007349
    291 rdf:type schema:CreativeWork
    292 https://doi.org/10.1016/j.neubiorev.2016.04.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052131235
    293 rdf:type schema:CreativeWork
    294 https://doi.org/10.1016/j.neuroimage.2013.09.073 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051010068
    295 rdf:type schema:CreativeWork
    296 https://doi.org/10.1016/j.neuron.2006.05.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024097994
    297 rdf:type schema:CreativeWork
    298 https://doi.org/10.1016/j.neuroscience.2008.11.038 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032136423
    299 rdf:type schema:CreativeWork
    300 https://doi.org/10.1016/j.ntt.2012.12.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042001650
    301 rdf:type schema:CreativeWork
    302 https://doi.org/10.1016/j.physbeh.2016.09.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021416767
    303 rdf:type schema:CreativeWork
    304 https://doi.org/10.1016/j.yhbeh.2010.08.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028254591
    305 rdf:type schema:CreativeWork
    306 https://doi.org/10.1016/j.yhbeh.2015.04.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035178200
    307 rdf:type schema:CreativeWork
    308 https://doi.org/10.1016/j.yhbeh.2015.06.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023125006
    309 rdf:type schema:CreativeWork
    310 https://doi.org/10.1016/j.yhbeh.2015.11.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035668404
    311 rdf:type schema:CreativeWork
    312 https://doi.org/10.1016/s0006-8993(00)02289-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001697907
    313 rdf:type schema:CreativeWork
    314 https://doi.org/10.1016/s0012-1606(02)00031-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002532397
    315 rdf:type schema:CreativeWork
    316 https://doi.org/10.1016/s0166-4328(05)80261-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1041770007
    317 rdf:type schema:CreativeWork
    318 https://doi.org/10.1016/s0197-4580(02)00004-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044737352
    319 rdf:type schema:CreativeWork
    320 https://doi.org/10.1016/s0959-4388(00)00182-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040619843
    321 rdf:type schema:CreativeWork
    322 https://doi.org/10.1016/s0959-4388(97)80078-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040575478
    323 rdf:type schema:CreativeWork
    324 https://doi.org/10.1016/s1364-6613(02)01904-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027124370
    325 rdf:type schema:CreativeWork
    326 https://doi.org/10.1021/acschemneuro.5b00096 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053782694
    327 rdf:type schema:CreativeWork
    328 https://doi.org/10.1093/brain/awt216 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014442860
    329 rdf:type schema:CreativeWork
    330 https://doi.org/10.1093/cercor/6.4.551 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049487642
    331 rdf:type schema:CreativeWork
    332 https://doi.org/10.1093/cercor/bhq137 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053090466
    333 rdf:type schema:CreativeWork
    334 https://doi.org/10.1093/hmg/ddi102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033215670
    335 rdf:type schema:CreativeWork
    336 https://doi.org/10.1093/scan/nsw027 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005606446
    337 rdf:type schema:CreativeWork
    338 https://doi.org/10.1111/j.1365-2826.1993.tb00523.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1035153914
    339 rdf:type schema:CreativeWork
    340 https://doi.org/10.1111/j.1460-9568.2008.06073.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1043450877
    341 rdf:type schema:CreativeWork
    342 https://doi.org/10.1111/j.1750-3639.2007.00102.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1028055642
    343 rdf:type schema:CreativeWork
    344 https://doi.org/10.1146/annurev.ne.07.030184.002213 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046061067
    345 rdf:type schema:CreativeWork
    346 https://doi.org/10.1146/annurev.neuro.22.1.511 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023851092
    347 rdf:type schema:CreativeWork
    348 https://doi.org/10.1155/2016/6810215 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042789494
    349 rdf:type schema:CreativeWork
    350 https://doi.org/10.1159/000437413 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052205467
    351 rdf:type schema:CreativeWork
    352 https://doi.org/10.1177/108705470200500302 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011790483
    353 rdf:type schema:CreativeWork
    354 https://doi.org/10.1192/bjp.161.4.556 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064171462
    355 rdf:type schema:CreativeWork
    356 https://doi.org/10.1210/en.2009-0305 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064249965
    357 rdf:type schema:CreativeWork
    358 https://doi.org/10.1210/endo-103-6-1985 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064253922
    359 rdf:type schema:CreativeWork
    360 https://doi.org/10.1210/endo-106-1-306 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064254608
    361 rdf:type schema:CreativeWork
    362 https://doi.org/10.1210/endo-116-5-1845 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064258802
    363 rdf:type schema:CreativeWork
    364 https://doi.org/10.1242/dev.117903 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046721431
    365 rdf:type schema:CreativeWork
    366 https://doi.org/10.1289/ehp.1104832 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038468343
    367 rdf:type schema:CreativeWork
    368 https://doi.org/10.1289/ehp.1104833 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007014196
    369 rdf:type schema:CreativeWork
    370 https://doi.org/10.1289/ehp.9773 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042039590
    371 rdf:type schema:CreativeWork
    372 https://doi.org/10.1371/journal.pone.0038355 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051171563
    373 rdf:type schema:CreativeWork
    374 https://doi.org/10.1371/journal.pone.0060189 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050120751
    375 rdf:type schema:CreativeWork
    376 https://doi.org/10.1507/endocrj1954.30.277 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008933486
    377 rdf:type schema:CreativeWork
    378 https://doi.org/10.1523/jneurosci.5372-11.2012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022510461
    379 rdf:type schema:CreativeWork
    380 https://doi.org/10.3389/neuro.04.018.2009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051116178
    381 rdf:type schema:CreativeWork
    382 https://doi.org/10.3791/52919 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071425198
    383 rdf:type schema:CreativeWork
    384 https://www.grid.ac/institutes/grid.27860.3b schema:alternateName University of California, Davis
    385 schema:name Clinical and Translational Science Center, Department of Public Health Sciences, Division of Biostatistics, University of California, Davis, CA, United States
    386 Department of Molecular Biosciences, School of Veterinary Medicine, University of California Davis, Davis, CA, USA
    387 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...