Disrupting glutamine metabolic pathways to sensitize gemcitabine-resistant pancreatic cancer View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-12

AUTHORS

Ru Chen, Lisa A Lai, Yumi Sullivan, Melissa Wong, Lei Wang, Jonah Riddell, Linda Jung, Venu G. Pillarisetty, Teresa A. Brentnall, Sheng Pan

ABSTRACT

Pancreatic cancer is a lethal disease with poor prognosis. Gemcitabine has been the first line systemic treatment for pancreatic cancer. However, the rapid development of drug resistance has been a major hurdle in gemcitabine therapy leading to unsatisfactory patient outcomes. With the recent renewed understanding of glutamine metabolism involvement in drug resistance and immuno-response, we investigated the anti-tumor effect of a glutamine analog (6-diazo-5-oxo-L-norleucine) as an adjuvant treatment to sensitize chemoresistant pancreatic cancer cells. We demonstrate that disruption of glutamine metabolic pathways improves the efficacy of gemcitabine treatment. Such a disruption induces a cascade of events which impacts glycan biosynthesis through Hexosamine Biosynthesis Pathway (HBP), as well as cellular redox homeostasis, resulting in global changes in protein glycosylation, expression and functional effects. The proteome alterations induced in the resistant cancer cells and the secreted exosomes are intricately associated with the reduction in cell proliferation and the enhancement of cancer cell chemosensitivity. Proteins associated with EGFR signaling, including downstream AKT-mTOR pathways, MAPK pathway, as well as redox enzymes were downregulated in response to disruption of glutamine metabolic pathways. More... »

PAGES

7950

References to SciGraph publications

  • 2015-01. Intracellular annexin A2 regulates NF-κB signaling by binding to the p50 subunit: implications for gemcitabine resistance in pancreatic cancer in CELL DEATH & DISEASE
  • 2017-02. Exosomes confer chemoresistance to pancreatic cancer cells by promoting ROS detoxification and miR-155-mediated suppression of key gemcitabine-metabolising enzyme, DCK in BRITISH JOURNAL OF CANCER
  • 2009-07. Activation of ER stress and inhibition of EGFR N-glycosylation by tunicamycin enhances susceptibility of human non-small cell lung cancer cells to erlotinib in CANCER CHEMOTHERAPY AND PHARMACOLOGY
  • 2007-12. Development and Characterization of Gemcitabine-Resistant Pancreatic Tumor Cells in ANNALS OF SURGICAL ONCOLOGY
  • 1985-08. Amplification of P-glycoprotein genes in multidrug-resistant mammalian cell lines in NATURE
  • 2013-04. Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway in NATURE
  • 2007-10. Analysis and validation of proteomic data generated by tandem mass spectrometry in NATURE METHODS
  • 2009-01. Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources in NATURE PROTOCOLS
  • 2017-03. Cancer-associated fibroblast exosomes regulate survival and proliferation of pancreatic cancer cells in ONCOGENE
  • 2011-04. Transient silencing of galectin-3 expression promotes both in vitro and in vivo drug-induced apoptosis of human pancreatic carcinoma cells in CLINICAL & EXPERIMENTAL METASTASIS
  • 2015-09. Glycosylation in cancer: mechanisms and clinical implications in NATURE REVIEWS CANCER
  • 1980. The Rediscovery of DON (6-Diazo-5-oxo-L-norleucine) in CANCER CHEMO- AND IMMUNOPHARMACOLOGY
  • 2010-12. Role of 14-3-3σ in poor prognosis and in radiation and drug resistance of human pancreatic cancers in BMC CANCER
  • 2015-01. Proteins associated with pancreatic cancer survival in patients with resectable pancreatic ductal adenocarcinoma in LABORATORY INVESTIGATION
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41598-017-08436-6

    DOI

    http://dx.doi.org/10.1038/s41598-017-08436-6

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1091090392

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/28801576


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biochemistry and Cell Biology", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biological Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cell Line, Tumor", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cell Proliferation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cell Survival", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Deoxycytidine", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Diazooxonorleucine", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Drug Resistance, Neoplasm", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Drug Synergism", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Glutamine", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Metabolic Networks and Pathways", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Oxidation-Reduction", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Pancreatic Neoplasms", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Proteomics", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "University of Washington", 
              "id": "https://www.grid.ac/institutes/grid.34477.33", 
              "name": [
                "Department of Medicine, University of Washington, 98195, Seattle, WA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Chen", 
            "givenName": "Ru", 
            "id": "sg:person.0674537271.69", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0674537271.69"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Washington", 
              "id": "https://www.grid.ac/institutes/grid.34477.33", 
              "name": [
                "Department of Medicine, University of Washington, 98195, Seattle, WA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lai", 
            "givenName": "Lisa A", 
            "id": "sg:person.01167466371.58", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01167466371.58"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Washington", 
              "id": "https://www.grid.ac/institutes/grid.34477.33", 
              "name": [
                "Department of Medicine, University of Washington, 98195, Seattle, WA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Sullivan", 
            "givenName": "Yumi", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Washington", 
              "id": "https://www.grid.ac/institutes/grid.34477.33", 
              "name": [
                "Department of Medicine, University of Washington, 98195, Seattle, WA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Wong", 
            "givenName": "Melissa", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Washington", 
              "id": "https://www.grid.ac/institutes/grid.34477.33", 
              "name": [
                "Department of Medicine, University of Washington, 98195, Seattle, WA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Wang", 
            "givenName": "Lei", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Cell Signaling Technology (United States)", 
              "id": "https://www.grid.ac/institutes/grid.420530.0", 
              "name": [
                "Cell Signaling Technology, Inc, 01923, Danvers, MA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Riddell", 
            "givenName": "Jonah", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Cell Signaling Technology (United States)", 
              "id": "https://www.grid.ac/institutes/grid.420530.0", 
              "name": [
                "Cell Signaling Technology, Inc, 01923, Danvers, MA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Jung", 
            "givenName": "Linda", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Washington", 
              "id": "https://www.grid.ac/institutes/grid.34477.33", 
              "name": [
                "Department of Surgery, University of Washington, 98195, Seattle, WA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Pillarisetty", 
            "givenName": "Venu G.", 
            "id": "sg:person.01135135021.15", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01135135021.15"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Washington", 
              "id": "https://www.grid.ac/institutes/grid.34477.33", 
              "name": [
                "Department of Medicine, University of Washington, 98195, Seattle, WA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Brentnall", 
            "givenName": "Teresa A.", 
            "id": "sg:person.01036061773.00", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01036061773.00"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Washington", 
              "id": "https://www.grid.ac/institutes/grid.34477.33", 
              "name": [
                "Department of Medicine, University of Washington, 98195, Seattle, WA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Pan", 
            "givenName": "Sheng", 
            "id": "sg:person.01302214013.32", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01302214013.32"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-08-1366", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001228343"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.bbagen.2012.03.017", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003757679"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-09-3331", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004699819"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature12040", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005310785", 
              "https://doi.org/10.1038/nature12040"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.freeradbiomed.2017.01.004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006383942"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/prca.201400164", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006939206"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.gtc.2011.12.004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006964714"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cmet.2015.12.006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006979730"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.abb.2013.12.019", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007814874"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00280-008-0902-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009614650", 
              "https://doi.org/10.1007/s00280-008-0902-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00280-008-0902-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009614650", 
              "https://doi.org/10.1007/s00280-008-0902-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/med.20239", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009674536"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1155/2015/690492", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009965457"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1245/s10434-007-9583-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010878884", 
              "https://doi.org/10.1245/s10434-007-9583-5"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3390/molecules200813689", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011417235"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3390/molecules200813689", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011417235"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0163-7258(90)90094-i", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011695626"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0163-7258(90)90094-i", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011695626"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0140-6736(10)62307-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013414907"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10585-011-9376-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015207925", 
              "https://doi.org/10.1007/s10585-011-9376-x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.canlet.2015.11.032", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016249809"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1600-0854.2011.01225.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017346916"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/bcp.13021", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017447596"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/onc.2016.353", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017555795", 
              "https://doi.org/10.1038/onc.2016.353"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/(sici)1522-2683(19991001)20:14<2952::aid-elps2952>3.0.co;2-h", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024839499"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-2407-10-598", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025706542", 
              "https://doi.org/10.1186/1471-2407-10-598"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.bcmd.2005.12.001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026104648"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/labinvest.2014.128", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026713479", 
              "https://doi.org/10.1038/labinvest.2014.128"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-3-642-81488-4_30", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027174024", 
              "https://doi.org/10.1007/978-3-642-81488-4_30"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3322/caac.21149", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027213871"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ijc.25431", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028934946"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ijc.25431", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028934946"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3389/fonc.2015.00138", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029023709"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/316817a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031296454", 
              "https://doi.org/10.1038/316817a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-07-0440", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031556735"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/ac0348625", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032462723"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/ac0348625", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032462723"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1530/erc-15-0019", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036217439"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.1985910", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036259666"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc3982", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036508003", 
              "https://doi.org/10.1038/nrc3982"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.semcancer.2015.04.001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038291332"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/pr700758r", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038395269"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nprot.2008.211", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039987283", 
              "https://doi.org/10.1038/nprot.2008.211"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0030219", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041064451"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/pr4010184", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041558428"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1039/c2mb25268f", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043899963"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/cddis.2014.558", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044063463", 
              "https://doi.org/10.1038/cddis.2014.558"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-07-6389", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044480154"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.5009/gnl.2013.7.6.739", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045545509"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.18632/oncotarget.11405", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045579696"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.bcp.2011.12.037", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045750768"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2012.01.058", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046605803"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.canlet.2012.03.007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047083402"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nmeth1088", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051930348", 
              "https://doi.org/10.1038/nmeth1088"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/cb4004173", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055226484"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1089/ars.2006.8.1249", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1059230372"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3748/wjg.v22.i42.9288", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1071374144"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1077404152", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1078569379", 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/bjc.2017.18", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1083523365", 
              "https://doi.org/10.1038/bjc.2017.18"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2017-12", 
        "datePublishedReg": "2017-12-01", 
        "description": "Pancreatic cancer is a lethal disease with poor prognosis. Gemcitabine has been the first line systemic treatment for pancreatic cancer. However, the rapid development of drug\u00a0resistance has been a major hurdle in gemcitabine therapy leading to unsatisfactory patient outcomes. With the recent renewed understanding of glutamine metabolism involvement in drug resistance and immuno-response, we investigated the anti-tumor effect of a glutamine analog (6-diazo-5-oxo-L-norleucine) as an adjuvant treatment to sensitize chemoresistant pancreatic cancer cells. We demonstrate that disruption of glutamine metabolic pathways improves the efficacy of gemcitabine treatment. Such a disruption induces a cascade of events which impacts glycan biosynthesis through Hexosamine Biosynthesis Pathway (HBP), as well as cellular redox homeostasis, resulting in global changes in protein glycosylation, expression and functional effects. The proteome alterations induced in the resistant cancer cells and the secreted exosomes are intricately associated with the reduction in cell proliferation and the enhancement of cancer cell chemosensitivity. Proteins associated with EGFR signaling, including downstream AKT-mTOR pathways, MAPK pathway, as well as redox enzymes were downregulated in response to disruption of glutamine metabolic pathways.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/s41598-017-08436-6", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.2421464", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.3536350", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1045337", 
            "issn": [
              "2045-2322"
            ], 
            "name": "Scientific Reports", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "1", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "7"
          }
        ], 
        "name": "Disrupting glutamine metabolic pathways to sensitize gemcitabine-resistant pancreatic cancer", 
        "pagination": "7950", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "8228bfd3b8494b5db5ab6ddcf7b10334b38dce7e4b96aa41be154a8be490524f"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "28801576"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "101563288"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/s41598-017-08436-6"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1091090392"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/s41598-017-08436-6", 
          "https://app.dimensions.ai/details/publication/pub.1091090392"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-11T13:24", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000369_0000000369/records_68965_00000001.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://www.nature.com/articles/s41598-017-08436-6"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41598-017-08436-6'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41598-017-08436-6'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41598-017-08436-6'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41598-017-08436-6'


     

    This table displays all metadata directly associated to this object as RDF triples.

    363 TRIPLES      21 PREDICATES      97 URIs      34 LITERALS      22 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/s41598-017-08436-6 schema:about N1a1928ed9b8e48749751b2a1c7add369
    2 N4e74216f103a4dfc8d8dfadd75c4a285
    3 N59c23dd51bfb41eab584099e66b6d724
    4 N68318c3aa3c04dbaa38bb28c4bf2afd2
    5 N6db1b06261da4e6cbff6561dc0111c25
    6 N77260f69492d4ca6ac5e65f8c7a3b847
    7 N8dd1f0f8dbe54ce4bbd0cd9427224763
    8 N8f25385da4b94a3e9cf557dc3a392064
    9 Na731c80f1246418a8dc8fcb1285722c2
    10 Naf03c800541c49b389590fcc038e6925
    11 Nd8db34d4b4a24e7f80cb088249e35ef6
    12 Ndc0af2e9221740e9b004aefaa9c7eaec
    13 Ne10a7e3dd113484e9292abffa2693d88
    14 anzsrc-for:06
    15 anzsrc-for:0601
    16 schema:author N44c56818ef0a425bbcf9f7e161a41044
    17 schema:citation sg:pub.10.1007/978-3-642-81488-4_30
    18 sg:pub.10.1007/s00280-008-0902-8
    19 sg:pub.10.1007/s10585-011-9376-x
    20 sg:pub.10.1038/316817a0
    21 sg:pub.10.1038/bjc.2017.18
    22 sg:pub.10.1038/cddis.2014.558
    23 sg:pub.10.1038/labinvest.2014.128
    24 sg:pub.10.1038/nature12040
    25 sg:pub.10.1038/nmeth1088
    26 sg:pub.10.1038/nprot.2008.211
    27 sg:pub.10.1038/nrc3982
    28 sg:pub.10.1038/onc.2016.353
    29 sg:pub.10.1186/1471-2407-10-598
    30 sg:pub.10.1245/s10434-007-9583-5
    31 https://app.dimensions.ai/details/publication/pub.1077404152
    32 https://app.dimensions.ai/details/publication/pub.1078569379
    33 https://doi.org/10.1002/(sici)1522-2683(19991001)20:14<2952::aid-elps2952>3.0.co;2-h
    34 https://doi.org/10.1002/ijc.25431
    35 https://doi.org/10.1002/med.20239
    36 https://doi.org/10.1002/prca.201400164
    37 https://doi.org/10.1016/0163-7258(90)90094-i
    38 https://doi.org/10.1016/j.abb.2013.12.019
    39 https://doi.org/10.1016/j.bbagen.2012.03.017
    40 https://doi.org/10.1016/j.bcmd.2005.12.001
    41 https://doi.org/10.1016/j.bcp.2011.12.037
    42 https://doi.org/10.1016/j.canlet.2012.03.007
    43 https://doi.org/10.1016/j.canlet.2015.11.032
    44 https://doi.org/10.1016/j.cell.2012.01.058
    45 https://doi.org/10.1016/j.cmet.2015.12.006
    46 https://doi.org/10.1016/j.freeradbiomed.2017.01.004
    47 https://doi.org/10.1016/j.gtc.2011.12.004
    48 https://doi.org/10.1016/j.semcancer.2015.04.001
    49 https://doi.org/10.1016/s0140-6736(10)62307-0
    50 https://doi.org/10.1021/ac0348625
    51 https://doi.org/10.1021/cb4004173
    52 https://doi.org/10.1021/pr4010184
    53 https://doi.org/10.1021/pr700758r
    54 https://doi.org/10.1039/c2mb25268f
    55 https://doi.org/10.1089/ars.2006.8.1249
    56 https://doi.org/10.1101/gad.1985910
    57 https://doi.org/10.1111/bcp.13021
    58 https://doi.org/10.1111/j.1600-0854.2011.01225.x
    59 https://doi.org/10.1155/2015/690492
    60 https://doi.org/10.1158/0008-5472.can-07-0440
    61 https://doi.org/10.1158/0008-5472.can-07-6389
    62 https://doi.org/10.1158/1078-0432.ccr-08-1366
    63 https://doi.org/10.1158/1078-0432.ccr-09-3331
    64 https://doi.org/10.1371/journal.pone.0030219
    65 https://doi.org/10.1530/erc-15-0019
    66 https://doi.org/10.18632/oncotarget.11405
    67 https://doi.org/10.3322/caac.21149
    68 https://doi.org/10.3389/fonc.2015.00138
    69 https://doi.org/10.3390/molecules200813689
    70 https://doi.org/10.3748/wjg.v22.i42.9288
    71 https://doi.org/10.5009/gnl.2013.7.6.739
    72 schema:datePublished 2017-12
    73 schema:datePublishedReg 2017-12-01
    74 schema:description Pancreatic cancer is a lethal disease with poor prognosis. Gemcitabine has been the first line systemic treatment for pancreatic cancer. However, the rapid development of drug resistance has been a major hurdle in gemcitabine therapy leading to unsatisfactory patient outcomes. With the recent renewed understanding of glutamine metabolism involvement in drug resistance and immuno-response, we investigated the anti-tumor effect of a glutamine analog (6-diazo-5-oxo-L-norleucine) as an adjuvant treatment to sensitize chemoresistant pancreatic cancer cells. We demonstrate that disruption of glutamine metabolic pathways improves the efficacy of gemcitabine treatment. Such a disruption induces a cascade of events which impacts glycan biosynthesis through Hexosamine Biosynthesis Pathway (HBP), as well as cellular redox homeostasis, resulting in global changes in protein glycosylation, expression and functional effects. The proteome alterations induced in the resistant cancer cells and the secreted exosomes are intricately associated with the reduction in cell proliferation and the enhancement of cancer cell chemosensitivity. Proteins associated with EGFR signaling, including downstream AKT-mTOR pathways, MAPK pathway, as well as redox enzymes were downregulated in response to disruption of glutamine metabolic pathways.
    75 schema:genre research_article
    76 schema:inLanguage en
    77 schema:isAccessibleForFree true
    78 schema:isPartOf N6769cbc3f8a8402ab3ae5e26f47b645d
    79 Ne0b9eb766932424fbbf99e056eeebcf3
    80 sg:journal.1045337
    81 schema:name Disrupting glutamine metabolic pathways to sensitize gemcitabine-resistant pancreatic cancer
    82 schema:pagination 7950
    83 schema:productId N0cc88da701584422a09de19825c9b0ea
    84 N7a95211366b14a33865762bed6b6c5b0
    85 Na6f855fdea174f8083af1dc13faf98c6
    86 Nc96603ecc2c547bc869c45a00b00abdf
    87 Ndf0cea2221ee42f2a8492ac82bcb4cb0
    88 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091090392
    89 https://doi.org/10.1038/s41598-017-08436-6
    90 schema:sdDatePublished 2019-04-11T13:24
    91 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    92 schema:sdPublisher N361cee0894fa411f8c2380a8404f7606
    93 schema:url https://www.nature.com/articles/s41598-017-08436-6
    94 sgo:license sg:explorer/license/
    95 sgo:sdDataset articles
    96 rdf:type schema:ScholarlyArticle
    97 N03a974a3a23d46a298ae0657be7fd511 schema:affiliation https://www.grid.ac/institutes/grid.34477.33
    98 schema:familyName Wang
    99 schema:givenName Lei
    100 rdf:type schema:Person
    101 N0cc88da701584422a09de19825c9b0ea schema:name dimensions_id
    102 schema:value pub.1091090392
    103 rdf:type schema:PropertyValue
    104 N1a1928ed9b8e48749751b2a1c7add369 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    105 schema:name Humans
    106 rdf:type schema:DefinedTerm
    107 N23bcec45392c49deabcd99c6b85c2967 rdf:first N6b556fe24cc64fd39ec189da3afbbf1a
    108 rdf:rest N297b8977e77c455ba1de6ee6b82d1244
    109 N297b8977e77c455ba1de6ee6b82d1244 rdf:first Nc44865c7c65f4fe98ee144a0037c5b50
    110 rdf:rest N351029ef531f416c97968a1232a5af6f
    111 N30179779216d42e98358e8cbeed949da rdf:first Nb43e7c0e36e34b9488b929c01191a8ae
    112 rdf:rest Nac4c4e96ce85412bb83310e245bf4291
    113 N351029ef531f416c97968a1232a5af6f rdf:first sg:person.01135135021.15
    114 rdf:rest N56d57454c0284edb9e7bae9e1847b436
    115 N361cee0894fa411f8c2380a8404f7606 schema:name Springer Nature - SN SciGraph project
    116 rdf:type schema:Organization
    117 N44c56818ef0a425bbcf9f7e161a41044 rdf:first sg:person.0674537271.69
    118 rdf:rest N7bed6f51cba0470cb518cfbafe1c0b49
    119 N4e74216f103a4dfc8d8dfadd75c4a285 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    120 schema:name Proteomics
    121 rdf:type schema:DefinedTerm
    122 N56d57454c0284edb9e7bae9e1847b436 rdf:first sg:person.01036061773.00
    123 rdf:rest N85f96cd73bb84f6c934508e71f217934
    124 N59c23dd51bfb41eab584099e66b6d724 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    125 schema:name Glutamine
    126 rdf:type schema:DefinedTerm
    127 N64ec43a143584b1b967b4ac69aa9a2ba rdf:first N03a974a3a23d46a298ae0657be7fd511
    128 rdf:rest N23bcec45392c49deabcd99c6b85c2967
    129 N6769cbc3f8a8402ab3ae5e26f47b645d schema:volumeNumber 7
    130 rdf:type schema:PublicationVolume
    131 N68318c3aa3c04dbaa38bb28c4bf2afd2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    132 schema:name Deoxycytidine
    133 rdf:type schema:DefinedTerm
    134 N6b556fe24cc64fd39ec189da3afbbf1a schema:affiliation https://www.grid.ac/institutes/grid.420530.0
    135 schema:familyName Riddell
    136 schema:givenName Jonah
    137 rdf:type schema:Person
    138 N6db1b06261da4e6cbff6561dc0111c25 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    139 schema:name Oxidation-Reduction
    140 rdf:type schema:DefinedTerm
    141 N77260f69492d4ca6ac5e65f8c7a3b847 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    142 schema:name Cell Proliferation
    143 rdf:type schema:DefinedTerm
    144 N7a95211366b14a33865762bed6b6c5b0 schema:name doi
    145 schema:value 10.1038/s41598-017-08436-6
    146 rdf:type schema:PropertyValue
    147 N7bed6f51cba0470cb518cfbafe1c0b49 rdf:first sg:person.01167466371.58
    148 rdf:rest N30179779216d42e98358e8cbeed949da
    149 N85f96cd73bb84f6c934508e71f217934 rdf:first sg:person.01302214013.32
    150 rdf:rest rdf:nil
    151 N8dd1f0f8dbe54ce4bbd0cd9427224763 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    152 schema:name Cell Line, Tumor
    153 rdf:type schema:DefinedTerm
    154 N8f25385da4b94a3e9cf557dc3a392064 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    155 schema:name Drug Synergism
    156 rdf:type schema:DefinedTerm
    157 Na6f855fdea174f8083af1dc13faf98c6 schema:name nlm_unique_id
    158 schema:value 101563288
    159 rdf:type schema:PropertyValue
    160 Na731c80f1246418a8dc8fcb1285722c2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    161 schema:name Diazooxonorleucine
    162 rdf:type schema:DefinedTerm
    163 Nac4c4e96ce85412bb83310e245bf4291 rdf:first Nd2c87c534eaa4caeab9a58eba22692cc
    164 rdf:rest N64ec43a143584b1b967b4ac69aa9a2ba
    165 Naf03c800541c49b389590fcc038e6925 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    166 schema:name Pancreatic Neoplasms
    167 rdf:type schema:DefinedTerm
    168 Nb43e7c0e36e34b9488b929c01191a8ae schema:affiliation https://www.grid.ac/institutes/grid.34477.33
    169 schema:familyName Sullivan
    170 schema:givenName Yumi
    171 rdf:type schema:Person
    172 Nc44865c7c65f4fe98ee144a0037c5b50 schema:affiliation https://www.grid.ac/institutes/grid.420530.0
    173 schema:familyName Jung
    174 schema:givenName Linda
    175 rdf:type schema:Person
    176 Nc96603ecc2c547bc869c45a00b00abdf schema:name pubmed_id
    177 schema:value 28801576
    178 rdf:type schema:PropertyValue
    179 Nd2c87c534eaa4caeab9a58eba22692cc schema:affiliation https://www.grid.ac/institutes/grid.34477.33
    180 schema:familyName Wong
    181 schema:givenName Melissa
    182 rdf:type schema:Person
    183 Nd8db34d4b4a24e7f80cb088249e35ef6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    184 schema:name Metabolic Networks and Pathways
    185 rdf:type schema:DefinedTerm
    186 Ndc0af2e9221740e9b004aefaa9c7eaec schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    187 schema:name Drug Resistance, Neoplasm
    188 rdf:type schema:DefinedTerm
    189 Ndf0cea2221ee42f2a8492ac82bcb4cb0 schema:name readcube_id
    190 schema:value 8228bfd3b8494b5db5ab6ddcf7b10334b38dce7e4b96aa41be154a8be490524f
    191 rdf:type schema:PropertyValue
    192 Ne0b9eb766932424fbbf99e056eeebcf3 schema:issueNumber 1
    193 rdf:type schema:PublicationIssue
    194 Ne10a7e3dd113484e9292abffa2693d88 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    195 schema:name Cell Survival
    196 rdf:type schema:DefinedTerm
    197 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    198 schema:name Biological Sciences
    199 rdf:type schema:DefinedTerm
    200 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
    201 schema:name Biochemistry and Cell Biology
    202 rdf:type schema:DefinedTerm
    203 sg:grant.2421464 http://pending.schema.org/fundedItem sg:pub.10.1038/s41598-017-08436-6
    204 rdf:type schema:MonetaryGrant
    205 sg:grant.3536350 http://pending.schema.org/fundedItem sg:pub.10.1038/s41598-017-08436-6
    206 rdf:type schema:MonetaryGrant
    207 sg:journal.1045337 schema:issn 2045-2322
    208 schema:name Scientific Reports
    209 rdf:type schema:Periodical
    210 sg:person.01036061773.00 schema:affiliation https://www.grid.ac/institutes/grid.34477.33
    211 schema:familyName Brentnall
    212 schema:givenName Teresa A.
    213 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01036061773.00
    214 rdf:type schema:Person
    215 sg:person.01135135021.15 schema:affiliation https://www.grid.ac/institutes/grid.34477.33
    216 schema:familyName Pillarisetty
    217 schema:givenName Venu G.
    218 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01135135021.15
    219 rdf:type schema:Person
    220 sg:person.01167466371.58 schema:affiliation https://www.grid.ac/institutes/grid.34477.33
    221 schema:familyName Lai
    222 schema:givenName Lisa A
    223 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01167466371.58
    224 rdf:type schema:Person
    225 sg:person.01302214013.32 schema:affiliation https://www.grid.ac/institutes/grid.34477.33
    226 schema:familyName Pan
    227 schema:givenName Sheng
    228 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01302214013.32
    229 rdf:type schema:Person
    230 sg:person.0674537271.69 schema:affiliation https://www.grid.ac/institutes/grid.34477.33
    231 schema:familyName Chen
    232 schema:givenName Ru
    233 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0674537271.69
    234 rdf:type schema:Person
    235 sg:pub.10.1007/978-3-642-81488-4_30 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027174024
    236 https://doi.org/10.1007/978-3-642-81488-4_30
    237 rdf:type schema:CreativeWork
    238 sg:pub.10.1007/s00280-008-0902-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009614650
    239 https://doi.org/10.1007/s00280-008-0902-8
    240 rdf:type schema:CreativeWork
    241 sg:pub.10.1007/s10585-011-9376-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1015207925
    242 https://doi.org/10.1007/s10585-011-9376-x
    243 rdf:type schema:CreativeWork
    244 sg:pub.10.1038/316817a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031296454
    245 https://doi.org/10.1038/316817a0
    246 rdf:type schema:CreativeWork
    247 sg:pub.10.1038/bjc.2017.18 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083523365
    248 https://doi.org/10.1038/bjc.2017.18
    249 rdf:type schema:CreativeWork
    250 sg:pub.10.1038/cddis.2014.558 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044063463
    251 https://doi.org/10.1038/cddis.2014.558
    252 rdf:type schema:CreativeWork
    253 sg:pub.10.1038/labinvest.2014.128 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026713479
    254 https://doi.org/10.1038/labinvest.2014.128
    255 rdf:type schema:CreativeWork
    256 sg:pub.10.1038/nature12040 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005310785
    257 https://doi.org/10.1038/nature12040
    258 rdf:type schema:CreativeWork
    259 sg:pub.10.1038/nmeth1088 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051930348
    260 https://doi.org/10.1038/nmeth1088
    261 rdf:type schema:CreativeWork
    262 sg:pub.10.1038/nprot.2008.211 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039987283
    263 https://doi.org/10.1038/nprot.2008.211
    264 rdf:type schema:CreativeWork
    265 sg:pub.10.1038/nrc3982 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036508003
    266 https://doi.org/10.1038/nrc3982
    267 rdf:type schema:CreativeWork
    268 sg:pub.10.1038/onc.2016.353 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017555795
    269 https://doi.org/10.1038/onc.2016.353
    270 rdf:type schema:CreativeWork
    271 sg:pub.10.1186/1471-2407-10-598 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025706542
    272 https://doi.org/10.1186/1471-2407-10-598
    273 rdf:type schema:CreativeWork
    274 sg:pub.10.1245/s10434-007-9583-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010878884
    275 https://doi.org/10.1245/s10434-007-9583-5
    276 rdf:type schema:CreativeWork
    277 https://app.dimensions.ai/details/publication/pub.1077404152 schema:CreativeWork
    278 https://app.dimensions.ai/details/publication/pub.1078569379 schema:CreativeWork
    279 https://doi.org/10.1002/(sici)1522-2683(19991001)20:14<2952::aid-elps2952>3.0.co;2-h schema:sameAs https://app.dimensions.ai/details/publication/pub.1024839499
    280 rdf:type schema:CreativeWork
    281 https://doi.org/10.1002/ijc.25431 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028934946
    282 rdf:type schema:CreativeWork
    283 https://doi.org/10.1002/med.20239 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009674536
    284 rdf:type schema:CreativeWork
    285 https://doi.org/10.1002/prca.201400164 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006939206
    286 rdf:type schema:CreativeWork
    287 https://doi.org/10.1016/0163-7258(90)90094-i schema:sameAs https://app.dimensions.ai/details/publication/pub.1011695626
    288 rdf:type schema:CreativeWork
    289 https://doi.org/10.1016/j.abb.2013.12.019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007814874
    290 rdf:type schema:CreativeWork
    291 https://doi.org/10.1016/j.bbagen.2012.03.017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003757679
    292 rdf:type schema:CreativeWork
    293 https://doi.org/10.1016/j.bcmd.2005.12.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026104648
    294 rdf:type schema:CreativeWork
    295 https://doi.org/10.1016/j.bcp.2011.12.037 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045750768
    296 rdf:type schema:CreativeWork
    297 https://doi.org/10.1016/j.canlet.2012.03.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047083402
    298 rdf:type schema:CreativeWork
    299 https://doi.org/10.1016/j.canlet.2015.11.032 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016249809
    300 rdf:type schema:CreativeWork
    301 https://doi.org/10.1016/j.cell.2012.01.058 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046605803
    302 rdf:type schema:CreativeWork
    303 https://doi.org/10.1016/j.cmet.2015.12.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006979730
    304 rdf:type schema:CreativeWork
    305 https://doi.org/10.1016/j.freeradbiomed.2017.01.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006383942
    306 rdf:type schema:CreativeWork
    307 https://doi.org/10.1016/j.gtc.2011.12.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006964714
    308 rdf:type schema:CreativeWork
    309 https://doi.org/10.1016/j.semcancer.2015.04.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038291332
    310 rdf:type schema:CreativeWork
    311 https://doi.org/10.1016/s0140-6736(10)62307-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013414907
    312 rdf:type schema:CreativeWork
    313 https://doi.org/10.1021/ac0348625 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032462723
    314 rdf:type schema:CreativeWork
    315 https://doi.org/10.1021/cb4004173 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055226484
    316 rdf:type schema:CreativeWork
    317 https://doi.org/10.1021/pr4010184 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041558428
    318 rdf:type schema:CreativeWork
    319 https://doi.org/10.1021/pr700758r schema:sameAs https://app.dimensions.ai/details/publication/pub.1038395269
    320 rdf:type schema:CreativeWork
    321 https://doi.org/10.1039/c2mb25268f schema:sameAs https://app.dimensions.ai/details/publication/pub.1043899963
    322 rdf:type schema:CreativeWork
    323 https://doi.org/10.1089/ars.2006.8.1249 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059230372
    324 rdf:type schema:CreativeWork
    325 https://doi.org/10.1101/gad.1985910 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036259666
    326 rdf:type schema:CreativeWork
    327 https://doi.org/10.1111/bcp.13021 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017447596
    328 rdf:type schema:CreativeWork
    329 https://doi.org/10.1111/j.1600-0854.2011.01225.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1017346916
    330 rdf:type schema:CreativeWork
    331 https://doi.org/10.1155/2015/690492 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009965457
    332 rdf:type schema:CreativeWork
    333 https://doi.org/10.1158/0008-5472.can-07-0440 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031556735
    334 rdf:type schema:CreativeWork
    335 https://doi.org/10.1158/0008-5472.can-07-6389 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044480154
    336 rdf:type schema:CreativeWork
    337 https://doi.org/10.1158/1078-0432.ccr-08-1366 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001228343
    338 rdf:type schema:CreativeWork
    339 https://doi.org/10.1158/1078-0432.ccr-09-3331 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004699819
    340 rdf:type schema:CreativeWork
    341 https://doi.org/10.1371/journal.pone.0030219 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041064451
    342 rdf:type schema:CreativeWork
    343 https://doi.org/10.1530/erc-15-0019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036217439
    344 rdf:type schema:CreativeWork
    345 https://doi.org/10.18632/oncotarget.11405 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045579696
    346 rdf:type schema:CreativeWork
    347 https://doi.org/10.3322/caac.21149 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027213871
    348 rdf:type schema:CreativeWork
    349 https://doi.org/10.3389/fonc.2015.00138 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029023709
    350 rdf:type schema:CreativeWork
    351 https://doi.org/10.3390/molecules200813689 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011417235
    352 rdf:type schema:CreativeWork
    353 https://doi.org/10.3748/wjg.v22.i42.9288 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071374144
    354 rdf:type schema:CreativeWork
    355 https://doi.org/10.5009/gnl.2013.7.6.739 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045545509
    356 rdf:type schema:CreativeWork
    357 https://www.grid.ac/institutes/grid.34477.33 schema:alternateName University of Washington
    358 schema:name Department of Medicine, University of Washington, 98195, Seattle, WA, USA
    359 Department of Surgery, University of Washington, 98195, Seattle, WA, USA
    360 rdf:type schema:Organization
    361 https://www.grid.ac/institutes/grid.420530.0 schema:alternateName Cell Signaling Technology (United States)
    362 schema:name Cell Signaling Technology, Inc, 01923, Danvers, MA, USA
    363 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...